BDNF-Promoted Increases in Proximal Dendrites Occur via CREB-Dependent Transcriptional Regulation of Cypin
Open accessAbstract
Alterations in dendrite branching and morphology are present in many neurodegenerative diseases. These variations disrupt postsynaptic transmission and affect neuronal communication. Thus, it is important to understand the molecular mechanisms that regulate dendritogenesis and how they go awry during disease states. Previously, our laboratory showed that cypin, a mammalian guanine deaminase, increases dendrite number when overexpressed and decreases dendrite number when knocked down in cultured hippocampal neurons. Here, we report that exposure to brain-derived neurotrophic factor (BDNF), an important mediator of dendrite arborization, for 72 h but not for 24 h or less increases cypin mRNA and protein levels in rat hippocampal neurons. BDNF signals through cypin to regulate dendrite number, since knocking down cypin blocks the effects of BDNF. Furthermore, BDNF increases cypin levels via mitogen-activated protein kinase and transcription-dependent signaling pathways. Moreover, the cypin promoter region contains putative conserved cAMP response element (CRE) regions, which we found can be recognized and activated by CRE-binding protein (CREB). In addition, exposure of the neurons to BDNF increased CREB binding to the cypin promoter and, in line with these data, expression of a dominant negative form of CREB blocked BDNF-promoted increases in cypin protein levels and proximal dendrite branches. Together, these studies suggest that BDNF increases neuronal cypin expression by the activation of CREB, increasing cypin transcription leading to increased protein expression, thus identifying a novel pathway by which BDNF shapes the dendrite network.
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mBDNF-TrkB-signaling pathways regulate multiple events, such as apoptosis and survival of neurons, dendritic growth, spine maturation and stabilization, development of synapses, and learning- and memory-processes-dependent synaptic plasticity.
“mBDNF-TrkB-signaling pathways regulate multiple events, such as apoptosis and survival of neurons [90,91,92], dendritic growth [93,94,95,96], spine maturation and stabilization, development of synapses [96,97,98], learning- and memory-processes-dependent synaptic plasticity [99,100].”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [94]
BDNF-TrkB signaling pathways regulate dendritic growth, synapse development, learning- and memory-processes-dependent synaptic plasticity, apoptosis, and survival of neurons.
“BDNF-TrkB signaling pathways regulate multiple events, such as dendritic growth, pine maturation and stabilization [41,42,43], development of synapses [44,45], learning- and memory-processes-dependent synaptic plasticity [40,46,47], apoptosis, and survival of neurons [48,49,50,51].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [42]
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Cites
The Nerve Growth Factor 35 Years Later
Levi‐Montalcini, R. (1987) · Science · doi:10.1126/science.3306916 · Cited by 3,109 · see citing works
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Dyk, D. E. V., Pitts, W. J., Earl, R. A., Hobbs, F. W., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18623 · Cited by 3,016 · see citing works
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298 · see citing works
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195 · see citing works
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,887 · see citing works
Purification of a new neurotrophic factor from mammalian brain.
Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822 · see citing works
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL
Heinemeyer, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.1.362 · Cited by 1,462 · see citing works
Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Science · doi:10.1126/science.2321006 · Cited by 1,322 · see citing works
Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease
Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B. R., Goffredo, D., Conti, L., MacDonald, M. E., Friedlander, R. M., Silani, V., Hayden, M. R., et al. (2001) · Science · doi:10.1126/science.1059581 · Cited by 1,319 · see citing works
The Trk family of neurotrophin receptors
Barbacid, M. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251107 · Cited by 1,281 · see citing works
Nagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., Wang, L., Blesch, A., Kim, A., Conner, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1912 · Cited by 1,034 · see citing works
Neurotrophins regulate dendritic growth in developing visual cortex
McAllister, A. K., Lo, D. C., & Katz, L. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90171-x · Cited by 959 · see citing works
Hallböök, F., Ibáñez, C. F., & Persson, H. (1991) · Neuron · doi:10.1016/0896-6273(91)90180-8 · Cited by 834 · see citing works
An, J. J., Gharami, K., Liao, G., Woo, N. H., Lau, A. G., Vanevski, F., Torre, E. R., Jones, K. R., Feng, Y., Lu, B., et al. (2008) · Cell · doi:10.1016/j.cell.2008.05.045 · Cited by 670 · see citing works
Activity-dependent regulation of dendritic growth and patterning
Wong, R. O. L., & Ghosh, A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn941 · Cited by 635 · see citing works
Levine, E. S., Dreyfus, C. F., Black, I. B., & Plummer, M. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.8074 · Cited by 611 · see citing works
Neves-Pereira, M., Mundo, E., Muglia, P., King, N. A., Macciardi, F. M., & Kennedy, J. L. (2002) · The American Journal of Human Genetics · doi:10.1086/342288 · Cited by 594 · see citing works
Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways
Kumar, V., Zhang, M.-X., Swank, M. W., Kunz, J., & Wu, G.-Y. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2284-05.2005 · Cited by 588 · see citing works
Jaworski, J., Spangler, S. A., Seeburg, D. P., Hoogenraad, C. C., & Sheng, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2270-05.2005 · Cited by 576 · see citing works
Opposing Roles for Endogenous BDNF and NT-3 in Regulating Cortical Dendritic Growth
McAllister, A. K., Katz, L. C., & Lo, D. C. (1997) · Neuron · doi:10.1016/s0896-6273(00)80316-5 · Cited by 570 · see citing works
Sklar, P. B., Gabriel, S., McInnis, M. G., Bennett, P., Lim, Y.-M., Tsan, G., Schaffner, S. F., Kirov, G., Jones, I. R., Owen, M. J., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001058 · Cited by 563 · see citing works
Actinomycin and DNA transcription.
Sobell, H. (1985) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.82.16.5328 · Cited by 553 · see citing works
Neurotrophin Regulation of Cortical Dendritic Growth Requires Activity
McAllister, A. K., Katz, L. C., & Lo, D. C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80239-1 · Cited by 503 · see citing works
Dendritic arbor development and synaptogenesis
Cline, H. T. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00182-3 · Cited by 499 · see citing works
Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42
Threadgill, R., Bobb, K., & Ghosh, A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80376-1 · Cited by 492 · see citing works
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C. (2005) · Nature Neuroscience · doi:10.1038/nn1374 · Cited by 485 · see citing works
Wayman, G. A., Impey, S., Marks, D., Saneyoshi, T., Grant, W. F., Derkach, V., & Soderling, T. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.008 · Cited by 466 · see citing works
S ELECTIVITY IN N EUROTROPHIN S IGNALING : Theme and Variations
Segal, R. A. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131421 · Cited by 447 · see citing works
Takei, N., Inamura, N., Kawamura, M., Namba, H., Hara, K., Yonezawa, K., & Nawa, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1427-04.2004 · Cited by 442 · see citing works
