Precursor Diversity and Complexity of Lineage Relationships in the Outer Subventricular Zone of the Primate
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Long-term ex vivo live imaging combined with unbiased sampling of cycling precursors shows that macaque outer subventricular zone (OSVZ) includes four distinct basal radial glial (bRG) cell morphotypes, bearing apical and/or basal processes in addition to nonpolar intermediate progenitors (IPs). Each of the five precursor types exhibits extensive self-renewal and proliferative capacities as well as the ability to directly generate neurons, albeit with different frequencies. Cell-cycle parameters exhibited an unusual stage-specific regulation with short cell-cycle duration and increased rates of proliferative divisions during supragranular layer production at late corticogenesis. State transition analysis of an extensive clonal database reveals bidirectional transitions between OSVZ precursor types as well as stage-specific differences in their progeny and topology of the lineage relationships. These results explore rodent-primate differences and show that primate cortical neurons are generated through complex lineages by a mosaic of precursors, thereby providing an innovative framework for understanding specific features of primate corticogenesis.
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Germinal layers contain various cortical progenitors including RG in VZ, IP in SZi, and ORG in SZo, and these RG may be diverse.
“Germinal layers contain various cortical progenitors including RG in the VZ, intermediate progenitors (IP) in the SZi, and ORG in the SZo (reviewed in41), and these RG may be quite diverse42.”
From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [42]
Humans, non-human primates, and placental mammals with an enlarged brain have an additional expanded germinal zone called the outer subventricular zone, where outer or basal RG cells are abundant.
“Remarkably, humans, non-human primates, and placental mammals with an enlarged brain have an additional, expanded germinal zone called the outer subventricular zone (OSVZ), where a unique population of neocortical progenitors called outer or basal RG cells are abundant (Betizeau et al., 2013; Fietz et al., 2010; Hansen et al 2010; Lui et al., 2011; Reillo et al., 2011; Smart et al., 2002).”
From Genetic Changes Shaping the Human Brain (2015) · cites this paper as Betizeau et al., 2013
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- Authors
- Betizeau, M., Cortay, V., Patti, D., Pfister, S., Gautier, E., Bellemin-Ménard, A., Afanassieff, M., Huissoud, C., Douglas, R. J., Kennedy, H., & Dehay, C.
- Affiliations
- Lyon 1 Université (FR)
- ETH Zurich (CH)
- Corresponding author
- Dehay, Colette
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 80
- Issue
- 2
- Pages
- 442-457
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2060631152
- Cited by
- 462
- References
- 59
- Citations by year
- 2026: 22 · 2025: 27 · 2024: 27 · 2023: 32 · 2022: 37 · 2021: 46 · 2020: 48 · 2019: 35 · 2018: 35 · 2017: 31 · 2016: 41 · 2015: 33 · 2014: 43 · 2013: 4
- FWCI
- 14.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-IDEX-0007, ANR-11-LABX-0042)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- outer subventricular zone, intermediate progenitor cells, cortical neurogenesis, cell cycle regulation, lineage relationships, state transition analysis, clonal analysis, macaque
- MeSH terms
- PAX6 Transcription Factor, Animals, Cell Cycle, Cells, Cultured, Cerebral Cortex, Eye Proteins, Macaca fascicularis, Repressor Proteins, Homeodomain Proteins, Gene Expression Regulation, Developmental, Cell Lineage, Lateral Ventricles, T-Box Domain Proteins, Paired Box Transcription Factors, Neurogenesis, Neural Stem Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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