mTOR Signaling in Disease

Dazert, Eva, Hall, Michael N·2011·Current Opinion in Cell Biology

DOI 10.1016/j.ceb.2011.09.003

Cited by (461)

Items 201–300 of 461

Astrocytes in Down Syndrome Across the Lifespan
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An overview of the mTOR pathway as a target in cancer therapy
Ryan D. Gentzler, Jessica Kaplan Altman, Leonidas C. Platanias · 2012 · Expert Opinion on Therapeutic Targets
mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells
Brandon R. Beagle, Duc Minh Nguyen, Sharmila Mallya, Sarah S. K. Tang, Mengrou Lu, Zhihong Zeng, Marina Y Konopleva, Thanh-Trang T. Vo, David A. Fruman · 2014 · Oncotarget
Mutational Analysis of Oncogenic AKT1 Gene Associated with Breast Cancer Risk in the High Altitude Ecuadorian Mestizo Population
Andrés López‐Cortés, Paola Leone, Byron Freire‐Paspuel, Nathaly Arcos-Villacis, Patricia Guevara‐Ramírez, Felipe Rosales, César Paz‐y‐Miño · 2018 · BioMed Research International
Rapamycin Extends Life Span in ApcMin/+ Colon Cancer FAP Model
Manish Parihar, Sherry G. Dodds, Gene B. Hubbard, Martin A. Javors, Randy Strong, Paul Hasty, Zelton Dave Sharp · 2020 · Clinical Colorectal Cancer
Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR
Boah Lee, Seung Ju Park, Seulgi Lee, Jin Wook Lee, Eunbeol Lee, Eun-Seon Yoo, Won‐Suk Chung, Jong‐Woo Sohn, Byung‐Chul Oh, Seyun Kim · 2022 · Cell Death and Disease
Polymorphisms in mTORC1 Genes Modulate Risk of Esophageal Squamous Cell Carcinoma in Eastern Chinese Populations
Meiling Zhu, Hongping Yu, Ting‐Yan Shi, Jing He, Mengyun Wang, Qiao-Xin Li, Meng-Hong Sun, Jin Li, Ya-Jun Yang, Jiu-Cun Wang et al. · 2013 · Journal of Thoracic Oncology
Metformin: The Winding Path from Understanding Its Molecular Mechanisms to Proving Therapeutic Benefits in Neurodegenerative Disorders
Laura Mihaela Isop, Andrea Elena Neculau, Radu Dan Necula, Cristian Kakucs, Marius Moga, Lorena Dima · 2023 · Pharmaceuticals
Role of Rab GTPases and their interacting proteins in mediating metabolic signalling and regulation
Christelle En Lin Chua, Bor Luen Tang · 2015 · Cellular and Molecular Life Sciences
Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia-Reperfusion Injury in Diabetic Rats
Juchen Li, Yixing Ren, Enyi Shi, Zhibin Tan, Jian Xiong, Lihui Yan, Xiaojing Jiang · 2016 · The Annals of Thoracic Surgery
mTORC1 Activation Promotes Spermatogonial Differentiation and Causes Subfertility in Mice
C. Wang, Zhipeng Wang, Z. Xiong, H. Dai, Zhenhong Zou, C. Jia, Xiaochun Bai, Zhenguo Chen · 2016 · Biology of Reproduction
Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice
Hongmei Zhang, Vivian Diaz, Michael E. Walsh, Yiqiang Zhang · 2017 · Scientific Reports
Promise of metformin for preventing age-related cognitive dysfunction
Ashok Kumar Shetty, Leelavathi Narayana Madhu, Maheedhar Kodali · 2021 · Neural Regeneration Research
Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells
Tito T. Jesus, Pedro Fontes Oliveira, Joaquina Silva, Alberto Barros, Rita M. Ferreira, Mário Sousa, C. Yan Cheng, Branca Maria Silva, Marco Gouveia Alves · 2015 · Fertility and Sterility
