Moffat, Jason

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart, T., Chandrashekhar, M., Aregger, M., Steinhart, Z., Brown, K. R., MacLeod, G., Mis, M., Zimmermann, M., Fradet-Turcotte, A., Sun, S., et al. (2015) · Cell

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 1,571

Exploration of Essential Gene Functions via Titratable Promoter Alleles

Mnaimneh, S., Davierwala, A. P., Haynes, J., Moffat, J., Peng, W.-T., Zhang, W., Yang, X., Pootoolal, J., Chua, G., Lopez, A., et al. (2004) · Cell

Fungal and yeast genetics researchBioinformatics and Genomic Networks

Cited by 604

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

Hart, T., Tong, A. H. Y., Chan, K., Van Leeuwen, J., Seetharaman, A., Aregger, M., Chandrashekhar, M., Hustedt, N., Seth, S., Noonan, A., et al. (2017) · G3 Genes|Genomes|Genetics

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 599

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

Gupta, G. D., Coyaud, É., Gonçalves, J., Mojarad, B. A., Liu, Y., Wu, Q., Gheiratmand, L., Comartin, D., Tkach, J. M., Cheung, S. W. T., et al. (2015) · Cell

Genetic and Kidney Cyst DiseasesBiotin and Related Studies

Cited by 538

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

Rehman, S. K., Haynes, J., Collignon, E., Brown, K. R., Wang, Y., Nixon, A. M. L., Bruce, J. P., Wintersinger, J. A., Singh Mer, A., Lo, E. B. L., et al. (2021) · Cell

Cancer Cells and MetastasisMathematical Biology Tumor Growth

Cited by 495

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Lawson, K. A., Sousa, C. M., Zhang, X., Kim, E., Akthar, R., Caumanns, J. J., Yao, Y., Mikolajewicz, N., Ross, C., Brown, K. R., et al. (2020) · Nature

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 443

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

Hart, T., Brown, K. R., Sircoulomb, F., Rottapel, R., & Moffat, J. (2014) · Molecular Systems Biology

CRISPR and Genetic EngineeringBioinformatics and Genomic Networks

Cited by 398

Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis

Chong, Y. T., Koh, J. L. Y., Friesen, H., Kaluarachchi Duffy, S., Cox, M. J., Moses, A., Moffat, J., Boone, C., & Andrews, B. J. (2015) · Cell

Advanced Fluorescence Microscopy TechniquesAdvanced Proteomics Techniques and Applications

Cited by 274

Global Genetic Networks and the Genotype-to-Phenotype Relationship

Costanzo, M., Kuzmin, E., van Leeuwen, J., Mair, B., Moffat, J., Boone, C., & Andrews, B. (2019) · Cell

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 241

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

Zhang, W., Wu, K.-P., Sartori, M. A., Kamadurai, H. B., Ordureau, A., Jiang, C., Mercredi, P. Y., Murchie, R., Hu, J., Persaud, A., et al. (2016) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 168

Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform

Gonatopoulos-Pournatzis, T., Aregger, M., Brown, K. R., Farhangmehr, S., Braunschweig, U., Ward, H. N., Ha, K. C. H., Weiss, A., Billmann, M., Durbic, T., et al. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 142

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

Ivarsson, Y., Arnold, R., McLaughlin, M., Nim, S., Joshi, R., Ray, D., Liu, B., Teyra, J., Pawson, T., Moffat, J., et al. (2014) · Proceedings of the National Academy of Sciences

Chemical Synthesis and AnalysisAdvanced Proteomics Techniques and Applications

Cited by 135

Transcriptional Coregulation by the Cell Integrity Mitogen-Activated Protein Kinase Slt2 and the Cell Cycle Regulator Swi4

Baetz, K., Moffat, J., Haynes, J., Chang, M., & Andrews, B. (2001) · Molecular and Cellular Biology

Fungal and yeast genetics researchGenomics and Chromatin Dynamics

Cited by 125

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

Chang, C. A., Jen, J., Jiang, S., Sayad, A., Mer, A. S., Brown, K. R., Nixon, A. M. L., Dhabaria, A., Tang, K. H., Venet, D., et al. (2022) · Cancer Discovery

HER2/EGFR in Cancer ResearchCancer Cells and Metastasis

Cited by 119

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1

Cullis, J., Meiri, D., Sandi, M. J., Radulovich, N., Kent, O. A., Medrano, M., Mokady, D., Normand, J., Larose, J., Marcotte, R., et al. (2014) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 100

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs

Hunter, F. W., Young, R. J., Shalev, Z., Vellanki, R. N., Wang, J., Gu, Y., Joshi, N., Sreebhavan, S., Weinreb, I., Goldstein, D. P., et al. (2015) · Cancer Research

Cancer, Hypoxia, and MetabolismPharmacogenetics and Drug Metabolism

Cited by 82

CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae

Koh, J. L. Y., Chong, Y. T., Friesen, H., Moses, A., Boone, C., Andrews, B. J., & Moffat, J. (2015) · G3 Genes|Genomes|Genetics

Cell Image Analysis TechniquesFungal and yeast genetics research

Cited by 80

Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma

Kameda-Smith, M. M., Zhu, H., Luo, E.-C., Suk, Y., Xella, A., Yee, B., Chokshi, C., Xing, S., Tan, F., Fox, R. G., et al. (2022) · Nature Communications

Glioma Diagnosis and TreatmentCancer-related molecular mechanisms research

Cited by 7