LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
Shackelford, David B., Abt, Evan, Gerken, Laurie, Vasquez, Debbie S., Seki, Atsuko, Leblanc, Mathias, Wei, Liu, Fishbein, Michael C., Czernin, Johannes, Mischel, Paul S., Shaw, Reuben J.·2013·Cancer Cell
Cited by (585)
Items 501–585 of 585
- A redox-dependent mechanism for AMPK dysregulation interrupts metabolic adaptation of cancer under glucose deprivationYounghwan Lee, Yoko Itahana, Choon Chen Ong, Koji Itahana · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancerPhaedra C. Ghazi, Kayla T. O’Toole, Sanjana Srinivas Boggaram, Michael T. Scherzer, Mark R. Silvis, Yun Zhang, Madhumita Jagannathan‐Bogdan, Bryan D. Smith, Guillermina Lozano, Daniel Lee Flynn et al. · 2024 · eLife
- Modeling compound lipid homeostasis using stable isotope tracingKarl A. Wessendorf-Rodriguez, Maureen L. Ruchhoeft, Ethan L. Ashley, Hector M. Galvez, Christopher W. Murray, Yi Huang, Grace H. McGregor, Shrikaar Kambhampati, Reuben J. Shaw, Christian M. Metallo · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activityZhen Sun, Bernard Linares, Cassidy Urdiales, Fiyad Al-sarmi, Nagireddy Putluri, Jeanine L. Van Nostrand · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Top 100 most-cited articles on apoptosis of non-small cell lung cancer over the past two decades: a bibliometrics analysisLin Ma, Jing Zhang, Zi Dai, Pei Liao, Jieshan Guan, Zhijie Luo · 2025 · Frontiers in Immunology
- Alu-Sc-mediated exonization generated a mitochondrial LKB1 gene variant found only in higher order primatesIvan Tan, Sonia Pankaj Chothani, Hong Hwa Lim, Kong‐Peng Lam · 2025 · Scientific Reports
- Re/99mTc Tricarbonyl Phenformin Complexes Targeting Mitochondria as Pancreatic Cancer TheranosticsChiyi Xiong, Boping Jing, Qizhen Cao, Junjie Li, Merve Alpay, Haiyan Chen, Wai-Kin Chan, Huamin Wang, Amir Mohammad Gholizadeh, Diana S‐L Chow et al. · 2025 · Journal of Medicinal Chemistry
- Mitochondrial reprogramming in lung cancer: a therapeutic vulnerability and a strategy for reversing drug resistanceWoo Hyun Park · 2026 · The Journal of Pathology
- LKB1 inactivation elicits an NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancerWen Mi, Xinyi Xia, Yun Xue, Liucheng Li, Li Yang, Xincheng Yang, Jie Xu, Xinlei Cai, Yijia Zhou, Lingzhi Zhu et al. · 2026 · Cell Reports
- Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in non-small cell lung cancerPeiqiang Yan, Weiwei Jiang, Xutong Xue, Tao Hou, Jingchao Wang, Daoyuan Huang, Li Chen, Hiroyuki Inuzuka, Xiaoming Dai, Wenyi Wei · 2026 · Cancer Letters
- Biologie moléculaire et prise en charge des patients atteints d’adénocarcinomes du poumonLaure Gibault, Aurélie Cazes, Céline Narjoz, Hélène Blons · 2014 · Revue de Pneumologie Clinique
- Oxidative Stress in Cell Signaling and Cell Fate Determination Under Glucose StarvationYi Ren, Charlie Cheong, Han‐Ming Shen · 2021 · Springer eBooks
- Monitoring vascular normalization: new opportunities for mitochondrial inhibitors in breast cancerSilvana Andrea Mouron, María J. Bueno, Manuel Muñoz, Miguel Quintela-Fino · 2021 · Oncoscience
- Targeting Fatty Acid Metabolism in Head and Neck CancerJi Hoon Kim, Minhee Ku, Jaemoon Yang, Hyung Kwon Byeon · 2021 · Korean Journal of Otorhinolaryngology - Head and Neck Surgery
- Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung CancerMilica Momcilovic, Sean T. Bailey, Jason T. Lee, Charles Zamilpa, Anthony Jones, G. A. Abdelhady, James Robert Mansfield, Kevin P. Francis, David B. Shackelford · 2018 · Journal of Visualized Experiments
- Improving platinum-based treatments for advanced non-small cell lung cancerAda W.Y. Leung · 2016 · cIRcle (University of British Columbia)
- A polypeptide D-TTK001 targeting HBx controls cccDNA against HBVXiaodong Zhang, Hongfeng Yuan, Shuai Zhang, Shuqin Zhang, Lina Zhao, Hongwei Gao, Guang Yang, Shuai Zhang, Haolin Yun, Changliang Shan et al. · 2020 · Research Square
- Metformin Resistant MDA-MB-468 Cells Exhibit EMT-like Phenotype and Increased Migration CapacityŞahika Cıngır Köker, Banu Yalçin, İrem Doğan · 2021 · Research Square
