mTOR Signaling in Disease

Hallmarks of Cancer: The Next Generation

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The hallmarks of cancer

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Sorafenib in advanced hepatocellular carcinoma

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Mutations of the BRAF gene in human cancer

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TOR signaling in growth and metabolism

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Sorafenib in Advanced Hepatocellular Carcinoma

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A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization

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mTOR: from growth signal integration to cancer, diabetes and ageing

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

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High Frequency of Mutations of the PIK3CA Gene in Human Cancers

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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Targeting RAS signalling pathways in cancer therapy

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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PI3K pathway alterations in cancer: variations on a theme

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An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

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High frequency of BRAF mutations in nevi

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Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

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BRAF mutation in thyroid cancer

Xing, M. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.0978 · Cited by 1,300 · see citing works

mTOR differentially regulates effector and regulatory T cell lineage commitment

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293 · see citing works

Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

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The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis

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Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent <i>in vivo</i> antitumor activity

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mTOR signaling: At the crossroads of plasticity, memory and disease

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Tuberous sclerosis

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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

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Influence of TOR kinase on lifespan in C. elegans

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Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

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Mutation of the PIK3CA Gene in Ovarian and Breast Cancer

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Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis

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Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial Precancers

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The role of signaling pathways in the development and treatment of hepatocellular carcinoma

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

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The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

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Guilty as charged

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PTEN loss in the continuum of common cancers, rare syndromes and mouse models

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

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Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

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eIF-4E expression and its role in malignancies and metastases

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Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

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PTEN: Life as a Tumor Suppressor

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With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

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Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

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Activation of mTORC2 by Association with the Ribosome

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mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

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Phase III Study to Evaluate Temsirolimus Compared With Investigator's Choice Therapy for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

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Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

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PTEN Mutation, EGFR Amplification, and Outcome in Patients With Anaplastic Astrocytoma and Glioblastoma Multiforme

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The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity

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Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1

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Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance

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Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

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4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

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Untitled work

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PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas

Lee, J. W., Soung, Y. H., Kim, S. Y., Lee, H. W., Park, W. S., Nam, S. W., Kim, S. H., Lee, J. Y., Yoo, N. J., & Lee, S. H. (2004) · Oncogene · doi:10.1038/sj.onc.1208304 · Cited by 508 · see citing works

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

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Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

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Survival of acute myeloid leukemia cells requires PI3 kinase activation

Xu, Q., Simpson, S.-E., Scialla, T. J., Bagg, A., & Carroll, M. P. (2003) · Blood · doi:10.1182/blood-2002-11-3429 · Cited by 469 · see citing works

High Frequency of Coexistent Mutations of PIK3CA and PTEN Genes in Endometrial Carcinoma

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Rapamycin Protects against Neuron Death inIn VitroandIn VivoModels of Parkinson's Disease

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

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Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

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Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era

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PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

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Metformin: Taking away the candy for cancer?

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Architecture of human mTOR complex 1

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The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

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The Therapeutic Potential of Metformin in Neurodegenerative Diseases

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Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

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Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging.

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Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis

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Mutations in the mammalian target of rapamycin pathway regulators <i>NPRL2</i> and <i>NPRL3</i> cause focal epilepsy

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Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro

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Cancer stem cell metabolism: a potential target for cancer therapy

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mTOR pathway activation drives lung cell senescence and emphysema

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The G Protein-Coupled Taste Receptor T1R1/T1R3 Regulates mTORC1 and Autophagy

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Answering the ultimate question “What is the Proximal Cause of Aging?”

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mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions

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A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors

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Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height

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Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice

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Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy

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BRAF V600E Mutation Is Associated with mTOR Signaling Activation in Glioneuronal Tumors

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Targeting the Metabolic Microenvironment of Tumors

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mTORC1 pathway in DNA damage response.

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Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

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Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR

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MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling

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mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases

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Cardiac mTOR protects the heart against ischemia-reperfusion injury

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Geroconversion: irreversible step to cellular senescence

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Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy

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Longevity and aging

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Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF‐1 signaling pathways in C. elegans

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mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse

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A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials

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Rapamycin-inspired macrocycles with new target specificity

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Proteasome-dependent Activation of Mammalian Target of Rapamycin Complex 1 (mTORC1) Is Essential for Autophagy Suppression and Muscle Remodeling Following Denervation

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Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington’s disease

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New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis

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Mosaic Disorders of the PI3K/PTEN/AKT/TSC/mTORC1 Signaling Pathway

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p53 induces transcriptional and translational programs to suppress cell proliferation and growth

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Milk’s Role as an Epigenetic Regulator in Health and Disease

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Differential Activation of mTOR Complex 1 Signaling in Human Brain with Mild to Severe Alzheimer's Disease

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Milk—A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation

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Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

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Role of AMPK/mTOR, mitochondria, and ROS in the pathogenesis of endometriosis

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Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription via the mTORC1/NF-κB Signaling Pathways

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The 3.2-Å resolution structure of human mTORC2

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Neuroprotective effects of dietary restriction: Evidence and mechanisms

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Regulation of TOR by small GTPases

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Molecular signatures of multiple myeloma progression through single cell RNA-Seq

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Xuefu Zhuyu decoction, a traditional Chinese medicine, provides neuroprotection in a rat model of traumatic brain injury via an anti-inflammatory pathway

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Reactive Oxygen Species a Double-Edged Sword for Mesothelioma

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Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway

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TAK ‐228 (formerly MLN 0128), an investigational oral dual TORC 1/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non‐Hodgkin lymphoma, or Waldenström's macroglobulinemia

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Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin

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4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1

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The role of mTOR signaling pathway in spinal cord injury

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Translational Tolerance of Mitochondrial Genes to Metabolic Energy Stress Involves TISU and eIF1-eIF4GI Cooperation in Start Codon Selection

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The microRNA-99 family modulates hepatitis B virus replication by promoting IGF-1R/PI3K/Akt/mTOR/ULK1 signaling-induced autophagy

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Rheb/mTORC1 Signaling Promotes Kidney Fibroblast Activation and Fibrosis

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Current updates and future perspectives on the management of renal cell carcinoma

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Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells

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The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis

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mTOR Signaling in T Cell Immunity and Autoimmunity

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Molecular damage in cancer: an argument for mTOR-driven aging

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Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia

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Differential Contribution of Insulin and Amino Acids to the mTORC1-Autophagy Pathway in the Liver and Muscle

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Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin

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Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway

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Regulation of Blood–Testis Barrier (BTB) Dynamics during Spermatogenesis via the “Yin” and “Yang” Effects of Mammalian Target of Rapamycin Complex 1 (mTORC1) and mTORC2

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Suppression of replicative senescence by rapamycin in rodent embryonic cells

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Rapalogs in cancer prevention

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mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics

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