Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing
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miRNAs direct translational repression by partial binding to the 3' UTR of mRNAs after incorporation into an RNA-induced silencing complex containing Argonaute-2 (Ago2).
“miRNAs direct translational repression by partial binding to the 3Ј UTR of mRNAs after first being incorporated into an RNA-induced silencing complex containing Argonaute-2 (Ago2) (Gregory et al., 2005;Chekulaeva and Filipowicz, 2009;Ha and Kim, 2014).”
From MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models (2017) · cites this paper as Gregory et al., 2005
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- [1]1. Bartel, D.P. MicroRNAs: genomics, biogenesis, mechanism, and function Cell. 2004; 116:281-297 Full Text Full Text (PDF) Scopus (31424) PubMed Google Scholar
- [2]2. Bernstein, E. ∙ Caudy, A.A. ∙ Hammond, S.M. ... Role for a bidentate ribonuclease in the initiation step of RNA interference Nature. 2001; 409:363-366 Crossref Scopus (3958) PubMed Google Scholar
- [3]3. Caudy, A.A. ∙ Myers, M. ∙ Hannon, G.J. ... Fragile X-related protein and VIG associate with the RNA interference machinery Genes Dev. 2001; 16:2491-2496 Crossref Scopus (542) Google Scholar
- [4]4. Chendrimada, T.P. ∙ Gregory, R.I. ∙ Kumaraswamy, E. ... TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing Nature. 2005; 436:740-744 Published online June 22, 2005 Crossref Scopus (1687) PubMed Google Scholar
- [5]5. Denli, A.M. ∙ Tops, B.B. ∙ Plasterk, R.H. ... Processing of primary microRNAs by the Microprocessor complex Nature. 2004; 432:231-235 Crossref Scopus (2201) PubMed Google Scholar
- [6]6. Doi, N. ∙ Zenno, S. ∙ Ueda, R. ... Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors Curr. Biol. 2003; 13:41-46 Full Text Full Text (PDF) Scopus (195) PubMed Google Scholar
- [7]7. Elbashir, S.M. ∙ Harborth, J. ∙ Lendeckel, W. ... Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature. 2001; 411:494-498 Crossref Scopus (8359) PubMed Google Scholar
- [8]8. Filipowicz, W. RNAi: the nuts and bolts of the RISC machine Cell. 2005; 122:17-20 Full Text Full Text (PDF) Scopus (431) PubMed Google Scholar
- [9]9. Fire, A. ∙ Xu, S. ∙ Montgomery, M.K. ... Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature. 1998; 391:806-811 Crossref Scopus (12480) PubMed Google Scholar
- [10]10. Forstemann, K. ∙ Tomari, Y. ∙ Du, T. ... Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein PLoS Biol. 2005; 3:e236 Crossref Scopus (436) PubMed Google Scholar
- [11]11. Gregory, R.I. ∙ Yan, K.P. ∙ Amuthan, G. ... The Microprocessor complex mediates the genesis of microRNAs Nature. 2004; 432:235-240 Crossref Scopus (2220) PubMed Google Scholar
- [12]12. Grishok, A. ∙ Tabara, H. ∙ Mello, C.C. Genetic requirements for inheritance of RNAi in C. elegans Science. 2000; 287:2494-2497 Crossref Scopus (376) PubMed Google Scholar
- [13]13. Grishok, A. ∙ Pasquinelli, A.E. ∙ Conte, D. ... Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing Cell. 2001; 106:23-34 Full Text Full Text (PDF) Scopus (1578) PubMed Google Scholar
- [14]14. Haley, B. ∙ Zamore, P.D. Kinetic analysis of the RNAi enzyme complex Nat. Struct. Mol. Biol. 2004; 11:599-606 Crossref Scopus (436) PubMed Google Scholar
- [15]15. Hammond, S.M. ∙ Bernstein, E. ∙ Beach, D. ... An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells Nature. 2000; 404:293-296 Crossref Scopus (2491) PubMed Google Scholar
