Cited by 1,796DNA Repair MechanismsGenomics and Chromatin DynamicsUbiquitin and proteasome pathways

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PCNA, the Maestro of the Replication Fork

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Moldovan, George-Lucian, Pfander, Boris, Jentsch, Stefan·2007·Cell

DOI 10.1016/j.cell.2007.05.003

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Abstract

Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.

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Authors: Moldovan, G.-L., Pfander, B., & Jentsch, S.
Affiliations: Harvard University (US)
Cancer Research UK (GB)
Max Planck Institute of Biochemistry (DE)
Corresponding author: Jentsch, Stefan
ORCID: Moldovan, George-Lucian
Pfander, Boris
Jentsch, Stefan
Venue: Cell
Publisher: Elsevier BV
Published: 2007-05
Volume: 129
Issue: 4
Pages: 665-679
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2007.05.003
OpenAlex: W2072747624
Cited by: 1,796
References: 110
Citations by year: 2026: 53 · 2025: 70 · 2024: 77 · 2023: 84 · 2022: 80 · 2021: 86 · 2020: 87 · 2019: 97 · 2018: 87 · 2017: 111 · 2016: 113 · 2015: 92 · 2014: 113 · 2013: 106 · 2012: 125
FWCI: 8.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2269 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: proliferating cell nuclear antigen, PCNA, DNA replication, replication fork, genome stability, epigenetic inheritance, whole-genome duplication, protein-protein interaction, phosphorylation, ubiquitination, SUMOylation, proteolysis, chromatin inheritance
MeSH terms: Animals, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, DNA-Binding Proteins, Humans, S Phase, Cell Cycle Proteins, Proliferating Cell Nuclear Antigen, Genomic Instability, Epigenesis, Genetic

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PCNA, the Maestro of the Replication Fork

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