LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

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Items 501–585 of 585

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  9. LKB1 inactivation elicits an NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer
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  12. Oxidative Stress in Cell Signaling and Cell Fate Determination Under Glucose Starvation
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  15. Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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  16. Improving platinum-based treatments for advanced non-small cell lung cancer
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  18. Metformin Resistant MDA-MB-468 Cells Exhibit EMT-like Phenotype and Increased Migration Capacity
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  19. Metformin decreases Cyp26a1 to prevent hepatocarcinogenesis through down- regulating CD8 + T cells
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  20. LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS -mutant lung cancers
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  21. Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer
    Phaedra C. Ghazi, Kayla T. O’Toole, Sanjana Srinivas Boggaram, Michael T. Scherzer, Mark R. Silvis, Yun Zhang, Madhumita Jagannathan‐Bogdan, Bryan D. Smith, Guillermina Lozano, Daniel Lee Flynn et al. · 2024 · eLife
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  24. Targeting Redox Homeostasis in LKB1-deficient NSCLC
    Jamey D. Young, Young Mi Whang · 2014 · Defense Technical Information Center (DTIC)
  25. Novel Posttranslational Modification in LKB1 Activation and Function
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  27. Metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in NCI-H460 human lung cancer cells* Metformina sinergicamente potencializa os efeitos antiproliferativos de cisplatina e etoposídeo em linhagem de células de câncer humano de pulmão NCI-H460
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  28. Metformin aktiviert im Duodenum einen AMPK-abhängigen Signalweg
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  29. Metformin and Cancer: past, present, future
    Camille Loubière, Béatrice Dirat, Frédéric Bost · 2014
  30. Coactivation d’AMPK et de mTORC1
    Jérôme Tamburini, Laury Poulain, Didier Bouscary, Pierre Sujobert · 2015 · médecine/sciences
  31. Characterization of mTOR Inhibition and Autophagy Inhibition in Non-Small Cell Lung Cancer
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  32. Biomarkers for Early Detection of Familial Breast Cancer
    Burak Yılmaz, Catherine A. Moroski-Erkul, Ömer Faruk Hatipoğlu, Esra Gündüz, Debmalya Barh, Mehmet Gündüz · 2015 · CRC Press eBooks
  33. Omics of Hereditary Breast Cancer
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  34. Metformin as Adjuvant Therapy in Ovarian and Endometrial Cancers
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  35. Targeting CAIX with small molecules
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  36. An investigation of metabolic vulnerabilities in chronic myeloid leukaemic stem cells
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  37. Investigating Cooperation between KEAP1 and LKB1 Inactivation in Lung Adenocarcinoma
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  39. ENHANCING RADIATION SENSITIVITY IN NON-SMALL CELL LUNG CANCER
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  40. Mechanisms of activation and inhibition of the metabolic regulator AMP-activated protein kinase (AMPK)
    Toby A. Dite · 2018 · Minerva Access (University of Melbourne)
  41. Unravelling Lung Cancer Heterogeneity and Associated Therapeutic Responses using in vivo and ex vivo Model Systems
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  42. Liver Kinase B1 (LKB1) Loss Has its p-ERKs: ERK Inactivation as a Vulnerability in NSCLC With LKB1 Mutations
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  43. Crosstalk between PIM and LKB1 kinases regulates AMPK phosphorylation and tumorigenic growth
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  45. Metformin Resistant MDA-MB-468 Cells Exhibit EMT-like Phenotype and Increased Migration Capacity
    Şahika Cıngır Köker, Banu Yalçin, İrem Doğan · 2021 · Research Square
  46. Faculty Opinions recommendation of The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.
    Kristiina Vuori, Ming Zhao · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  47. Impacto da via de sinalização AMPK na modulação da resposta imune antitumoral por linfócitos T CD4>sup<+>/sup< e CD8>sup<+>/sup<
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  48. CAIX
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  49. Faculty Opinions recommendation of In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
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  50. Data from Altered Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates an Exploitable Vulnerability
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  51. Data from Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non–Small Cell Lung Cancer
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  52. Data from Quantitative In Vivo Analyses Reveal a Complex Pharmacogenomic Landscape in Lung Adenocarcinoma
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  53. Data from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
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  54. Data from LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma
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  56. Data from Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma
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  62. Additional file 3 of PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1
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  63. Additional file 2 of PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1
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