Exploration of Essential Gene Functions via Titratable Promoter Alleles

Gene Ontology: tool for the unification of biology

Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works

Neural networks for pattern recognition

Bishop, C. (1994) · Choice Reviews Online · doi:10.5860/choice.31-5500 · Cited by 18,537 · see citing works

Cluster analysis and display of genome-wide expression patterns

Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 12,617 · see citing works

Functional organization of the yeast proteome by systematic analysis of protein complexes

Gavin, A., Böesche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J. M., Michon, A., Cruciat, C., et al. (2002) · Nature · doi:10.1038/415141a · Cited by 4,729 · see citing works

A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., Lockshon, D., Narayan, V., Srinivasan, M., Pochart, P., et al. (2000) · Nature · doi:10.1038/35001009 · Cited by 4,706 · see citing works

Functional profiling of the Saccharomyces cerevisiae genome

Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature · doi:10.1038/nature00935 · Cited by 4,316 · see citing works

Global analysis of protein localization in budding yeast

Huh, W.-K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., & O'Shea, E. K. (2003) · Nature · doi:10.1038/nature02026 · Cited by 4,248 · cited 1× · see citing works

Global analysis of protein expression in yeast

Ghaemmaghami, S., Huh, W.-K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., & Weissman, J. S. (2003) · Nature · doi:10.1038/nature02046 · Cited by 3,750 · see citing works

Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation.

Yang, Y., Dudoit, S., Luu, P., Lin, D., Peng, V., Ngai, J., & Speed, T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.e15 · Cited by 3,722 · see citing works

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

Ho, Y., Gruhler, A., Heilbut, A. M., Bader, G. D., Moore, L., Adams, S., Millar, A., Taylor, P. P., Bennett, K. L., Boutilier, K., et al. (2002) · Nature · doi:10.1038/415180a · Cited by 3,573 · see citing works

A comprehensive two-hybrid analysis to explore the yeast protein interactome

Ito, T., Chiba, T., Ozawa, R., Yoshida, M., Hattori, M., & Sakaki, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061034498 · Cited by 3,566 · see citing works

Functional Discovery via a Compendium of Expression Profiles

Hughes, T. R., Marton, M. J., Jones, A. R., Roberts, C. J., Stoughton, R. B., Armour, C. D., Bennett, H. A., Coffey, E. M., Dai, H. A., He, Y. D., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00015-5 · Cited by 2,534 · see citing works

Knowledge-based analysis of microarray gene expression data by using support vector machines

Brown, M. P. S., Noble, W. S., Lin, D. M., Cristianini, N., Sugnet, C. W., Furey, T. S., Ares, M., & Haussler, D. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.262 · Cited by 2,310 · see citing works

Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

Tong, A. H. Y., Evangelista, M., Parsons, A. B., Xu, H., Bader, G. D., Pagé, N., Robinson, M., Raghibizadeh, S., Hogue, C. W. V., Bussey, H., et al. (2001) · Science · doi:10.1126/science.1065810 · Cited by 2,138 · see citing works

Global Mapping of the Yeast Genetic Interaction Network

Tong, A. H. Y., Lesage, G., Bader, G. D., Ding, H., Xu, H., Xin, X., Young, J., Berriz, G. F., Brost, R. L., Chang, M., et al. (2004) · Science · doi:10.1126/science.1091317 · Cited by 2,070 · see citing works

Sequencing and comparison of yeast species to identify genes and regulatory elements

Kellis, M., Patterson, N. J., Endrizzi, M. G., Birren, B. W., & Lander, E. S. (2003) · Nature · doi:10.1038/nature01644 · Cited by 1,731 · see citing works

Genetic Control of the Cell Division Cycle in Yeast

Hartwell, L. H., Culotti, J. G., Pringle, J. R., & Reid, B. J. (1974) · Science · doi:10.1126/science.183.4120.46 · Cited by 1,567 · see citing works

The Yeast Nuclear Pore Complex

Rout, M. P., Aitchison, J. D., Suprapto, A., Hjertaas, K., Zhao, Y., & Chait, B. T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.4.635 · Cited by 1,403 · see citing works

A Concise Guide to cDNA Microarray Analysis

Hegde, P. S., Qi, R., Abernathy, K., Gay, C. G., Dharap, S. S., Gaspard, R. M., Hughes, J. E., Snesrud, E. C., Lee, N., & Quackenbush, J. F. (2000) · BioTechniques · doi:10.2144/00293bi01 · Cited by 949 · see citing works

The proteome of Saccharomyces cerevisiae mitochondria

Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R. P., Meyer, H. E., Schönfisch, B., Perschil, I., Chacińska, A., Guiard, B., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135385100 · Cited by 895 · see citing works

Finding Functional Features in Saccharomyces Genomes by Phylogenetic Footprinting

Cliften, P. F., Sudarsanam, P., Desikan, A., Fulton, L. A., Fulton, B., Majors, J. E., Waterston, R., Cohen, B. A., & Johnston, M. (2003) · Science · doi:10.1126/science.1084337 · Cited by 805 · see citing works

A Bayesian missing value estimation method for gene expression profile data

Oba, S., Sato, M.-A., Takemasa, I., Monden, M., Matsubara, K., & Ishii, S. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btg287 · Cited by 755 · see citing works

Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast

Jorgensen, P., Nishikawa, J. L., Breitkreutz, B., & Tyers, M. (2002) · Science · doi:10.1126/science.1070850 · Cited by 753 · see citing works

Subcellular localization of the yeast proteomePreprint

Kumar, A., Agarwal, S., Heyman, J. A., Matson, S., Heidtman, M. I., Piccirillo, S., Umansky, L., Drawid, A., Jansen, R., Liu, Y., et al. (2002) · Genes & Development · doi:10.1101/gad.970902 · Cited by 737 · see citing works

Saccharomyces genome database

Issel‐Tarver, L., Christie, K., Dolinski, K. J., Andrada, R., Balakrishnan, R., Ball, C. A., Binkley, G., Dong, S., Dwight, S. S., Fisk, D. G., et al. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)50972-1 · Cited by 672 · see citing works

A Set of Vectors with a Tetracycline‐Regulatable Promoter System for Modulated Gene Expression in Saccharomyces cerevisiae

Garí, E., Piedrafita, L., Aldea, M., & Herrero, E. (1997) · Yeast · doi:10.1002/(sici)1097-0061(199707)13:9 · Cited by 669 · see citing works

Genetic Control of the Cell-Division Cycle in Yeast, I. Detection of Mutants

Hartwell, L. H., Culotti, J. G., & Reid, B. J. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.66.2.352 · Cited by 576 · see citing works

Genomic profiling of drug sensitivities via induced haploinsufficiency

Giaever, G. N., Shoemaker, D. D., Jones, T., Liang, H., Winzeler, E. A., Astromoff, A., & Davis, R. W. (1999) · Nature Genetics · doi:10.1038/6791 · Cited by 570 · see citing works

Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast

Giaever, G. N., Flaherty, P., Kumm, J., Proctor, M. J., Nislow, C., Jaramillo, D. F., Chu, A. M., Jordan, M. I., Arkin, A. P., & Davis, R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307490100 · Cited by 506 · see citing works

Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes

Lum, P. Y., Armour, C. D., Stepaniants, S. B., Cavet, G., Wolf, M. K., Butler, J. S., Hinshaw, J. C., Garnier, P., Prestwich, G. D., Leonardson, A. S., et al. (2004) · Cell · doi:10.1016/s0092-8674(03)01035-3 · Cited by 481 · see citing works

Exploring the conditional coregulation of yeast gene expression through fuzzy k-means clustering

Gasch, A. P., & Eisen, M. B. (2002) · Genome biology · doi:10.1186/gb-2002-3-11-research0059 · Cited by 475 · see citing works

Making ribosomes

Fatica, A., & Tollervey, D. W. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00336-8 · Cited by 446 · see citing works

Normalization for cDNA microarry data

Yang, J. Y. H., Dudoit, S., Luu, P., & Speed, T. P. (2001) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.427982 · Cited by 442 · see citing works

FunSpec: a web-based cluster interpreter for yeast

Robinson, M. D., Grigull, J., Mohammad, N., & Hughes, T. R. (2002) · BMC Bioinformatics · doi:10.1186/1471-2105-3-35 · Cited by 404 · see citing works

High-Definition Macromolecular Composition of Yeast RNA-Processing Complexes

Krogan, N. J., Peng, W., Cagney, G., Robinson, M. D., Haw, R., Zhong, G., Guo, X., Zhang, X., Canadien, V., Richards, D. P., et al. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00003-6 · Cited by 380 · see citing works

Maturation of cellular Fe–S proteins: an essential function of mitochondria

Lill, R., & Kispal, G. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01589-9 · Cited by 358 · see citing works

Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters

Wu, L. F., Hughes, T. R., Davierwala, A. P., Robinson, M. D., Stoughton, R. B., & Altschuler, S. J. (2002) · Nature Genetics · doi:10.1038/ng906 · Cited by 349 · see citing works

Heat-Inducible Degron: a Method for Constructing Temperature-Sensitive Mutants

Dohmen, R. J., Wu, P., & Varshavsky, A. J. (1994) · Science · doi:10.1126/science.8122109 · Cited by 348 · see citing works

Maturation of cellular Fe-S proteins: an essential function of mitochondria

Gray, H. B. (2000) · Cited by 307 · see citing works

Upc2p and Ecm22p, Dual Regulators of Sterol Biosynthesis in <i>Saccharomyces cerevisiae</i>

Vik, Å., & Rine, J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6395-6405.2001 · Cited by 277 · see citing works

Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria

Baker, K. P., & Schatz, G. (1991) · Nature · doi:10.1038/349205a0 · Cited by 275 · see citing works

Assigning Function to Yeast Proteins by Integration of Technologies

Hazbun, T. R., Malmström, L., Anderson, S., Graczyk, B., Fox, B., Riffle, M. E., Sundin, B. A., Aranda, J. D., McDonald, W. H., Chiu, C.-H., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00476-3 · Cited by 263 · see citing works

Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents

Birrell, G. W., Brown, J. A. L., Wu, H. I., Giaever, G. N., Chu, A. M., Davis, R. W., & Brown, J. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132275199 · Cited by 255 · see citing works

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo

Kanemaki, M. T., Sánchez‐Díaz, A., Gambus, A., & Labib, K. P. M. (2003) · Nature · doi:10.1038/nature01692 · Cited by 254 · see citing works

A Panoramic View of Yeast Noncoding RNA Processing

Peng, W.-T., Robinson, M. D., Mnaimneh, S., Krogan, N. J., Cagney, G., Morris, Q., Davierwala, A. P., Grigull, J., Yang, X., Zhang, W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00466-5 · Cited by 246 · see citing works

The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl‐ and glutamyl‐tRNA synthetases.