Schwartz, P. M., Borghesani, P. R., Levy, R. L., Pomeroy, S. L., & Segal, R. A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80938-1 · Cited by 438 · see citing works
Schratt, G. M., Nigh, E. A., Chen, W., Hu, L. S., & Greenberg, M. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1739-04.2004 · Cited by 401 · see citing works
Cellular and Molecular Mechanisms of Dendrite Growth
McAllister, A. K. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.963 · Cited by 382 · see citing works
Davies, A. M., Lee, K., & Jaenisch, R. (1993) · Neuron · doi:10.1016/0896-6273(93)90069-4 · Cited by 354 · see citing works
Destabilization of Cortical Dendrites and Spines by BDNF
Horch, H. W., Krüttgen, A., Portbury, S. D., & Katz, L. C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80785-0 · Cited by 345 · see citing works
Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons
Ji, Y., Lü, Y., Yang, F., Shen, W., Tang, T. T.-T., Feng, L., Duan, S., & Lu, B. (2010) · Nature Neuroscience · doi:10.1038/nn.2505 · Cited by 340 · see citing works
Jagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Keßler, T., Saxe, M., Gage, F. H., Song, H., & Lie, D. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1054-09.2009 · Cited by 328 · see citing works
Fink, C. C., Bayer, K.-U., Myers, J. W., Ferrell, J. E., Schulman, H., & Meyer, T. (2003) · Neuron · doi:10.1016/s0896-6273(03)00428-8 · Cited by 328 · see citing works
Ji, Y., Pang, P. T., Feng, L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1381 · Cited by 326 · see citing works
Genes regulating dendritic outgrowth, branching, and routing in DrosophilaPreprint
Gao, F., Brenman, J. E., Jan, L. Y., & Jan, Y. N. (1999) · Genes & Development · doi:10.1101/gad.13.19.2549 · Cited by 325 · see citing works
Mahadeo, D. C., Kaplan, L., Chao, M. V., & Hempstead, B. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37458-6 · Cited by 320 · see citing works
Grueber, W. B., Jan, L. Y., & Jan, Y. N. (2003) · Cell · doi:10.1016/s0092-8674(03)00160-0 · Cited by 315 · see citing works
Schumacher, J. H., Jamra, R. A., Becker, T., Ohlraun, S., Klopp, N., Binder, E. B., Schulze, T. G., Deschner, M., Schmäl, C., Höfels, S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.006 · Cited by 305 · see citing works
Conditional Deletion of TrkB but Not BDNF Prevents Epileptogenesis in the Kindling Model
He, X.-P., Kotloski, R. J., Nef, S., Luikart, B. W., Parada, L. F., & McNamara, J. O. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.019 · Cited by 304 · see citing works
Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo
Li, Z., Aelst, L. V., & Cline, H. T. (2000) · Nature Neuroscience · doi:10.1038/72920 · Cited by 293 · see citing works
Dendrite Development Regulated by CREST, a Calcium-Regulated Transcriptional Activator
Aizawa, H., Hu, S., Bobb, K., Balakrishnan, K., Ince-Dunn, G., Gurevich, I., Cowan, M., & Ghosh, A. (2004) · Science · doi:10.1126/science.1089845 · Cited by 282 · see citing works
Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth
Yacoubian, T. A., & Lo, D. C. (2000) · Nature Neuroscience · doi:10.1038/73911 · Cited by 278 · see citing works
Biffo, S., Offenhäuser, N., Carter, B. D., & Barde, Y. (1995) · Development · doi:10.1242/dev.121.8.2461 · Cited by 270 · see citing works
Molecular Control of Cortical Dendrite Development
Whitford, K. L., Dijkhuizen, P. A., Polleux, F., & Ghosh, A. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142932 · Cited by 266 · see citing works
Frisén, J., Verge, V. M. K., Fried, K., Risling, M., Persson, H., Trotter, J., Hökfelt, T. G. M., & Lindholm, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.4971 · Cited by 259 · see citing works
Wetmore, C., & Olson, L. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903530113 · Cited by 244 · see citing works
Signaling Mechanisms Underlying Reversible, Activity-Dependent Dendrite Formation
Vaillant, A., Zanassi, P., Walsh, G. S., Aumont, A., Alonso, Á., & Miller, F. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00717-1 · Cited by 242 · see citing works
Nakajima, T., Uchida, C., Anderson, S. F., Parvin, J. D., & Montminy, M. (1997) · Genes & Development · doi:10.1101/gad.11.6.738 · Cited by 238 · see citing works
