Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents☆
Abstract
Oxytocin (OT) and vasopressin (AVP) mediate their biological actions by acting on four known receptors: The OT (uterine) and the AVP V(1a) (vasopressor), V(1b) (pituitary), V(2) (renal) receptors and a fifth putative AVP V(1c)? (vasodilating) receptor. This presentation will summarize some highlights of the recent progress, in the design and synthesis of selective peptide agonists, antagonists, radioiodinated ligands, fluorescent ligands and bivalent ligands for these receptors. Here we present published and unpublished pharmacological data on the most widely used agonists, antagonists and labelled ligands. The pharmacological properties of promising new selective OT antagonists and V(1b) agonists are also presented. This review should serve as a useful guide for the selection of the most appropriate ligand for a given study. The current status of non-peptide OT and AVP antagonists and agonists is also summarized. The relative merits of peptide and non-peptide AVP and OT agonists and antagonists as: (1) research tools and (2) therapeutic agents will be evaluated. Many of the receptor selective peptide agonists and antagonists from this and other laboratories are far more widely used as pharmacological tools for studies on the peripheral and central effects of OT and AVP than their non-peptide counterparts. In addition to OT and to a lesser extent AVP (pitressin), a number of OT and AVP analogues; such as carbetocin (OT agonist) dDAVP (desmopressin, V(2) agonist), terlipressin (V(1a) agonist), felypressin (V(1a) agonist) and atosiban (Tractocile OT antagonist) are also in clinical use. Despite much early promise, no non-peptide V(1a) or OT antagonists are currently in clinical trials. While a number of orally active non-peptide V(2) antagonists (Vaptans); notably, Tolvaptan, Lixivaptan and Satavaptan, are currently in Phase III clinical trials; to date, only the mixed V(2)/V(1a), antagonist Conivaptan (Vaprisol), has been approved by the US FDA for clinical use (by i.v. administration), for the treatment of euvolemic and hypervolemic hyponatremia in hospitalized patients. Promising new non-peptide V(1b) and OT antagonists, as well as non-peptide V(2) and OT agonists are now in pre-clinical development.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies using recombinant expression systems for human, rat, and mouse OT and AVP receptors have shown that only the human OTR is selective for OT by a standard criterion.
“For example, studies employing recombinant expression systems to examine selectivity of human, rat, and mouse OT and AVP receptors have shown that only the human OTR is selective for OT using a standard criterion [34; 35] (Table 1).”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [34]
Oxytocin could enter the central nervous system through intracellular junctions of the olfactory epithelia to mimic endogenous oxytocin release.
“could enter the central nervous system through intracellular junctions of the olfactory epithelia 76 to mimic endogenous oxytocin release 77”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [77]
Cites
Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide
Merrifield, R. B. (1963) · Journal of the American Chemical Society · doi:10.1021/ja00897a025 · Cited by 7,645 · see citing works
A highly sensitive adenylate cyclase assay
Salomon, Y., Londos, C., & Rodbell, M. (1974) · Analytical Biochemistry · doi:10.1016/0003-2697(74)90222-x · Cited by 4,188 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
Tolvaptan, a Selective Oral Vasopressin V <sub>2</sub> -Receptor Antagonist, for Hyponatremia
Schrier, R. W., Gross, P., Gheorghiade, M., Berl, T., Verbalis, J. G., Czerwiec, F. S., & Orlandi, C. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa065181 · Cited by 1,215 · see citing works
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173 · see citing works
Merrifield, B. (1986) · Science · doi:10.1126/science.3961484 · Cited by 1,005 · see citing works
More than one reason to rethink the use of peptides in vaccine design
Purcell, A. W., McCluskey, J., & Rossjohn, J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2224 · Cited by 853 · see citing works
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · see citing works
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · see citing works
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689 · see citing works
Structure and expression of a human oxytocin receptor
Kimura, T., Tanizawa, O., Mori, K., Brownstein, M., & Okayama, H. (1992) · Nature · doi:10.1038/356526a0 · Cited by 631 · see citing works
Molecular cloning of the receptor for human antidiuretic hormone
Birnbaumer, M., Seibold, A. M., Gilbert, S., Ishido, M., Barberis, C., Antaramián, A., Brabet, P., & Rosenthal, W. (1992) · Nature · doi:10.1038/357333a0 · Cited by 539 · see citing works
Lolait, S. J., O'Carroll, A.-M., McBride, O. W., Konig, M., Morel, A., & Brownstein, M. J. (1992) · Nature · doi:10.1038/357336a0 · Cited by 524 · see citing works
Prevention and Treatment of Major Blood Loss
Mannucci, P. M., & Levi, M. M. (2007) · New England Journal of Medicine · doi:10.1056/nejmra067742 · Cited by 492 · see citing works
Molecular cloning and expression of a rat Via arginine vasopressin receptor
Morel, A., O'Carroll, A.-M., Brownstein, M. J., & Lolaft, S. J. (1992) · Nature · doi:10.1038/356523a0 · Cited by 477 · see citing works
Griebel, G., Simiand, J., Serradeil-Le Gal, C., Wagnon, J., Pascal, M., Scatton, B., Maffrand, J.-P., & Soubrié, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092012099 · Cited by 471 · see citing works
Kruszynski, M., Lammek, B., Manning, M., Seto, J., Haldar, J., & Sawyer, W. H. (1980) · Journal of Medicinal Chemistry · doi:10.1021/jm00178a003 · Cited by 450 · see citing works
Self-citationBrain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439 · see citing works
du Vigneaud, V., Ressler, C., SWAN, J. M., Roberts, C. W., & Katsoyannis, P. G. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01641a004 · Cited by 422 · see citing works
Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor.
Sugimoto, T., Saito, M., Mochizuki, S., Watanabe, Y., Hashimoto, S., & Kawashima, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47129-3 · Cited by 376 · see citing works
Science review: Vasopressin and the cardiovascular system part 1--receptor physiology.