- Metformin decreases Cyp26a1 to prevent hepatocarcinogenesis through down- regulating CD8 + T cellsWeizhi He, Miaomiao Chen, Chong V. Li, Xicheng Wang, Wenjian Chen, Lili Pan, Yangyang Cui, Yu Zhao, Guoxiu Wu, Yang Yang et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS -mutant lung cancersChendi Li, Mohammed Usman Syed, Anahita Nimbalkar, Yi Shen, Cameron Fraser, Zintis Inde, Xingping Qin, Jian Ouyang, Johannes Kreuzer, Sarah Elizabeth Clark et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancerPhaedra C. Ghazi, Kayla T. O’Toole, Sanjana Srinivas Boggaram, Michael T. Scherzer, Mark R. Silvis, Yun Zhang, Madhumita Jagannathan‐Bogdan, Bryan D. Smith, Guillermina Lozano, Daniel Lee Flynn et al. · 2024 · eLife
- Exposome du cancer : reprogrammation métabolique du cancer du poumon par les nitrosamines spécifiques de la fumée de tabacSaharnaz Sarlak · 2021 · theses.fr (ABES)
- THE METABOLOMIC EFFECTS OF METFORMIN ON COLON CANCERJennifer W. Harris · 2015 · UKnowledge (University of Kentucky)
- Targeting Redox Homeostasis in LKB1-deficient NSCLCJamey D. Young, Young Mi Whang · 2014 · Defense Technical Information Center (DTIC)
- Novel Posttranslational Modification in LKB1 Activation and FunctionSzu-Wei Lee · 2014 · Digital Commons-TMC (Texas Medical Center)
- Determining the Role of Autophagy in HER2/neu-Induced Mammary Tumor Dormancy and RecurrenceSamantha Dwyer · 2013 · Scholarly Commons (University of Pennsylvania)
- Metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in NCI-H460 human lung cancer cells* Metformina sinergicamente potencializa os efeitos antiproliferativos de cisplatina e etoposídeo em linhagem de células de câncer humano de pulmão NCI-H460Sarah Fernandes Teixeira, Ian Victor Silva, Letícia Batista Azevedo Rangel · 2013
- Metformin aktiviert im Duodenum einen AMPK-abhängigen SignalwegMarie‐Christine Simon · 2015 · Info Diabetologie
- Metformin and Cancer: past, present, futureCamille Loubière, Béatrice Dirat, Frédéric Bost · 2014
- Coactivation d’AMPK et de mTORC1Jérôme Tamburini, Laury Poulain, Didier Bouscary, Pierre Sujobert · 2015 · médecine/sciences
- Characterization of mTOR Inhibition and Autophagy Inhibition in Non-Small Cell Lung CancerRebecca R. Britt · 2014
- Biomarkers for Early Detection of Familial Breast CancerBurak Yılmaz, Catherine A. Moroski-Erkul, Ömer Faruk Hatipoğlu, Esra Gündüz, Debmalya Barh, Mehmet Gündüz · 2015 · CRC Press eBooks
- Omics of Hereditary Breast CancerCatherine A. Moroski-Erkul, Burak Yılmaz, Esra Gündüz, Mehmet Gündüz · 2014 · Springer eBooks
- Metformin as Adjuvant Therapy in Ovarian and Endometrial CancersLeslie Horn Clark, Victoria Lin Bae-Jump · 2017 · Energy balance and cancer
- Targeting CAIX with small moleculesParvathaneni · 2017
- An investigation of metabolic vulnerabilities in chronic myeloid leukaemic stem cellsElodie M. Kuntz · 2017 · Enlighten: Theses (The University of Glasgow)
- Investigating Cooperation between KEAP1 and LKB1 Inactivation in Lung AdenocarcinomaLandon J. Inge · 2017
- The role of respiration in supporting cell proliferationDan Y. Gui · 2017 · DSpace@MIT (Massachusetts Institute of Technology)
- ENHANCING RADIATION SENSITIVITY IN NON-SMALL CELL LUNG CANCERYifan Wang · 2018 · Digital Commons-TMC (Texas Medical Center)
- Mechanisms of activation and inhibition of the metabolic regulator AMP-activated protein kinase (AMPK)Toby A. Dite · 2018 · Minerva Access (University of Melbourne)
- Unravelling Lung Cancer Heterogeneity and Associated Therapeutic Responses using in vivo and ex vivo Model SystemsAshwini Sakrepatna Nagaraj · 2018 · Työväentutkimus Vuosikirja
- Liver Kinase B1 (LKB1) Loss Has its p-ERKs: ERK Inactivation as a Vulnerability in NSCLC With LKB1 MutationsIrati Macaya, Rodrigo Entrialgo‐Cadierno, Karmele Valencia, Silvestre Vicent · 2020 · Journal of Thoracic Oncology
- Crosstalk between PIM and LKB1 kinases regulates AMPK phosphorylation and tumorigenic growthKwan Long Mung, William B. Eccleshall, Niina M. Santio, Adolfo Rivero‐Müller, Päivi J. Koskinen · 2021 · Research Square