Emoto, K., He, Y., Ye, B., Grueber, W. B., Adler, P. N., Jan, L. Y., & Jan, Y.-N. (2004) · Cell · doi:10.1016/j.cell.2004.09.036 · Cited by 235 · see citing works
Peng, S., Garzon, D. J., Marchese, M., Klein, W. L., Ginsberg, S. D., Francis, B. M., Mount, H. T. J., Mufson, E. J., Salehi, A., & Fahnestock, M. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4736-08.2009 · Cited by 216 · see citing works
Segal, R. A., Pomeroy, S. L., & Stiles, C. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-04970.1995 · Cited by 212 · see citing works
The Neuronal Architecture ofXenopusRetinal Ganglion Cells Is Sculpted by Rho-Family GTPasesIn Vivo
Ruchhoeft, M. L., Ohnuma, S., McNeill, L., Holt, C. E., & Harris, W. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08454.1999 · Cited by 193 · see citing works
Lynch, G., Kramar, E. A., Rex, C. S., Jia, Y., Chappas, D., Gall, C. M., & Simmons, D. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5113-06.2007 · Cited by 181 · see citing works
Dijkhuizen, P., & Ghosh, A. (2005) · Journal of Neurobiology · doi:10.1002/neu.20100 · Cited by 171 · see citing works
Dendritic Growth and Spine Formation in Response to Estrogen in the Developing Purkinje Cell
Sakamoto, H., Mezaki, Y., Shikimi, H., Ukena, K., & Tsutsui, K. (2003) · Endocrinology · doi:10.1210/en.2003-0307 · Cited by 170 · see citing works
Astroglial neurotrophic and neurite-promoting factors
Müller, H. W. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)00047-7 · Cited by 167 · see citing works
Neurotrophic Factor Receptors and Their Signal Transduction Capabilities in Rat Astrocytes
Rudge, J. S., Li, Y., Pasnikowski, E. M., Mattsson, K., Pan, L., Yancopoulos, G. D., Wiegand, S. J., Lindsay, R. M., & Ip, N. Y. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00981.x · Cited by 162 · see citing works
Activity-Independent Regulation of Dendrite Patterning by Postsynaptic Density Protein PSD-95
Charych, E. I., Akum, B. F., Goldberg, J. S., Jörnsten, R. J., Rongo, C., Zheng, J. Q., & Firestein, B. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2379-06.2006 · Cited by 141 · see citing works
Self-citationCypin regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly
Akum, B. F., Chen, M., Gunderson, S., Riefler, G. M., Scerri-Hansen, M. M., & Firestein, B. L. (2004) · Nature Neuroscience · doi:10.1038/nn1179 · Cited by 141 · see citing works
Self-citationJin, X., Hu, H., Mathers, P. H., & Agmon, A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05662.2003 · Cited by 137 · see citing works
hamlet , a Binary Genetic Switch Between Single- and Multiple- Dendrite Neuron Morphology
Moore, A. W., Jan, L. Y., & Jan, Y. N. (2002) · Science · doi:10.1126/science.1072387 · Cited by 137 · see citing works
Langhammer, C. G., Previtera, M. L., Sweet, E. S., Sran, S. S., Chen, M., & Firestein, B. L. (2010) · Cytometry Part A · doi:10.1002/cyto.a.20954 · Cited by 135 · see citing works
Self-citationTruncated and Catalytic Isoforms of trkB are Co‐expressed in Neurons of Rat and Mouse CNS
Armanini, M. P., McMahon, S. B., Sutherland, J. S., Shelton, D. L., & PHILLIPS, H. S. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01132.x · Cited by 128 · see citing works
Strauss, J., Barr, C. L., George, C. J., Devlin, B., Vetró, Á., Kiss, É., Baji, I., King, N. A., Shaikh, S. A., Lanktree, M. B., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001685 · Cited by 110 · see citing works
Early Days of the Nerve Growth Factor Proteins
Shooter, E. M. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.601 · Cited by 110 · see citing works
RhoA Regulates Dendrite Branching in Hippocampal Neurons by Decreasing Cypin Protein Levels
Chen, H., & Firestein, B. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0872-07.2007 · Cited by 107 · see citing works
Self-citationRegulation of dendritic development by calcium signaling
Redmond, L., & Ghosh, A. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.01.009 · Cited by 105 · see citing works
Expression of trk receptors in the developing and adult human central and peripheral nervous system
Muragaki, Y., Timothy, N., Leight, S., Hempstead, B. L., Chao, M. V., Trojanowski, J. Q., & Lee, V. M. ‐. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903560306 · Cited by 105 · see citing works