(2003) · Critical Care · doi:10.1186/cc2337 · Cited by 356 · see citing works
Yamamura, Y., Ogawa, H., Yamashita, H., Chihara, T., Miyamoto, H., Nakamura, S., Onogawa, T., Yamashita, T., Hosokawa, T., Mori, T., et al. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09058.x · Cited by 346 · see citing works
Yamamura, Y., Nakamura, S., Itoh, S., Hirano, T., Onogawa, T., Yamashita, T., Yamada, Y., Tsujimae, K., Aoyama, M., Kotosai, K., et al. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37873-5 · Cited by 338 · see citing works
Terrillon, S., Durroux, T., Mouillac, B., Breit, A., Ayoub, M. A., Taulan‐Cadars, M., Jockers, R., Barberis, C., & Bouvier, M. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0222 · Cited by 323 · see citing works
Self-citationRing, R. H., Malberg, J. E., Potestio, L., Ping, J., Boikess, S., Luo, B., Schechter, L. E., Rizzo, S., Rahman, Z., & Rosenzweig-Lipson, S. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0293-z · Cited by 319 · see citing works
Treschan, T. A., Peters, J., & Warltier, D. C. (2006) · Anesthesiology · doi:10.1097/00000542-200609000-00026 · Cited by 317 · see citing works
Romero, R. J., Sibai, B. M., Sanchez‐Ramos, L., Valenzuela, G. J., Veille, J., Tabor, B. L., Perry, K. G., Varner, M. W., Goodwin, T. M., Lane, R., et al. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.95834 · Cited by 316 · see citing works
Munsick, R. A. (1960) · Endocrinology · doi:10.1210/endo-66-3-451 · Cited by 302 · see citing works
Daniels, D. J., Lenard, N. R., Etienne, C. L., Law, P., Roerig, S. C., & Portoghese, P. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506627102 · Cited by 297 · see citing works
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 289 · see citing works
Thibonnier, M., Auzan, C., Madhun, Z. T., Wilkins, P. L., Berti‐Mattera, L. N., & Clauser, É. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41863-1 · Cited by 281 · see citing works
Jard, S., Gaillard, R. C., Guillon, G., Marie, J., Schoenenberg, P., Muller, A. F., Manning, M., & Sawyer, W. H. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10336-2 · Cited by 276 · see citing works
Self-citationGal, C. S., Wagnon, J., Garcia, C., Lacour, C., Guiraudou, P., Christophe, B., Villanova, G., Nisato, D., Maffrand, J., & Fur, G. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116554 · Cited by 272 · see citing works
OPC-21268, an Orally Effective, Nonpeptide Vasopressin V1 Receptor Antagonist
Yamamura, Y., Ogawa, H., Chihara, T., Kondo, K., Onogawa, T., Nakamura, S., Mori, T., Tominaga, M., & Yabuuchi, Y. (1991) · Science · doi:10.1126/science.1850553 · Cited by 271 · see citing works
Centrally released oxytocin mediates mating-induced anxiolysis in male rats
Waldherr, M., & Neumann, I. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705860104 · Cited by 261 · see citing works
THE QUANTITATIVE ASSAY OF VASOPRESSIN
Dekanski, J. (1952) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1952.tb00723.x · Cited by 259 · see citing works
Social facilitation of wound healing
Detillion, C. E., Craft, T. K. S., Glasper, E. R., Prendergast, B. J., & DeVries, A. C. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.10.003 · Cited by 259 · see citing works
Gal, C. S., Lacour, C., Valette, G., Garcia, G., Foulon, L., Galindo, G., Bankir, L., Pouzet, B., Guillon, G., Barberis, C., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119098 · Cited by 249 · see citing works
Self-citation125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT: a selective oxytocin receptor ligand
Elands, J., Barberis, C., Jard, S., Tribollet, E., Dreifuss, J.-J., Bankowski, K., Manning, M., & Sawyer, W. H. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90778-9 · Cited by 245 · see citing works
Self-citationPharmacologic Chaperones as a Potential Treatment for X-Linked Nephrogenic Diabetes Insipidus
Bernier, V., Morello, J.-P., ZARRUK, A. R., Debrand, N., Salahpour, A., Lonergan, M., Arthus, M., Laperrière, A., Brouard, R., Bouvier, M., et al. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005080854 · Cited by 244 · see citing works
A MODIFICATION OF THE METHOD OF DALE AND LAIDLAW FOR STANDARDIZATION OF POSTERIOR PITUITARY EXTRACT
Holton, P. (1948) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1948.tb00396.x · Cited by 242 · see citing works
Bone, E. A., Fretten, P., Palmer, S., Kirk, C. J., & Michell, R. H. (1984) · Biochemical Journal · doi:10.1042/bj2210803 · Cited by 221 · see citing works
Recent Advances in Protein and Peptide Drug Delivery Systems
Malik, D. K., Baboota, S., Ahuja, A., Hasan, S., & Ali, J. (2007) · Current Drug Delivery · doi:10.2174/156720107780362339 · Cited by 216 · see citing works
Gal, C. S.-L., Wagnon, J., Simiand, J., Griebel, G., Lacour, C., Guillon, G., Barberis, C., Brossard, G., Soubrié, P., Nisato, D., et al. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.1122 · Cited by 211 · see citing works
Self-citationSensitivity to Intranasal Oxytocin in Adult Men with Early Parental Separation
Meinlschmidt, G., & Heim, C. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.007 · Cited by 210 · see citing works
Cloning and characterization of the human V3 pituitary vasopressin receptor
de Keyzer, Y., Auzan, C., Lenne, F., Beldjord, C., Thibonnier, M., Bertagna, X., & Clauser, E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01268-7 · Cited by 209 · see citing works
Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.002 · Cited by 204 · see citing works
Ebner, K., Bosch, O. J., Krömer, S. A., Singewald, N., & Neumann, I. D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300607 · Cited by 200 · see citing works
Science Review: Vasopressin and the cardiovascular system part 2 - clinical physiology.
Holmes, C. L., Landry, D. W., & Granton, J. T. (2003) · Critical Care · doi:10.1186/cc2338 · Cited by 195 · see citing works
Ghali, J. K., Koren, M. J., Taylor, J. R., Brooks-Asplund, E. M., Fan, K., Long, W. A., & Smith, N. N. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2287 · Cited by 193 · see citing works
A SYNTHETIC PREPARATION POSSESSING BIOLOGICAL PROPERTIES ASSOCIATED WITH ARGININEVASOPRESSIN
du Vigneaud, V., Gish, D. T., & Katsoyannis, P. G. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01647a089 · Cited by 192 · see citing works
Cantau, B., Keppens, S., WULF, H. D., & Jard, S. (1980) · Journal of Receptor Research · doi:10.3109/10799898009044096 · Cited by 164 · see citing works
Novel Ligand Specificity of Pituitary Vasopressin Receptors in the Rat
Antoni, F. A. (2008) · Neuroendocrinology · doi:10.1159/000123976 · Cited by 159 · see citing works
Discovery, development, and some uses of vasopressin and oxytocin antagonists.
Manning, M., & Sawyer, W. H. (1989) · PubMed · Cited by 151 · see citing works
Self-citationAlbright, J. D., Reich, M. F., Santos, E. G. D., Dusza, J. P., Sum, F., Venkatesan, A. M., Coupet, J., Chan, P. S., Ru, X., Mazandarani, H., et al. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm980179c · Cited by 151 · see citing works
Maintenance treatment of preterm labor with the oxytocin antagonist atosiban
Valenzuela, G. J., Sanchez‐Ramos, L., Romero, R. J., Silver, H. M., Koltun, W. D., Millar, L. K., Hobbins, J. C., Rayburn, W. F., Shangold, G. A., Wang, J., et al. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.105816 · Cited by 151 · see citing works
The Basic and Clinical Pharmacology of Nonpeptide Vasopressin Receptor Antagonists
Thibonnier, M., Coles, P., Thibonnier, A., & Shoham, M. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.175 · Cited by 146 · see citing works
Zaoral, M., Kolc, J., & Šorm, F. (1967) · Collection of Czechoslovak Chemical Communications · doi:10.1135/cccc19671250 · Cited by 142 · see citing works
The Central Vasopressinergic System: Examining the Opportunities for Psychiatric Drug Development
Ring, R. H. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382241 · Cited by 141 · see citing works
Tahara, A., Tomura, Y., Wada, K., Kusayama, T., Tsukada, J., Takanashi, M., Yatsu, T., Uchida, W., & Tanaka, A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36784-9 · Cited by 140 · see citing works
The oxytocin receptor antagonist atosiban inhibits cell growth via a “biased agonist” mechanism
Reversi, A., Rimoldi, V., Marrocco, T., Cassoni, P., Bussolati, G., Parenti, M., & Chini, B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409945200 · Cited by 139 · see citing works
Self-citationBoccia, M. L., Goursaud, A.-P. S., Bachevalier, J., Anderson, K. D., & Pedersen, C. A. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.009 · Cited by 136 · see citing works
Sawyer, W. H., Acosta, M., Baláspiri, L., JUDD, J., & Manning, M. (1974) · Endocrinology · doi:10.1210/endo-94-4-1106 · Cited by 135 · see citing works
Self-citationSynthetic antagonists of the myometrial response to vasopressin and oxytocin
Melin, P., Trojnar, J., Johansson, B., Vilhardt, H., & Åkerlund, M. (1986) · Journal of Endocrinology · doi:10.1677/joe.0.1110125 · Cited by 132 · see citing works
Miranda-Cardenas, Y., Rojas‐Piloni, G., Martı́nez-Lorenzana, G., Rodríguez-Jiménez, J., López-Hidalgo, M. A., Freund‐Mercier, M. J., & Condés‐Lara, M. (2006) · Pain · doi:10.1016/j.pain.2006.01.029 · Cited by 131 · see citing works
Abraham, W. T., Shamshirsaz, A. A., McFann, K., Oren, R. M., & Schrier, R. W. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.11.071 · Cited by 130 · see citing works
Thibonnier, M., Preston, J. A., Dulin, N. O., Wilkins, P. L., Berti‐Mattera, L. N., & Mattera, R. (1997) · Endocrinology · doi:10.1210/endo.138.10.5432 · Cited by 129 · see citing works
The involvement of the vasopressin system in stress-related disorders
Landgraf, R. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706776359664 · Cited by 127 · see citing works
Saito, M., Sugimoto, T., Tahara, A., & Kawashima, H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2033 · Cited by 124 · see citing works
Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges
Chini, B., & Manning, M. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350737 · Cited by 123 · see citing works
Self-citationButlen, D., Guillon, G., Rajerison, R. M., Jard, S., Sawyer, W. H., & Manning, M. (1978) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13565-7 · Cited by 122 · see citing works
Self-citationRobben, J. H., Sze, M., Knoers, N. V. A. M., & Deen, P. M. T. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00247.2006 · Cited by 119 · see citing works
Bosch, O. J., Krömer, S. A., & Neumann, I. D. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04576.x · Cited by 115 · see citing works
Hirsch, A. T., Dzau, V. J., Majzoub, J. A., & Creager, M. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114182 · Cited by 115 · see citing works
Vasopressin Analogs That Antagonize Antidiuretic Responses by Rats to the Antidiuretic Hormone
Sawyer, W. H., Pang, P. K. T., SETO, J., McEnroe, M., Lammek, B., & Manning, M. (1981) · Science · doi:10.1126/science.7209515 · Cited by 115 · see citing works
Self-citationTherapeutic Potential of Vasopressin Receptor Antagonists
Ali, F., Guglin, M. E., Vaitkevicius, P. V., & Ghali, J. K. (2007) · Drugs · doi:10.2165/00003495-200767060-00002 · Cited by 114 · see citing works
DESIGN AND SYNTHESIS OF POTENTIN VIVOANTAGONISTS OF OXYTOCIN
Bańkowski, K., Manning, M., Seto, J., Haldar, J., & Sawyer, W. H. (1980) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1980.tb02962.x · Cited by 112 · see citing works
Self-citationDiabetes insipidus: diagnosis and treatment of a complex disease.
