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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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Defining the role of mTOR in cancer

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

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ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

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Autophagy: molecular machinery for self-eating

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ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

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LC3-association with the parasitophorous vacuole membrane ofPlasmodium bergheiliver stages follows a noncanonical autophagy pathway

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The applications of nanozymes in cancer therapy: based on regulating pyroptosis, ferroptosis and autophagy of tumor cells

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Regulation and Functional Significance of Autophagy in Respiratory Cell Biology and Disease

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Impact of the Autophagy Machinery on Hepatitis C Virus Infection

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Caspase-3 controls AML1-ETO–driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

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Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy

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High mobility group A1 protein modulates autophagy in cancer cells

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The Transcription Factor p8 Regulates Autophagy in Response to Palmitic Acid Stress via a Mammalian Target of Rapamycin (mTOR)-independent Signaling Pathway

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Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1–AMPK signaling and autophagy

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Acidocalcisome is required for autophagy inTrypanosoma brucei

Li, F., & He, C. Y. (2014) · Autophagy · doi:10.4161/auto.36183 · Cited by 56

TheC. elegansATG101 homolog EPG-9 directly interacts with EPG-1/Atg13 and is essential for autophagy

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Anti‐cell death engineering of CHO cells: Co‐overexpression of Bcl‐2 for apoptosis inhibition, Beclin‐1 for autophagy induction

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Evolutionary Dynamics and Molecular Mechanisms of HORMA Domain Protein Signaling

Gu, Y., Desai, A., & Corbett, K. D. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-090920-103246 · Cited by 53

UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury

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Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy

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Rosiglitazone and Fenofibrate Exacerbate Liver Steatosis in a Mouse Model of Obesity and Hyperlipidemia. A Transcriptomic and Metabolomic Study

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The Role of Macroautophagy in Development of Filamentous Fungi

Bartoszewska, M., & Kiel, J. A. K. W. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3528 · Cited by 52

Investigating the Role of Everolimus in mTOR Inhibition and Autophagy Promotion as a Potential Host-Directed Therapeutic Target in Mycobacterium tuberculosis Infection

Cerni, S., Shafer, D., To, K., & Venketaraman, V. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020232 · Cited by 54

The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer

Jing, J., Wang, B., & Liu, P. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.37008 · Cited by 51

Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases

Panda, P. K., Fahrner, A., Vats, S., Seranova, E., Sharma, V., Chipara, M., Desai, P., Torresi, J., Rosenstock, T., Kumar, D., et al. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00038 · Cited by 50

The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase

Namkoong, S., Lee, K. I., Lee, J. I., Park, R., Lee, E., Jang, I., & Park, J. (2015) · Autophagy · doi:10.1080/15548627.2015.1034412 · Cited by 49

Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer - a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation

Chang, W., Hsu, L., Leu, W., Chen, C., & Guh, J. (2015) · Oncotarget · doi:10.18632/oncotarget.5655 · Cited by 49

Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration

Edens, B. M., Miller, N., & Ma, Y. C. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00044 · Cited by 52

Ginsenoside Rg1 inhibits angiotensin II‐induced podocyte autophagy via AMPK/mTOR/PI3K pathway

Mao, N., Tan, R., Wang, S., Wei, C., Shi, X., Fan, J., & Wang, L. (2016) · Cell Biology International · doi:10.1002/cbin.10634 · Cited by 50

Several Routes to the Same Destination: Inhibition of Phagosome-Lysosome Fusion by Mycobacterium tuberculosis

Carranza, C., & Chávez‐Galán, L. (2018) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2018.12.003 · Cited by 53

Physical Activity Alleviates Cognitive Dysfunction of Alzheimer’s Disease through Regulating the mTOR Signaling Pathway

Kou, X., Chen, D., & Chen, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071591 · Cited by 52

Lowering Mutant Huntingtin Levels and Toxicity: Autophagy-Endolysosome Pathways in Huntington's Disease

Valionyte, E., Yang, Y., Roberts, S. L., Kelly, J., Lu, B., & Luo, S. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.11.012 · Cited by 51

Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer’s Disease?