- [16]16. Hammond, S.M. ∙ Boettcher, S. ∙ Caudy, A.A. ... Argonaute2, a link between genetic and biochemical analyses of RNAi Science. 2001; 293:1146-1150 Crossref Scopus (1234) PubMed Google Scholar
- [17]17. Han, J. ∙ Lee, Y. ∙ Yeom, K.H. ... The Drosha-DGCR8 complex in primary microRNA processing Genes Dev. 2004; 18:3016-3027 Crossref Scopus (1715) PubMed Google Scholar
- [18]18. Hutvagner, G. ∙ Zamore, P.D. A microRNA in a multiple-turnover RNAi enzyme complex Science. 2002; 297:2056-2060 Crossref Scopus (1700) PubMed Google Scholar
- [19]19. Hutvagner, G. ∙ McLachlan, J. ∙ Pasquinelli, A.E. ... A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA Science. 2001; 293:834-838 Crossref Scopus (2258) PubMed Google Scholar
- [20]20. Jiang, F. ∙ Ye, X. ∙ Liu, X. ... Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila Genes Dev. 2005; 19:1674-1679 Crossref Scopus (250) PubMed Google Scholar
- [21]21. Ketting, R.F. ∙ Fischer, S.E. ∙ Bernstein, E. ... Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans Genes Dev. 2001; 15:2654-2659 Crossref Scopus (1505) PubMed Google Scholar
- [22]22. Khvorova, A. ∙ Reynolds, A. ∙ Jayasena, S.D. Functional siRNAs and miRNAs exhibit strand bias Cell. 2003; 115:209-216 Full Text Full Text (PDF) Scopus (2095) PubMed Google Scholar
- [23]23. Kim, D.H. ∙ Behlke, M.A. ∙ Rose, S.D. ... Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy Nat. Biotechnol. 2005; 23:222-226 Crossref Scopus (768) PubMed Google Scholar
- [24]24. Kim, V.N. MicroRNA biogenesis: coordinated cropping and dicing Nat. Rev. Mol. Cell Biol. 2005; 6:376-385 Crossref Scopus (2094) PubMed Google Scholar
- [25]25. Lee, Y.S. ∙ Nakahara, K. ∙ Pham, J.W. ... Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways Cell. 2004; 117:69-81 Full Text Full Text (PDF) Scopus (1062) PubMed Google Scholar
- [26]26. Lim, L.P. ∙ Lau, N.C. ∙ Garrett-Engele, P. ... Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs Nature. 2005; 433:769-773 Crossref Scopus (4149) PubMed Google Scholar
- [27]27. Lingel, A. ∙ Simon, B. ∙ Izaurralde, E. ... Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain Nature. 2003; 426:465-469 Crossref Scopus (360) PubMed Google Scholar
- [28]28. Liu, J. ∙ Carmell, M.A. ∙ Rivas, F.V. ... Argonaute2 is the catalytic engine of mammalian RNAi Science. 2004; 305:1437-1441 Crossref Scopus (2171) PubMed Google Scholar
- [29]29. Liu, Q. ∙ Rand, T.A. ∙ Kalidas, S. ... R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway Science. 2003; 301:1921-1925 Crossref Scopus (573) PubMed Google Scholar
- [30]30. Ma, J.B. ∙ Ye, K. ∙ Patel, D.J. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain Nature. 2004; 429:318-322 Crossref Scopus (572) PubMed Google Scholar
- [31]31. Ma, J.B. ∙ Yuan, Y.R. ∙ Meister, G. ... Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein Nature. 2005; 434:666-670 Crossref Scopus (519) PubMed Google Scholar
- [32]32. Martinez, J. ∙ Patkaniowska, A. ∙ Urlaub, H. ... Single-stranded antisense siRNAs guide target RNA cleavage in RNAi Cell. 2002; 110:563-574 Full Text Full Text (PDF) Scopus (1233) PubMed Google Scholar
- [33]33. Meister, G. ∙ Landthaler, M. ∙ Patkaniowska, A. ... Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs Mol. Cell. 2004; 15:185-197 Full Text Full Text (PDF) Scopus (1555) PubMed Google Scholar
- [34]34. Mourelatos, Z. ∙ Dostie, J. ∙ Paushkin, S. ... miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs Genes Dev. 2000; 16:720-728 Crossref Scopus (897) Google Scholar
