Target-dependent biogenesis of cognate microRNAs in human cells
Open accessAbstract
Extensive research has established how miRNAs regulate target mRNAs by translation repression and/or endonucleolytic degradation in metazoans. However, information related to the effect of target mRNA on biogenesis and stability of corresponding miRNAs in animals is limited. Here we report regulated biogenesis of cognate miRNAs by their target mRNAs. Enhanced pre-miRNA processing by AGO-associated DICER1 contributes to this increased miRNP formation. The processed miRNAs are loaded onto AGO2 to form functionally competent miRISCs both in vivo and also in a cell-free in vitro system. Thus, we identify an additional layer of posttranscriptional regulation that helps the cell to maintain requisite levels of mature forms of respective miRNAs by modulating their processing in a target-dependent manner, a process happening for miR-122 during stress reversal in human hepatic cells.
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Low miRNA levels can be compensated for when target mRNA levels are high by stimulating increased loading of cognate miRNA into AGO, thereby improving RNAi activity.
“Inversely, low miRNA levels can be compensated for, when target mRNA levels are high, by stimulating increased loading of cognate miRNA into AGO, thereby improving RNAi activity (103).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [103]
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- Authors
- Bose, M., & Bhattacharyya, S. N.
- Affiliations
- Indian Institute of Chemical Biology (IN)
- Corresponding author
- Bhattacharyya, Suvendra N.
- Venue
- Nature Communications
- Published
- 2016-07-22
- Volume
- 7
- Issue
- 1
- Pages
- 12200-12200
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4961841
- OpenAlex
- W2492541041
- Cited by
- 38
- References
- 54
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 1 · 2018: 5 · 2017: 3
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Independent Social Research Foundation
- Wellcome Trust (084324/Z/07/A, 084324)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- microRNA biogenesis, miRNA target mRNAs, pre-miRNA processing, DICER1, Argonaute 2, miRNA-induced silencing complex, post-transcriptional regulation, miR-122, stress reversal, miRNA stability
- MeSH terms
- Amino Acids, Cell Line, Cells, Humans, Models, Biological, RNA, Messenger, Stress, Physiological, MicroRNAs, Ribonuclease III, Argonaute Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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