mTOR Signaling in Disease

Dazert, Eva, Hall, Michael N·2011·Current Opinion in Cell Biology
DOI 10.1016/j.ceb.2011.09.003

Cited by (461)

Items 101–200 of 461

  1. Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin
    Bumsup Kwon, Henry W. Querfurth · 2015 · Biochimie
  2. Effect of treadmill exercise on PI3K/AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice
    Eun‐Bum Kang, Joon-Yong Cho · 2015 · Physical Activity and Nutrition
  3. MiR-424/503-Mediated Rictor Upregulation Promotes Tumor Progression
    Chitose Oneyama, Yoriko Kito, Rei Asai, Jun‐ichiro Ikeda, Takuya Yoshida, Daisuke Okuzaki, Rie Kokuda, Kyoko Kakumoto, Ken‐ichi Takayama, Satoshi Inoue et al. · 2013 · PLoS ONE
  4. Activation of PI3K/Akt/mTOR Pathway and Dual Inhibitors of PI3K and mTOR in Endometrial Cancer
    Jiezhong Chen, Kong‐Nan Zhao, Rui Li, Renfu Shao, Chen Chen · 2014 · Current Medicinal Chemistry
  5. mTORC2 controls cancer cell survival by modulating gluconeogenesis
    Md. Wasim Khan, Dipsikha Biswas, Monisankar Ghosh, Sapan Mandloi, Saikat Chakrabarti, Partha Chakrabarti · 2015 · Cell Death Discovery
  6. Glutamine metabolism in advanced age
    Dominique Meynial‐Denis · 2016 · Nutrition Reviews
  7. mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice
    Alexandre Boyer, M. Girard, D. S. Thimmanahalli, Adrien Levasseur, Christophe Céleste, Marilène Paquet, Rajesha Duggavathi, Derek Boerboom · 2016 · Biology of Reproduction
  8. The β-glucan fromLentinus edodessuppresses cell proliferation and promotes apoptosis in estrogen receptor positive breast cancers
    Hui Min Xu, Siwei Zou, Xiaojuan Xu · 2017 · Oncotarget
  9. Trilateral association of autophagy, mTOR and Alzheimer’s disease: Potential pathway in the development for Alzheimer’s disease therapy
    Arunkumar Subramanian, T. Tamilanban, Abdulrhman Alsayari, Gobinath Ramachawolran, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Vetriselvan Subramaniyan, Suresh V. Chinni, Nur Najihah Izzati Mat Rani et al. · 2022 · Frontiers in Pharmacology
  10. Targeting the mTOR-DEPTOR Pathway by CRL E3 Ubiquitin Ligases: Therapeutic Application
    Yongchao Zhao, Yi Sun · 2012 · Neoplasia
  11. mTOR Inhibitors Induce Cell-Cycle Arrest and Inhibit Tumor Growth in Epstein–Barr Virus–Associated T and Natural Killer Cell Lymphoma Cells
    Jun‐ichi Kawada, Yoshinori Ito, Seiko Iwata, Michio Suzuki, Yoshihiko Kawano, Tetsuhiro Kanazawa, Mohammed Nure Alam Siddiquey, Hiroshi Kimura · 2014 · Clinical Cancer Research
  12. Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice
    Shih‐Yin Tsai, Ariana A. Rodriguez, Somasish Ghosh Dastidar, Elizabeth Del Greco, Kaili Lia Carr, Joanna M. Sitzmann, Emmeline C. Academia, Christian Michael Viray, Lizbeth Leon Martinez, Brian Kaplowitz et al. · 2016 · Cell Reports
  13. mTOR Hyperactivation in Down Syndrome Hippocampus Appears Early During Development
    Iyer, Anand M., van Scheppingen, Jackelien, Milenkovic, Ivan, Anink, Jasper J., Adle-Biassette, Homa, Kovacs, Gabor G., Aronica, Eleonora · 2014 · Journal of Neuropathology & Experimental Neurology
  14. Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats
    Temiz-Resitoglu, Meryem, Kucukkavruk, Sefika Pinar, Guden, Demet Sinem, Cecen, Pelin, Sari, Ayse Nihal, Tunctan, Bahar, Gorur, Aysegul, Tamer-Gumus, Lulufer, Buharalioglu, Cuneyt Kemal, Malik, Kafait U. et al. · 2017 · European Journal of Pharmacology
  15. Rapamycin protects against apoptotic neuronal death and improves neurologic function after traumatic brain injury in mice via modulation of the mTOR-p53-Bax axis
    Ke Ding, Handong Wang, Yong Gui Wu, Li Zhang, Jianguo Xu, Tao Li, Yu Ding, Lin Zhu, Jin He · 2014 · Journal of Surgical Research
  16. Mammalian target of rapamycin, insulin resistance and hidradenitis suppurativa: a possible metabolic loop
    Giuseppe Monfrecola, Anna Balato, Giuseppina Caiazzo, Valerio De Vita, Roberta Di Caprio, Marianna Donnarumma, Serena Lembo, Gabriella Fabbrocini · 2015 · Journal of the European Academy of Dermatology and Venereology
  17. Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo
    Hironao Nakayama, Sarah Bruneau, Nora M. Kochupurakkal, Sílvia Coma, David Michael Briscoe, Michael Klagsbrun · 2015 · Scientific Reports
  18. mTor-signaling is required for the formation of proliferating Müller glia-derived progenitor cells in the chick retina
