Exploration of Essential Gene Functions via Titratable Promoter Alleles

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Items 101–200 of 600

1. Exploring functional relationships between components of the gene expression machinery
   Todd Burckin, Roland Nagel, Yael Mandel‐Gutfreund, Lily Shiue, Tyson A. Clark, Jean-Leon Chong, Tien‐Hsien Chang, Sharon L. Squazzo, Grant A. Hartzog, Manuel Ares · 2005 · Nature Structural & Molecular Biology
2. Inhibition of Sterol Biosynthesis Reduces Tombusvirus Replication in Yeast and Plants
   Monika Sharma, Zsuzsanna Sasvári, Peter D. Nagy · 2009 · Journal of Virology
3. Gene association analysis: a survey of frequent pattern mining from gene expression data
   Ronnie Cley de Oliveira Alves, Domingo S. Rodríguez–Baena, Jesús S. Aguilar–Ruiz · 2009 · Briefings in Bioinformatics
4. Yeast-based functional genomics and proteomics technologies: the first 15 years and beyond
   Bernhard Suter, Daniel Auerbach, Igor Štagljar · 2006 · BioTechniques
5. Hmo1 Is Required for TOR-Dependent Regulation of Ribosomal Protein Gene Transcription
   Axel Bernhard Berger, Laurence Decourty, Gwenaël Badis, Ulf Nehrbass, Alain Jacquier, Olivier Gadal · 2007 · Molecular and Cellular Biology
6. Global Genomics and Proteomics Approaches to Identify Host Factors as Targets to Induce Resistance Against Tomato Bushy Stunt Virus
   Peter D. Nagy, Judit Pogany · 2010 · Advances in virus research
7. A crucial role of Mim2 in the biogenesis of mitochondrial outer membrane proteins
   Kai Stefan Dimmer, Dražen Papić, Benjamin Schumann, Desirée Sperl, Katrin Krumpe, Dirk M. Walther, Doron Rapaport · 2012 · Journal of Cell Science
8. Mim1, a protein required for the assembly of the TOM complex of mitochondria
   Thomas Waizenegger, Simone Schmitt, Jelena Živković, Walter Neupert, Doron Rapaport · 2004 · EMBO Reports
9. Proteome analysis of mitochondrial outer membrane from Neurospora crassa
   Simone Schmitt, Holger Prokisch, Tilman Schlunck, David Camp, Uwe Ahting, Thomas Waizenegger, Curt Scharfe, Thomas Meitinger, Axel Imhof, Walter Neupert et al. · 2005 · PROTEOMICS
10. Inferring activity changes of transcription factors by binding association with sorted expression profiles
    Chao Cheng, Xiting Yan, Fengzhu Sun, Lei M. Li · 2007 · BMC Bioinformatics
11. Global Screening of Genes Essential for Growth in High-Pressure and Cold Environments: Searching for Basic Adaptive Strategies Using a Yeast Deletion Library
    Abe, Fumiyoshi, Minegishi, Hiroaki · 2008 · Genetics
12. The Cotranscriptional Assembly of snoRNPs Controls the Biosynthesis of H/ACA snoRNAs in Saccharomyces cerevisiae
    Monica Ballarino, Mariangela Morlando, Francesca Pagano, Alessandro Fatica, Irene Bozzoni · 2005 · Molecular and Cellular Biology
13. Dual Targeting of Nfs1 and Discovery of Its Novel Processing Enzyme, Icp55
    Adi Naamati, Neta Regev‐Rudzki, Shlomi Galperin, Roland Lill, Ophry Pines · 2009 · Journal of Biological Chemistry
14. Microarray detection of novel nuclear RNA substrates for the exosome
    Rym Houalla, Frédéric Devaux, Alessandro Fatica, Joanna Kufel, J. David Barrass, Claire Torchet, David W. Tollervey · 2006 · Yeast
15. Impaired tRNA Nuclear Export Links DNA Damage and Cell-Cycle Checkpoint
