IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis
Varfolomeev, Eugene, Blankenship, John W., Wayson, Sarah M., Fedorova, Anna V., Kayagaki, Nobuhiko, Garg, Parie, Zobel, Kerry, Dynek, Jasmin N. +7 more·2007·Cell
Cited by (1,000)
Items 101–200 of 1,000
- NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward SignalingBiton, Sharon, Ashkenazi, Avi · 2011 · Cell
- IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesisMads Gyrd‐Hansen, Maurice Darding, Maria Miasari, Massimo Mattia Santoro, Lars Zender, Wen Xue, Tencho Tenev, Paula C. A. da Fonseca, Marketa Zvelebil, Janusz Marek Bujnicki et al. · 2008 · Nature Cell Biology
- Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)Flygare, John A., Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T., Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail et al. · 2012 · Journal of Medicinal Chemistry
- Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint BlockadeGu, Shengqing Stan, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia et al. · 2021 · Cancer Discovery
- TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF ReceptorSandra Gardam, Frédéric Sierro, Antony Basten, Fabienne Mackay, Robert Adrian Brink · 2008 · Immunity
- RIP kinases as modulators of inflammation and immunitySudan He, Xiaodong Wang · 2018 · Nature Immunology
- Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell deathKenta Moriwaki, John Bertin, Peter J. Gough, Gregory M. Orlowski, F KM Chan · 2015 · Cell Death and Disease
- Apoptosis in cancer: Key molecular signaling pathways and therapy targetsClaudia Cristina Burz, Ioana Berindan‐Neagoe, Ovidiu Bălăcescu, Alexandru Irimie · 2009 · Acta Oncologica
- X-Linked Inhibitor of Apoptosis Protein – A Critical Death Resistance Regulator and Therapeutic Target for Personalized Cancer TherapyPetra Obexer, Michael J. Ausserlechner · 2014 · Frontiers in Oncology
- Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitmentPeter Geserick, Mike Hupe, Maryline Moulin, Wendy Wei-Lynn Wong, Maria Feoktistova, Beate Kellert, Harald P. M. Gollnick, John Silke, Martin Leverkus · 2009 · The Journal of Cell Biology
- A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting MechanismPribluda, Ariel, Elyada, Ela, Wiener, Zoltan, Hamza, Haya, Goldstein, Robert E., Biton, Moshe, Burstain, Ido, Morgenstern, Yael, Brachya, Guy, Billauer, Hana et al. · 2013 · Cancer Cell
- TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced ApoptosisJames Edward Vince, Delara Pantaki-Eimany, Rebecca Feltham, Peter D. Mace, Stephanie M. Cordier, Anna C. Schmukle, Angelina J. Davidson, Bernard Andrew Callus, Wendy Wei-Lynn Wong, Ian Edward Gentle et al. · 2009 · Journal of Biological Chemistry
- In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)Ohoka, Nobumichi, Okuhira, Keiichiro, Ito, Masahiro, Nagai, Katsunori, Shibata, Norihito, Hattori, Takayuki, Ujikawa, Osamu, Shimokawa, Kenichiro, Sano, Osamu, Koyama, Ryokichi et al. · 2017 · Journal of Biological Chemistry
- TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFαJames Edward Vince, Diep Chau, Bernard Andrew Callus, Wendy Wei-Lynn Wong, Christine J. Hawkins, Pascal Schneider, Mark A. McKinlay, Christopher A. Benetatos, Stephen M. Condon, Srinivas K. Chunduru et al. · 2008 · The Journal of Cell Biology
- The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β ActivationJames Edward Vince, Dominic De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine M. Hall, Kate McArthur, Daniel S. Simpson, Swarna Lekha Vijayaraj, Lisa Lindqvist, Philippe Bouillet et al. · 2018 · Cell Reports
- Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cellsChristy C. Ong, Adrian M. Jubb, Peter M. Haverty, Wei Zhou, Victoria Tran, Tom Truong, Helen Turley, Tom O'Brien, Domagoj Vucic, Adrian Llewellyn Harris et al. · 2011 · Proceedings of the National Academy of Sciences
- Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell deathB Schenk, Simone Fulda · 2015 · Oncogene
- Living with death: the evolution of the mitochondrial pathway of apoptosis in animalsAndrew Oberst, Christian Bender, Douglas R. Green · 2008 · Cell Death and Differentiation
