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mTOR signaling in disease
Abstract
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.
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“Signaling via mTOR is linked to accelerated aging and dysregulation of mTOR signaling is also linked to the progression of cancer, inflammatory and neurological diseases, as well as T2DM (59).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [59]
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A lipid-mTORC1 nutrient sensing pathway regulates animal development by peroxisome-derived hormonesPreprint
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Kunnath, A. N., Parker, S. K., Crasta, D. N., Kunhiraman, J. P., Madhvacharya, V. V., Kumari, S., Nayak, G., Vani Lakshmi, R., Modi, P. K., Prasad, T. S. K., et al. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117039 · Cited by 1
Metadata
- Authors
- Dazert, E., & Hall, M. N.
- Affiliations
- University of Basel (CH)
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 23
- Issue
- 6
- Pages
- 744-755
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2076457380
- Cited by
- 460
- References
- 171
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 24 · 2021: 26 · 2020: 18 · 2019: 19 · 2018: 38 · 2017: 34 · 2016: 34 · 2015: 38 · 2014: 65 · 2013: 51 · 2012: 54
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Louis-Jeantet Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mTOR signaling, mammalian target of rapamycin, serine/threonine kinase, cell growth regulation, metabolism, aging, cancer, metabolic disorders, neurological disorders, inflammation, nutrient sensing
- MeSH terms
- Animals, Disease Models, Animal, Humans, Mammals, Neoplasms, Signal Transduction, Cell Proliferation, TOR Serine-Threonine Kinases
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