Cited by 215Cellular transport and secretionAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Lysosome-related organelles: driving post-Golgi compartments into specialisation

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Raposo, Graça, Marks, Michael S, Cutler, Daniel F·2007·Current Opinion in Cell Biology

Abstract

Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct. Ubiquitous trafficking machineries cooperate with cell type specific cargoes to produce these organelles. Several genetic diseases are caused by dysfunctional LRO formation and/or motility. Many genes affected by these diseases have been recently identified, revealing new cellular components of the trafficking machinery. Current research reveals how the products of these genes cooperate to generate LROs and how these otherwise diverse organelles are related by the mechanisms through which they form.

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Crossref · 10.1016/j.ceb.2007.05.001

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Authors
Raposo, G., Marks, M. S., & Cutler, D. F.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • University of Pennsylvania (US)
  • MRC Laboratory for Molecular Cell Biology (GB)
Corresponding author
  • Raposo, Graça
  • Cutler, Daniel F
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2007-08
Volume
19
Issue
4
Pages
394-401
ISSN
0955-0674 (ISSN-L)
OpenAlex
W2062800617
Cited by
215
References
59
Citations by year
2026: 2 · 2025: 7 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 14 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 10 · 2016: 17 · 2015: 11 · 2014: 10 · 2013: 20 · 2012: 16
FWCI
1.24
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Centre National de la Recherche Scientifique
  • National Institutes of Health (5r01ar048155-13)
  • Medical Research Council
  • National Eye Institute (R01EY015625)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR-048155)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords
lysosome-related organelles, late endosomes, lysosomes, post-Golgi trafficking, organelle biogenesis, organelle motility, lysosomal storage disease
MeSH terms
rab27 GTP-Binding Proteins, Animals, Cell Compartmentation, Golgi Apparatus, Humans, Lysosomes, Endosomes, Organelles, Melanosomes, rab GTP-Binding Proteins, Protein Sorting Signals

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