- Antagonists Induce a Conformational Change in cIAP1 That Promotes AutoubiquitinationErin C. Dueber, Allyn J. Schoeffler, Andreas Lingel, J. Michael Elliott, Anna V. Fedorova, Anthony M. Giannetti, Kerry Zobel, Brigitte Maurer, Eugene E. Varfolomeev, Ping Wu et al. · 2011 · Science
- Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited MechanismsAli Ertürk, Yuanyuan Wang, Morgan Sheng · 2014 · Journal of Neuroscience
- E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment PointsAleša Bricelj, Christian Steinebach, Robert D. Kuchta, Michael Gütschow, Izidor Sosič · 2021 · Frontiers in Chemistry
- Targeting the apoptosis pathway in hematologic malignanciesShadia Zaman, Rui Chen Wang, Varsha V. Gandhi · 2013 · Leukemia & lymphoma/Leukemia and lymphoma
- Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic CellsSean P. Cullen, Conor M. Henry, Conor J. Kearney, Susan E. Logue, Maria Feoktistova, Graham A. Tynan, Ed C. Lavelle, Martin Leverkus, Séamus J. Martin · 2013 · Molecular Cell
- Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expressionKezhou Zhu, Wei Ping Liang, Zaijun Ma, Daichao Xu, Shuangyi Cao, Xiaojuan Lu, Nan Liu, Bing Shan, Lihui Qian, Junying Yuan · 2018 · Cell Death and Disease
- Signaling Mechanisms in Mammalian Myoblast FusionSajedah M. Hindi, Marjan M. Tajrishi, Ashok Kumar · 2013 · Science Signaling
- Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor EngagementLaurence Calzone, Laurent Tournier, Simon Fourquet, Denis Thieffry, Boris Zhivotovsky, Emmanuel Barillot, Andrei Y. Zinovyev · 2010 · PLoS Computational Biology
- Small-molecule SMAC mimetics as new cancer therapeuticsLongchuan Bai, David Carl Smith, Shaomeng Wang · 2014 · Pharmacology & Therapeutics
- A novel role for RIP1 kinase in mediating TNFα productionDana E. Christofferson, Ying Li, Junichi Hitomi, Wenchang Zhou, C. Upperman, Hong Zhu, Scott A. Gerber, Steven P. Gygi, Jing Yuan · 2012 · Cell Death and Disease
- RINGs hold the key to ubiquitin transferRhesa Budhidarmo, Yoshio Nakatani, Catherine L. Day · 2011 · Trends in Biochemical Sciences
- Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and RegulationChao Zheng, Venkataraman Kabaleeswaran, Yaya Wang, Genhong Cheng, Hao Wu · 2010 · Molecular Cell
- The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunityMikyoung Chang, Wei Jin, Jae‐Hoon Chang, Yichuan Xiao, George C. Brittain, Jiayi Yu, Xiaofei Zhou, Yi-Hong Wang, Xuhong Cheng, Pingwei Li et al. · 2011 · Nature Immunology
- SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAPJianfeng Lü, Longchuan Bai, Haiying Sun, Zaneta Nikolovska‐Coleska, Donna McEachern, Su Qiu, Rebecca S. Miller, Yi Han, Sanjeev Kumar Shangary, Yi Sun et al. · 2008 · Cancer Research
- Measuring apoptosis by microscopy and flow cytometryConor M. Henry, Émilie Hollville, Séamus J. Martin · 2013 · Methods
- A Caspase Cascade Regulating Developmental Axon DegenerationDavid J. Simon, Robby M. Weimer, Todd McLaughlin, Dara Y. Kallop, Karen Stanger, Jing Hui Yang, Dennis D.M. O’Leary, Rami N. Hannoush, Marc Tessier‐Lavigne · 2012 · Journal of Neuroscience
- Roles of NF-κB in health and disease: mechanisms and therapeutic potentialEe Tsin Wong, Vinay Tergaonkar · 2009 · Clinical Science
- IAPs limit activation of RIP kinases by TNF receptor 1 during developmentMoulin, Maryline, Anderton, Holly, Voss, Anne K, Thomas, Tim, Wong, Wendy Wei‐Lynn, Bankovacki, Aleksandra, Feltham, Rebecca, Chau, Diep, Cook, Wendy D, Silke, John et al. · 2012 · The EMBO Journal
- The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactionsArkin, Michelle R, Whitty, Adrian · 2009 · Current Opinion in Chemical Biology
- Regulation of apoptosis by XIAP ubiquitin-ligase activityAndrew J. Schile, María García-Fernández, Hermann Steller · 2008 · Genes & Development
- Cellular Inhibitors of Apoptosis Are Global Regulators of NF-κB and MAPK Activation by Members of the TNF Family of ReceptorsEugene E. Varfolomeev, Tatiana Goncharov, Heather L. Maecker, Kerry Zobel, László G. Kömüves, Kurt Deshayes, Domagoj Vucic · 2012 · Science Signaling