Makaryus, A. N., & McFarlane, S. I. (2006) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.73.1.65 · Cited by 112 · see citing works
Gal, C. S., Wagnon, J., Valette, G., Garcia, G., Pascal, M., Maffrand, J., & Fur, G. L. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39017-4 · Cited by 111 · see citing works
Orally active vasopressin V1a receptor antagonist, SRX251, selectively blocks aggressive behavior
Ferris, C. F., Lu, S., Messenger, T. L., Guillon, C. D., Heindel, N. D., Miller, M., KOPPEL, G. A., Bruns, F., & Simon, N. G. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.01.001 · Cited by 111 · see citing works
Gal, C. S., Wagnon, J., Tonnerre, B., Roux, R., Garcia, G., Griebel, G., & Aulombard, A. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00035.x · Cited by 110 · see citing works
Solid-phase synthesis of 16 potent (selective and nonselective) in vivo antagonists of oxytocin
Manning, M., Kruszynski, M., Bańkowski, K., Olma, A., Lammek, B., Cheng, L., Kliś, W. A., Seto, J., Haldar, J., & Sawyer, W. H. (1989) · Journal of Medicinal Chemistry · doi:10.1021/jm00122a016 · Cited by 106 · see citing works
Self-citationStymiest, J. L., Mitchell, B. F., Wong, S., & Vederas, J. C. (2005) · The Journal of Organic Chemistry · doi:10.1021/jo050539l · Cited by 105 · see citing works
Oshikawa, S., Tanoue, A., Koshimizu, T.-A., Kitagawa, Y., & Tsujimoto, G. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.3.623 · Cited by 105 · see citing works
Manning, M., Miteva, K., Pancheva, S. N., STOEV, S., Wo, N. C., & Chan, W. Y. (1995) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1995.tb00596.x · Cited by 99 · see citing works
Self-citationLowbridge, J., Manning, M., Haldar, J., & Sawyer, W. H. (1977) · Journal of Medicinal Chemistry · doi:10.1021/jm00211a025 · Cited by 98 · see citing works
Self-citationOxytocin agonists for preventing postpartum haemorrhage
Su, L.-L., Chong, Y. S., & Samuel, M. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005457.pub2 · Cited by 96 · see citing works
Barberis, C., Balestre, M., Jard, S., Tribollet, E., Arsenijévic, Y., Dreifuss, J. J., Bańkowski, K., Manning, M., Chan, W. Y., Schlosser, S. S., et al. (2008) · Neuroendocrinology · doi:10.1159/000126998 · Cited by 95 · see citing works
Self-citationParaventricular hypothalamic influences on spinal nociceptive processing
Condés‐Lara, M., Rojas‐Piloni, G., Martı́nez-Lorenzana, G., Rodríguez-Jiménez, J., López-Hidalgo, M. A., & Freund‐Mercier, M. J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.050 · Cited by 94 · see citing works
Carboxy terminus of vasopressin required for activity but not binding
Manning, M., Olma, A., Kliś, W. A., Kolodziejczyk, A. M., Nawrocka, E., Misicka, A., Seto, J., & Sawyer, W. H. (1984) · Nature · doi:10.1038/308652a0 · Cited by 91 · see citing works
Self-citationWindle, R. J., Gamble, L. E., Kershaw, Y. M., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2006) · Endocrinology · doi:10.1210/en.2005-1079 · Cited by 90 · see citing works
Manning, M., & Sawyer, W. H. (1993) · Journal of Receptor Research · doi:10.3109/10799899309073655 · Cited by 90 · see citing works
Self-citationMorin, D., de la Cotte, N., Balestre, M., Mouillac, B., Manning, M., Breton, C., & Barberis, C. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01585-3 · Cited by 89 · see citing works
Self-citationTocolytic treatment for the management of preterm labour: a systematic review.