    Ata Ghavidel, Thomas Kislinger, Oxana Pogoutse, Richelle Sopko, Igor Jurišica, Andrew Emili · 2007 · Cell
16. A nuclear-based quality control pathway for non-imported mitochondrial proteins
    Viplendra P. S. Shakya, William A. Barbeau, Tianyao Xiao, Christina S Knutson, Max-Hinderk Schuler, Adam L. Hughes · 2021 · eLife
17. Size control goes global
    Mike Cook, Mike Tyers · 2007 · Current Opinion in Biotechnology
18. Rpb9 Subunit Controls Transcription Fidelity by Delaying NTP Sequestration in RNA Polymerase II
    Céline Walmacq, Maria L. Kireeva, Jordan D. Irvin, Yuri A. Nedialkov, Lucyna Lubkowska, Francisco Malagón, Jeffrey N. Strathern, Mikhail Kashlev · 2009 · Journal of Biological Chemistry
19. Broad network-based predictability of Saccharomyces cerevisiaegene loss-of-function phenotypes
    Kriston L. McGary, Insuk Lee, Edward M. Marcotte · 2007 · Genome biology
20. A map of human protein interactions derived from co‐expression of human mRNAs and their orthologs
    Ramani, Arun K, Li, Zhihua, Hart, G Traver, Carlson, Mark W, Boutz, Daniel R, Marcotte, Edward M · 2008 · Molecular Systems Biology
21. The Transcriptional Response to a Peroxisome Proliferator-activated Receptor α Agonist Includes Increased Expression of Proteome Maintenance Genes
    Steven P. Anderson, Paul C. Howroyd, Jie Liu, Xun Qian, Rainer Bahnemann, Cynthia L. Swanson, Mi-Kyoung Kwak, Thomas W. Kensler, J. Christopher Corton · 2004 · Journal of Biological Chemistry
22. Incorporating functional inter-relationships into protein function prediction algorithms
    Gaurav Shankar Pandey, Chad L. Myers, Vipin Kumar · 2009 · BMC Bioinformatics
23. The mechanism of pentabromopseudilin inhibition of myosin motor activity
    Roman Fedorov, Markus Böhl, Georgios Tsiavaliaris, Falk K. Hartmann, Manuel H. Taft, P. Baruch, Bernhard Brenner, René Martin, Hans‐Joachim Knölker, Herwig O. Gutzeit et al. · 2009 · Nature Structural & Molecular Biology
24. An Integrative Multi-Network and Multi-Classifier Approach to Predict Genetic Interactions
    Gaurav Shankar Pandey, Bin Zhang, Aaron N. Chang, Chad L. Myers, Jun Zhu, Vipin Kumar, Eric E. Schadt · 2010 · PLoS Computational Biology
25. The Nedd4-Type Rsp5p Ubiquitin Ligase Inhibits Tombusvirus Replication by Regulating Degradation of the p92 Replication Protein and Decreasing the Activity of the Tombusvirus Replicase
    Daniel Barajas, Zhenghe Li, Peter D. Nagy · 2009 · Journal of Virology
26. Global identification of noncoding RNAs in Saccharomyces cerevisiae by modulating an essential RNA processing pathway
    Manoj Pratim Samanta, Waraporn Tongprasit, Himanshu Sethi, Chen-Shan Chin, Viktor Štolc · 2006 · Proceedings of the National Academy of Sciences
27. Chemical-genetic profile analysis of five inhibitory compounds in yeast
    Md. Shah Alamgir, Veronika Erukova, Matthew Jessulat, Ali Azizi, Ashkan Golshani · 2010 · BMC Chemical Biology
28. The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast
    Johannes Förtsch, Eric Hummel, Melanie Krist, Benedikt Westermann · 2011 · The Journal of Cell Biology
29. Engineering promoter regulation
    Elke Nevoigt, Curt R. Fischer, Oliver Mucha, Falk Matthäus, Ulf Ståhl, Gregory N Stephanopoulos · 2006 · Biotechnology and Bioengineering