Simos, G., Segref, A., Fasiolo, F., Hellmuth, K., Shevchenko, A. A., Mann, M., & Hurt, E. C. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00927.x · Cited by 229 · see citing works

Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341

Fleming, J., Lightcap, E. S., Sadis, S., Thoroddsen, V., Bulawa, C., & Blackman, R. K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032516399 · Cited by 198 · see citing works

Multiple sorting pathways between the late Golgi and the vacuole in yeast

Conibear, E., & Stevens, T. H. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00058-5 · Cited by 195 · see citing works

Molecular cloning, structure and expression of the yeast proliferating cell nuclear antigen gene

Bauer, G. A., & Burgers, M. J. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.2.261 · Cited by 190 · see citing works

Ssf1p Prevents Premature Processing of an Early Pre-60S Ribosomal Particle

Fatica, A., Cronshaw, A. D., Dlakić, M., & Tollervey, D. W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00458-6 · Cited by 171 · see citing works

Delta‐ and zeta‐COP, two coatomer subunits homologous to clathrin‐associated proteins, are involved in ER retrieval.

Cosson, P., Démollière, C., Hennecke, S., Duden, R., & Letourneur, F. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00528.x · Cited by 139 · see citing works

Genetic and Physical Interactions Between Factors Involved in Both Cell Cycle Progression and Pre-mRNA Splicing in Saccharomyces cerevisiae

Ben‐Yehuda, S., Dix, I., RUSSELL, C. S., McGarvey, M., Beggs, J. D., & Kupiec, M. (2000) · Genetics · doi:10.1093/genetics/156.4.1503 · Cited by 119 · see citing works

The Specificities of Four Yeast Dihydrouridine Synthases for Cytoplasmic tRNAs

Xing, F., Hiley, S. L., Hughes, T. R., & Phizicky, E. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401221200 · Cited by 113 · see citing works

Asparagine-linked glycosylation in Saccharomyces cerevisiae: genetic analysis of an early step.

Barnes, G., Hansen, W. J., Holcomb, C. L., & Rine, J. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.11.2381 · Cited by 112 · see citing works

Yeast and drug discovery

Hughes, T. R. (2002) · Functional & Integrative Genomics · doi:10.1007/s10142-002-0059-1 · Cited by 104 · see citing works

The Coatomer-interacting Protein Dsl1p Is Required for Golgi-to-Endoplasmic Reticulum Retrieval in Yeast

Andag, U., Neumann, T., & Schmitt, H. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105833200 · Cited by 96 · see citing works

Golgi-to-Endoplasmic Reticulum (ER) Retrograde Traffic in Yeast Requires Dsl1p, a Component of the ER Target Site that Interacts with a COPI Coat Subunit

Reilly, B., Kraynack, B. A., VanRheenen, S. M., & Waters, M. G. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.12.3783 · Cited by 88 · see citing works

Autoregulation in the Biosynthesis of Ribosomes

Zhao, Y., Sohn, J., & Warner, J. R. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.699-707.2003 · Cited by 78 · see citing works

Has1p, a member of the DEAD‐box family, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae†

Emery, B., de la Cruz, J., Ročak, S., Deloche, O., & Linder, P. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2003.03973.x · Cited by 77 · see citing works

Synthetic Lethality with Conditional dbp6 Alleles Identifies Rsa1p, a Nucleoplasmic Protein Involved in the Assembly of 60S Ribosomal Subunits

Kressler, D., Doère, M., Rojo, M., & Linder, P. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8633 · Cited by 62 · see citing works

Multicopy tRNA Genes Functionally Suppress Mutations in Yeast eIF-2α Kinase GCN2: Evidence for Separate Pathways Coupling GCN4 Expression to Uncharged tRNA

de Aldana, C. R. V., Wek, R. C., San-Segundo, P. A., Truesdell, A. G., & Hinnebusch, A. G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.7920-7932.1994 · Cited by 59 · see citing works

Using yeast to place human genes in functional categories

Zhang, N., Osborn, M. J., Gitsham, P., Yen, K., Miller, J., & Oliver, S. G. (2003) · Gene · doi:10.1016/s0378-1119(02)01142-3 · Cited by 52 · see citing works

Mutational analysis of Cak1p, an essential protein kinase that regulates cell cycle progression

Chun, K. T., & Goebl, M. G. (1997) · Molecular and General Genetics MGG · doi:10.1007/s004380050580 · Cited by 26 · see citing works

Biochemistry, cell biology and molecular biology of lipids ofSaccharomyces cerevisiae