    Christopher Paul Zelinka, Leo I. Volkov, Zachary A. Goodman, Levi J. Todd, Isabella Palazzo, William A. Bishop, Andy J. Fischer · 2016 · Development
  19. Molecular Targets for the Treatment of Multiple Myeloma
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  21. Brain response to calorie restriction
    Salvatore Fusco, Giovambattista Pani · 2012 · Cellular and Molecular Life Sciences
  22. IFN-γ orchestrates mesenchymal stem cell plasticity through the signal transducer and activator of transcription 1 and 3 and mammalian target of rapamycin pathways
    Tiziana Vigo, Claudio Procaccini, Giovanni Battista Ferrara, Sergio E. Baranzini, Jorge R. Oksenberg, Giuseppe Matarese, Alberto Diaspro, Nicole Kerlero de Rosbo, Antonio Uccelli · 2016 · Journal of Allergy and Clinical Immunology
  23. Endometriosis-Associated Ovarian Carcinomas: How PI3K/AKT/mTOR Pathway Affects Their Pathogenesis
    Tatiana S. Driva, Christoph Schatz, Johannes Haybaeck · 2023 · Biomolecules
  24. Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations
    Lorna W. Harries, Alexander D. Fellows, Luke C. Pilling, Dena G. Hernandez, Andrew Singleton, Stefania Bandinelli, Jack M. Guralnik, Jonathan Powell, Luigi Ferrucci, David R. Melzer · 2012 · Mechanisms of Ageing and Development
  25. mTOR controls kidney epithelia in health and disease
    Florian Grahammer, Nicola Wanner, Tobias Bruno Huber · 2014 · Nephrology Dialysis Transplantation
  26. mTOR in health and in sickness
    Dritan Liko, Michael N. Hall · 2015 · Journal of Molecular Medicine
  27. Role of mTORC1 Controlling Proteostasis after Brain Ischemia
    María José Pérez-Álvarez, Mario Villa-González, Irene Benito‐Cuesta, Francisco G. Wandosell · 2018 · Frontiers in Neuroscience
  28. Architecture and activation of phosphatidylinositol 3-kinase related kinases
    Stefan Imseng, Christopher H. S. Aylett, Timm Maier · 2018 · Current Opinion in Structural Biology
  29. Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1
    Ling Hu, Kuan Tian, Tao Zhang, Chunhua Fan, Peng Zhou, Di Zeng, Shuang Zhao, Lisha Li, Hendrea Shaniqua Smith, Jing Li et al. · 2019 · Molecules
  30. A review of fasting effects on the response of cancer to chemotherapy
    Mehdi Sadeghian, Sepideh Rahmani, Saman Khalesi, Ehsan Hejazi · 2020 · Clinical Nutrition
  31. Berberine decelerates glucose metabolism via suppression of mTOR‑dependent HIF‑1α protein synthesis in colon cancer cells
    Liyuan Mao, Qiongyun Chen, Ke Gong, Xiaolin Xu, Yurou Xie, Wenqing Zhang, Hanwei Cao, Tianhui Hu, Xiaoting Hong, Yan-yan Zhan · 2018 · Oncology Reports
  32. Behavioral, neurochemical and molecular changes after acute deep brain stimulation of the infralimbic prefrontal cortex
    Laura Jiménez-Sánchez, Raquel Linge, Leticia Campa, Elsa M. Valdizán, Ángel Pazos, Álvaro Díaz, Albert Adell · 2016 · Neuropharmacology
  33. Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines
    Li Wang, JIANZHONG WU, Jianwei Lu, Rong Ma, Dawei Sun, Jinhai Tang · 2014 · Molecular Medicine Reports · Retracted
  34. Mesenchymal stem cells-derived IL-6 activates AMPK/mTOR signaling to inhibit the proliferation of reactive astrocytes induced by hypoxic-ischemic brain damage
    Mulan He, Xia Shi, Miao Yang, Ting Yang, Tingyu Li, Jie Chen · 2018 · Experimental Neurology
  35. Convergence of Ubiquitylation and Phosphorylation Signaling in Rapamycin-treated Yeast Cells
    Vytautas Iešmantavičius, Brian Tate Weinert, Chunaram Choudhary · 2014 · Molecular & Cellular Proteomics
  36. Down Syndrome iPSC-Derived Astrocytes Impair Neuronal Synaptogenesis and the mTOR Pathway In Vitro
    Araujo, Bruno H. S., Kaid, Carolini, De Souza, Janaina S., Gomes da Silva, Sérgio, Goulart, Ernesto, Caires, Luiz C. J., Musso, Camila M., Torres, Laila B., Ferrasa, Adriano, Herai, Roberto et al. · 2018 · Molecular Neurobiology
  37. mTOR regulate EMT through RhoA and Rac1 pathway in prostate cancer
    XianGuo Chen, Haiyan Cheng, Tengfei Pan, Yi Liu, Su Yang, Cuiping Ren, Dake Huang, Xiaojun Zha, Chang Yin Liang · 2014 · Molecular Carcinogenesis
  38. Fertilization-Induced Autophagy in Mouse Embryos is Independent of mTORC11
    Atsushi Yamamoto, Noboru Mizushima, Satoshi Tsukamoto · 2014 · Biology of Reproduction