Tan, T. C., Devendra, K. P., Tan, L., & Tan, H. K. (2006) · PubMed · Cited by 88 · see citing works
Schmidt, A., Audigier, S., Barberis, C., Jard, S., Manning, M., Kołodziejczyk, A. S., & Sawyer, W. H. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80448-c · Cited by 83 · see citing works
Self-citation1-desamino-8-d-arginine vasopressin (DDAVP) as an agonist on V1b vasopressin receptor
Saito, M., Tahara, A., & Sugimoto, T. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00070-1 · Cited by 82 · see citing works
Pedersen, C. A., & Boccia, M. L. (2002) · Hormones and Behavior · doi:10.1006/hbeh.2001.1736 · Cited by 81 · see citing works
Vasopressin-induced pulmonary vasodilation in rats
Walker, B. R., Haynes, J., Wang, H. L., & Voelkel, N. F. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.257.2.h415 · Cited by 80 · see citing works
Tian, Y., Sandberg, K. L., Murase, T., Baker, E. A., Speth, R. C., & Verbalis, J. G. (2000) · Endocrinology · doi:10.1210/endo.141.1.7256 · Cited by 80 · see citing works
Orally active, nonpeptide oxytocin antagonists
Evans, B., Leighton, J. L., Rittle, K. E., Gilbert, K. F., Lundell, G. F., Gould, N. P., Hobbs, D. W., DiPardo, R. M., Veber, D. F., Pettibone, D. J., et al. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00099a020 · Cited by 79 · see citing works
Berde, B., & Boissonnas, R. A. (1968) · Springer eBooks · doi:10.1007/978-3-642-46127-9_16 · Cited by 77 · see citing works
Selective Agonists and Antagonists of Vasopressin
Manning, M., Bańkowski, K., & Sawyer, W. H. (1987) · Springer eBooks · doi:10.1007/978-1-4615-8129-1_8 · Cited by 77 · see citing works
Self-citationSmith, M. P., Ayad, V. J., Mundell, S. J., McArdle, C. A., Kelly, E., & Bernal, A. L. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0031 · Cited by 76 · see citing works
Derick, S., Cheng, L. L., Voirol, M. J., Stoev, S., Giacomini, M., Wo, N. C., Szeto, H. H., Ben Mimoun, M., Andres, M., Gaillard, R. C., et al. (2002) · Endocrinology · doi:10.1210/en.2002-220363 · Cited by 76 · see citing works
Cassoni, P., Marrocco, T., Bussolati, B., Allìa, E., Munaron, L., Sapino, A., & Bussolati, G. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0024 · Cited by 76 · see citing works
Design of more potent antagonists of the antidiuretic responses to arginine-vasopressin
Manning, M., Olma, A., Kliś, W. A., Kolodziejczyk, A. M., Seto, J., & Sawyer, W. H. (1982) · Journal of Medicinal Chemistry · doi:10.1021/jm00343a009 · Cited by 75 · see citing works
Self-citationAzetidinones as vasopressin V1a antagonists
Guillon, C. D., KOPPEL, G. A., Brownstein, M., Chaney, M. O., Ferris, C. F., Lu, S., Fabio, K. M., Miller, M. J., Heindel, N. D., Hunden, D. C., et al. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.12.031 · Cited by 74 · see citing works
O’Donnell, M. E., Duong, V., Suvatne, J., Foroutan, S., & Johnson, D. M. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00001.2005 · Cited by 73 · see citing works
de la Cotte, N., Balestre, M., Phalipou, S., Hibert, M., Manning, M., Barberis, C., & Mouillac, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29462 · Cited by 72 · see citing works
Self-citationLam, K. S. L., Wat, M. S., CHOI, K. L., Ip, T., Pang, R. W. C., & Kumana, C. R. (1996) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1996.39914.x · Cited by 72 · see citing works
Molecular pharmacology of AVP and OT receptors and therapeutic potential
Barberis, C., Morin, D., Durroux, T., Mouillac, B., Guillon, G., Seyer, R., Hibert, M., Tribollet, E., & Manning, M. (1999) · Drug News & Perspectives · doi:10.1358/dnp.1999.12.5.863621 · Cited by 71 · see citing works
Self-citationBernadich, C., Bandi, J. C., Melin, P., & Bosch, J. (1998) · Hepatology · doi:10.1002/hep.510270206 · Cited by 71 · see citing works
Rojas-Piloni, G., López-Hidalgo, M., Martínez-Lorenzana, G., Rodríguez-Jiménez, J., & Condés-Lara, M. (2007) · Brain Research · doi:10.1016/j.brainres.2006.12.045 · Cited by 67 · see citing works
Howl, J., Ismail, T., Strain, A. J., Kirk, C. J., Anderson, D., & Wheatley, M. (1991) · Biochemical Journal · doi:10.1042/bj2760189 · Cited by 67 · see citing works
Robert, J., Auzan, C., Ventura, M. A., & Clauser, É. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510180200 · Cited by 66 · see citing works
CHINI, B., MANNING, M., & GUILLON, G. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00438-x · Cited by 65 · see citing works
Self-citationPettibone, D. J., Kishel, M. T., Woyden, C. J., Clineschmidt, B. V., Bock, M. G., Freidinger, R. M., Veber, D. F., & Williams, P. D. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90524-s · Cited by 64 · see citing works
Vasopressin Antagonists as Aquaretic Agents for the Treatment of Hyponatremia
Palm, C., Pistrosch, F., Herbrig, K., & Gross, P. A. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.05.014 · Cited by 63 · see citing works
Manning, M., Baláspiri, L., Moehring, J., Haldar, J., & Sawyer, W. H. (1976) · Journal of Medicinal Chemistry · doi:10.1021/jm00228a023 · Cited by 62 · see citing works
Self-citationPitt, G. R. W., Batt, A. R., Haigh, R. M., Penson, A., Robson, P. A., Rooker, D. P., Tartar, A. L., Trim, J. E., Yea, C., & Roe, M. B. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.04.107 · Cited by 61 · see citing works
Griffante, C., Green, A., Curcuruto, O., Haslam, C. P., Dickinson, B. A., & Arban, R. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706383 · Cited by 60 · see citing works
Ma, S., Shipston, M. J., Morilak, D. A., & Russell, J. A. (2005) · Endocrinology · doi:10.1210/en.2004-1368 · Cited by 60 · see citing works
Bell, I. M., Erb, J. M., Freidinger, R. M., Gallicchio, S. N., Guare, J. P., Guidotti, M. T., Halpin, R. A., Hobbs, D. W., Homnick, C. F., Kuo, M. S., et al. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm9800797 · Cited by 60 · see citing works
Manning, M., Baláspiri, L., Acosta, M., & Sawyer, W. H. (1973) · Journal of Medicinal Chemistry · doi:10.1021/jm00267a004 · Cited by 59 · see citing works
Self-citationAVP receptor antagonists as aquaretics: review and assessment of clinical data.
Verbalis, J. G. (2006) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.73.suppl_3.s24 · Cited by 58 · see citing works
Antagonists of the antidiuretic activity of vasopressin
Kinter, L. B., Huffman, W. F., & Stassen, F. L. (1988) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1988.254.2.f165 · Cited by 58 · see citing works
Pharmacokinetics of Tocolytic Agents
Tsatsaris, V., CABROL, D., & Carbonne, B. (2004) · Clinical Pharmacokinetics · doi:10.2165/00003088-200443130-00001 · Cited by 58 · see citing works
Clinical evaluation of inhaled insulin
Mastrandrea, L. D., & Quattrin, T. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.019 · Cited by 58 · see citing works
Gal, C. S., Valette, G., Foulon, L., Germain, G., Advenier, C., Naline, E., Bardou, M., Martinolle, J.-P., Pouzet, B., Raufaste, D., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.061200 · Cited by 56 · see citing works
Williams, P. D., Clineschmidt, B. V., Erb, J. M., Freidinger, R. M., Guidotti, M. T., Lis, E. V., Pawluczyk, J. M., Pettibone, D. J., & Reiss, D. R. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00023a002 · Cited by 55 · see citing works
Tahara, A., Saito, M., Sugimoto, T., Tomura, Y., Wada, K., Kusayama, T., Tsukada, J., Ishii, N., Yatsu, T., Uchida, W., et al. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005139 · Cited by 53 · see citing works
Terrillon, S., Cheng, L., Stoev, S. B., Mouillac, B., Barberis, C., Manning, M., & Durroux, T. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm010526+ · Cited by 48 · see citing works
Self-citationVasopressin receptors. A historical survey.