30. Direct Inhibition of Tombusvirus Plus-Strand RNA Synthesis by a Dominant Negative Mutant of a Host Metabolic Enzyme, Glyceraldehyde-3-Phosphate Dehydrogenase, in Yeast and Plants
    Tyng-Shyan Huang, Peter D. Nagy · 2011 · Journal of Virology
31. Nonredundant Roles of Mitochondria-associated F-Box Proteins Mfb1 and Mdm30 in Maintenance of Mitochondrial Morphology in Yeast
    Mark Dürr, Mafalda Escobar‐Henriques, Sandra Merz, Stefan Geimer, Thomas Langer, Benedikt Westermann · 2006 · Molecular Biology of the Cell
32. An Integrated Approach to Functional Genomics: Construction of a Novel Reporter Gene Fusion Library forSinorhizobium meliloti
    Alison Cowie, Jiujun Cheng, Christopher D. Sibley, Ying Fong, Rahat Zaheer, Cheryl L. Patten, Richard M. Morton, G. Brian Golding, Turlough M. Finan · 2006 · Applied and Environmental Microbiology
33. ESCRT-III is required for scissioning new peroxisomes from the endoplasmic reticulum
    Fred David Mast, Thurston Herricks, Kathleen M. Strehler, Leslie R. Miller, Ramsey A. Saleem, Richard A. Rachubinski, John D. Aitchison · 2018 · The Journal of Cell Biology
34. A Screen for Genes of Heme Uptake Identifies the FLC Family Required for Import of FAD into the Endoplasmic Reticulum
    Olga V. Protchenko, Roberto J. Rodriguez-Suarez, Rachel Androphy, Howard Bussey, Caroline C. Philpott · 2006 · Journal of Biological Chemistry
35. The Small Subunit Processome Is Required for Cell Cycle Progression at G1
    Kara Anne Bernstein, Susan J. Baserga · 2004 · Molecular Biology of the Cell
36. Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity
    Sanchari Bhattacharyya, Shimon Bershtein, Jin Yan, Tijda Argun, Amy I. Gilson, Sunia A. Trauger, Eugene I. Shakhnovich · 2016 · eLife
37. Dynamic modular architecture of protein-protein interaction networks beyond the dichotomy of ‘date’ and ‘party’ hubs
    Xiao Chang, Tao Xu, Yun Li, Kai Wang · 2013 · Scientific Reports
38. Endoplasmic Reticulum-Associated Secretory Proteins Sec20p, Sec39p, and Dsl1p Are Involved in Peroxisome Biogenesis
    Ryan J. Perry, Fred David Mast, Richard A. Rachubinski · 2009 · Eukaryotic Cell
39. The Hog1 Mitogen-Activated Protein Kinase Mediates a Hypoxic Response in Saccharomyces cerevisiae
    Hickman, Mark J, Spatt, Dan, Winston, Fred · 2011 · Genetics
40. Yeast and human RNA helicases involved in ribosome biogenesis: Current status and perspectives
    Olga Rodríguez‐Galán, Juan José García-Gómez, Jesús de la Cruz · 2013 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
41. Novel cargo-binding site in the β and δ subunits of coatomer
    Kai Michelsen, Volker Schmid, Jutta Metz, Katja Heusser, Urban Liebel, Torsten F. Schwede, Anne Spang, Blanche Schwappach · 2007 · The Journal of Cell Biology
42. A systematic exploration of the interactions between bacterial effector proteins and host cell membranes
    Bethany A. Weigele, Robert C. Orchard, Alyssa Jimenez, Gregory W. Cox, Neal M. Alto · 2017 · Nature Communications
43. Construction of a stress-induced system in Escherichia coli for efficient polyhydroxyalkanoates production
    Zhen Kang, Qian Wang, Haojun Zhang, Qingsheng Qi · 2008 · Applied Microbiology and Biotechnology
44. Perturbations to uncover gene networks
    Jesper N. Tegner, Johan Björkegren · 2006 · Trends in Genetics