Daum, G., Lees, N. D., Bard, M., & Dickson, R. (1998) · Yeast · doi:10.1002/(sici)1097-0061(199812)14:16

A global genetic interaction network maps a wiring diagram of cellular function

Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science · doi:10.1126/science.aaf1420 · Cited by 1,240 · see citing works

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

Zhu, Z., Chung, W.-H., Shim, E. Y., Lee, S. E., & Ira, G. (2008) · Cell · doi:10.1016/j.cell.2008.08.037 · Cited by 1,041 · see citing works

Tuning genetic control through promoter engineering

Alper, H. S., Fischer, C. R., Nevoigt, E., & Stephanopoulos, G. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504604102 · Cited by 894 · see citing works

Gene essentiality and synthetic lethality in haploid human cells

Blomen, V. A., Májek, P., Jae, L. T., Bigenzahn, J. W., Nieuwenhuis, J., Staring, J., Sacco, R., van Diemen, F. R., Olk, N., Stukalov, A., et al. (2015) · Science · doi:10.1126/science.aac7557 · Cited by 857 · see citing works

Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile

Schuldiner, M., Collins, S. R., Thompson, N. J., Denic, V., Bhamidipati, A., Punna, T., Ihmels, J., Andrews, B., Boone, C., Greenblatt, J. F., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.031 · Cited by 870 · see citing works

Mitochondrial protein import: from proteomics to functional mechanisms

Schmidt, O., Pfanner, N., & Meisinger, C. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2959 · Cited by 717 · see citing works

Mapping Pathways and Phenotypes by Systematic Gene Overexpression

Sopko, R., Huang, D., Preston, N., Chua, G., Papp, B., Kafadar, K. A., Snyder, M., Oliver, S. G., Cyert, M., Hughes, T. R., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.12.011 · Cited by 650 · see citing works

Exploring genetic interactions and networks with yeast

Boone, C., Bussey, H., & Andrews, B. J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2085 · Cited by 661 · see citing works

Efflux-Mediated Antifungal Drug Resistance

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., & Monk, B. C. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-08 · Cited by 608 · see citing works

Progress in Metabolic Engineering of Saccharomyces cerevisiae

Nevoigt, E. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00025-07 · Cited by 597 · see citing works

Mechanisms of Haploinsufficiency Revealed by Genome-Wide Profiling in Yeast

Deutschbauer, A. M., Jaramillo, D. F., Proctor, M., Kumm, J., Hillenmeyer, M. E., Davis, R. W., Nislow, C., & Giaever, G. (2005) · Genetics · doi:10.1534/genetics.104.036871 · Cited by 535 · see citing works

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome

Breslow, D. K., Cameron, D. M., Collins, S. R., Schuldiner, M., Stewart-Ornstein, J., Newman, H. W., Braun, S. J., Madhani, H. D., Krogan, N. J., & Weissman, J. S. (2008) · Nature Methods · doi:10.1038/nmeth.1234 · Cited by 517 · see citing works

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

Schuldiner, M., Metz, J., Schmid, V., Denic, V., Rakwalska, M., Schmitt, H. D., Schwappach, B., & Weissman, J. S. (2008) · Cell · doi:10.1016/j.cell.2008.06.025 · Cited by 522 · see citing works

Synthetic Genetic Array Analysis in Saccharomyces cerevisiae

Tong, A. H. Y., & Boone, C. M. (2005) · Humana Press eBooks · doi:10.1385/1-59259-958-3:171 · Cited by 489 · see citing works

The dependence of viral RNA replication on co-opted host factors

Nagy, P. D., & Pogany, J. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2692 · Cited by 447 · see citing works

Systematic Analysis of the Protein Interaction Network for the Human Transcription Machinery Reveals the Identity of the 7SK Capping Enzyme

Jerónimo, C., Forget, D., Bouchard, A., Li, Q., Chua, G., Poitras, C., Thérien, C., Bergeron, D., Bourassa, S., Greenblatt, J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.027 · Cited by 444 · see citing works

Systematic humanization of yeast genes reveals conserved functions and genetic modularity

Kachroo, A. H., Laurent, J. M., Yellman, C. M., Meyer, A. G., Wilke, C. O., & Marcotte, E. M. (2015) · Science · doi:10.1126/science.aaa0769 · Cited by 423 · see citing works

Genetic reconstruction of a functional transcriptional regulatory network

Hu, Z., Killion, P. J., & Iyer, V. R. (2007) · Nature Genetics · doi:10.1038/ng2012 · Cited by 415 · see citing works

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

Li, Z., Vizeacoumar, F. J., Bahr, S., Li, J., Warringer, J., Vizeacoumar, F. S., Min, R., VanderSluis, B., Bellay, J., DeVit, M. J., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1832 · Cited by 404 · see citing works

Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

Ehrt, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni013 · Cited by 383 · see citing works

PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone

Park, S.-H., Kukushkin, Y., Gupta, R., Chen, T., Konagai, A., Hipp, M. S., Hayer-Hartl, M. K., & Hartl, F. U. (2013) · Cell · doi:10.1016/j.cell.2013.06.003 · Cited by 358 · see citing works