Murphy, K. E., & Park, J. C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061168 · Cited by 49

BAF is a cytosolic DNA sensor that leads to exogenous DNA avoiding autophagy

Kobayashi, S., Koujin, T., Kojidani, T., Osakada, H., Mori, C., Hiraoka, Y., & Haraguchi, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501235112 · Cited by 48

Endoplasmic reticulum stress is involved in the connection between inflammation and autophagy in type 2 diabetes

Liu, H., Cao, M.-M., Wang, Y., Li, L.-C., Zhu, L., Xie, G., & Li, Y. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.09.006 · Cited by 48

WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma

Tsai, C.-W., Lai, F.-J., Sheu, H.-M., Lin, Y.-S., Chang, T.-H., Jan, M.-S., Chen, S. M., Hsu, P.-C., Huang, T.-T., Huang, T.-C., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.308 · Cited by 48

mTOR inhibitors radiosensitize PTEN‐deficient non‐small‐cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy

Kim, E. J., Jeong, J., Bae, S., Kang, S., Kim, C. H., & Lim, Y. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24465 · Cited by 48

Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing

Xu, G., Li, T., Chen, J., Li, C., Zhao, H., Yao, C., Dong, H., Wen, K., Wang, K., Zhao, J., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1501251 · Cited by 48

Autophagy Modulators and Neuroinflammation

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Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease

Guo, Y., Duan, W., Lu, D.-H., Ma, X., Li, X., Zhao, L., Bi, W., Kurihara, H., Liu, H., Li, Y., et al. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0454-y · Cited by 49

The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload

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The autophagy-related gene Atg101 in Drosophila regulates both neuron and midgut homeostasis

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The evolution of autophagy proteins – diversification in eukaryotes and potential ancestors in prokaryotes

Zhang, S., Hama, Y., & Mizushima, N. (2021) · Journal of Cell Science · doi:10.1242/jcs.233742 · Cited by 47

Physiological functions of ULK1/2

Pareek, G., & Kundu, M. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2024.168472 · Cited by 55

Autophagy and inflammatory bowel disease: Association between variants of the autophagy-related IRGM gene and susceptibility to Crohn's disease

Rufini, S., Ciccacci, C., Fusco, D. D., Ruffa, A., Pallone, F., Novelli, G., Biancone, L., & Borgiani, P. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.05.012 · Cited by 47

Cellular stress responses in hepatitis C virus infection: Mastering a two-edged sword

Vasallo, C., & Gastaminza, P. (2015) · Virus Research · doi:10.1016/j.virusres.2015.03.013 · Cited by 47

ULK1, Mammalian Target of Rapamycin, and Mitochondria: Linking Nutrient Availability and Autophagy

Kundu, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3809 · Cited by 48

Cancerous Inhibitor of Protein Phosphatase 2A Mediates Bortezomib-Induced Autophagy in Hepatocellular Carcinoma Independent of Proteasome

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The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

Schaaf, M. B. E., Cojocari, D., Keulers, T. G., Jutten, B., Starmans, M. H. W., de Jong, M. C., Begg, A. C., Savelkouls, K. G. M., Bussink, J., Vooijs, M., et al. (2013) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2013.06.015 · Cited by 46

Autophagy-associated Targeting Pathways of Natural Products during Cancer Treatment

Zhang, S., Wang, X., Yang, X., & Chen, N. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.24.10557 · Cited by 46

MicroRNA-106a targets autophagy and enhances sensitivity of lung cancer cells to Src inhibitors

Rothschild, S. I., Gautschi, O. P., Batliner, J., Gugger, M., Fey, M. F., & Tschan, M. P. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.06.004 · Cited by 47

Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells

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Autophagy—A Story of Bacteria Interfering with the Host Cell Degradation Machinery

Riebisch, A. K., Mühlen, S., Beer, Y. Y., & Schmitz, I. (2021) · Pathogens · doi:10.3390/pathogens10020110 · Cited by 48