Ko, M., Zou, K., Minagawa, H., Yu, W., Gong, J.-S., Yanagisawa, K., & Michikawa, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509164200 · Cited by 87 · see citing works
Relationships Between Neuronal Structure and Function
Miller, J. P., & Jacobs, G. A. (1984) · Journal of Experimental Biology · doi:10.1242/jeb.112.1.129 · Cited by 81 · see citing works
Hartmann, M., Brigadski, T., Erdmann, K. S., Holtmann, B., Sendtner, M., Narz, F., & Leßmann, V. (2004) · Journal of Cell Science · doi:10.1242/jcs.01511 · Cited by 78 · see citing works
Baker, R. E., Dijkhuizen, P. A., van Pelt, J., & Verhaagen, J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00118.x · Cited by 67 · see citing works
Carrel, D., Du, Y., Komlos, D., Hadzimichalis, N. M., Kwon, M., Wang, B., Brzustowicz, L. M., & Firestein, B. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5287-08.2009 · Cited by 66 · see citing works
Self-citationTojima, T., Kobayashi, S., & Ito, E. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10754 · Cited by 65 · see citing works
Automated Sholl Analysis of Digitized Neuronal Morphology at Multiple Scales
Kutzing, M. K., Langhammer, C. G., Luo, V. M., et al. (2010) · Journal of Visualized Experiments · doi:10.3791/2354 · Cited by 62 · see citing works
BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth
Spencer, T. K., Mellado, W., & Filbin, M. T. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.02.005 · Cited by 58 · see citing works
Multiple functions for the cadherin/catenin complex during neuronal development
Yu, X., & Malenka, R. C. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.031 · Cited by 57 · see citing works
Control of dendritic diversity
Landgraf, M., & Evers, J. F. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.005 · Cited by 23 · see citing works
Audesirk, T., Cabell, L., Kern, M., & Audesirk, G. J. (2003) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(03)00032-7 · Cited by 21 · see citing works
Kuwahara, H., Araki, N., Makino, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32204 · Cited by 21 · see citing works
Fernández, J. R., Welsh, W. J., & Firestein, B. L. (2007) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.21683 · Cited by 21 · see citing works
Self-citationChao, W., Liu, H., Hanahan, D. J., et al. (1992) · Biochemical Journal · doi:10.1042/bj2880777 · Cited by 18 · see citing works
Maturation of dendritic architecture: Lessons from insect identified neurons
Libersat, F. (2005) · Journal of Neurobiology · doi:10.1002/neu.20142 · Cited by 10 · see citing works
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- Authors
- Kwon, M., Fernandez, J. R., Zegarek, G. F., Lo, S. B., & Firestein, B. L.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Firestein, B. L.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-06-29
- Volume
- 31
- Issue
- 26
- Pages
- 9735-9745
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3139247
- OpenAlex
- W2123387448
- Cited by
- 115
- References
- 87
- Citations by year
- 2025: 8 · 2024: 8 · 2023: 15 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 12 · 2015: 8 · 2014: 3 · 2013: 11 · 2012: 9
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0548543, 0333196, 0919747)
- March of Dimes Foundation (1-FY04-107, 1-FY08-464)
- American Heart Association
- National Institute of General Medical Sciences (R25GM055145)
- Division of Graduate Education
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain-derived neurotrophic factor, CREB, dendritic branching, dendritogenesis, hippocampal neurons, transcriptional regulation, cAMP response element, mitogen-activated protein kinase, guanine deaminase, neuronal morphology, neurodegenerative diseases
- MeSH terms
- Animals, Carrier Proteins, Cells, Cultured, Dendrites, Gene Expression Regulation, Guanine Deaminase, Hippocampus, Immunohistochemistry, Neurons, RNA, Messenger, Transcription, Genetic, Blotting, Western, Signal Transduction, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Reverse Transcriptase Polymerase Chain Reaction, Chromatin Immunoprecipitation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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