Rapid acting antidepressants in the mTOR pathway: Current evidence
K V Athira, Arathy S Mohan, Sumana Chakravarty · 2020 · Brain Research Bulletin
An evaluation of sirolimus in renal transplantation
Fabian Halleck, Michael Duerr, Johannes Waiser, Lu Huber, Mareen Matz, Susanne Brakemeier, Lutz Liefeldt, H.‐H. Neumayer, Klemens Budde · 2012 · Expert Opinion on Drug Metabolism & Toxicology
Anti‐ TNF ‐α therapy modulates mTORC 1 signalling in hidradenitis suppurativa
Anna Balato, Giuseppina Caiazzo, Maria Carmela Annunziata, Claudio Marasca, Emanuele Scala, Sara Cacciapuoti, Gabriella Fabbrocini · 2018 · Journal of the European Academy of Dermatology and Venereology
Kochia scoparia seed extract suppresses VEGF-induced angiogenesis via modulating VEGF receptor 2 and PI3K/AKT/mTOR pathways
Hyun‐Dong Cho, Jeong‐Ho Kim, Junkyu Park, Seong‐Min Hong, Du‐Hyun Kim, Kwon‐Il Seo · 2019 · Pharmaceutical Biology
Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress
Chenyue Liu, Jianbei Chen, Yueyun Liu, Xueming Zhou, Man Zhang, You-Ming Jiang, Qingyu Ma, Zhe Xue, Zongyao Zhao, Xiaojuan Li et al. · 2022 · Chinese Medicine
Functional protection of learning and memory abilities in rats with vascular dementia
Hui-Yun Yang, O. Shi, Yan-Jiao Jin, P. Henrich-Noack, Haixuan Qiao, Chun-Quan Cai, H. Tao, Xin Tian · 2014 · Restorative Neurology and Neuroscience
AMP-Activated Protein Kinase Alleviates Extracellular Matrix Accumulation in High Glucose-Induced Renal Fibroblasts through mTOR Signaling Pathway
Xia Luo, Lingyan Deng, Laxmi Pangeni Lamsal, Wenjuan Xu, Cheng Xiang, Liming Cheng · 2015 · Cellular Physiology and Biochemistry
Characterization of the Translationally Controlled Tumor Protein (TCTP) Interactome Reveals Novel Binding Partners in Human Cancer Cells
Siting Li, Minghai Chen, Qian Xiong, Jia Zhang, Zongqiang Cui, Feng Ge · 2016 · Journal of Proteome Research
Targeting snoRNAs as an emerging method of therapeutic development for cancer.
Di Zhang, Juan Zhou, Jie Gao, Ri-Ying Wu, Yinglong Huang, Qinwen Jin, Jiansi Chen, Weizhong Tang, Lin‐Hai Yan · 2019 · PubMed Central
AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension
Karen Flores, Patricia Siqués, Julio Brito, Silvia Magdalena Arribas · 2022 · International Journal of Molecular Sciences
Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology
Marilena Gîlcă, Dorin Dragoș · 2017 · Evidence-based Complementary and Alternative Medicine
How Bacterial Pathogens Coordinate Appetite with Virulence
Nick D. Pokorzynski, Eduardo A. Groisman · 2023 · Microbiology and Molecular Biology Reviews
Hybrid models of cell and tissue dynamics in tumor growth
Hans G. Othmer, Yangjin Kim · 2015 · Mathematical Biosciences & Engineering
A combination of eicosapentaenoic acid-free fatty acid, epigallocatechin-3-gallate and proanthocyanidins has a strong effect on mTOR signaling in colorectal cancer cells