Jard, S. (1998) · PubMed · Cited by 48 · see citing works
Janknegt, R. A., Zweers, H. M. M., Delaere, K. P. J., Kloet, A. G., Khoe, S. G. S., & Arendsen, H. J. (1997) · PubMed · Cited by 48 · see citing works
Small molecule ligands for oxytocin and vasopressin receptors
Freidinger, R. M., & Pettibone, D. J. (1997) · Medicinal Research Reviews · doi:10.1002/(sici)1098-1128(199701)17:1 · Cited by 48 · see citing works
Pyridobenzodiazepines: A novel class of orally active, vasopressin V2 receptor selective agonists
Failli, A. A., Shumsky, J. S., Steffan, R. J., Caggiano, T. J., Williams, D. K., Trybulski, E. J., Ning, X., Lock, Y., Tanikella, T., Hartmann, D., et al. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.10.107 · Cited by 46 · see citing works
Chan, W. Y., & Kelley, N. (1967) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27606-6 · Cited by 45 · see citing works
McKee, D. T., Poletini, M. O., Bertram, R., & Freeman, M. E. (2007) · Endocrinology · doi:10.1210/en.2007-0646 · Cited by 44 · see citing works
L-368,899, a potent orally active oxytocin antagonist for potential use in preterm labor
Pettibone, D. J., Clineschmidt, B. V., Guidotti, M. T., Lis, E. V., Reiss, D. R., Woyden, C. J., Bock, M. G., Evans, B. E., Freidinger, R. M., Hobbs, D. W., et al. (1993) · Drug Development Research · doi:10.1002/ddr.430300305 · Cited by 43 · see citing works
Neumann, I. D., Torner, L., Toschi, N., & Veenema, A. H. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00763.2005 · Cited by 43 · see citing works
Mapping the Binding Site of Arginine Vasopressin to V 1a and V 1b Vasopressin Receptors
Rodrigo, J., Peña, A., Murat, B., Trueba, M., Durroux, T., Guillon, G., & Rognan, D. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0202 · Cited by 43 · see citing works
Self-citationNeumann, I. D., Bosch, O. J., Toschi, N., Torner, L., & Douglas, A. J. (2003) · Endocrinology · doi:10.1210/en.2003-0037 · Cited by 43 · see citing works
Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network
Hansenne, I., Rasier, G., Péqueux, C., Brilot, F., Renard, C., Breton, C., Greimers, R., Legros, J.-J., Geenen, V. G., & Martens, H. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.08.007 · Cited by 43 · see citing works
Chan, W. Y., Wo, N. C., Stoev, S., Cheng, L. L., & Manning, M. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00003.x · Cited by 41 · see citing works
Self-citationDobruch, J. T., Cudnoch‐Jędrzejewska, A., & Szczepanska‐Sadowska, E. K. (2005) · Stress · doi:10.1080/10253890500456287 · Cited by 40 · see citing works
MARCHINGO, A. J., Abrahams, J. M., Woodcock, E. A., Smith, A. I., Mendelsohn, F. A. O., & Johnston, C. I. (1988) · Endocrinology · doi:10.1210/endo-122-4-1328 · Cited by 40 · see citing works
Manning, M., Stoev, S. B., Kolodziejczyk, A. M., Kliś, W. A., Kruszynski, M., Misicka, A., Olma, A., Wo, N. C., & Sawyer, W. H. (1990) · Journal of Medicinal Chemistry · doi:10.1021/jm00173a027 · Cited by 40 · see citing works
Self-citationDesign of Oxytocin Antagonists, which are more Selective than Atosiban
Manning, M., Stoev, S. B., Cheng, L., Wo, N. C., & Chan, W. Y. (2001) · Journal of Peptide Science · doi:10.1002/psc.339 · Cited by 39 · see citing works
Self-citationFE 200 440: a selective oxytocin antagonist on the term-pregnant human uterus
Nilsson, L., Reinheimer, T. M., Steinwall, M., & Åkerlund, M. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2003.02540.x · Cited by 39 · see citing works
V2 Receptor-Mediated Vasodilation in Healthy Humans
Tagawa, T., Imaizumi, T., Shiramoto, M., Endo, T., Hironaga, K., & Takeshita, A. (1995) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199503000-00006 · Cited by 39 · see citing works
Liu, X., Tribollet, E., Ogier, R., Barberis, C., & Raggenbass, M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02625.x · Cited by 38 · see citing works
Manning, M., Stoev, S. B., Bańkowski, K., Misicka, A., Lammek, B., Wo, N. C., & Sawyer, W. H. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00080a027 · Cited by 38 · see citing works
Self-citationHuguenin, R. L. (1964) · Helvetica Chimica Acta · doi:10.1002/hlca.19640470733 · Cited by 37 · see citing works
Reinheimer, T. M., Bee, W. H., Resendez, J. C., Meyer, J. K., Haluska, G. J., & Chellman, G. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2120 · Cited by 37 · see citing works
Peña, A., Murat, B., Trueba, M., Ventura, M. A., Bertrand, G., Cheng, L., Stoev, S. B., Szeto, H. H., Wo, N. C., Brossard, G., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1633 · Cited by 37 · see citing works
Self-citationA POTENT NEW SYNTHETIC ANALOG OF VASOPRESSIN WITH RELATIVE AGONIST SPECIFICITY FOR THE PITUITARY
Schwartz, J., Derdowska, I., Sobocińska, M. K., & Kupryszewski, G. (1991) · Endocrinology · doi:10.1210/endo-129-2-1107 · Cited by 36 · see citing works
The role of arginine vasopressin and its receptors in the normal and failing rat heart
Chandrashekhar, Y. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00053-1 · Cited by 36 · see citing works
Dyckes, D. F., NESTOR, J. J. J., Ferger, M. F., & du Vigneaud, V. (1974) · Journal of Medicinal Chemistry · doi:10.1021/jm00248a028 · Cited by 35 · see citing works
Gal, C. S.-L., Raufaste, D., Derick, S., Blankenstein, J., Allen, J., Pouzet, B., Pascal, M., Wagnon, J., & Ventura, M. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00062.2007 · Cited by 35 · see citing works
Guillon, G., Derick, S., Peña, A., Cheng, L., Stoev, S., Seyer, R., Morgat, J. L., Barberis, C., Gal, C. S., Wagnon, J., et al. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01163.x · Cited by 35 · see citing works
Self-citationCirillo, R., Tos, E. G., Schwarz, M. K., Quattropani, A., Scheer, A., Missotten, M., Dorbais, J., Nichols, A. C., Borrelli, F., Giachetti, C., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049395 · Cited by 34 · see citing works
Andrés, M., Trueba, M., & Guillon, G. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704634 · Cited by 33 · see citing works
Self-citationChimeric strategies for the rational design of bioactive analogs of small peptide hormones
Howl, J., Langel, Ü., Hawtin, S. R., Valkna, A., YARWOOD, N. J., Saar, K., & Wheatley, M. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.7.9212082 · Cited by 32 · see citing works
Wilson, R. J., Allen, M. J., Nandi, M., Giles, H., & Thornton, S. (2001) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2001.00226.x · Cited by 32 · see citing works
Cheng, L., Stoev, S. B., Manning, M., Derick, S., Peña, A., Mimoun, M. B., & Guillon, G. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030611c · Cited by 32 · see citing works
Self-citationTargeting the oxytocin receptor to relax the myometrium
Åkerlund, M. (2006) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.10.3.423 · Cited by 32 · see citing works
Chan, W. Y., Wo, N. C., Cheng, L., & Manning, M. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12959-5 · Cited by 31 · see citing works
Self-citationFluorescent Pseudo-Peptide Linear Vasopressin Antagonists: Design, Synthesis, and Applications,
Durroux, T., Peter, M., Turcatti, G., Chollet, A., Balestre, M., Barberis, C., & Seyer, R. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm9804782 · Cited by 31 · see citing works
Self-citationYang, J., Chen, J.-M., Liu, W., Song, C.-Y., & Lin, B.-C. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.07.004 · Cited by 31 · see citing works
van Lieburg, A. F., Knoers, N. V. A. M., Monnens, L. A. H., & Smits, P. (1995) · Journal of Hypertension · doi:10.1097/00004872-199512010-00034 · Cited by 31 · see citing works
Manning, M., Cheng, L., Stoev, S. B., Wo, N. C., Chan, W. Y., Szeto, H. H., Durroux, T., Mouillac, B., & Barberis, C. (2005) · Journal of Peptide Science · doi:10.1002/psc.667 · Cited by 31 · see citing works
Self-citationHowl, J., Wang, X. F., Kirk, C. J., & Wheatley, M. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17811.x · Cited by 30 · see citing works
Evaluation and management of hyponatremia: an emerging role for vasopressin receptor antagonists
Chen, S., Jalandhara, N., & BATLLE, D. C. (2007) · Nature Reviews Nephrology · doi:10.1038/ncpneph0401 · Cited by 30 · see citing works
Manning, M., Bańkowski, K., Barberis, C., Jard, S., Elands, J., & Chan, W. Y. (1992) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1992.tb00300.x · Cited by 29 · see citing works
Self-citationQuattropani, A., Dorbais, J., Covini, D., Pittet, P.-A., Colovray, V., Thomas, R. J., Coxhead, R., Halazy, S., Scheer, A., Missotten, M., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050645f · Cited by 29 · see citing works
Kappa Receptor Bivalent Ligands
Peng, X., & Neumeyer, J. L. (2007) · Current Topics in Medicinal Chemistry · doi:10.2174/156802607779941251 · Cited by 29 · see citing works
Regulation of 5α-Reductase Isoforms by Oxytocin in the Rat Ventral Prostate
Assinder, S. J., Johnson, C., King, K., & Nicholson, H. D. (2004) · Endocrinology · doi:10.1210/en.2004-0711 · Cited by 28 · see citing works
Peña, A., Murat, B., Trueba, M., Ventura, M. A., Wo, N. C., Szeto, H. H., Cheng, L., Stoev, S. B., Guillon, G., & Manning, M. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm060928n · Cited by 27 · see citing works
