Prioritizing cancer-related key miRNA-target interactions by integrative genomics
Open accessAbstract
Accumulating evidence indicates that microRNAs (miRNAs) can function as oncogenes or tumor suppressor genes by controlling few key targets, which in turn contribute to the pathogenesis of cancer. The identification of cancer-related key miRNA-target interactions remains a challenge. We performed a systematic analysis of known cancer-related key interactions manually curated from published papers based on different aspects including sequence, expression and function. Known cancer-related key interactions show more miRNA binding sites (especially for 8mer binding sites), more reliable binding of miRNA to the target region, higher expression associations and broader functional coverage when compared to non-disease-related interactions. Through integrating these sequence, expression and function features, we proposed a bioinformatics approach termed PCmtI to prioritize cancer-related key interactions. Ten-fold cross-validation of our approach revealed that it can achieve an area under the receiver operating characteristic curve of 93.9%. Subsequent leave-one-miRNA-out cross-validation also demonstrated the performance of our approach. Using miR-155 as a case, we found that the top ranked interactions can account for most functions of miR-155. In addition, we further demonstrated the power of our approach by 23 recently identified cancer-related key interactions. The approach described here offers a new way for the discovery of novel cancer-related key miRNA-target interactions.
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miRNAs are important participants in the pathogenesis of depression.
“recent evidence has emerged indicating that miRNAs are important participants in the pathogenesis of depression.25”
From Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression (2022) · cites this paper as [25]
The Introduction links miRNAs to the pathogenesis of cancer, not depression. Searches for depression and related psychiatric terms found no passage in our copy addressing a role for miRNAs in depression. (LLM, conf=0.78)
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Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works
KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077 · see citing works
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232 · see citing works
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728 · see citing works
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400 · see citing works
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462 · see citing works
Integrated genomic analyses of ovarian carcinoma
Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927 · see citing works
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735 · see citing works
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697 · see citing works
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works
Mammalian microRNAs predominantly act to decrease target mRNA levels
Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886 · see citing works
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766 · see citing works
miR-15 and miR-16 induce apoptosis by targeting BCL2
Cimmino, A., Calin, G. A., Fabbri, M., Iorio, M. V., Ferracin, M., Shimizu, M., Wojcik, S. E., Aqeilan, R. I., Zupo, S., Dono, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506654102 · Cited by 3,510 · see citing works
A gene atlas of the mouse and human protein-encoding transcriptomes
Su, A. I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K. A., Block, D., Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400782101 · Cited by 3,475 · see citing works
Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders
Hamosh, A. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki033 · Cited by 3,443 · see citing works
Human Protein Reference Database--2009 update
Prasad, T. S. K., Goel, R., Kandasamy, K., Keerthikumar, S., Kumar, S., Mathivanan, S., Telikicherla, D., Raju, R., Shafreen, R. B., Venugopal, A., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn892 · Cited by 3,205 · see citing works
A census of human cancer genes
Futreal, P. A., Coin, L., Marshall, M., Down, T., Hubbard, T., Wooster, R., Rahman, N., & Stratton, M. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1299 · Cited by 3,184 · see citing works