Leonarda D’Angelo, Giulia Piazzi, Annalisa Pacilli, Anna Prossomariti, Chiara Fazio, Lorenzo Montanaro, Giulia Graziani, Vincenzo Fogliano, Alessandra Munarini, Franca Bianchi et al. · 2014 · Carcinogenesis
Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin
Perundurai Subramaniam Dhandapany, Soojeong Kang, Deepak K. Kashyap, Raksha Rajagopal, Nagalingam Ravi Sundaresan, Rajvir Singh, Kumarasamy Thangaraj K, Shilpa Jayaprakash, Cholenahally Nanjappa Manjunath, Jayaprakash Shenthar et al. · 2021 · Science Advances
Metformin induces degradation of mTOR protein in breast cancer cells
Mohamed A. Alalem, Alpana Ray, Bimal K. Ray · 2016 · Cancer Medicine
TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres
Adiel Cohen, Aline Habib, Dana Laor Bar‐Yosef, Sudhanshu Yadav, Martin Kupiec, Ronit Weisman · 2018 · Journal of Biological Chemistry
Rapamycin protects neurons from brain contusion-induced inflammatory reaction via modulation of microglial activation
QI SONG, Dujiang Xie, SHIYONG PAN, WEIJUN XU · 2015 · Molecular Medicine Reports
Ezh2 promotes mammary tumor initiation through epigenetic regulation of the Wnt and mTORC1 signaling pathways
Linshan Liu, Bin Xiao, Alison Hirukawa, Harvey W. Smith, Dongmei Zuo, Virginie Sanguin‐Gendreau, Luke Martin McCaffrey, Alice Jisoo Nam, William J. Muller · 2023 · Proceedings of the National Academy of Sciences
Dietary supplementation of A-type procyanidins from litchi pericarp improves glucose homeostasis by modulating mTOR signaling and oxidative stress in diabetic ICR mice
Xiaopeng Li, Qian Wu, Yong Sui, Shuyi Li, Bijun Xie, Zhida Sun · 2018 · Journal of Functional Foods
Effects of auriculasin on vascular endothelial growth factor (VEGF)-induced angiogenesis via regulation of VEGF receptor 2 signaling pathways in vitro and in vivo
Hyun‐Dong Cho, Kwang‐Deog Moon, Ki Hun Park, Yong-Suk Lee, Kwon‐Il Seo · 2018 · Food and Chemical Toxicology
Rapamycin Paradox Resolved
Katherine J. Hughes, Brian Keith Kennedy · 2012 · Science
Milk protein synthesis is regulated by T1R1/T1R3, a G protein-coupled taste receptor, through the mTOR pathway in the mouse mammary gland
Junqiang Liu, Yanhong Wang, Dewei Li, Yanhuan Wang, Menglu Li, Caifa Chen, Xingtang Fang, Hong Chen, Chunlei Zhang · 2017 · Molecular Nutrition & Food Research
mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex Model
Alice Polchi, Alessandro Magini, Danila Di Meo, Brunella Tancini, Carla Emiliani · 2018 · International Journal of Molecular Sciences
The FKBP–Rapamycin Binding Domain of Human TOR Undergoes Strong Conformational Changes in the Presence of Membrane Mimetics with and without the Regulator Phosphatidic Acid
Diana C. Rodriguez Camargo, Nina M. Link, Sonja A. Dames · 2012 · Biochemistry
Amino acid restriction, aging, and longevity: an update
Steven N. Austad, Julian R. Smith, Jessica M. Hoffman · 2024 · Frontiers in Aging
Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
Yan Luo, Lei Liu, Yang Wu, Karnika Singh, Bing Su, Nan Zhang, Xiaowei Liu, Yangmei Shen, Shile Huang · 2015 · Oncotarget
The paradox of elongation factor 4: highly conserved, yet of no physiological significance?