  39. Inhibition of AMP-activated protein kinase alleviates focal cerebral ischemia injury in mice: Interference with mTOR and autophagy
    Le Fu, Liang Huang, Chunshui Cao, Qin Yin, Jian Liu · 2016 · Brain Research
  40. mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses
    Lilin Ye, Junghwa Lee, Lifan Xu, Ata‐Ur‐Rasheed Mohammed, Weiyan Li, J. Scott Hale, Wendy G. Tan, Tuoqi Wu, Carl W. Davis, Rafi Ahmed et al. · 2017 · Journal of Virology
  41. The Mitochondria-Targeted Antioxidant SkQ1 but Not N-Acetylcysteine Reverses Aging-Related Biomarkers in Rats
    Kolosova, Nataliya G., Stefanova, Natalia A., Muraleva, Natalia A., Skulachev, Vladimir P. · 2012 · Aging
  42. Mechanisms of epileptogenesis and preclinical approach to antiepileptogenic therapies
    Krzysztof Łukawski, Marta Andres‐Mach, Mirosław Czuczwar, Jarogniew Jacek Łuszczki, Krzysztof Kruszyński, Stanisław Jerzy Czuczwar · 2017 · Pharmacological Reports
  43. Mechanisms of cancer stem cell therapy
    Ali Akbar Samadani, Arman Keymoradzdeh, Shima Shams, Armin Soleymanpour, Seyedeh Elham Norollahi, Sogand Vahidi, Ali Rashidy‐Pour, Ali Ashraf, Ebrahim Mirzajani, Korosh Khanaki et al. · 2020 · Clinica Chimica Acta
  44. NCI's provocative questions on cancer: some answers to ignite discussion
    Mikhail V. Blagosklonny · 2011 · Oncotarget
  45. Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
    Olga V. Leontieva, Geraldine Paszkiewicz, Mikhail V. Blagosklonny · 2012 · Aging
  46. Rapamycin Inhibits ALDH Activity, Resistance to Oxidative Stress, and Metastatic Potential in Murine Osteosarcoma Cells
    Xiaodong Mu, Christian E. Isaac, Trevor Schott, Johnny Huard, Kurt Richard Weiss · 2013 · Sarcoma
  47. mTOR Inhibition: From Aging to Autism and Beyond
    Matt R. Kaeberlein · 2013 · Scientifica
  48. Rapamycin increases mitochondrial efficiency by mtDNA-dependent reprogramming of mitochondrial metabolism in Drosophila
    Eugenia Villa-Cuesta, Marissa A. Holmbeck, David M. Rand · 2014 · Journal of Cell Science
  49. Keloid Disease Can Be Inhibited by Antagonizing Excessive mTOR Signaling With a Novel Dual TORC1/2 Inhibitor
    Farhatullah Syed, David Sherris, Ralf Paus, Shohreh Varmeh, Pier Paolo Pandolfi, Ardeshir Bayat · 2012 · American Journal Of Pathology
  50. mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling
    Huiyuan Zhang, Jun Dou, Yang Yu, Yanling Zhao, Yihui Fan, Jin Cheng, Xin Yi Xu, Wei Yong Liu, Shan Guan, Zhenghu Chen et al. · 2014 · APOPTOSIS
  51. Methylglyoxal Activates the Target of Rapamycin Complex 2-Protein Kinase C Signaling Pathway in Saccharomyces cerevisiae
    Wataru Nomura, Yoshiharu Inoue · 2015 · Molecular and Cellular Biology
  52. Insulin-like Growth Factor 2 mRNA-Binding Protein 2—a Potential Link Between Type 2 Diabetes Mellitus and Cancer
    Junguo Cao, Weijia Yan, Xiujian Ma, Haiyan Huang, HONG HUA YAN · 2021 · The Journal of Clinical Endocrinology & Metabolism
  53. Immunosuppressants in cancer prevention and therapy
    Mikhail V. Blagosklonny · 2013 · OncoImmunology
  54. Vertical inhibition of PI3K/Akt/mTOR signaling demonstrates in vitro and in vivo anti-fibrotic activity
    Minrui Liang, Jiaoyan Lv, Haiyan Chu, Jiucun Wang, Xiangjun Chen, Xiaoxia Zhu, Yu Xue, Ming Guan, Hejian Zou · 2014 · Journal of Dermatological Science
  55. Activation of AMPK inhibits PDGF-induced pulmonary arterial smooth muscle cells proliferation and its potential mechanisms
    Yang Song, Yuanyuan Wu, Xiaofan Su, Yanting Zhu, Lu Liu, Yilin Pan, Bo Zhu, Lan Yang, Li Gao, Manxiang Li · 2016 · Pharmacological Research
  56. Attenuated mTOR Signaling and Enhanced Glucose Homeostasis by Dietary Supplementation with Lotus Seedpod Oligomeric Procyanidins in Streptozotocin (STZ)-Induced Diabetic Mice
    Xiaopeng Li, Yong Sui, Qian Wu, Bijun Xie, Zhida Sun · 2017 · Journal of Agricultural and Food Chemistry
  57. Therapeutic potency of mTOR signaling pharmacological inhibitors in the treatment of proinflammatory diseases, current status, and perspectives
    Arash Soltani, Amirhossein Bahreyni, Nadia Boroumand, Mostafa Karimi Roshan, Majid Khazaei, Mikhail Ryzhikov, Saman Soleimanpour, Amir Avan, Seyed Mahdi Hassanian · 2017 · Journal of Cellular Physiology
  58. Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome
    Wayne A. Cabral, Urraca L. Tavarez, Indeevar R. Beeram, Diana Yeritsyan, Yoseph D. Boku, Michael Eckhaus, Ara Nazarian, Michael R. Erdos, Francis S. Collins · 2021 · Aging Cell
  59. Mtor As A Potential Treatment Target For Epilepsy
    Michael Wong · 2012 · Future Neurology
  60. The role of metabolic ecosystem in cancer progression — metabolic plasticity and mTOR hyperactivity in tumor tissues
    Anna Réka Sebestyén, Titanilla Dankó, Dániel Sztankovics, Dorottya Moldvai, Regina Eszter Raffay, Catherine Cervi, Ildikó Krencz, Viktória Zsiros, András Jeney, Gábor Petővári · 2021 · Cancer and Metastasis Reviews
  61. [Retracted] Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines
    Li Wang, Jianzhong Wu, Jianwei Lu, Rong Ma, Dawei Sun, Jinhai Tang · 2021 · Molecular Medicine Reports · Retracted
  62. Targeting c-Met in melanoma
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  63. Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling
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  64. PHYSIOLOGY SYMPOSIUM: Postnatal consequences of in utero heat stress in pigs1,2
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  65. Downregulation of MicroRNA-193b-3p Promotes Autophagy and Cell Survival by Targeting TSC1/mTOR Signaling in NSC-34 Cells
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  66. Tissue-Specific Responses of IGF-1/Insulin and mTOR Signaling in Calorie Restricted Rats
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  67. TAK-228 (formerly MLN0128), an investigational dual TORC1/2 inhibitor plus paclitaxel, with/without trastuzumab, in patients with advanced solid malignancies
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  68. Correction of glycogen storage disease type III with rapamycin in a canine model
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  69. Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet
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  70. Cancer-related cognitive impairment is associated with perturbations in inflammatory pathways
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  71. Selective anti-cancer agents as anti-aging drugs
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  72. mTOR Inhibition Promotes TTF1-Dependent Redifferentiation and Restores Iodine Uptake in Thyroid Carcinoma Cell Lines
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  73. The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?
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  74. Senescence regulation by mTOR
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  75. An mTOR kinase inhibitor slows disease progression in a rat model of polycystic kidney disease
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  76. An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2
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  77. Koschei the immortal and anti-aging drugs
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  78. How to save Medicare: the anti-aging remedy
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  79. Biochemistry of Sertoli cell/germ cell junctions, germ cell transport, and spermiation in the seminiferous epithelium
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  80. Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis†
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  82. Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease
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  92. Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion
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  93. St. John’s Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway
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  94. TORC2 Is Required to Maintain Genome Stability during S Phase in Fission Yeast
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  96. Emerging role of mTOR in tumor immune contexture: Impact on chemokine-related immune cells migration
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  97. Pseudoacromegaly
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  98. Aurora kinase A suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells
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  100. The TOR pathway modulates cytoophidium formation in Schizosaccharomyces pombe
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