CoChat
Sign Up
Cited by 38Ion Channels and ReceptorsIon channel regulation and functionCalcium signaling and nucleotide metabolism

Segregation of calcium signalling mechanisms in magnocellular neurones and terminals

Dayanithi, Govindan, Forostyak, Oksana, Ueta, Yoichi, Verkhratsky, Alexei, Toescu, Emil C.·2012·Cell Calcium
DOI 10.1016/j.ceca.2012.02.002
Open this paper in CoChat — free account

Abstract

Every cell or neuronal type utilizes its own specific organization of its Ca(2+) homeostasis depending on its specific function and its physiological needs. The magnocellular neurones, with their somata situated in the supraoptic and paraventricular nuclei of the hypothalamus and their nerve terminals populating the posterior hypophysis (neural lobe) are a typical and classical example of a neuroendocrine system, and an important experimental model for attempting to understand the characteristics of the neuronal organization of Ca(2+) homeostasis. The magnocellular neurones synthesize, in a cell specific manner, two neurohormones: arginine-vasopressin (AVP) and oxytocin (OT), which can be released, in a strict Ca(2+)-dependent manner, both at the axonal terminals, in the neural lobe, and at the somatodendritic level. The two types of neurones show also distinct type of bioelectrical activity, associated with specific secretory patterns. In these neurones, the Ca(2+) homeostatic pathways such as the Na(+)/Ca(2+) exchanger (NCX), the endoplasmic reticulum (ER) Ca(2+) pump, the plasmalemmal Ca(2+) pump (PMCA) and the mitochondria are acting in a complementary fashion in clearing Ca(2+) loads that follow neuronal stimulation. The somatodendritic AVP and OT release closely correlates with intracellular Ca(2+) dynamics. More importantly, the ER Ca(2+) stores play a major role in Ca(2+) homeostatic mechanism in identified OT neurones. The balance between the Ca(2+) homeostatic systems that are in the supraoptic neurones differ from those active in the terminals, in which mainly Ca(2+) extrusion through the Ca(2+) pump in the plasma membrane and uptake by mitochondria are active. In both AVP and OT nerve terminals, no functional ER Ca(2+) stores can be evidenced experimentally. We conclude that the physiological significance of the complexity of Ca(2+) homeostatic mechanisms in the somatodendritic region of supraoptic neurones and their terminals can be multifaceted, attributable, in major part, to their specialized electrical activity and Ca(2+)-dependent neurohormone release.

Integrity signals

Registry

Crossref · 10.1016/j.ceca.2012.02.002

Cites

106 of 106 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Dayanithi, G., Forostyak, O., Ueta, Y., Verkhratsky, A., & Toescu, E. C.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Czech Academy of Sciences (CZ)
  • University of Occupational and Environmental Health Japan (JP)
  • University of Birmingham (GB)
ORCID
Venue
Cell Calcium
Publisher
Elsevier BV
Published
2012-03
Volume
51
Issue
3-4
Pages
293-299
ISSN
0143-4160 (ISSN-L)
DOI
10.1016/j.ceca.2012.02.002
OpenAlex
W2066043959
Cited by
38
References
106
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 3
FWCI
0.53
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cell Calcium (publishedVersion)
  • PubMed (publishedVersion)
  • ASEP (submittedVersion, public-domain)
  • Research Explorer (The University of Manchester) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
  • Grant Agency of the Czech Republic (GACR 303/11/0192)
  • Centre National de la Recherche Scientifique
  • Japanese Society for Promotion of Science Fellowship Programs
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords
calcium homeostasis, magnocellular neurons, supraoptic nucleus, paraventricular nucleus, neurohypophysis, vasopressin, oxytocin, neurohormone release, axonal terminals, Na+/Ca2+ exchanger, endoplasmic reticulum calcium stores, plasma membrane Ca2+ pump, mitochondrial calcium uptake
MeSH terms
Animals, Homeostasis, Humans, Nerve Endings, Neurosecretion, Oxytocin, Pituitary Gland, Vasopressins, Calcium Channels, Presynaptic Terminals, Calcium Signaling, Receptor Cross-Talk

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review