Dejiu Zhang, Yan Qin · 2013 · Biochemical Journal
Protective effects of salvianolic acid B against hydrogen peroxide‑induced apoptosis of human umbilical vein endothelial cells and underlying mechanisms
Shan Gao, Shiqin Li, Qin Li, Fuyong Zhang, Mengqi Sun, Zi-Lin Wan, Shu‐Rong Wang · 2019 · International Journal of Molecular Medicine
Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes
Sandra Kissing, Sönke Rudnik, Markus Daμμe, Renate Lüllmann‐Rauch, Atsuhiro Ichihara, Uwe Kornak, Eeva‐Liisa Eskelinen, Sabrina Jabs, Jörg Heeren, Jef K. De Brabander et al. · 2017 · Autophagy
PI3K-mTOR-S6K Signaling Mediates Neuronal Viability via Collapsin Response Mediator Protein-2 Expression
Eun J. Na, Hye Yeon Nam, Jiyoung Park, Myung-Ah Chung, Hyun Ae Woo, Hwa‐Jung Kim · 2017 · Frontiers in Molecular Neuroscience
Intravenous infusion of xenon‐containing liposomes generates rapid antidepressant‐like effects
Manoj P. Dandekar, Tao Peng, D. McPherson, J. Quevedo, J. Soares, Shao-Ling Huang · 2018 · Progress in Neuro-psychopharmacology and Biological Psychiatry
Rapamycin Treatment of Healthy Pigs Subjected to Acute Myocardial Ischemia-Reperfusion Injury Attenuates Cardiac Functions and Increases Myocardial Necrosis
Antonio D. Lassaletta, Nassrene Y. Elmadhun, Arthus Vilar Deolindo Zanetti, Jun Feng, Javier Anduaga, Reginald Gohh, Frank William Sellke, Cesario F. Bianchi · 2013 · The Annals of Thoracic Surgery
The mTOR Pathway and the Role of Energy Balance Throughout Life in Colorectal Cancer Etiology and Prognosis: Unravelling Mechanisms Through a Multidimensional Molecular Epidemiologic Approach
Matty P. Weijenberg, Laura Hughes, Martijn J.L. Bours, Colinda C.J.M. Simons, Manon van Engeland, Piet A. van den Brandt · 2013 · Current Nutrition Reports
Mammalian Target of Rapamycin at the Crossroad Between Alzheimer’s Disease and Diabetes
Hanyu Liang, Jia Nie, Candice E. Van Skike, Joseph M. Valentine, Miranda E. Orr · 2019 · Advances in experimental medicine and biology
Hydrogen sulfide ameliorates high glucose-induced pro-inflammation factors in HT-22 cells: Involvement of SIRT1-mTOR/NF-κB signaling pathway
Xinrui Li, Peiquan Yu, Yinghua Yu, Ting Xu, Jiao Liu, Yuan Guo Cheng, Xia Yang, Xiaoying Cui, Yin Cui, Yi Liu · 2021 · International Immunopharmacology
Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
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eCF309 : a potent, selective and cell-permeable mTOR inhibitor
Craig Fraser, Neil O. Carragher, Asier Unciti‐Broceta · 2015 · MedChemComm
Fasting levels of hepatic p-S6 are increased in old mice
Olga V. Leontieva, Geraldine Paszkiewicz, Mikhail V. Blagosklonny · 2014 · Cell Cycle
Autophagy sensitivity of neuroendocrine lung tumor cells
Seung‐Keun Hong, Jin Hwan Kim, Dmytro Starenki, Jong‐In Park · 2013 · International Journal of Oncology
Metabolic reprogramming of glutamine involved in tumorigenesis, multidrug resistance and tumor immunity
Xiaoyan Wang, Yang Xiao-xia, Shang Peng-Fei, Zheng Zong-Xue, Guo Xiu-li · 2022 · European Journal of Pharmacology
The EGFR-mTOR pathway and laryngeal cancer angiogenesis
Marco Lionello, Andrea Lovato, A. Staffieri, Stella Blandamura, Cristian Turato, Luciano Giacomelli, Claudia Staffieri, Gino Marioni · 2013 · European Archives of Oto-Rhino-Laryngology
