The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Protein Tyrosine Phosphatases in the Human Genome
Open accessAbstract
Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed.
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“Twenty-five genes encode for DUSPs in the human genome, with DUSP24 and DUSP27 lacking enzymatic activity.12”
From Molecular basis of MAP kinase regulation (2013) · cites this paper as [12]
Citations
Cites
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Flagged first, then by citations
Research works printed but not linked: 3
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Cited by
Sorted by citations
Protein tyrosine phosphatases: from genes, to function, to disease
Tonks, N. K. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2039 · Cited by 1,710
ERK1/2 MAP kinases: Structure, function, and regulation
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Metadata
- Authors
- Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., & Mustelin, T.
- Affiliations
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Salk Institute for Biological Studies (US)
- University of California San Diego (US)
- Corresponding author
- Mustelin, Tomas
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 117
- Issue
- 6
- Pages
- 699-711
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2043617798
- Cited by
- 1,886
- References
- 75
- Citations by year
- 2026: 34 · 2025: 30 · 2024: 63 · 2023: 62 · 2022: 56 · 2021: 78 · 2020: 67 · 2019: 77 · 2018: 69 · 2017: 95 · 2016: 67 · 2015: 97 · 2014: 110 · 2013: 133 · 2012: 118
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3333 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- protein tyrosine phosphatase, human genome, tyrosine phosphorylation, tyrosine kinase, enzyme structure-function, enzyme regulation, human disease
- MeSH terms
- Amino Acid Sequence, Humans, Phosphorylation, Phylogeny, Tyrosine, Signal Transduction, Genome, Human, Gene Expression Regulation, Enzymologic, Protein Tyrosine Phosphatases, Protein Structure, Tertiary
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