A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets

Fei, W., Shui, G., Zhang, Y., Krahmer, N., Ferguson, C., Kapterian, T. S., Lin, R. C. Y., Dawes, I. W., Brown, A. J., Li, P., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002201 · Cited by 358 · see citing works

Trait Variation in Yeast Is Defined by Population History

Warringer, J., Zörgö, E., Cubillos, F. A., Zia, A., Gjuvsland, A. B., Simpson, J. T., Forsmark, A., Durbin, R. M., Omholt, S. W., Louis, E. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002111 · Cited by 338 · see citing works

Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks

di Bernardo, D., Thompson, M. J., Gardner, T. S., Chobot, S. E., Eastwood, E. L., Wojtovich, A. P., Elliott, S. J., Schaus, S. E., & Collins, J. J. (2005) · Nature Biotechnology · doi:10.1038/nbt1075 · Cited by 347 · see citing works

25 Yeast Genetic Strain and Plasmid Collections

Entian, K., & Kötter, P. (2007) · Methods in microbiology · doi:10.1016/s0580-9517(06)36025-4 · Cited by 310 · see citing works

Systematic Mapping of Genetic Interaction Networks

Dixon, S. J., Costanzo, M., Baryshnikova, A., Andrews, B., & Boone, C. M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.114751 · Cited by 290 · see citing works

Emerging and evolving concepts in gene essentiality

Rancati, G. I., Moffat, J., Typas, A., & Pavelka, N. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.74 · Cited by 272 · see citing works

Tunable and reversible drug control of protein production via a self-excising degron

Chung, H. K., Jacobs, C. L., Huo, Y., Yang, J., Krumm, S. A., Plemper, R. K., Tsien, R. Y., & Lin, M. Z. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1869 · Cited by 233 · see citing works

The synthetic genetic interaction spectrum of essential genes

Davierwala, A. P., Haynes, J., Li, Z., Brost, R. L., Robinson, M. D., Yu, L. X., Mnaimneh, S., Ding, H., Zhu, H., Chen, Y., et al. (2005) · Nature Genetics · doi:10.1038/ng1640 · Cited by 221 · see citing works

Toward a Comprehensive Temperature-Sensitive Mutant Repository of the Essential Genes of Saccharomyces cerevisiae

Ben‐Aroya, S., Coombes, C. E., Kwok, T., O’Donnell, K. A., Boeke, J. D., & Hieter, P. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.021 · Cited by 213 · see citing works

Synthetic Genetic Array (SGA) Analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe

Baryshnikova, A., Costanzo, M., Dixon, S. J., Vizeacoumar, F. J., Myers, C. L., Andrews, B., & Boone, C. M. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)70007-0 · Cited by 201 · see citing works

One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy

Yofe, I., Weill, U., Meurer, M., Chuartzman, S. G., Zalckvar, E., Goldman, O., Ben‐Dor, S., Schütze, C., Wiedemann, N., Knop, M., et al. (2016) · Nature Methods · doi:10.1038/nmeth.3795 · Cited by 202 · see citing works

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress

Saad, S., Cereghetti, G., Feng, Y., Picotti, P., Peter, M., & Dechant, R. C. (2017) · Nature Cell Biology · doi:10.1038/ncb3600 · Cited by 186 · see citing works

RSC Mobilizes Nucleosomes To Improve Accessibility of Repair Machinery to the Damaged Chromatin

Shim, E. Y., Hong, S. J., Oum, J.-H., Yanez, Y., Zhang, Y., & Lee, S. E. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01956-06 · Cited by 183 · see citing works

Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation

Zhao, R., Kakihara, Y., Gribun, A., Huen, J., Yang, G., Khanna, M., Costanzo, M., Brost, R. L., Boone, C. M., Hughes, T. R., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709061 · Cited by 185 · see citing works

Identifying transcription factor functions and targets by phenotypic activation

Chua, G., Morris, Q., Sopko, R., Robinson, M. D., Ryan, O. W., Chan, E. T., Frey, B. J., Andrews, B., Boone, C. M., & Hughes, T. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605140103 · Cited by 183 · see citing works

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

Fang, N. N., Chan, G. T., Zhu, M., Comyn, S. A., Persaud, A. K., Deshaies, R. J., Rotin, D., Gsponer, J., & Mayor, T. (2014) · Nature Cell Biology · doi:10.1038/ncb3054 · Cited by 179 · see citing works

Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution

Tucker, K., & Park, E. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0339-2 · Cited by 161 · see citing works

Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics

Li, Z., Lee, I., Moradi, E. K., Hung, N., Johnson, A. M., & Marcotte, E. M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000213 · Cited by 176 · see citing works

Essence of life: essential genes of minimal genomes

Juhas, M., Eberl, L., & Glass, J. I. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.07.005 · Cited by 178 · see citing works

Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3

Baird, D., Stefan, C. J., Audhya, A., Weys, S., & Emr, S. D. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200804003 · Cited by 168 · see citing works

The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components

Stirling, P. C., Bloom, M. S., Solanki-Patil, T., Smith, S. N., Sipahimalani, P., Li, Z., Kofoed, M., Ben‐Aroya, S., Myung, K., & Hieter, P. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002057 · Cited by 166 · see citing works