45. A genome‐scale yeast library with inducible expression of individual genes
    Yuko Arita, Griffin Kim, Zhijian Li, Helena Friesen, Gina M. Turco, Rebecca Y. Wang, Dale Climie, Matej Ušaj, Manuel Hotz, Emily H. Stoops et al. · 2021 · Molecular Systems Biology
46. A shuttle vector series for precise genetic engineering of Saccharomyces cerevisiae
    Robert Gnügge, Thomas Liphardt, Fabian Rudolf · 2015 · Yeast
47. The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro
    Drążkowska, Karolina, Tomecki, Rafał, Stoduś, Krystian, Kowalska, Katarzyna, Czarnocki-Cieciura, Mariusz, Dziembowski, Andrzej · 2013 · Nucleic Acids Research
48. Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) Reveals a Low-Molecular-Mass Complex Containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p Involved in Early Steps of 60S Ribosomal Subunit Biogenesis
    Iván V. Rosado, Christophe Dez, Simon Lebaron, Michèle Caizergues‐Ferrer, Yves A.L. Henry, Jesús de la Cruz · 2006 · Molecular and Cellular Biology
49. Detection and discovery of RNA modifications using microarrays
    Shawna L. Hiley · 2005 · Nucleic Acids Research
50. High Confidence Prediction of Essential Genes in Burkholderia Cenocepacia
    Mario Juhas, Manuel Stark, Christian von Mering, Putthapoom Lumjiaktase, Derrick W. Crook, Miguel A. Valvano, Leo Eberl · 2012 · PLoS ONE
51. Transmembrane signaling in Saccharomyces cerevisiae as a model for signaling in metazoans: State of the art after 25years
    David Engelberg, Riki Perlman, Alexander Levitzki · 2014 · Cellular Signalling
52. Genome-Wide Screen for Inner Nuclear Membrane Protein Targeting in Saccharomyces cerevisiae
    Athulaprabha Murthi, Anita K. Hopper · 2005 · Genetics
53. Peroxins Pex30 and Pex29 Dynamically Associate with Reticulons to Regulate Peroxisome Biogenesis from the Endoplasmic Reticulum
    Fred David Mast, Arvind P. Jamakhandi, Ramsey A. Saleem, David J. Dilworth, Richard S. Rogers, Richard A. Rachubinski, John D. Aitchison · 2016 · Journal of Biological Chemistry
54. Membrane Topology and Essential Amino Acid Residues of Phs1, a 3-Hydroxyacyl-CoA Dehydratase Involved in Very Long-chain Fatty Acid Elongation*
    Akio Kihara, Hiroko Sakuraba, Mika Ikeda, Aki Denpoh, Yasuyuki Igarashi · 2008 · Journal of Biological Chemistry
55. High Confidence Rule Mining for Microarray Analysis
    Tara McIntosh, Sanjay Chawla · 2007 · IEEE Transactions on Computational Biology and Bioinformatics
56. Humanized yeast to model human biology, disease and evolution
    Aashiq Hussain Kachroo, Michelle Vandeloo, Brittany M. Greco, Mudabir Abdullah · 2022 · Disease Models & Mechanisms
57. Viral Replication Protein Inhibits Cellular Cofilin Actin Depolymerization Factor to Regulate the Actin Network and Promote Viral Replicase Assembly
    Muhammad Shah Nawaz‐ul‐Rehman, K. Reddisiva Prasanth, Kai Xu, Zsuzsanna Sasvári, Nikolay Kovalev, Isabel Fernández de Castro, Daniel Barajas, Cristina Risco, Peter D. Nagy · 2016 · PLoS Pathogens
58. Targeted protein depletion in Saccharomyces cerevisiae by activation of a bidirectional degron
    Marc Jungbluth, Christian CR Renicke, Christof Taxis · 2010 · BMC Systems Biology
59. YGR198w (YPP1) targets A30P α-synuclein to the vacuole for degradation
