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The role of the Atg1/ULK1 complex in autophagy regulation
Abstract
The Atg1/ULK complex plays an essential role in the initiation of autophagy: receiving signals of cellular nutrient status, recruiting downstream Atg proteins to the autophagosome formation site, and governing autophagosome formation. Recent studies of mammalian Atg1 homologs (ULK1 and ULK2) have identified several novel interacting proteins, FIP200, mAtg13, and Atg101. FIP200 and Atg101 are not conserved in Saccharomyces cerevisiae, despite the high conservation rates of other downstream Atg proteins between the yeast and mammals. Furthermore, through studies of the Atg1/ULK1 complex, the molecular mechanism by which (m)TORC1 regulates autophagy is now being clarified in detail.
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“ATG1/ULK1 is crucial for autophagy initiation[25]”
From Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster (2019) · cites this paper as [25]
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Metadata
- Authors
- Mizushima, N.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Corresponding author
- Mizushima, Noboru
- ORCID
- Mizushima, Noboru
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 22
- Issue
- 2
- Pages
- 132-139
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2065592028
- Cited by
- 1,062
- References
- 78
- Citations by year
- 2026: 19 · 2025: 47 · 2024: 58 · 2023: 45 · 2022: 64 · 2021: 61 · 2020: 73 · 2019: 66 · 2018: 61 · 2017: 61 · 2016: 88 · 2015: 86 · 2014: 79 · 2013: 85 · 2012: 65
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Takeda Science Foundation
- Korea Toray Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- autophagy initiation, autophagosome formation, ULK1, ULK2, FIP200, ATG101, TORC1 signaling, nutrient sensing, autophagy regulation
- MeSH terms
- Animals, Autophagy, Neurons, Saccharomyces cerevisiae, Protein Serine-Threonine Kinases
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