Atlastin 2/3 regulate ER targeting of the ULK1 complex to initiate autophagy

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LncRNA Sox2OT-V7 promotes doxorubicin-induced autophagy and chemoresistance in osteosarcoma via tumor-suppressive miR-142/miR-22

Zhu, K., Yang, Y., Wen, J., Chen, D., Zhu, W., Ouyang, Z., & Wang, W. (2020) · Aging · doi:10.18632/aging.103004 · Cited by 46

Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR‐ and BECLIN1‐complex

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Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency

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Sestrin 2, a potential star of antioxidant stress in cardiovascular diseases

Liu, Y., Li, M., Du, X., Huang, Z., & Quan, N. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.11.015 · Cited by 45

Autophagy and cancer: Basic mechanisms and inhibitor development

Hama, Y., Ogasawara, Y., & Noda, N. N. (2023) · Cancer Science · doi:10.1111/cas.15803 · Cited by 47

Survival by self-destruction: A role for autophagy in the placenta?

Bildirici, İ., Longtine, M. S., Chen, B., & Nelson, D. M. (2012) · Placenta · doi:10.1016/j.placenta.2012.04.011 · Cited by 44

Chronic mTOR activation promotes cell survival in Merkel cell carcinoma

Lin, Z., McDermott, A., Shao, L., Kannan, A., Morgan, M., Stack, B. C., Moreno, M. A., Davis, D. A., Cornelius, L. A., & Gao, L. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.11.005 · Cited by 46

Differential control of muscle mass in type 1 and type 2 diabetes mellitus

Sala, D., & Antonio Zorzano, A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1954-7 · Cited by 45

Autophagy: An Integral Component of the Mammalian Stress Response.

Ryter, S. W., & Choi, A. M. K. (2013) · PubMed · Cited by 44

Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response

Dash, S., Chava, S. P., Chandra, P. K., Balart, L. A., Wu, T., & Aydın, Y. (2016) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s63700 · Cited by 46

Autophagy in Chronic Kidney Diseases

Liu, N., Shi, Y., & Zhuang, S. (2016) · Kidney Diseases · doi:10.1159/000444841 · Cited by 44

Sphingolipids as Regulators of Autophagy and Endocytic Trafficking

Young, M. M., & Wang, H. (2018) · Advances in cancer research · doi:10.1016/bs.acr.2018.04.008 · Cited by 45

The plant TOR kinase tunes autophagy and meristem activity for nutrient stress-induced developmental plasticity

Dong, Y., Aref, R., Forieri, I., Schiel, D., Leemhuis, W., Meyer, C., Hell, R., & Wirtz, M. (2022) · The Plant Cell · doi:10.1093/plcell/koac201 · Cited by 43

Engineered Exosomes with ATF5-Modified mRNA Loaded in Injectable Thermogels Alleviate Osteoarthritis by Targeting the Mitochondrial Unfolded Protein Response

Ma, T., Xu, G., Gao, T., Zhao, G., Huang, G., Shi, J., Chen, J., Song, J., Xia, J., & Ma, X. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c17209 · Cited by 43

The Putative HORMA Domain Protein Atg101 Dimerizes and Is Required for Starvation-Induced and Selective Autophagy inDrosophila

Hegedűs, K., Nagy, P., Gáspári, Z., & Juhász, G. (2014) · BioMed Research International · doi:10.1155/2014/470482 · Cited by 47

The Regulation of the Autophagic Network and Its Implications for Human Disease

Yang, J. H., Carra, S., Zhu, W., & Kampinga, H. H. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.6666 · Cited by 45

Energy restriction and potential energy restriction mimetics

Nikolai, S., Pallauf, K., Huebbe, P., & Rimbach, G. H. (2015) · Nutrition Research Reviews · doi:10.1017/s0954422415000062 · Cited by 43

Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells

Huang, N. J., Liu, Z., Zhu, J., Cui, Z., Li, Y., Yu, Y., Sun, F., Pan, Q., & Yang, Q. (2017) · Tumor Biology · doi:10.1177/1010428317708532 · Cited by 43