- BURNOUT IN HIGH PRESSURE WATER. AN APPRECIATION OF RECENT AMERICAN CORRELATIONSRobert W. Bowring, Huey A. Roberts, Richard W. Scott · 1958 · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
- Metformin Resistant MDA-MB-468 Cells Exhibit EMT-like Phenotype and Increased Migration CapacityŞahika Cıngır Köker, Banu Yalçin, İrem Doğan · 2021 · Research Square
- Faculty Opinions recommendation of The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.Kristiina Vuori, Ming Zhao · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Impacto da via de sinalização AMPK na modulação da resposta imune antitumoral por linfócitos T CD4>sup<+>/sup< e CD8>sup<+>/sup<Amanda Campelo Melo Feitosa · 2020 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- CAIXSimon Johannes Antonius van Kuijk · 2016
- Faculty Opinions recommendation of In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.Navdeep S. Chandel · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Data from Altered Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates an Exploitable VulnerabilityChen-Hua Chuang, Madeleine Dorsch, Philip Dujardin, Sukrit Silas, Kristina Ueffing, Johanna Maria Hölken, Dian Yang, Monte M. Winslow, Barbara M. Grüner · 2023
- Data from Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non–Small Cell Lung CancerRui Li, Ramin Salehi‐Rad, William Crosson, Milica Momcilovic, Raymond J. Lim, Stephanie L. Ong, Zi Ling Huang, Tian-hao Zhang, Jensen W. Abascal, Camelia Dumitras et al. · 2023
- Data from Quantitative In Vivo Analyses Reveal a Complex Pharmacogenomic Landscape in Lung AdenocarcinomaChuan Li, Wen-Yang Lin, Hira A. Rizvi, Hongchen Cai, Christopher D. McFarland, Zoe N. Rogers, Maryam Yousefi, Ian P. Winters, Charles M. Rudin, Dmitri A. Petrov et al. · 2023
- Data from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy ResponseVanessa E. Zannella, Alan Dal Pra, Hala Muaddi, Trevor D. McKee, Shawn Stapleton, Jenna R. Sykes, Rachel Glicksman, Selim Chaib, Paul Zamiara, Michael Milosevic et al. · 2023
- Data from LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung AdenocarcinomaBenjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos et al. · 2023
- Data from LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung AdenocarcinomaBenjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos et al. · 2023
- Data from Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell CarcinomaSanchareeka Dey, Adnin Ashrafi, Chantal Vidal, Nivesh Jain, Sarada Preeta Kalainayakan, Poorva Ghosh, Parinaz Sadat Alemi, Narges Salamat, Purna Chaitanya Konduri, Jung‐whan Kim et al. · 2023
- Data from Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell CarcinomaSanchareeka Dey, Adnin Ashrafi, Chantal Vidal, Nivesh Jain, Sarada Preeta Kalainayakan, Poorva Ghosh, Parinaz Sadat Alemi, Narges Salamat, Purna Chaitanya Konduri, Jung‐whan Kim et al. · 2023
- Nomogram of myelosuppression and survival prognosis in patients with brain metastases from non-small cell lung adenocarcinoma by intrathecal injection of pemetrexed via the Ommaya ReservoirJunhao Luo, Yue Shen, Bin Li, Xiangping Li · 2023 · Research Square
- eLife Assessment: Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancerRachel Evans · 2024 · eLife
- Reviewer #2 (Public Review): Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer2024 · eLife
- Author response: Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancerPhaedra C. Ghazi, Kayla T. O’Toole, Sanjana Srinivas Boggaram, Michael T. Scherzer, Mark R. Silvis, Yun Zhang, Madhumita Jagannathan‐Bogdan, Bryan D. Smith, Guillermina Lozano, Daniel Lee Flynn et al. · 2024 · eLife
- Additional file 3 of PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1Mung, Kwan Long, William B. Eccleshall, Niina M. Santio, Adolfo Rivero‐Müller, Päivi J. Koskinen · 2021 · Figshare
- Additional file 2 of PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1Mung, Kwan Long, William B. Eccleshall, Niina M. Santio, Adolfo Rivero‐Müller, Päivi J. Koskinen · 2021 · Figshare
