Cited by 1,886Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase SignalingProtease and Inhibitor Mechanisms

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Protein Tyrosine Phosphatases in the Human Genome

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Alonso, Andres, Sasin, Joanna, Bottini, Nunzio, Friedberg, Ilan, Friedberg, Iddo, Osterman, Andrei, Godzik, Adam, Hunter, Tony, Dixon, Jack, Mustelin, Tomas·2004·Cell

DOI 10.1016/j.cell.2004.05.018

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Abstract

Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed.

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Authors: Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., & Mustelin, T.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Salk Institute for Biological Studies (US)
University of California San Diego (US)
Corresponding author: Mustelin, Tomas
ORCID: Bottini, Nunzio
Friedberg, Iddo
Osterman, Andrei
Godzik, Adam
Hunter, Tony
Dixon, Jack
Mustelin, Tomas
Venue: Cell
Publisher: Elsevier BV
Published: 2004-06
Volume: 117
Issue: 6
Pages: 699-711
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2004.05.018
OpenAlex: W2043617798
Cited by: 1,886
References: 75
Citations by year: 2026: 34 · 2025: 30 · 2024: 63 · 2023: 62 · 2022: 56 · 2021: 78 · 2020: 67 · 2019: 77 · 2018: 69 · 2017: 95 · 2016: 67 · 2015: 97 · 2014: 110 · 2013: 133 · 2012: 118
FWCI: 7.71
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3333 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords: protein tyrosine phosphatase, human genome, tyrosine phosphorylation, tyrosine kinase, enzyme structure-function, enzyme regulation, human disease
MeSH terms: Amino Acid Sequence, Humans, Phosphorylation, Phylogeny, Tyrosine, Signal Transduction, Genome, Human, Gene Expression Regulation, Enzymologic, Protein Tyrosine Phosphatases, Protein Structure, Tertiary

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Protein Tyrosine Phosphatases in the Human Genome

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