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

Zhao, X., Nedvetsky, P. I., Stanchi, F., Vion, A.-C., Popp, O., Zühlke, K., Dittmar, G., Klußmann, E., & Gerhardt, H. (2019) · eLife · doi:10.7554/elife.46380 · Cited by 40

Reduced mitophagy in the cochlea of aged C57BL/6J mice

Oh, J., Youn, C. K., Jun, Y., Jo, E.-R., & Cho, S. I. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110946 · Cited by 44

The interplay between oxidative stress and autophagy in chronic obstructive pulmonary disease

Zhao, X., Zhang, Q., & Zheng, R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1004275 · Cited by 48

Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective

López-Méndez, T. B., Sánchez‐Álvarez, M., Trionfetti, F., Pedraz, J. L., Tripodi, M., Cordani, M., Strippoli, R., & González‐Valdivieso, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-00986-9 · Cited by 42

Resistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?

Aveic, S., & Tonini, G. P. (2016) · Cancer Cell International · doi:10.1186/s12935-016-0341-2 · Cited by 44

Autophagy - A Double-Edged Sword - Cell Survival or Death?

Bailly, Y. J. R. (2013) · InTech eBooks · doi:10.5772/50855 · Cited by 43

Autophagy Promoted the Degradation of Mutant ATXN3 in Neurally Differentiated Spinocerebellar Ataxia-3 Human Induced Pluripotent Stem Cells

Ou, Z., Luo, M., Niu, X., Chen, Y., Xie, Y., He, W., Song, B., Xian, Y., Fan, D., Ouyang, S., et al. (2016) · BioMed Research International · doi:10.1155/2016/6701793 · Cited by 42

Autophagy and Schizophrenia: A Closer Look at How Dysregulation of Neuronal Cell Homeostasis Influences the Pathogenesis of Schizophrenia

Schneider, J. L., Miller, A. M., & Woesner, M. E. (2017) · Einstein Journal of Biology and Medicine · doi:10.23861/ejbm201631752 · Cited by 42

Role and mechanisms of autophagy in alcohol-induced liver injury

Chao, X., & Ding, W. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.01.008 · Cited by 43

ANXA6 suppresses the tumorigenesis of cervical cancer through autophagy induction

Sun, X., Shu, Y., Xu, M., Jiang, J.-K., Wang, L., Wang, J., Huang, D., & Zhang, J. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.208 · Cited by 41

Autophagy and HIV

Dinkins, C., Arko‐Mensah, J., & Deretic, V. P. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.04.004 · Cited by 46

ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression

Zhu, Y., Wang, C., Yu, M., Cui, J., Liu, L., & Xu, Z. (2013) · Protein & Cell · doi:10.1007/s13238-013-3910-3 · Cited by 42

Rapamycin treatment inhibits CHO cell death in a serum‐free suspension culture by autophagy induction

Lee, J. S., & Lee, G. M. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24567 · Cited by 45

Dietary Leucine Improves Fish Intestinal Barrier Function by Increasing Humoral Immunity, Antioxidant Capacity, and Tight Junction

Zhao, J., Zhao, Y., Liu, H., Cao, Q., Feng, L., Zhang, Z., Jiang, W., Wu, P., Liu, Y., Luo, W., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054716 · Cited by 41

Ferritinophagy: Molecular mechanisms and role in disease

Zhu, Q., Zhai, J., Chen, Z., Guo, Z., Wang, N., Zhang, C., Deng, H., Wang, S., & Wang, S. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155553 · Cited by 47

Cannabinoid-associated cell death mechanisms in tumor models

Calvaruso, G., Pellerito, O., Notaro, A., & Giuliano, M. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1476 · Cited by 42

Characterization of early autophagy signaling by quantitative phosphoproteomics

Rigbolt, K. T. G., Zarei, M., Sprenger, A., Becker, A. C., Diedrich, B., Huang, X., Eiselein, S., Kristensen, A. R., Gretzmeier, C., Andersen, J., et al. (2013) · Autophagy · doi:10.4161/auto.26864 · Cited by 41

BRAFV600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells

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