- Additional file 1 of Effect of the STK11 mutation on therapeutic efficacy and prognosis in patients with non-small cell lung cancer: a comprehensive study based on meta-analyses and bioinformatics analysesXu, Ke, Weinan Lu, Airu Yu, Wu, Hongwei, He, Jie · 2024 · Figshare
- Effects of Metformin on Leukemia: Biological Mechanisms, Targets, and Treatment PossibilitiesParisa Dana, Abdolkhalegh Deezagi · 2025 · Journal of Blood and Cancer
- Hereditary cancer syndromes linked to oxidative phosphorylation insufficiencyBob Kaplan, Tomás Duraj, Derek C. Lee, Thomas N. Seyfried · 2025 · ONCOLOGIE
- OLD DRUG, NEW USES: A COMPREHENSIVE REVIEW OF THE EVOLVING ROLE OF METFORMIN IN ONCOLOGYBernard Myszewski, Maria Rajkowska, Aleksandra Włodarczyk, Norbert Grabias, Jędrzej Piotrowski, Paulina Jarząbek, Julia Weronika Mieszkowska, Radosław Gryko, Anna Kinga Tejchma, Łukasz Dominik Woźniak · 2026 · International Journal of Innovative Technologies in Social Science
- Caractérisation fonctionnelle du complexe LKB1/STRADß au cil primaire et les conséquences au cours de la tumorigenèsePauline Maurin · 2016 · theses.fr (ABES)
- Targeting CAIX with small molecules : design, synthesis and biological efficacyNanda Kumar Parvathaneni · 2017
- Biochemical characterization of mTORC1 regulation by glutamine metabolismClément Bodineau · 2020 · theses.fr (ABES)
- Chimiothérapie métronomique : stratégie thérapeutique prometteuse de prise en charge de l'hétérogénéité intratumorale par action sur le métabolisme énergétique pour contrôler la résistance aux traitements anti-cancéreuxMaryna Bondarenko · 2021 · theses.fr (ABES)
- Modulation of tumor immunogenicity with AMPK activation in acute myeloid leukemiaJohanna Mondésir · 2021 · theses.fr (ABES)
- EVT-701 : targeting electron transport chain complex I as therapeutic approach in cancerRaquel Luna Yolba · 2021 · theses.fr (ABES)
- Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activityZhen Sun, Bernard Linarés, Cassidy Urdiales, Fiyad Al-sarmi, Boyuan Sang, Nagireddy Putluri, Jeanine L. Van Nostrand · 2026 · Science Advances
- LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR InhibitionXueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie · 2026 · Molecular Carcinogenesis
- Antitumor efficacy of repurposed phenformin in preclinical models of epithelial ovarian cancerJae‐Joong Kim, Ju‐Yeon Choi, J D Seo, Young‐Jae Cho, Ji‐Yoon Ryu, Jae Ryoung Hwang, Jung‐Joo Choi, Jeong‐Won Lee · 2026 · Biomedicine & Pharmacotherapy
- SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinomaEmily A. Costa, Barbara Vaz de Mello, Corrin A. Wohlhieter, Subhiksha Nandakumar, Samuel Tischfield, Yingqian Ada Zhan, Harsha Sridhar, Dennis Kinyua, Elisa de Stanchina, Wenfei Kang et al. · 2026 · Translational Oncology
- The interplay between BECN1-mediated autophagy, metabolism and the cellular response to ionising radiationLingyi Cai, Verena Jendrossek, Johann Matschke, Silvia Vega-Rubín-de-Celis · 2026 · International review of cytology
- STK11/LKB1 Loss in Cancer: From Developmental Constraint to Stress-Adapted MalignancyYu Kang, Yanhong Gao, Xiaoyan Zhang, Hai-Ou Liu, Congjian Xu, Yanying Huo · 2026 · Cancers
- Disease-Oriented Drug Repurposing in Lung Cancer: Targeting Metabolic Plasticity and Therapy ResistanceTahereh Alinejad, Zeinab Alinejad, Reyhaneh Nekounam Ghadirli, Shabnam Modarresi, Subha Bhassu · 2026 · Pharmaceutical science.
- Geno-guided targeting of ferroptosis: a multi-layered network to overcome radioresistance in lung cancerShifang Sang, Guangchao Lv, Shiyun Feng, Hui Zhao, Yulong Ren, Dianlong Jin, Kaizhong Wang · 2026 · Frontiers in Cell and Developmental Biology
- Genes, fuel, and fate in lung cancerJulia S. Scott, Catrin Lutz, Stefan Preković · 2026 · Biochemical Society Transactions
- BindingDB Entry 50048921: New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.BindingDB · 2019 · UC San Diego
- BindingDB Entry 50015393: Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179.BindingDB · 2023 · UC San Diego
- Mechanisms and Molecular Biology of Major Tumor SuppressorsBrienne E. Engel · 2014 · Digital Commons - University of South Florida (University of South Florida)