    Todd R. Flower, Cheryl Clark-Dixon, Cheynita F. Metoyer, Hui Yang, Runhua Shi, Zhaojie Zhang, Stephan N. Witt · 2007 · The Journal of Cell Biology
60. Towards a compendium of essential genes – From model organisms to synthetic lethality in cancer cells
    Tianzuo Zhan, Michael Boutros · 2015 · Critical Reviews in Biochemistry and Molecular Biology
61. The SUN41 and SUN42 genes are essential for cell separation in Candida albicans
    Arnaud Firon, Sylvie Aubert, Ismaïl Iraqui, Stéphanie Guadagnini, Sophie Goyard, Marie‐Christine Prévost, Guilhem Janbon, Christophe d’Enfert · 2007 · Molecular Microbiology
62. Doxycycline, the drug used to control the tet‐regulatable promoter system, has no effect on global gene expression in Saccharomyces cerevisiae
    Jill A. Wishart, Andrew Hayes, Leanne Wardleworth, Nianshu Zhang, Stephen G. Oliver · 2005 · Yeast
63. RiboSys, a high-resolution, quantitative approach to measure the in vivo kinetics of pre-mRNA splicing and 3′-end processing in Saccharomyces cerevisiae
    Ross D. Alexander, J. David Barrass, Beatriz Solange Dichtl, Martin Koš, Tomasz Obtułowicz, Marie-Cécile Robert, Michał Koper, Iwona Karkusiewicz, Luisa Mariconti, David W. Tollervey et al. · 2010 · RNA
64. A method for high‐throughput production of sequence‐verified DNA libraries and strain collections
    Justin Smith, Ulrich Schlecht, Weihong Xu, Sundari Suresh, Joe Horecka, Michael J. Proctor, Raeka S. Aiyar, Richard A. O. Bennett, Angela M. Chu, Yong Fuga Li et al. · 2017 · Molecular Systems Biology
65. Saccharomyces cerevisiae: a versatile eukaryotic system in virology
    Rui Pedro Galão, Nicoletta Scheller, Isabel Alves‐Rodrigues, Tanja Breinig, Andreas Meyerhans, Juana Díez · 2007 · Microbial Cell Factories
66. A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis
    Jaspal Singh, Mike Tyers · 2009 · Genes & Development
67. From the baker to the bedside: yeast models of Parkinson's disease
    Regina Menezes, Sandra Tenreiro, Diana Macedo, Cláudia Nunes dos Santos, Tiago F. Outeiro · 2015 · Microbial Cell
68. Nonlinear Fitness Consequences of Variation in Expression Level of a Eukaryotic Gene
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69. iAID: an improved auxin-inducible degron system for the construction of a ‘tight’ conditional mutant in the budding yeastSaccharomyces cerevisiae
    Seiji Tanaka, Mayumi Miyazawa‐Onami, Tetsushi Iida, Hiroyuki Araki · 2015 · Yeast
70. Primers‐4‐Yeast: a comprehensive web tool for planning primers for Saccharomyces cerevisiae
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71. Yeast as a tool to uncover the cellular targets of drugs
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72. Functional Interaction between Phosducin-like Protein 2 and Cytosolic Chaperonin Is Essential for Cytoskeletal Protein Function and Cell Cycle Progression
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73. Changing perspectives in yeast research nearly a decade after the genome sequence
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74. Yeast screens for host factors in positive-strand RNA virus replication based on a library of temperature-sensitive mutants
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75. Tetracycline-regulated gene expression in the pathogen Ustilago maydis.