miRBase: integrating microRNA annotation and deep-sequencing data
Kozomara, A., & Griffiths-Jones, S. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1027 · Cited by 3,042 · see citing works
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
Yanaihara, N., Caplen, N., Bowman, E., Seike, M., Kumamoto, K., Yi, M., Stephens, R. M., Okamoto, A., Yokota, J., Tanaka, T., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.01.025 · Cited by 3,023 · see citing works
Causes and consequences of microRNA dysregulation in cancer
Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,003 · see citing works
Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation
Vasudevan, S., Tong, Y., & STEITZ, J. A. (2007) · Science · doi:10.1126/science.1149460 · Cited by 2,806 · see citing works
Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA
Jopling, C. L., Yi, M., Lancaster, A. M., Lemon, S. M., & Sarnow, P. (2005) · Science · doi:10.1126/science.1113329 · Cited by 2,503 · see citing works
miR2Disease: a manually curated database for microRNA deregulation in human disease
Jiang, Q., Wang, Y., Hao, Y., Juan, L., Teng, M., Zhang, X., Li, M., Wang, G., & Liu, Y. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn714 · Cited by 1,415 · see citing works
miRTarBase: a database curates experimentally validated microRNA–target interactions
Hsu, S.-D., Lin, F., Wu, W.-Y., Liang, C., Huang, W.-C., Chan, W.-L., Tsai, W.-T., Chen, G.-Z., Lee, C.-J., Chiu, C.-M., et al. (2010) · Nucleic Acids Res. · doi:10.1093/nar/gkq1107 · Cited by 1,387 · see citing works
MicroRNA control of signal transduction
Inui, M., Martello, G., & Piccolo, S. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2868 · Cited by 1,262 · see citing works
Genetic variation in microRNA networks: the implications for cancer research
Ryan, B. M., Robles, A. I., & Harris, C. C. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2867 · Cited by 1,253 · see citing works
MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb
Xiao, C., Calado, D. P., Galler, G. R., Thai, T., Patterson, H. C., Wang, J., Rajewsky, N., Bender, T. P., & Rajewsky, K. (2007) · Cell · doi:10.1016/j.cell.2007.07.021 · Cited by 1,041 · see citing works
MicroRNA Control in the Immune System: Basic Principles
Xiao, C., & Rajewsky, K. (2009) · Cell · doi:10.1016/j.cell.2008.12.027 · Cited by 1,008 · see citing works
The Genetic Association Database
Becker, K. G., Barnes, K. C., Bright, T. J., & Wang, S. A. (2004) · Nature Genetics · doi:10.1038/ng0504-431 · Cited by 971 · see citing works
Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice
Costinean, S., Zanesi, N. A. O., Pekarsky, Y., Tili, E., Volinia, S., Heerema, N. A., & Croce, C. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602266103 · Cited by 952 · see citing works
An Analysis of Human MicroRNA and Disease Associations
Lü, M., Zhang, Q., Deng, M., Miao, J., Guo, Y., Gao, W., & Cui, Q. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003420 · Cited by 899 · see citing works
Gene prioritization through genomic data fusion
Aerts, S., Lambrechts, D., Maity, S., Loo, P. V., Coessens, B., Smet, F. D., Tranchevent, L.-C., Moor, B. D., Marynen, P., Hassan, B. A., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1203 · Cited by 891 · see citing works
Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders
Hamosh, A. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.52 · Cited by 762 · see citing works
miRDB: A microRNA target prediction and functional annotation database with a wiki interface
Wang, X. (2008) · RNA · doi:10.1261/rna.965408 · Cited by 712 · see citing works
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
Melton, C. A., Judson, R. L., & Blelloch, R. H. (2010) · Nature · doi:10.1038/nature08725 · Cited by 693 · see citing works
Kluiver, J. L., Poppema, S., de Jong, D., Blokzijl, T., Harms, G., Jacobs, S. C., Kroesen, B., & van den Berg, A. (2005) · The Journal of Pathology · doi:10.1002/path.1825 · Cited by 672 · see citing works
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
Garzon, R., Volinia, S., Liu, C., Fernandez-Cymering, C., Palumbo, T., Pichiorri, F., Fabbri, M., Coombes, K. R., Alder, H., Nakamura, T., et al. (2008) · Blood · doi:10.1182/blood-2007-07-098749 · Cited by 631 · see citing works
Silencing of microRNA families by seed-targeting tiny LNAs