Tomato bushy stunt virus Co-Opts the RNA-Binding Function of a Host Metabolic Enzyme for Viral Genomic RNA Synthesis

Wang, R., & Nagy, P. D. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.005 · Cited by 167 · see citing works

Yeast as a Model Host to Explore Plant Virus-Host Interactions

Nagy, P. D. (2008) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.121407.093958 · Cited by 166 · see citing works

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L

Huber, A., French, S. L., Tekotte, H., Yerlikaya, S., Ståhl, M., Perepelkina, M. P., Tyers, M., Rougemont, J., Beyer, A. L., & Loewith, R. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.221 · Cited by 166 · see citing works

Role of Essential Genes in Mitochondrial Morphogenesis inSaccharomyces cerevisiae

Altmann, K., & Westermann, B. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0678 · Cited by 165 · see citing works

Tam41 Is a CDP-Diacylglycerol Synthase Required for Cardiolipin Biosynthesis in Mitochondria

Tamura, Y., Harada, Y., Nishikawa, S., Yamano, K., Kamiya, M., Shiota, T., Kuroda, T., Kuge, O., Sesaki, H., Imai, K., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.018 · Cited by 163 · see citing works

Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity

Fendt, S., Buescher, J. M., Rudroff, F., Picotti, P., Zamboni, N., & Sauer, U. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.11 · Cited by 159 · see citing works

Systems-level antimicrobial drug and drug synergy discovery

Roemer, T., & Boone, C. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1205 · Cited by 159 · see citing works

Transcriptome-Wide Binding Sites for Components of the Saccharomyces cerevisiae Non-Poly(A) Termination Pathway: Nrd1, Nab3, and Sen1

Creamer, T. J., Darby, M. M., Jamonnak, N., Schaughency, P., Hao, H., Wheelan, S. J., & Corden, J. L. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002329 · Cited by 160 · see citing works

Biogenesis of the Mitochondrial TOM Complex

Becker, T., Pfannschmidt, S., Guiard, B., Stojanovski, D., Milenkovic, D., Kutik, S., Pfanner, N., Meisinger, C., & Wiedemann, N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706997200 · Cited by 153 · see citing works

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia

Boczonadi, V., Müller, J. S., Pyle, A., Munkley, J., Dor, T., Quartararo, J., Ferrero, I., Karcagi, V., Giunta, M., Polvikoski, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms5287 · Cited by 149 · see citing works

Regulation of Yeast NRD1 Expression by Premature Transcription Termination

Arigo, J. T., Carroll, K. L., Ames, J. M., & Corden, J. L. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.02.005 · Cited by 144 · see citing works

GeneWeaver: a web-based system for integrative functional genomics

Baker, E. J., Jay, J. J., Bubier, J. A., Langston, M. A., & Chesler, E. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr968 · Cited by 140 · see citing works

Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes

Krumpe, K., Frumkin, I., Herzig, Y., Rimon, N., Özbalci, C., Brügger, B., Rapaport, D., & Schuldiner, M. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-12-0994 · Cited by 137 · see citing works

Biogenesis of β-barrel membrane proteins of mitochondria

Paschen, S. A., Neupert, W., & Rapaport, D. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.08.009 · Cited by 137 · see citing works

Cytosolic pH Regulates Cell Growth through Distinct GTPases, Arf1 and Gtr1, to Promote Ras/PKA and TORC1 Activity

Dechant, R. C., Saad, S., Ibáñez, A. J., & Peter, M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.002 · Cited by 135 · see citing works

A prototrophic deletion mutant collection for yeast metabolomics and systems biology

Mülleder, M., Capuano, F., Pir, P., Christen, S., Sauer, U., Oliver, S. G., & Ralser, M. (2012) · Nature Biotechnology · doi:10.1038/nbt.2442 · Cited by 133 · see citing works

Cdc34p Ubiquitin-Conjugating Enzyme Is a Component of the Tombusvirus Replicase Complex and Ubiquitinates p33 Replication Protein

Li, Z., Barajas, D., Panavas, T., Herbst, D. A., & Nagy, P. D. (2008) · Journal of Virology · doi:10.1128/jvi.00702-08 · Cited by 132 · see citing works

The Glc7 Phosphatase Subunit of the Cleavage and Polyadenylation Factor Is Essential for Transcription Termination on snoRNA Genes

Nedea, E. C., Nalbant, D., Xia, D., Theoharis, N. T., Suter, B., Richardson, C. J., Tatchell, K., Kislinger, T., Greenblatt, J. F., & Nagy, P. L. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.031 · Cited by 128 · see citing works

Charging it up: global analysis of protein phosphorylation

Ptacek, J., & Snyder, M. P. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.08.005 · Cited by 128 · see citing works

Identification of the Neuroblastoma-amplified Gene Product as a Component of the Syntaxin 18 Complex Implicated in Golgi-to-Endoplasmic Reticulum Retrograde Transport

Aoki, T., Ichimura, S., Itoh, A., Kuramoto, M., Shinkawa, T., Isobe, T., & Tagaya, M. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-11-1104 · Cited by 125 · see citing works

A Compendium of Nucleosome and Transcript Profiles Reveals Determinants of Chromatin Architecture and Transcription

van Bakel, H., Tsui, K., Gebbia, M., Mnaimneh, S., Hughes, T. R., & Nislow, C. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003479 · Cited by 124 · see citing works

