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Targeting Metabolic Bottlenecks in Lung Cancer

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cGAS-STING Pathway as the Target of Immunotherapy for Lung Cancer

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Targeting Mutant KRAS for Anticancer Therapy

Chen, F., Alphonse, M. P., Liu, Y., & Liu, Q. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190902151307 · Cited by 15

The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation

Kim, I., Kim, M., Park, M. K., Naik, R., Park, J. H., Kim, B., Choi, Y., Chang, K. Y., Won, M., Ban, H. S., et al. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00523-5 · Cited by 16

PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1

Mung, K. L., Eccleshall, W. B., Santio, N. M., Rivero‐Müller, A., & Koskinen, P. J. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00749-4 · Cited by 16

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells

Hodeib, M., Ogrodzinski, M. P., Vergnes, L., Reue, K., Karlan, B. Y., Lunt, S. Y., & Aspuria, P.-J. P. (2017) · Oncotarget · doi:10.18632/oncotarget.23661 · Cited by 15

The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations

Wang, T., Guo, H., Li, Q., Wu, W., Yu, M., Zhang, L., Li, C., Song, J., Wang, Z., Zhang, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111210 · Cited by 15

Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8+ T cells

He, W., Wang, X., Chen, M., Li, C., Chen, W., Pan, L., Cui, Y., Yu, Z., Wu, G., Yang, Y., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1465 · Cited by 17

LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of PD-L1 protein in non-small cell lung cancer

Lv, L., Miao, Q., Zhan, S., Chen, P., Liu, W., Lv, J., Yan, W., Wang, D., Liu, H., Yin, J., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009444 · Cited by 15

Synergistic Effect of Novel EGFR Inhibitor AZD8931 and p38α siRNA in Lung Adenocarcinoma Cancer Cells

Zarredar, H., Farajnia, S., Ansarin, K., Baradaran, B., Aria, M., & Asadi, M. (2019) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520619666190301125203 · Cited by 16

The Marine-Derived Macrolactone Mandelalide A Is an Indirect Activator of AMPK

Mattos, D. R., Wan, X., Serrill, J., Nguyen, M. H., Humphreys, I., Viollet, B., Smith, A. B., McPhail, K. L., & Ishmael, J. E. (2022) · Marine Drugs · doi:10.3390/md20070418 · Cited by 16

EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition

Zucal, C., D’Agostino, V., Casini, A., Mantelli, B., Thongon, N., Soncini, D., Caffa, I., Cea, M., Ballestrero, A., Quattrone, A., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1845-1 · Cited by 15

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes

Coperchini, F., Croce, L., Denegri, M., Awwad, O., Ngnitejeu, S. T., Magri, F., Chiovato, L., & Rotondi, M. (2019) · Oncotarget · doi:10.18632/oncotarget.27266 · Cited by 15

High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy

Sun, X., Cai, X.-T., Li, S., Pi, R., Guo, Z.-Q., Jiang, J., Wang, P., Xiong, J., Liu, Z., Rong, Z., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102291 · Cited by 14

Cancer metabolism: targeting cancer universality

Kim, S. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0551-5 · Cited by 14

Effect of the STK11 mutation on therapeutic efficacy and prognosis in patients with non-small cell lung cancer: a comprehensive study based on meta-analyses and bioinformatics analyses

Xu, K., Lu, W., Yu, A., Wu, H., & He, J. (2024) · BMC Cancer · doi:10.1186/s12885-024-12130-y · Cited by 18

Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

Ghazi, P. C., O’Toole, K. T., Boggaram, S. S., Scherzer, M. T., Silvis, M. R., Zhang, Y., Jagannathan‐Bogdan, M., Smith, B. D., Lozano, G., Flynn, D. L., et al. (2024) · eLife · doi:10.7554/elife.96992 · Cited by 40

AMPK: An energy sensor for non-small cell lung cancer progression and treatment

Zhong, Z.-T., Wang, X., Pan, Y., Zhou, K., Chen, J.-H., Gao, Y., Dai, B., Zhou, Z., & Wang, R. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107592 · Cited by 16