Obad, S., dos Santos, C. O., Petri, A., Heidenblad, M., Broom, O. J., Ruse, C. I., Fu, C., Lindow, M., Stenvang, J., Straarup, E. M., et al. (2011) · Nature Genetics · doi:10.1038/ng.786 · Cited by 627 · see citing works
Online Predicted Human Interaction Database
Brown, K. R., & Jurišica, I. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti273 · Cited by 601 · see citing works
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
Chekulaeva, M., & Filipowicz, W. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.04.009 · Cited by 595 · see citing works
High expression of precursor microRNA‐155/BIC RNA in children with Burkitt lymphoma
Metzler, M., Wilda, M., Busch, K., Viehmann, S. F., & Borkhardt, A. (2003) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10316 · Cited by 543 · see citing works
Kislinger, T., Cox, B., Kannan, A., Chung, C., Hu, P., Ignatchenko, A., Scott, M. S., Gramolini, A. O., Morris, Q., Hallett, M. T., et al. (2006) · Cell · doi:10.1016/j.cell.2006.01.044 · Cited by 482 · see citing works
Franke, L., Bakel, H. V., Fokkens, L., de Jong, E. D., Egmont-Petersen, M., & Wijmenga, C. (2006) · The American Journal of Human Genetics · doi:10.1086/504300 · Cited by 476 · see citing works
MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation
Dorsett, Y., McBride, K. M., Janković, M., Gazumyan, A., Thai, T., Robbiani, D. F., Virgilio, M. D., Reina‐San‐Martin, B., Heidkamp, G. F., Schwickert, T. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.002 · Cited by 456 · see citing works
MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase
Teng, G., Hakimpour, P., Landgraf, P., Rice, A., Tuschl, T., Casellas, R. C., & Papavasiliou, F. N. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.015 · Cited by 446 · see citing works
Greither, T., Grochola, L. F., Udelnow, A., Lautenschläger, C., Würl, P., & Taubert, H. W. (2009) · International Journal of Cancer · doi:10.1002/ijc.24687 · Cited by 444 · see citing works
Coordinated Regulation of Cell Cycle Transcripts by p53-Inducible microRNAs, miR-192 and miR-215
Georges, S. A., Biery, M. C., Kim, S., Schelter, J. M., Guo, J., Chang, A. N., Jackson, A. L., Carleton, M. O., Linsley, P. S., Cleary, M. A., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1846 · Cited by 348 · see citing works
RNA editing of human microRNAs
Blow, M. J., Grocock, R., van Dongen, S., Enright, A. J., Dicks, E., Futreal, P. A., Wooster, R., & Stratton, M. R. (2006) · Genome biology · doi:10.1186/gb-2006-7-4-r27 · Cited by 339 · see citing works
The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma
Mestdagh, P., Boström, A.-K., Impens, F., Fredlund, E., Van Peer, G., De Antonellis, P., von Stedingk, K., Ghesquière, B., Schulte, S., Dews, M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.038 · Cited by 314 · see citing works
dbDEMC: a database of differentially expressed miRNAs in human cancers
Yang, Z., Ren, F., Liu, C., He, S., Sun, G. Z., Gao, Q., Yao, L., Zhang, Y., Miao, R., Cao, Y., et al. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-s4-s5 · Cited by 271 · see citing works
Self-citationTumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling
Rajasekhar, V. K., Studer, L., Gerald, W. L., Socci, N. D., & Scher, H. I. (2011) · Nature Communications · doi:10.1038/ncomms1159 · Cited by 260 · see citing works
Wang, X. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl068 · Cited by 215 · see citing works
Martínez-Nuñez, R. T., Louafi, F., Friedmann, P. S., & Sánchez-Elsner, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.011601 · Cited by 213 · see citing works
Protein interactions and disease: computational approaches to uncover the etiology of diseases
Kann, M. G. (2007) · Briefings in Bioinformatics · doi:10.1093/bib/bbm031 · Cited by 202 · see citing works
He, M. Y., Xu, Z., Ding, T., Kuang, D., & Zheng, L. (2009) · Cellular and Molecular Immunology · doi:10.1038/cmi.2009.45 · Cited by 199 · see citing works
Wang, D., Qiu, C., Zhang, H., Wang, J., Cui, Q., & Yin, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013067 · Cited by 196 · see citing works
High-risk myeloma is associated with global elevation of miRNAs and overexpression of EIF2C2/AGO2
Zhou, Y., Chen, L., Barlogie, B., Stephens, O., Wu, X., Williams, D. R., Cartron, M.-A., van Rhee, F., Nair, B. P., Waheed, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908441107 · Cited by 190 · see citing works