In Vivo Robustness Analysis of Cell Division Cycle Genes in Saccharomyces cerevisiae

Moriya, H., Shimizu‐Yoshida, Y., & Kitano, H. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020111 · Cited by 125 · see citing works

Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

Huang, X., Liu, J., & Dickson, R. C. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002493 · Cited by 124 · see citing works

The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae

Altmann, K., Frank, M., Neumann, D., Jakobs, S., & Westermann, B. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709099 · Cited by 124 · see citing works

Identification of Essential Host Factors Affecting Tombusvirus RNA Replication Based on the Yeast Tet Promoters Hughes Collection

Jiang, Y., Servienė, E., Gál, J., Panavas, T., & Nagy, P. D. (2006) · Journal of Virology · doi:10.1128/jvi.02686-05 · Cited by 122 · see citing works

Global Map of SUMO Function Revealed by Protein-Protein Interaction and Genetic Networks

Makhnevych, T., Sydorskyy, Y., Xin, X., Srikumar, T., Vizeacoumar, F. J., Jeram, S. M., Li, Z., Bahr, S., Andrews, B., Boone, C. M., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.025 · Cited by 121 · see citing works

16 High-Throughput Strain Construction and Systematic Synthetic Lethal Screening in

Tong, A. H. Y., & Boone, C. M. (2007) · Methods in microbiology · doi:10.1016/s0580-9517(06)36016-3 · Cited by 121 · see citing works

A general lack of compensation for gene dosage in yeast

Springer, M., Weissman, J. S., & Kirschner, M. W. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.19 · Cited by 122 · see citing works

Multiple pathways in the integration of proteins into the mitochondrial outer membrane

Dukanovic, J., & Rapaport, D. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.06.021 · Cited by 120 · see citing works

Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1

Escobar‐Henriques, M., Westermann, B., & Langer, T. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512079 · Cited by 119 · see citing works

Advanced Methods for High-Throughput Microscopy Screening of Genetically Modified Yeast Libraries

Cohen, Y., & Schuldiner, M. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-276-2_8 · Cited by 115 · see citing works

Still Stratus Not Altocumulus: Further Evidence against the Date/Party Hub Distinction

Batada, N. N., Reguly, T., Breitkreutz, A., Boucher, L., Breitkreutz, B., Hurst, L. D., & Tyers, M. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050154 · Cited by 115 · see citing works

Cellular and mitochondrial remodeling upon defects in iron-sulfur protein biogenesis

Hausmann, A., Samans, B., Lill, R., & Mühlenhoff, U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705570200 · Cited by 111 · see citing works

Mim1 Functions in an Oligomeric Form to Facilitate the Integration of Tom20 into the Mitochondrial Outer Membrane

Popov-Celeketic, J., Waizenegger, T., & Rapaport, D. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.12.006 · Cited by 111 · see citing works

Unsupervised pattern recognition: An introduction to the whys and wherefores of clustering microarray data

Boutros, P. C., & Okey, A. B. (2005) · Briefings in Bioinformatics · doi:10.1093/bib/6.4.331 · Cited by 108 · see citing works

Genetic Interaction Networks: Toward an Understanding of Heritability

Baryshnikova, A., Costanzo, M., Myers, C. L., Andrews, B., & Boone, C. M. (2013) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082509-141730 · Cited by 108 · see citing works

Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance

Shan, L., Xu, G., Yao, R.-W., Luan, P.-F., Huang, Y., Zhang, P.-H., Pan, Y.-H., Zhang, L., Gao, X., Li, Y., et al. (2023) · Nature · doi:10.1038/s41586-023-05767-5 · Cited by 109 · see citing works

The Transmembrane Segment of Tom20 Is Recognized by Mim1 for Docking to the Mitochondrial TOM Complex

Hulett, J. M., Lueder, F., Chan, N. C., Perry, A., Wolynec, P. P., Likić, V. A., Gooley, P. R., & Lithgow, T. J. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.12.021 · Cited by 109 · see citing works

Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae

Chemler, J. A., Yan, Y., & Koffas, M. A. G. (2006) · Microbial Cell Factories · doi:10.1186/1475-2859-5-20 · Cited by 109 · see citing works

Essential genes as antimicrobial targets and cornerstones of synthetic biology

Juhas, M., Eberl, L., & Church, G. M. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.08.002 · Cited by 108 · see citing works

Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae

Raskin, D. M., Judson, N., & Mekalanos, J. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611650104 · Cited by 108 · see citing works

Analysis of Transcriptional Activation at a Distance in Saccharomyces cerevisiae

Dobi, K. C., & Winston, F. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00459-07 · Cited by 106 · see citing works

Dsl1p, Tip20p, and the Novel Dsl3(Sec39) Protein Are Required for the Stability of the Q/t-SNARE Complex at the Endoplasmic Reticulum in Yeast

Kraynack, B. A., Chan, A., Rosenthal, E. H., Essid, M., Umansky, B., Waters, M. G., & Schmitt, H. D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0056 · Cited by 106 · see citing works

Efficient protein depletion by genetically controlled deprotection of a dormant N‐degron