Overview of KRAS‐Driven Genetically Engineered Mouse Models of Non‐Small Cell Lung Cancer

Sheridan, C., & Downward, J. (2015) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph1435s70 · Cited by 14

EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers

Yolba, R. L., Visentin, V., Hervé, C., Chiche, J., Ricci, J., Meneyrol, J., Paillasse, M. R., & Alet, N. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.854 · Cited by 12

Re-expression of LKB1 in LKB1-mutant EKVX cells leads to resistance to paclitaxel through the up-regulation of MDR1 expression

Mao, K., Liu, F., Liu, X., Khuri, F. R., Marcus, A. I., Li, M., & Zhou, W. (2015) · Lung Cancer · doi:10.1016/j.lungcan.2015.02.017 · Cited by 14

Metformine et cancer : de nouvelles perspectives pour un ancien médicament

Loubière, C., Dirat, B., Tanti, J., & Bost, F. (2013) · Annales d Endocrinologie · doi:10.1016/j.ando.2013.02.002 · Cited by 15

Multidrug and toxin extrusion 1 and human organic cation transporter 1 polymorphisms in patients with castration-resistant prostate cancer receiving metformin (SAKK 08/09)

Joerger, M., van Schaik, R. H. N., Becker, M. L., Hayoz, S., Pollak, M., Cathomas, R. L., Winterhalder, R., Gillessen, S., & Rothermundt, C. A. (2015) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2015.8 · Cited by 13

Cytoplasmic DNAs: Sources, sensing, and roles in the development of lung inflammatory diseases and cancer

He, X., Sun, Y., Lu, J., Naz, F., Ma, S., & Liu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1117760 · Cited by 14

Fine-tuning AMPK in physiology and disease using point-mutant mouse models

Ashraf, N., & Nostrand, J. L. V. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050798 · Cited by 14

Phenformin enhances the therapeutic effect of selumetinib in KRAS-mutant non-small cell lung cancer irrespective of LKB1 status

Zhang, J., Nannapaneni, S., Wang, D., Liu, F., Wang, X., Jin, R., Liu, X., Rahman, M. A., Peng, X., Qian, G., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19779 · Cited by 13

Metabolic Imaging as a Tool to Characterize Chemoresistance and Guide Therapy in Triple-Negative Breast Cancer (TNBC)

Sunassee, E. D., Jardim‐Perassi, B. V., Madonna, M. C., Ordway, B., & Ramanujam, N. (2023) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-1004 · Cited by 13

Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics

Arkwright, R. T., Deshmukh, R. R., Adapa, N., Stevens, R. A., Zonder, E., Zhang, Z., Farshi, P., Ahmed, R. S. I., El-Banna, H. A., Chan, T. H., et al. (2015) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520615666141216145417 · Cited by 15

Abstract 2449: Identifying therapy responsive and resistant LKB1 mutant non-small cell lung tumor populations

Abt, E. R., Momcilovic, M., Seki, A., McMickle, R., Stout, D., Fishbein, M. C., & Shackelford, D. B. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-2449

LKB1 Mutation Sensitizes NSCLC Cells to Phenformin

(2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2013-023 · Cited by 1

Abstract C114: The role of LKB1 and TP53 mutation status in determining sensitivity of non-small cell lung cancer cells to the metabolic inhibitors; metformin, phenformin and 2-DG

Cahill, F. F., Bokobza, S., Devery, A., Drobnitzky, N., Jiang, Y., Lourenço, L. M., Mumin, N. H., Weber, A. M., Ashton, T. M., & Ryan, A. J. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-15-c114

MA17.02 Identify Vulnerable Pathways and Improve Treatment Outcomes in LKB1-Deficient Lung Tumors

Welliver, M. X., Jin, F., Amann, J. M., Koenig, M. J., Mo, X. M., & Carbone, D. P. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.08.638

Heightening Energetic Stress Selectively Targets LKB1-Deficient Non–Small Cell Lung Cancers

Momcilovic, M., McMickle, R., Abt, E., Seki, A., Simko, S. A., Magyar, C., Stout, D. B., Fishbein, M. C., Walser, T. C., Dubinett, S. M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0797 · Cited by 46