Targeting the intragraft microenvironment and the development of chronic allograft rejection
Olivier Dormond, Marc Dufour, Tatsuichiro Seto, Sarah Bruneau, David Michael Briscoe · 2012 · Human Immunology
Ketamine Exhibits Different Neuroanatomical Profile After Mammalian Target of Rapamycin Inhibition in the Prefrontal Cortex: the Role of Inflammation and Oxidative Stress
Helena M. Abelaira, Gislaine Z. Réus, Zuleide Maria Ignácio, Maria Augusta B. dos Santos, Airam Barbosa de Moura, Danyela Matos, Júlia P. Demo, Júlia B.I. da Silva, Lucinéia Gainski Danielski, Fabricia Cardoso Petronilho et al. · 2016 · Molecular Neurobiology
AMPKα2 Regulates Bladder Cancer Growth through SKP2-Mediated Degradation of p27
Stavros Kopsiaftis, Katie L. Sullivan, Isha Garg, John Arthur Taylor, Kevin P. Claffey · 2016 · Molecular Cancer Research
Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight, and obese men
Kostas Tsintzas, Robert Jones, Pardeep Pabla, Joanne E. Mallinson, David A. Barrett, Dong‐Hyun Kim, Scott Cooper, Amanda Davies, Tariq Taylor, Carolyn Chee et al. · 2020 · American Journal of Physiology-Endocrinology and Metabolism
An Autism Case History to Review the Systematic Analysis of Large-Scale Data to Refine the Diagnosis and Treatment of Neuropsychiatric Disorders
Isaac S. Kohane · 2014 · Biological Psychiatry
Aging and energetics’ ‘Top 40’ future research opportunities 2010-2013
David B. Allison, Lisa H. Antoine, Scott W. Ballinger, Marcas M. Bamman, Peggy R. Biga, Victor M. Darley-Usmar, Gordon Fisher, Julia M. Gohlke, Ganesh V. Halade, John L. Hartman et al. · 2014 · F1000Research
The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation
Inna M. Yasinska, Bernhard F. Gibbs, Gurprit S. Lall, Vadim V. Sumbayev · 2013 · Cellular and Molecular Life Sciences
mTOR signaling in the neuropathophysiology of depression: current evidence
Ana Lúcia S. Rodrigues, Gislaine Z. Réus, João Quevedo · 2015 · Journal of Receptor Ligand and Channel Research
Tuberous sclerosis complex is required for tumor maintenance in MYC‐driven Burkitt's lymphoma
Götz Hartleben, Christine Müller, Andreas Krämer, Heiko Schimmel, Laura M Zidek, Carsten Dornblut, René Winkler, Sabrina Eichwald, Gertrud Kortman, Christian Kosan et al. · 2018 · The EMBO Journal
NV-5138 as a fast-acting antidepressant via direct activation of mTORC1 signaling
Hasegawa, Yuto, Zhu, Xiaolei, Kamiya, Atsushi · 2019 · Journal of Clinical Investigation
Inhibition of mTOR/S6K1/4E-BP1 Signaling by Nutraceutical SIRT1 Modulators
Sara Elis Bianchi, Luca Giovannini · 2018 · Nutrition and Cancer
Mammalian Target of Rapamycin in Inflammatory Skin Conditions
Anna Balato, Roberta Di Caprio, Serena Lembo, Martina Mattii, Matteo Megna, Maria Schiattarella, Giovanni Tarantino, Nicola Balato, Fabio Ayala, Giuseppe Monfrecola · 2014 · European Journal of Inflammation
Screening of mammalian target of rapamycin inhibitors in natural product extracts by capillary electrophoresis in combination with high performance liquid chromatography–tandem mass spectrometry
Yanmei Zhang, Feng Li, Mingxia Li, Jingwu Kang · 2015 · Journal of Chromatography A
Effect of dual mTOR inhibitor on TGFβ1-induced fibrosis in primary human urethral scar fibroblasts
Shanlong Huang, Chuance Yang, Min Li, Binxian Wang, Hongwei Chen, Delai Fu, Tie Chong · 2018 · Biomedicine & Pharmacotherapy