    K. Zarnack, S. P. Maurer, F. Kaffarnik, O. Ladendorf, A. Brachmann, J. Kämper, M. Feldbrügge · 2006 · Fungal Genetics and Biology
76. Data-driven assessment of eQTL mapping methods
    Jacob J. Michaelson, Rudi Alberts, Klaus Schughart, Andreas Beyer · 2010 · BMC Genomics
77. Members of the RSC Chromatin-Remodeling Complex Are Required for Maintaining Proper Nuclear Envelope Structure and Pore Complex Localization
    Laura C. Titus, Toni Renee Dawson, Deborah J. Rexer, Kathryn J. Ryan, Susan R. Wente · 2010 · Molecular Biology of the Cell
78. Multiplicative Mixture Models for Overlapping Clustering
    Qiang Fu, Arindam Banerjee · 2008 · Proceedings
79. Systematic screens for human disease genes, from yeast to human and back
    Fabiana Perocchi, Eugenio Mancera, Lars Michael Steinmetz · 2007 · Molecular BioSystems
80. Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space
    Veri, Amanda O., Miao, Zhengqiang, Shapiro, Rebecca S., Tebbji, Faiza, O’Meara, Teresa R., Kim, Sang Hu, Colazo, Juan, Tan, Kaeling, Vyas, Valmik K., Whiteway, Malcolm et al. · 2018 · PLoS Genetics
81. The S. cerevisiae SUMO stress response is a conjugation–deconjugation cycle that targets the transcription machinery
    Megan C. Lewicki, Tharan Srikumar, Erica S. Johnson, Brian Raught · 2014 · Journal of Proteomics
82. Heat‐Inducible Degron and the Making of Conditional Mutants
    R. Jürgen Dohmen, Alexander J. Varshavsky · 2005 · Methods in enzymology on CD-ROM/Methods in enzymology
83. Distinct Roles for the Essential MYST Family HAT Esa1p in Transcriptional Silencing
    Astrid S. Clarke, Eva Samal, Lorraine Pillus · 2006 · Molecular Biology of the Cell
84. The promise of functional genomics: completing the encyclopedia of a cell
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85. Accumulation of squalene is associated with the clustering of lipid droplets
    Minh Truong Ta, Tamar S. Kapterian, Weihua Fei, Ximing Du, Andrew John Brown, Ian W. Dawes, Hongyuan Yang · 2012 · FEBS Journal
86. An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes
    Kofoed, Megan, Milbury, Karissa L, Chiang, Jennifer H, Sinha, Sunita, Ben-Aroya, Shay, Giaever, Guri, Nislow, Corey, Hieter, Philip, Stirling, Peter C · 2015 · G3 Genes|Genomes|Genetics
87. Most azole resistance mutations in the Candida albicans drug target confer cross-resistance without intrinsic fitness cost
    Camille Bédard, Isabelle Gagnon‐Arsenault, Jonathan Boisvert, Samuel Plante, Alexandre K. Dubé, Alicia Pageau, Anna Fijarczyk, Jehoshua Sharma, Laetitia Maroc, Rebecca S. Shapiro et al. · 2024 · Nature Microbiology
88. The size and phospholipid composition of lipid droplets can influence their proteome
    Weihua Fei, Ling Zhong, Minh Truong Ta, Guanghou Shui, Markus Rene Wenk, Hongyuan Yang · 2011 · Biochemical and Biophysical Research Communications
89. Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness
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90. Computational Biology and Drug Discovery: From Single-Target to Network Drugs
    Ambesi-Impiombato, Alberto, Bernardo, Diego · 2006 · Current Bioinformatics
91. Advances in yeast genome engineering
    Florian David, Verena Siewers · 2014 · FEMS Yeast Research
92. A Genome-Wide Screen in Yeast Identifies Specific Oxidative Stress Genes Required for the Maintenance of Sub-Cellular Redox Homeostasis
    Anita Ayer, Sina Fellermeier, Christopher M. Fife, Simone S. Li, Gertien J. Smits, Andreas J. Meyer, Ian W. Dawes, Gabriel G. Perrone · 2012 · PLoS ONE
93. Development and application of proteomics technologies in Saccharomyces cerevisiae
    Annemieke Kolkman, Monique Slijper, Albert J. R. Heck · 2005 · Trends in biotechnology
94. TDP-43 toxicity in yeast
    Maria Armakola, Michael P. Hart, Aaron D. Gitler · 2010 · Methods
95. Beer and Bread to Brains and Beyond: Can Yeast Cells Teach Us about Neurodegenerative Disease?
    Aaron D. Gitler · 2007 · Neurosignals
96. Multiple Yeast Genes, Including Paf1 Complex Genes, Affect Telomere Length via Telomerase RNA Abundance
    Amy D. Mozdy, Elaine R. Podell, Thomas R. Cech · 2008 · Molecular and Cellular Biology
97. Independent evolution of functionally exchangeable mitochondrial outer membrane import complexes
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98. Systems for applied gene control in Saccharomyces cerevisiae
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99. Saccharomyces cerevisiae as a Model Organism to Study Mitochondrial Biology
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100. RNA-Based 5-Fluorouracil Toxicity Requires the Pseudouridylation Activity of Cbf5p
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