Self-citationPotent V2 vasopressin antagonists with structural changes at their C-terminals
Sawyer, W. H., Bańkowski, K., Misicka, A., Nawrocka, E., Kruszynski, M., Stoev, S., Kliś, W. A., Przybylski, J., & Manning, M. (1988) · Peptides · doi:10.1016/0196-9781(88)90022-8 · Cited by 27 · see citing works
Self-citationCudnoch‐Jędrzejewska, A., Dobruch, J. T., Puchalska, L., & Szczepanska‐Sadowska, E. K. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.01.010 · Cited by 26 · see citing works
Cardiovascular Effects of Felypressin
Cecanho, R., Junior, L. A. D. L., & Ranali, J. (2006) · Anesthesia Progress · doi:10.2344/0003-3006(2006)53[119:ceof]2.0.co;2 · Cited by 26 · see citing works
McCafferty, G., Pullen, M., Wu, C. W., Edwards, R., Allen, M., Woollard, P., Borthwick, A. D., Liddle, J., Hickey, D., Brooks, D. P., et al. (2007) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00057.2007 · Cited by 26 · see citing works
Vaptans: A promising therapy in the management of advanced cirrhosis
Ginès, P. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.03.007 · Cited by 26 · see citing works
Hyponatremia: Current Treatment Strategies and the Role of Vasopressin Antagonists
Cawley, M. J. (2007) · Annals of Pharmacotherapy · doi:10.1345/aph.1h502 · Cited by 26 · see citing works
Characterization of a novel and selective V1B receptor antagonist
Craighead, M. W., Milne, R. J., Campbell-Wan, L., WATSON, L., Presland, J. P., THOMSON, F. J., Marston, H. M., & MacSweeney, C. P. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00440-8 · Cited by 25 · see citing works
Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [3H]-SR 121463
Gal, C. S., Raufaste, D., Double-Cazanave, E., Guillon, G., Garcia, C., Pascal, M., & Maffrand, J. P. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00322.x · Cited by 25 · see citing works
Self-citationNovel linear antagonists of the antidiuretic (V2) and vasopressor (V1) responses to vasopressin
Manning, M., Kliś, W. A., Kruszynski, M., Przybylski, J., Olma, A., Wo, N. C., Pelton, G. H., & Sawyer, W. H. (1988) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1988.tb01376.x · Cited by 25 · see citing works
Self-citationOxytocin and Vasopressin Stimulate Anion Secretion by Human and Porcine Vas Deferens Epithelia1
Hagedorn, T. M., Carlin, R. W., & Schultz, B. D. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.106.056762 · Cited by 25 · see citing works
G-protein coupled receptors bivalent ligands and drug design
Halazy, S. (1999) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.9.4.431 · Cited by 25 · see citing works
Oxytocin does not directly affect vascular tone in vessels from nonpregnant and pregnant rats
Miller, M. E., Davidge, S. T., & Mitchell, B. F. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00774.2001 · Cited by 25 · see citing works
New bradykinin antagonists having very high potency at B1 receptors
Gera, L., Stewart, J. M., Whalley, E. T., Burkard, M., & Zuzack, J. S. (1996) · Immunopharmacology · doi:10.1016/0162-3109(96)00100-2 · Cited by 24 · see citing works
Derick, S., Peña, A., Durroux, T., Wagnon, J., Gal, C. S., Hibert, M., Rognan, D., & Guillon, G. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0124 · Cited by 24 · see citing works
Self-citationProperties of a new radioiodinated antagonist for human vasopressin V2 and V1a receptors
Ala, Y., Morin, D., Mahé, E., de la Cotte, N., Mouillac, B., Jard, S., Barberis, C., Tribollet, E., Dreifuss, J.-J., Sawyer, W. H., et al. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01021-2 · Cited by 23 · see citing works
Self-citationNakamura, S., Hirano, T., Tsujimae, K., Aoyama, M., Kondo, K., Yamamura, Y., Mori, T., & Tominaga, M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39000-7 · Cited by 23 · see citing works
Manning, M., Cheng, L., Stoev, S. B., Kliś, W. A., Nawrocka, E., Olma, A., Sawyer, W. H., Wo, N. C., & Chan, W. Y. (1997) · Journal of Peptide Science · doi:10.1002/(sici)1099-1387(199701)3:1 · Cited by 22 · see citing works
Self-citationBiologic assays for oxytocin and vasopressin.
Wh, S. (1961) · PubMed · Cited by 22 · see citing works
[3H]desGly-NH29-d(CH2)5[D-Ileu2,Ileu4]AVP: An AVP V2 receptor antagonist radioligand
Trinder, D., Stephenson, J. M., Gao, X., Phillips, P. A., Risvanis, J., & Johnston, C. I. (1991) · Peptides · doi:10.1016/0196-9781(91)90194-t · Cited by 22 · see citing works
Flagged first, then by citations
2 of the 265 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Trends in peptide drug discovery
Muttenthaler, M., King, G. F., Adams, D. J., & Alewood, P. F. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00135-8 · Cited by 2,022 · see citing works
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Oxytocin-dependent consolation behavior in rodents
Burkett, J. P., Andari, E., Johnson, Z. V., Curry, D. C., de Waal, F. B. M., & Young, L. J. (2016) · Science · doi:10.1126/science.aac4785 · Cited by 692 · see citing works
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423 · see citing works
Self-citationElabd, C., Cousin, W., Upadhyayula, P., Chen, R. Y., Chooljian, M. S., Li, J., Kung, S., Jiang, K. P., & Conboy, I. M. (2014) · Nature Communications · doi:10.1038/ncomms5082 · Cited by 411 · see citing works
Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems
Koshimizu, T., Nakamura, K., Egashira, N., Hiroyama, M., Nonoguchi, H., & Tanoue, A. (2012) · Physiological Reviews · doi:10.1152/physrev.00035.2011 · Cited by 413 · see citing works
Is oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394 · see citing works
Numan, M., & Young, L. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.015 · Cited by 355 · see citing works
Biased Oxytocinergic Modulation of Midbrain Dopamine Systems
Xiao, L., Priest, M. F., Nasenbeny, J., Lu, T., & Kozorovitskiy, Y. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.003 · Cited by 292 · see citing works
REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
Viéro, C., Shibuya, I., Kitamura, N., Verkhratsky, A., Fujihara, H., Katoh, A., Ueta, Y., Zingg, H. H., Chvátal, A., Syková, E., et al. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00185.x · Cited by 250 · see citing works
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244 · see citing works
Albers, H. E. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.07.001 · Cited by 200 · see citing works
Rahmeh, R., Damian, M., Cottet, M., Orcel, H., Mendre, C., Durroux, T., Sharma, K. S., Durand, G., Pucci, B., Trinquet, E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201093109 · Cited by 196 · see citing works
Self-citationBusnelli, M., Saulière, A., Manning, M., Bouvier, M., Galès, C., & Chini, B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277178 · Cited by 195 · see citing works
Self-citationHistone deacetylase inhibitors facilitate partner preference formation in female prairie voles
Wang, H., Duclot, F., Liu, Y., Wang, Z., & Kabbaj, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3420 · Cited by 173 · see citing works
Sex-specific modulation of juvenile social play by vasopressin
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.002 · Cited by 166 · see citing works
“…lateral ventricle of Ringer’s solution (vehicle) (pH 7.4; 5 ml Ringer; males n = 8; females n = 10), the specific V1aR antagonist d(CH2)5Tyr(Me2)AVP (Manning et al., 2008; 0.75 mg/5 ml Ringer; males n = 11; females n = 8), or the specific OTR antagonist des-GlyNH2,d(CH2)5[Tyr(Me) 2,Thr4]OVT…”
BackgroundInfluentialThe Oxytocin–Vasopressin Pathway in the Context of Love and Fear
Carter, C. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00356 · Cited by 162 · see citing works
Isotocin regulates paternal care in a monogamous cichlid fish
O’Connell, L. A., Matthews, B. J., & Hofmann, H. A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.03.009 · Cited by 156 · see citing works
Keebaugh, A. C., Barrett, C. E., Laprairie, J. L., Jenkins, J. J., & Young, L. J. (2015) · Social Neuroscience · doi:10.1080/17470919.2015.1040893 · Cited by 150 · see citing works
The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors
Juul, K. V., Bichet, D. G., Nielsen, S., & Nørgaard, J. P. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00604.2013 · Cited by 156 · see citing works
Bredewold, R., Smith, C. J. W., Dumais, K. M., & Veenema, A. H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00216 · Cited by 157 · see citing works
Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells
Merkle, F. T., Maroof, A. M., Wataya, T., Sasai, Y., Studer, L., Eggan, K. C., & Schier, A. F. (2015) · Development · doi:10.1242/dev.117978 · Cited by 152 · see citing works
Bowen, M. T., Carson, D. S., Spiro, A., Arnold, J. C., & McGregor, I. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027237 · Cited by 143 · see citing works
Kelly, A. M., & Goodson, J. L. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.005 · Cited by 141 · see citing works
Bredewold, R., & Veenema, A. H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.011 · Cited by 144 · see citing works
Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors
Pobbe, R. L. H., Pearson, B. L., Defensor, E. B., Bolivar, V. J., Young, W. S., Lee, H., Blanchard, D. C., & Blanchard, R. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.010 · Cited by 139 · see citing works
Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering
Muttenthaler, M., Andersson, Å., de Araujo, A. D., Dekan, Z., Lewis, R. J., & Alewood, P. F. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100989w · Cited by 138 · see citing works
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129 · see citing works
Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.125 · Cited by 128 · see citing works
Jurek, B., Slattery, D. A., Hiraoka, Y., Liu, Y., Nishimori, K., Aguilera, G., Neumann, I. D., & van den Burg, E. H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1345-14.2015 · Cited by 124 · see citing works
The Oxytocin-Oxytocin Receptor System and Its Antagonists as Tocolytic Agents
Vrachnis, N., Malamas, F. M., Sifakis, S., Deligeoroglou, E., & Iliodromiti, Z. (2011) · International Journal of Endocrinology · doi:10.1155/2011/350546 · Cited by 122 · see citing works
The neurobiological causes and effects of alloparenting
Kenkel, W. M., Perkeybile, A. M., & Carter, C. S. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22465 · Cited by 120 · see citing works
The orgasmic history of oxytocin: Love, lust, and labor
Magon, N., & Kalra, S. (2011) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.84851 · Cited by 127 · see citing works
Li, J. H., Chou, C., Li, B., Gavrilova, O., Eisner, C. B., Schnermann, J. B., Anderson, S. A., Deng, C., Knepper, M. A., & Wess, J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39680 · Cited by 116 · see citing works
Neurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish
Braida, D., Donzelli, A., Martucci, R., Capurro, V., Busnelli, M., Chini, B., & Sala, M. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2482-2 · Cited by 116 · see citing works
Self-citationThe vasopressin Avpr1b receptor: Molecular and pharmacological studies
Roper, J. A., O'Carroll, A.-M., Young, W. S., & Lolait, S. (2010) · Stress · doi:10.3109/10253890.2010.512376 · Cited by 116 · see citing works
Schorscher-Petcu, A., Dupré, A., & Tribollet, E. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.06.016 · Cited by 111 · see citing works
Physiology of invertebrate oxytocin and vasopressin neuropeptides
Gruber, C. W. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2013.072561 · Cited by 110 · see citing works
Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors
Busnelli, M., Bulgheroni, E., Manning, M., Kleinau, G., & Chini, B. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.202994 · Cited by 102 · see citing works
Self-citationToth, I., Neumann, I. D., & Slattery, D. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2702-4 · Cited by 107 · see citing works
Gruber, C. W., Muttenthaler, M., & Freissmuth, M. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210793292474 · Cited by 107 · see citing works
A brief history of oxytocin and its role in modulating psychostimulant effects
Carson, D. S., Guastella, A. J., Taylor, E. R., & McGregor, I. S. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112473788 · Cited by 105 · see citing works
Elucidating Solution Structures of Cyclic Peptides Using Molecular Dynamics Simulations
Damjanovic, J., Miao, J., Huang, H., & Lin, Y. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01087 · Cited by 104 · see citing works
Barrett, C. E., Keebaugh, A. C., Ahern, T. H., Bass, C. E., Terwilliger, E. F., & Young, L. J. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.01.005 · Cited by 100 · see citing works
Treatment of Neurohypophyseal Diabetes Insipidus
Oiso, Y., Robertson, G. L., Nørgaard, J. P., & Juul, K. V. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2326 · Cited by 101 · see citing works
Cataldo, I., Azhari, A., & Esposito, G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00027 · Cited by 95 · see citing works
Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date
Lee, M. R., Rohn, M. C. H., Tanda, G., & Leggio, L. (2016) · CNS Drugs · doi:10.1007/s40263-016-0313-z · Cited by 97 · see citing works
Yokoi, S., Okuyama, T., Kamei, Y., Naruse, K., Taniguchi, Y., Ansai, S., Kinoshita, M., Young, L. J., Takemori, N., Kubo, T., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005009 · Cited by 95 · see citing works
Alvares, G. A., Quintana, D. S., & Whitehouse, A. J. O. (2017) · Autism Research · doi:10.1002/aur.1692 · Cited by 91 · see citing works
Norman, G. J., Karelina, K., Morris, J. S., Zhang, N., Cochran, M., & Courtney DeVries, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181de8678 · Cited by 88 · see citing works
Gutzler, S. J., Karom, M., Erwin, W. D., & Albers, H. E. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07190.x · Cited by 86 · see citing works
Oxytocin receptor dynamics in the brain across development and species
Vaidyanathan, R., & Hammock, E. A. D. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22403 · Cited by 82 · see citing works
Sabihi, S., Dong, S. M., Maurer, S., Goodpaster, C. M., & Leuner, B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.024 · Cited by 84 · see citing works
Muttenthaler, M., Andersson, Å., Vetter, I., Menon, R., Busnelli, M., Ragnarsson, L. K. N., Bergmayr, C., Arrowsmith, S., Deuis, J. R., Chiu, H. S., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aan3398 · Cited by 79 · see citing works
Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C. W., Kassiou, M., Hunt, G. E., & McGregor, I. S. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02311.x · Cited by 73 · see citing works
Horie, K., Inoue, K., Suzuki, S., Adachi, S., Yada, S., Hirayama, T., Hidema, S., Young, L. J., & Nishimori, K. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.10.011 · Cited by 77 · see citing works
Social Novelty Investigation in the Juvenile Rat: Modulation by the μ‐Opioid System
Smith, C. J. W., Wilkins, K. B., Mogavero, J. N., & Veenema, A. H. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12301 · Cited by 72 · see citing works
Baracz, S. J., Everett, N. A., McGregor, I. S., & Cornish, J. L. (2014) · Addiction Biology · doi:10.1111/adb.12198 · Cited by 74 · see citing works
Desmopressin in treatment of haematological disorders and in prevention of surgical bleeding
Svensson, P. J., Bergqvist, P. B. F., Juul, K. V., & Berntorp, E. E. (2014) · Blood Reviews · doi:10.1016/j.blre.2014.03.001 · Cited by 74 · see citing works
Donaldson, Z. R., Spiegel, L., & Young, L. J. (2010) · Behavioral Neuroscience · doi:10.1037/a0018094 · Cited by 71 · see citing works
Dumais, K. M., Alonso, A. G., Immormino, M. A., Bredewold, R., & Veenema, A. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.007 · Cited by 72 · see citing works
A review of recent progress (2002-2012) on the biological activities of pyrazoles
Pérez‐Fernández, R., Goya, P., & Elguero, J. (2013) · ARKIVOC · doi:10.3998/ark.5550190.p008.131 · Cited by 71 · see citing works
The role of oxytocin in alcohol and drug abuse
King, C. E., Gano, A., & Becker, H. C. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146761 · Cited by 66 · see citing works
Logue, O. C., George, E. M., & Bidwell, G. L. (2016) · Clinical Science · doi:10.1042/cs20160108 · Cited by 66 · see citing works
Oxytocin - A Multifunctional Analgesic for Chronic Deep Tissue Pain
Goodin, B. R., Ness, T. J., & Robbins, M. T. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666141027111843 · Cited by 66 · see citing works
CHINI, B., MANNING, M., & GUILLON, G. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00438-x · Cited by 65 · see citing works
Self-citationVasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides
Glavaš, M., Gitlin‐Domagalska, A., Dębowski, D., Ptaszyńska, N., Łęgowska, A., & Rolka, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063068 · Cited by 62 · see citing works
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate
Anand, U., Bandyopadhyay, A., Jha, N. K., de la Lastra, J. M. P., & Dey, A. (2022) · BioFactors · doi:10.1002/biof.1913 · Cited by 62 · see citing works
Ophir, A. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00397 · Cited by 62 · see citing works
Insights into the molecular evolution of oxytocin receptor ligand binding
Koehbach, J., Stockner, T., Bergmayr, C., Muttenthaler, M., & Gruber, C. W. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120256 · Cited by 61 · see citing works
Arginine Vasotocin Regulation of Interspecific Cooperative Behaviour in a Cleaner Fish
Soares, M. C., Bshary, R., Mendonça, R., Grutter, A. S., & Oliveira, R. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039583 · Cited by 60 · see citing works
Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.001 · Cited by 59 · see citing works
The oxytocin receptor signalling system and breast cancer: a critical review
Liu, H., Gruber, C. W., Alewood, P. F., Möller, A., & Muttenthaler, M. (2020) · Oncogene · doi:10.1038/s41388-020-01415-8 · Cited by 58 · see citing works
Glasper, E. R., Kenkel, W. M., Bick, J. R., & Rilling, J. K. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.005 · Cited by 54 · see citing works
A constructive replication of the association between the oxytocin receptor genotype and parenting.