- Promises and Challenges of Smac Mimetics as Cancer TherapeuticsSimone Fulda · 2015 · Clinical Cancer Research
- Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila InfectionAnwari Akhter, Mikhail A. Gavrilin, Laura J. Frantz, Songcerae Washington, Cameron Ditty, Dominique H. Limoli, Colby Day, Anasuya Sarkar, Christie A. Newland, Jonathan P. Butchar et al. · 2009 · PLoS Pathogens
- Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond NecroptosisKelby W. Wegner, Danish Saleh, Alexei Degterev · 2017 · Trends in Pharmacological Sciences
- The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy.M. Cristina de Almagro, Domagoj Vucic · 2012 · PubMed
- The roles of E3 ubiquitin ligases in cancer progression and targeted therapyChibuzo Sampson, Qiuping Wang, Wuxiyar Otkur, Haifeng Zhao, Yun Lu, Xiaolong Liu, Hai‐long Piao · 2023 · Clinical and Translational Medicine
- RIPK1 is not essential for TNFR1-induced activation of NF-κBWendy Wei-Lynn Wong, Ian Edward Gentle, Ueli Nachbur, Holly Anderton, David Lawrence Vaux, John Silke · 2009 · Cell Death and Differentiation
- Oxidative Modification of miR-184 Enables It to Target Bcl-xL and Bcl-wJianxun Wang, Jie Gao, Su-Ling Ding, Kun Wang, Jian-Qin Jiao, Yin Wang, Teng Sun, Lu‐Yu Zhou, Bo Long, Xiao-Jie Zhang et al. · 2015 · Molecular Cell
- Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradationXiao, Yichuan, Jin, Jin, Chang, Mikyoung, Chang, Jae-Hoon, Hu, Hongbo, Zhou, Xiaofei, Brittain, George C, Stansberg, Christine, Torkildsen, Øivind, Wang, Xiaodong et al. · 2013 · Nature Medicine
- The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemiaG. Brumatti, Chun-Yan Ma, N. Lalaoui, Nhu-Y. N. Nguyen, M. Navarro, M. Tanzer, J. Richmond, M. Ghisi, J. Salmon, N. Silke et al. · 2016 · Science Translational Medicine
- Necroptosis: an alternative cell death program defending against cancerDongshi Chen, Jian Yu, Lin Zhang · 2016 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Diverse ubiquitin signaling in NF-κB activationKazuhiro Iwaï · 2012 · Trends in Cell Biology
- zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathwayYu‐Tzu Wu, H-L Tan, Qing Huang, Sun Xj, X Zhu, H-M Shen · 2010 · Cell Death and Differentiation
- TNFR signaling: ubiquitin‐conjugated TRAFfic signals control stop‐and‐go for MAPK signaling complexesMichael Karin, Ewen D. Gallagher · 2009 · Immunological Reviews
- Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-κB Activation, and Is Active in Patient-Derived Xenograft ModelsChristopher A. Benetatos, Yasuhiro Mitsuuchi, Jennifer M. Burns, Eric M. Neiman, Stephen M. Condon, Guangyao Yu, Martin E. Seipel, Gurpreet Singh Kapoor, Matthew G. LaPorte, Susan R. Rippin et al. · 2014 · Molecular Cancer Therapeutics
- Survey of the year 2007 commercial optical biosensor literatureRebecca L. Rich, David G. Myszka · 2008 · Journal of Molecular Recognition
- The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their ProcessingYoung Eun Choi, Michael Butterworth, Srinivas Malladi, Colin S. Duckett, Gerald M. Cohen, Shawn B. Bratton · 2009 · Journal of Biological Chemistry
- Targeting Apoptosis Pathways for New Cancer TherapeuticsLongchuan Bai, Shaomeng Wang · 2013 · Annual Review of Medicine
- Non‐canonical NF‐κB signaling activation and regulation: principles and perspectivesBahram Razani, Anna Devi Reichardt, Genhong Cheng · 2011 · Immunological Reviews
- Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell deathLukas Probst, Jasmin Dächert, Barbara Schenk, Simone Fulda · 2017 · Biochemical Pharmacology
- E3 ligase ligand chemistries: from building blocks to protein degradersIzidor Sosič, Aleša Bricelj, Christian Steinebach · 2022 · Chemical Society Reviews
- Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs)Jean Berthelet, Laurence Dubrez · 2013 · Cells
- Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) RecruitmentPeter D. Mace, Katrin Linke, Rebecca Feltham, Frances‐Rose Schumacher, Clyde A. Smith, David Lawrence Vaux, John Silke, Catherine L. Day · 2008 · Journal of Biological Chemistry