Taxis, C., Stier, G., Spadaccini, R., & Knop, M. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.25 · Cited by 107 · see citing works

Neuroblastoma amplified sequence gene is associated with a novel short stature syndrome characterised by optic nerve atrophy and Pelger–Huët anomaly

Максимова, Н. Р., Hara, K., Nikolaeva, I., Chun-Feng, T., Usui, T., Takagi, M., Nishihira, Y., Miyashita, A., Fujiwara, H., Oyama, T., et al. (2010) · Journal of Medical Genetics · doi:10.1136/jmg.2009.074815 · Cited by 106 · see citing works

Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers

Yan, Z., Costanzo, M., Heisler, L. E., Paw, J., Kaper, F., Andrews, B., Boone, C. M., Giaever, G. N., & Nislow, C. (2008) · Nature Methods · doi:10.1038/nmeth.1231 · Cited by 105 · see citing works

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer

Humphries‐Bickley, T., Castillo‐Pichardo, L., O'Farril, E. H., Borrero-García, L. D., Forestier-Román, I., Gerena, Y., Blanco, M., Rivera-Robles, M. J., Rodríguez-Medina, J. R., Cubano, L. A., et al. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0442 · Cited by 105 · see citing works

LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis

Castle, C. D., Cassimere, E. K., & Denicourt, C. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-06-0530 · Cited by 105 · see citing works

Transcriptome‐wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co‐transcriptional degradation in determining mRNA levels

Fadda, A. A., Ryten, M., Droll, D., Rojas, F., Färber, V., Haanstra, J. R., Merce, C., Bakker, B. M., Matthews, K. R., & CLAYTON, C. E. (2014) · Molecular Microbiology · doi:10.1111/mmi.12764 · Cited by 102 · see citing works

High-resolution network biology: connecting sequence with function

Ryan, C. J., Cimermančič, P., Szpiech, Z. A., Šali, A., Hernandez, R. D., & Krogan, N. J. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3574 · Cited by 98 · see citing works

A Survey of Essential Gene Function in the Yeast Cell Division Cycle

Yu, L. X., Peña‐Castillo, L., Mnaimneh, S., Hughes, T. R., & Brown, G. W. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-04-0368 · Cited by 102 · see citing works

A fast and efficient translational control system for conditional expression of yeast genes

Kötter, P., Weigand, J. E., Meyer, B., Entian, K., & Suess, B. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp578 · Cited by 101 · see citing works

Confirmation of Organized Modularity in the Yeast Interactome

Bertin, N., Simonis, N., Dupuy, D., Cusick, M. E., Han, J. J., Fraser, H. B., Roth, F. P., & Vidal, M. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050153 · Cited by 100 · see citing works

Screening of the Yeast yTHC Collection Identifies Essential Host Factors Affecting Tombusvirus RNA Recombination

Servienė, E., Jiang, Y., Cheng, C., Baker, J., & Nagy, P. D. (2006) · Journal of Virology · doi:10.1128/jvi.80.3.1231-1241.2006 · Cited by 99 · see citing works

Mutations in the Saccharomyces cerevisiae RPB1 Gene Conferring Hypersensitivity to 6-Azauracil

Malagón, F., Kireeva, M. L., Shafer, B. K., Lubkowska, L., Kashlev, M., & Strathern, J. N. (2006) · Genetics · doi:10.1534/genetics.105.052415 · Cited by 99 · see citing works

Simple is good: yeast models of neurodegeneration

Tenreiro, S., & Outeiro, T. F. (2010) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2010.00649.x · Cited by 98 · see citing works

Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex

Tripathi, A., Ren, Y., Jeffrey, P. D., & Hughson, F. M. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1548 · Cited by 98 · see citing works

Biallelic IARS Mutations Cause Growth Retardation with Prenatal Onset, Intellectual Disability, Muscular Hypotonia, and Infantile Hepatopathy

Kopajtich, R., Murayama, K., Janecke, A., Haack, T. B., Breuer, M., Knisely, A. S., Harting, I., Ohashi, T., Okazaki, Y., WATANABE, D., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.05.027 · Cited by 97 · see citing works

Systematic Exploration of Essential Yeast Gene Functions with Temperature-sensitive Mutants

Li, Z. (2011) · TSpace (University of Toronto)

6 Studying Essential Genes: Generating and Using Promoter Fusions and Conditional Alleles

Stark, M. J. R. (1998) · Methods in microbiology · doi:10.1016/s0580-9517(08)70327-1 · Cited by 8 · see citing works

Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis

Alamgir, M. S., Eroukova, V., Jessulat, M., Xu, J., & Golshani, A. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-583 · Cited by 49 · see citing works

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

Li, Z., Vizeacoumar, F. J., Bahr, S., Li, J., Warringer, J., Vizeacoumar, F. S., Min, R., VanderSluis, B., Bellay, J., DeVit, M. J., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1832 · Cited by 404 · see citing works

PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae

Jin, K., Li, J., Vizeacoumar, F. S., Li, Z., Min, R., Zamparo, L., Vizeacoumar, F. S., Datti, A., Andrews, B., Boone, C., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr827 · Cited by 16 · see citing works