- [35]35. Novina, C.D. ∙ Sharp, P.A. The RNAi revolution Nature. 2004; 430:161-164 Crossref Scopus (654) PubMed Google Scholar
- [36]36. Nykanen, A. ∙ Haley, B. ∙ Zamore, P.D. ATP requirements and small interfering RNA structure in the RNA interference pathway Cell. 2001; 107:309-321 Full Text Full Text (PDF) Scopus (853) PubMed Google Scholar
- [37]37. Okamura, K. ∙ Ishizuka, A. ∙ Siomi, H. ... Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways Genes Dev. 2004; 18:1655-1666 Crossref Scopus (675) PubMed Google Scholar
- [38]38. Pham, J.W. ∙ Pellino, J.L. ∙ Lee, Y.S. ... A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila Cell. 2004; 117:83-94 Full Text Full Text (PDF) Scopus (351) PubMed Google Scholar
- [39]39. Provost, P. ∙ Dishart, D. ∙ Doucet, J. ... Ribonuclease activity and RNA binding of recombinant human Dicer EMBO J. 2002; 21:5864-5874 Crossref Scopus (379) PubMed Google Scholar
- [40]40. Rivas, F.V. ∙ Tolia, N.H. ∙ Song, J.J. ... Purified Argonaute2 and an siRNA form recombinant human RISC Nat. Struct. Mol. Biol. 2005; 12:340-349 Crossref Scopus (599) PubMed Google Scholar
- [41]41. Saito, K. ∙ Ishizuka, A. ∙ Siomi, H. ... Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells PLoS Biol. 2005; 3:e235 Crossref Scopus (342) PubMed Google Scholar
- [42]42. Schwarz, D.S. ∙ Hutvagner, G. ∙ Du, T. ... Asymmetry in the assembly of the RNAi enzyme complex Cell. 2003; 115:199-208 Full Text Full Text (PDF) Scopus (2278) PubMed Google Scholar
- [43]43. Siolas, D. ∙ Lerner, C. ∙ Burchard, J. ... Synthetic shRNAs as potent RNAi triggers Nat. Biotechnol. 2005; 23:227-231 Crossref Scopus (380) PubMed Google Scholar
- [44]44. Song, J.J. ∙ Liu, J. ∙ Tolia, N.H. ... The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes Nat. Struct. Biol. 2003; 10:1026-1032 Crossref Scopus (459) PubMed Google Scholar
- [45]45. Song, J.J. ∙ Smith, S.K. ∙ Hannon, G.J. ... Crystal structure of Argonaute and its implications for RISC slicer activity Science. 2004; 305:1434-1437 Crossref Scopus (1163) PubMed Google Scholar
- [46]46. Sontheimer, E.J. Assembly and function of RNA silencing complexes Nat. Rev. Mol. Cell Biol. 2005; 6:127-138 Crossref Scopus (357) PubMed Google Scholar
- [47]47. Tabara, H. ∙ Yigit, E. ∙ Siomi, H. ... The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans Cell. 2002; 109:861-871 Full Text Full Text (PDF) Scopus (391) PubMed Google Scholar
- [48]48. Tahbaz, N. ∙ Kolb, F.A. ∙ Zhang, H. ... Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer EMBO Rep. 2004; 5:189-194 Crossref Scopus (179) PubMed Google Scholar
- [49]49. Tomari, Y. ∙ Matranga, C. ∙ Haley, B. ... A protein sensor for siRNA asymmetry Science. 2004; 306:1377-1380 Crossref Scopus (485) PubMed Google Scholar
- [50]50. Yan, K.S. ∙ Yan, S. ∙ Farooq, A. ... Structure and conserved RNA binding of the PAZ domain Nature. 2004; 426:468-474 Crossref Scopus (368) Google Scholar
- [51]51. Zhang, H. ∙ Kolb, F.A. ∙ Brondani, V. ... Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP EMBO J. 2002; 21:5875-5885 Crossref Scopus (496) PubMed Google Scholar
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“Usually, only one arm of the miRNA duplex is functional while the other arm is degraded [93, 94].”
Background
- Authors
- Gregory, R. I., Chendrimada, T. P., Cooch, N., & Shiekhattar, R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 123
- Issue
- 4
- Pages
- 631-640
- ISSN
- 0092-8674
- Cited by
- 1,268
- References
- 0
- Language
- en
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