Cited by 1,062Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolismUbiquitin and proteasome pathways

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The role of the Atg1/ULK1 complex in autophagy regulation

Mizushima, Noboru·2010·Current Opinion in Cell Biology

DOI 10.1016/j.ceb.2009.12.004

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Abstract

The Atg1/ULK complex plays an essential role in the initiation of autophagy: receiving signals of cellular nutrient status, recruiting downstream Atg proteins to the autophagosome formation site, and governing autophagosome formation. Recent studies of mammalian Atg1 homologs (ULK1 and ULK2) have identified several novel interacting proteins, FIP200, mAtg13, and Atg101. FIP200 and Atg101 are not conserved in Saccharomyces cerevisiae, despite the high conservation rates of other downstream Atg proteins between the yeast and mammals. Furthermore, through studies of the Atg1/ULK1 complex, the molecular mechanism by which (m)TORC1 regulates autophagy is now being clarified in detail.

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Authors: Mizushima, N.
Affiliations: Tokyo Medical and Dental University (JP)
Corresponding author: Mizushima, Noboru
ORCID: Mizushima, Noboru
Venue: Current Opinion in Cell Biology
Publisher: Elsevier BV
Published: 2010-04
Volume: 22
Issue: 2
Pages: 132-139
ISSN: 0955-0674 (ISSN-L)
DOI: 10.1016/j.ceb.2009.12.004
OpenAlex: W2065592028
Cited by: 1,062
References: 78
Citations by year: 2026: 19 · 2025: 47 · 2024: 58 · 2023: 45 · 2022: 64 · 2021: 61 · 2020: 73 · 2019: 66 · 2018: 61 · 2017: 61 · 2016: 88 · 2015: 86 · 2014: 79 · 2013: 85 · 2012: 65
FWCI: 9.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Takeda Science Foundation
Korea Toray Science Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: autophagy initiation, autophagosome formation, ULK1, ULK2, FIP200, ATG101, TORC1 signaling, nutrient sensing, autophagy regulation
MeSH terms: Animals, Autophagy, Neurons, Saccharomyces cerevisiae, Protein Serine-Threonine Kinases

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The role of the Atg1/ULK1 complex in autophagy regulation

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