Klahr, A. M., Klump, K. L., & Burt, S. A. (2014) · Journal of Family Psychology · doi:10.1037/fam0000034 · Cited by 53 · see citing works
Control of neurohypophysial hormone secretion, blood osmolality and volume in pregnancy.
Brunton, P. J., Velmurugan, S., & Ja, R. (2008) · PubMed · Cited by 52 · see citing works
Anxiolytic effects of oxytocin in cue-induced cocaine seeking behavior in rats
Morales-Rivera, A., Hernández-Burgos, M. M., Martínez-Rivera, A., Pérez-Colón, J., Rivera, R., Montalvo, J., Rodríguez-Borrero, E., & Maldonado-Vlaar, C. S. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3553-y · Cited by 50 · see citing works
Global map of oxytocin/vasopressin-like neuropeptide signalling in insects
Liutkevičiūtė, Z., Koehbach, J., Eder, T., Gil‐Mansilla, E., & Gruber, C. W. (2016) · Scientific Reports · doi:10.1038/srep39177 · Cited by 50 · see citing works
Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discovery
Gruber, C. W., Koehbach, J., & Muttenthaler, M. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.108 · Cited by 49 · see citing works
Harony, H., & Wagner, S. (2010) · Neurosignals · doi:10.1159/000321035 · Cited by 62 · see citing works
Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons
Yao, Y., Fu, L., Zhang, X., & van den Pol, A. N. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00452.2011 · Cited by 48 · see citing works
Oxytocin Promotes Accurate Fear Discrimination and Adaptive Defensive Behaviors
Olivera-Pasilio, V., & Dabrowska, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.583878 · Cited by 46 · see citing works
Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances
Melis, M. R., & Argiolas, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910376 · Cited by 44 · see citing works
Giglio, M. G. D., Muttenthaler, M., Harpsøe, K., Liutkevičiūtė, Z., Keov, P., Eder, T., Rattei, T., Arrowsmith, S., Wray, S., Marek, A., et al. (2017) · Scientific Reports · doi:10.1038/srep41002 · Cited by 44 · see citing works
Haram, M., Tesli, M., Bettella, F., Djurovic, S., Andreassen, O. A., & Melle, I. S. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00009 · Cited by 42 · see citing works
Smith, C. J. W., Mogavero, J. N., Tulimieri, M. T., & Veenema, A. H. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.05.005 · Cited by 42 · see citing works
Stadler, B., Whittaker, M. R., Exintaris, B., & Middendorff, R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.565731 · Cited by 41 · see citing works
Cysteine-Rich Mini-Proteins in Human Biology
Lavergne, V., Taft, R. J., & Alewood, P. F. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612802652411 · Cited by 41 · see citing works
Dumais, K. M., Alonso, A. G., Bredewold, R., & Veenema, A. H. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.036 · Cited by 40 · see citing works
Lindeyer, C. M., Langen, E. M. A., Swaney, W. T., & Reader, S. M. (2015) · Behaviour · doi:10.1163/1568539x-00003261 · Cited by 37 · see citing works
Neuropeptide signalling in the central nucleus of the amygdala
van den Burg, E. H., & Stoop, R. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2862-6 · Cited by 41 · see citing works
Cid-Jofré, V., Moreno, M., Reyes-Parada, M. I., & Renard, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222112077 · Cited by 39 · see citing works
Segregation of calcium signalling mechanisms in magnocellular neurones and terminals
Dayanithi, G., Forostyak, O., Ueta, Y., Verkhratsky, A., & Toescu, E. C. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.02.002 · Cited by 38 · see citing works
Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus
Baracz, S. J., & Cornish, J. L. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.12.003 · Cited by 38 · see citing works
Mayer, B., Németh, K., Krepuska, M., Myneni, V. D., Maric, D., Tisdale, J. F., Hsieh, M. M., Uchida, N., Lee, H., Nemeth, M. J., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aao1632 · Cited by 38 · see citing works
Baracz, S. J., Everett, N. A., & Cornish, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136132 · Cited by 37 · see citing works
Excitation of Tuberoinfundibular Dopamine Neurons by Oxytocin: Crosstalk in the Control of Lactation
Briffaud, V., Williams, P., Courty, J., & Broberger, C. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2633-14.2015 · Cited by 37 · see citing works
Chen, J., & Aguilera, G. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02054.x · Cited by 37 · see citing works
Cardoso, C., Orlando, M. A., Brown, C. A., & Ellenbogen, M. A. (2014) · Social Neuroscience · doi:10.1080/17470919.2013.873079 · Cited by 37 · see citing works
- Authors
- MANNING, M., STOEV, S., CHINI, B., DURROUX, T., MOUILLAC, B., & GUILLON, G.
- Affiliations
- University of Toledo (US)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- MANNING, M
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 170
- Pages
- 473-512
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1523553171
- Cited by
- 296
- References
- 265
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 14 · 2021: 23 · 2020: 10 · 2019: 15 · 2018: 19 · 2017: 23 · 2016: 15 · 2015: 29 · 2014: 23 · 2013: 20 · 2012: 25
- FWCI
- 46.73
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM25280, R01GM025280)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- vasopressin, oxytocin, vasopressin V1a receptor, vasopressin V1b receptor, V2 receptor, oxytocin receptor, peptide agonists, peptide antagonists, non-peptide agonists, non-peptide antagonists, radioiodinated ligands, fluorescent ligands, bivalent ligands, desmopressin, terlipressin, felypressin, atosiban, vasopressin receptor antagonists, conivaptan
- MeSH terms
- Terlipressin, Animals, Benzazepines, Clinical Trials as Topic, Deamino Arginine Vasopressin, Female, Humans, Hyponatremia, Lypressin, Oligopeptides, Oxytocin, Peptides, Structure-Activity Relationship, Uterus, Vasodilator Agents, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin, Antidiuretic Agents, Rats, Antidiuretic Hormone Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review