Trpm2 Ablation Accelerates Protein Aggregation by Impaired ADPR and Autophagic Clearance in the Brain
Yongwoo Jang, Byeongjun Lee, Hyungsup Kim, Seungmoon Jung, Sung Hoon Lee, So Young Lee, Ji Hyun Jeon, In‐Beom Kim, Seo-Ho Lee, Byoung‐Ju Kim et al. · 2018 · Molecular Neurobiology
mTOR sustains inflammatory response in celiac disease
Silvia Sedda, Vincenzo Dinallo, Irene Marafini, Eleonora Franzè, Omero Alessandro Paoluzi, Roberta Izzo, Paolo Giuffrida, Antonio Di Sabatino, Gino Roberto Corazza, Giovanni Monteleone · 2020 · Scientific Reports
Gluconeogenesis combats cancer: opening new doors in cancer biology
Md. Wasim Khan, Partha Chakrabarti · 2015 · Cell Death and Disease
mTOR Signaling in the Inner Ear as Potential Target to Treat Hearing Loss
Maurizio Cortada, Soledad Levano, Daniel Bodmer · 2021 · International Journal of Molecular Sciences
Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells
Eric Wauson, Marcy L. Guerra, Julia Dyachok, Kathleen McGlynn, Jennifer Giles, Elliott M. Ross, Melanie H. Cobb · 2015 · Molecular Endocrinology
Loss of TSC2 confers resistance to ceramide and nutrient deprivation
Garret Guenther, G Liu, Manuel U. Ramirez, Ryan J. McMonigle, Seong Min Kim, Alison N. McCracken, Y Joo, Irina Ushach, Nhat Nguyen, Aimee L. Edinger · 2013 · Oncogene
NMR- and Circular Dichroism-monitored Lipid Binding Studies Suggest a General Role for the FATC Domain as Membrane Anchor of Phosphatidylinositol 3-Kinase-related Kinases (PIKK)
Lisa A. M. Sommer, Martin Schaad, Sonja A. Dames · 2013 · Journal of Biological Chemistry
Searching for potential mTOR inhibitors: Ligand-based drug design, docking and molecular dynamics studies of rapamycin binding site
Roger Kist, Luís Fernando Saraiva Macedo Timmers, Rafael Andrade Caceres · 2017 · Journal of Molecular Graphics and Modelling
Chemokine signaling is required for homeostatic and injury-induced neurogenesis in the olfactory epithelium
Katja Senf, Julia Karius, Ralf K. Stumm, Eva Maria Neuhaus · 2021 · Stem Cells
mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior.
Verena Albert, M. Cornu, M. Hall · 2015 · Biochemical and Biophysical Research Communications - BBRC
hepaCAM and p-mTOR Closely Correlate in Bladder Transitional Cell Carcinoma and hepaCAM Expression Inhibits Proliferation via an AMPK/mTOR Dependent Pathway in Human Bladder Cancer Cells
Qiuju Wang, Chunli Luo, Xiaohou Wu, Hongfei Du, Xuedong Song, Yanru Fan · 2013 · The Journal of Urology
A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk
Na Li, Beilei Hua, Qing Chen, Fukang Teng, Meiyu Ruan, Mengnan Zhu, Li Zhang, Yinbo Huo, Hongqin Liu, Min Zhuang et al. · 2022 · Cell Reports
Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis
Geng Yin, Ying Wang, Xiao-min Cen, Yuan Yang, Min Yang, Qibing Xie · 2017 · Journal of Immunology Research
Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus
Fanny Urbain, Maharajah Ponnaiah, Farid Ichou, Marie Lhomme, Clément Materne, Sophie Galier, Julien Haroche, Éric Frisdal, Alexis Mathian, Hervé Durand et al. · 2023 · EBioMedicine
Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project
Amanda Erickson Coleman, Kate E. Creevy, Rozalyn M. Anderson, May J. Reed, Virginia R. Fajt, Kathleen M. Aicher, Genna F. Atiee, Brian G. Barnett, Ryan D. Baumwart, Beth Boudreau et al. · 2025 · GeroScience