MAGIA, a web-based tool for miRNA and Genes Integrated Analysis
Sales, G., Coppe, A., Bisognin, A., Biasiolo, M., Bortoluzzi, S., & Romualdi, C. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq423 · Cited by 156 · see citing works
Tiffin, N. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl381 · Cited by 144 · see citing works
TAM: A method for enrichment and depletion analysis of a microRNA category in a list of microRNAs
Lü, M., Shi, B., Wang, J., Cao, Q., & Cui, Q. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-419 · Cited by 130 · see citing works
Integrated genomic analyses of ovarian carcinoma
The Cancer Genome Atlas Research Network (2011) · Nature · doi:10.1038/nature10166 · Cited by 129 · see citing works
Coherent but overlapping expression of microRNAs and their targets during vertebrate developmentPreprint
Shkumatava, A., Stark, A., Sive, H. L., & Bartel, D. P. (2009) · Genes & Development · doi:10.1101/gad.1745709 · Cited by 112 · see citing works
Yin, Q., Wang, X., Fewell, C., Cameron, J. E., Zhu, H., Baddoo, M., Lin, Z. N., & Flemington, E. K. (2010) · Journal of Virology · doi:10.1128/jvi.00635-10 · Cited by 103 · see citing works
Xiang, X., Zhuang, X., Ju, S., Zhang, S., Jiang, H., Mu, J., Zhang, L., Miller, D. M., Grizzle, W. E., & Zhang, H. (2011) · Oncogene · doi:10.1038/onc.2011.54 · Cited by 96 · see citing works
The microRNA body map: dissecting microRNA function through integrative genomics
Mestdagh, P., Lefever, S., Pattyn, F., Ridzon, D., Fredlund, E., Fieuw, A., Ongenaert, M., Vermeulen, J., Paepe, A. D., Wong, L., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr646 · Cited by 86 · see citing works
miRNAs: Whys and Wherefores of miRNA-Mediated Regulation
Lai, E. C. (2005) · Current Biology · doi:10.1016/j.cub.2005.06.015 · Cited by 80 · see citing works
Li, X., Wang, Q., Zheng, Y., Lv, S., Ning, S., Sun, J., Huang, T., Zheng, Q., Ren, H., Xu, J., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr770 · Cited by 63 · see citing works
Self-citationXiao, Y., Xu, C., Guan, J., Ping, Y., Fan, H., Li, Y., Zhao, H., & Li, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032201 · Cited by 36 · see citing works
Self-citationPrioritization of candidate cancer genes—an aid to oncogenomic studies
Furney, S. J., Calvo, B., Larrañaga, P., Lozano, J. A., & López-Bigas, N. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn482 · Cited by 34 · see citing works
Xiao, Y., Xu, C., Ping, Y., Guan, J., Fan, H., Li, Y., & Li, X. (2011) · Genomics · doi:10.1016/j.ygeno.2011.04.001 · Cited by 15 · see citing works
Self-citationXiao, Y., Xu, C., Xu, L., et al. (2012) · Gene · doi:10.1016/j.gene.2012.03.039 · Cited by 8 · see citing works
Self-citationSales, G., Coppe, A., Bicciato, S., Bortoluzzi, S., & Romualdi, C. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1239 · Cited by 8 · see citing works
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Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression
Fan, C., Li, Y., Lan, T., Wang, W., Long, Y., & Yu, S. Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2021.11.006 · Cited by 227 · see citing works
Self-citation
- Authors
- Xiao, Y., Guan, J., Ping, Y., Xu, C., Huang, T., Zhao, H., Fan, H., Li, Y., Lv, Y., Zhao, T., Dong, Y., Ren, H., & Li, X.
- Affiliations
- Harbin Medical University (CN)
- Corresponding author
- Li, Xia
- ORCID
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-06-16
- Volume
- 40
- Issue
- 16
- Pages
- 7653-7665
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC3439920
- OpenAlex
- W1998484940
- Cited by
- 33
- References
- 74
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 8 · 2014: 7 · 2013: 2 · 2012: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Natural Science Foundation of China (61170154, 61073136)
- Specialized Research Fund for the Doctoral Program of Higher Education of China (20102307110022)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- microRNA, miRNA-target interactions, cancer, microRNA binding sites, gene expression, microRNA function, miR-155, integrative genomics
- MeSH terms
- Binding Sites, Humans, Neoplasms, RNA, Messenger, Software, 3' Untranslated Regions, Genomics, Protein Interaction Mapping, MicroRNAs, Cell Line, Tumor
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