In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of rapamycin signaling pathway
Samira Shirooie, Mousa Sahebgharani, Jamileh Esmaeili, Ahmad Reza Dehpour · 2018 · Journal of Cellular Physiology
Emerging roles of microRNAs in regulating the mTOR signaling pathway during tumorigenesis
Hossein Javid, Arash Soltani, Fariba Mohammadi, Seyed Isaac Hashemy · 2019 · Journal of Cellular Biochemistry
Phospholipase D-mTOR signaling is compromised in a rat model of depression
Pingfu Feng, Chunfa Huang · 2013 · Journal of Psychiatric Research
Negative Effects of Chronic High Intake of Fructose on Lung Diseases
Adrián Hernández-Díazcouder, Javier González-Ramírez, Fausto Sánchez‐Muñoz, José J. Leija-Martínez, Gustavo Martínez-Coronilla, Luis Manuel Amezcua-Guerra, Fausto Sánchez‐Muñoz · 2022 · Nutrients
Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
Woo-Jeong Shon, Jae Won Song, Seung Hoon Oh, Keon-Hee Lee, Hobin Seong, Hyun Ju You, Je Kyung Seong, Dong‐Mi Shin · 2023 · BMC Medicine
Renal tumours in a Tsc2+/− mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin
J Yang, Maria Kalogerou, Paulina A. Samsel, Yaotian Zhang, D F R Griffiths, John Gallacher, Julian R. Sampson, Ming Hong Shen · 2014 · Oncogene
Differential control of hypoxia-inducible factor 1 activity during pro-inflammatory reactions of human haematopoietic cells of myeloid lineage
Bernhard F. Gibbs, Inna M. Yasinska, Dmitri Pchejetski, Rafal Wlodzimierz Wyszynski, Vadim V. Sumbayev · 2012 · The International Journal of Biochemistry & Cell Biology
Insights from yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor
Stefan H. Millson, Peter W. Piper · 2014 · Oncotarget
AMPKα2 deficiency exacerbates hypoxia-induced pulmonary hypertension by promoting pulmonary arterial smooth muscle cell proliferation
Hai-Long Wang, Fuqin Tang, Yunhan Jiang, Yu Zhu, Jian Zhao, Yingbin Xiao · 2020 · Journal of Physiology and Biochemistry
New Insight on the Immune Modulation and Physical Barrier Protection Caused by Vitamin A in Fish Gills Infected With Flavobacterium columnare
Wei‐Dan Jiang, Li Zhang, Lin Feng, Pei Wu, Yang Liu, Sheng‐Yao Kuang, Shuwei Li, Ling Tang, Haifeng Mi, Lu Zhang et al. · 2022 · Frontiers in Immunology
Flavonoids from Litsea coreana Decreases TNF-α Secretion from Peritoneal Macrophages in Adjuvant-Induced Arthritis Rats via UPR Pathway
Jian Zhong, Taotao Ma, Cheng Huang, Huanzhong Liu, Zhaolin Chen, Lu Cao, Xiaohui Li, Jun Li · 2014 · The American Journal of Chinese Medicine
TOR links starvation responses to telomere length maintenance
Martin Kupiec, Ronit Weisman · 2012 · Cell Cycle
An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics
Jiangtao Zhou, Jiajing Wang, Deyun Li, Zhijia Zhang, Changjian Wang, Xuepeng Zhang, Xiexin Xu, Jianping Gao · 2024 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Ras transformation uncouples the kinesin-coordinated cellular nutrient response
Elma Zaganjor, Lauren M. Weil, Joshua X. Gonzales, John Dorrance Minna, Melanie H. Cobb · 2014 · Proceedings of the National Academy of Sciences
n-3 polyunsaturated fatty acids abrogate mTORC1/2 signaling and inhibit adrenocortical carcinoma growth in vitro and in vivo
Jun Liu, Meinian Xu, Yong-Bin Zhao, Chunping Ao, Yukun Wu, Zhenguo Chen, Bangqi Wang, Xiaochun Bai, Ming Li, HU Wei-lie · 2016 · Oncology Reports