- IAP antagonists induce anti-tumor immunity in multiple myelomaMarta Chesi, Noweeda N. Mirza, Victoria Marie Garbitt, Meaghen E. Sharik, Amylou Constance Dueck, Yan W. Asmann, Ilseyar Akhmetzyanova, Heidi Kosiorek, Arianna Calcinotto, Daniel L. Riggs et al. · 2016 · Nature Medicine
- The Diversification of Cell Death and Immunity: Memento MoriArnaud J. Legrand, Maria Konstantinou, E. Goode, Pascal Meier · 2019 · Molecular Cell
- Design of Small-Molecule Peptidic and Nonpeptidic Smac MimeticsHaiying Sun, Zaneta Nikolovska‐Coleska, Chao‐Yie Yang, Dongguang Qian, Jianfeng Lü, Su Qiu, Longchuan Bai, Yuefeng Peng, Qian Cai, Shaomeng Wang · 2008 · Accounts of Chemical Research
- RIPK-Dependent Necrosis and Its Regulation by Caspases: A Mystery in Five ActsDouglas R. Green, Andrew Oberst, Christopher P. Dillon, Ricardo Weinlich, Guy S. Salvesen · 2011 · Molecular Cell
- Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?Wade, Mark, Wahl, Geoffrey M. · 2009 · Molecular Cancer Research
- Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the InflammasomeKatherine Labbè, Christian R. McIntire, Karine Doiron, Philippe M. LeBlanc, Maya Saleh · 2011 · Immunity
- Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistanceNir Shahar, Sarit Larisch · 2020 · Drug Resistance Updates
- Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain DimerizationRebecca Feltham, Bodhi Bettjeman, Rhesa Budhidarmo, Peter D. Mace, Sarah Shirley, Stephen M. Condon, Srinivas K. Chunduru, Mark A. McKinlay, David Lawrence Vaux, John Silke et al. · 2011 · Journal of Biological Chemistry
- Absence of RIPK3 predicts necroptosis resistance in malignant melanomaPeter Geserick, J Wang, Ramon Schilling, Sebastian Horn, Philip A. Harris, John Bertin, Peter J. Gough, Maria Feoktistova, M. Leverkus · 2015 · Cell Death and Disease
- Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosisKathrin Weber, Ria Roelandt, Inge Bruggeman, Yann Estornes, Peter Vandenabeele · 2018 · Communications Biology
- SNIPERs—Hijacking IAP activity to induce protein degradationMikihiko Naito, Nobumichi Ohoka, Norihito Shibata · 2019 · Drug Discovery Today Technologies
- Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?Verena Labi, Francesca Grespi, Florian Baumgartner, Andreas Villunger · 2008 · Cell Death and Differentiation
- Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cellsLei Miao, Jingjing Qi, Qi Zhao, Qi-Nian Wu, Da‐Liang Wei, Xiaoli Wei, Jia Liu, Jun Chen, Zhao-Lei Zeng, Huai‐Qiang Ju et al. · 2019 · Theranostics
- dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8Yann Estornes, Florent Toscano, François Virard, Guillaume Jacquemin, Audrey Pierrot, Béatrice Vanbervliet, Marc Bonnin, Najoua Lalaoui, Perrine Mercier‐Gouy, Y. Pachéco et al. · 2012 · Cell Death and Differentiation
- cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent mannerWendy Wei-Lynn Wong, James Edward Vince, Najoua Lalaoui, Kate E. Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine Ann O’Reilly, Philipp Jakob Jost et al. · 2014 · Blood
- Inhibitors of apoptosis: clinical implications in cancerMervat Sayed Mohamed, Mai K. Bishr, Fahad M. Almutairi, Ayat G. Ali · 2017 · APOPTOSIS
- Spatial proteomics identifies JAKi as treatment for a lethal skin diseaseThierry M. Nordmann, Holly Anderton, Akito Hasegawa, Lisa Schweizer, Peng Zhang, Pia‐Charlotte Stadler, Ankit Sinha, Andreas Metousis, Florian A. Rosenberger, Maximilian Zwiebel et al. · 2024 · Nature
- Cleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF-κB ActivationShaun Rosebeck, Lisa M. Madden, Xiaohong Jin, Shufang Gu, Ingrid J. Apel, Alex Appert, Rifat Hamoudi, Heidi Noels, Xavier Sagaert, Peter Van Loo et al. · 2011 · Science
- Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexMatthew L. Bentley, Jacob E. Corn, Ken C. Dong, Qui T. Phung, Tommy K. Cheung, Andrea G. Cochran · 2011 · The EMBO Journal
- Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death PathwaysAdeeb Derakhshan, Zhong Chen, Carter Van Waes · 2016 · Clinical Cancer Research
- The molecular regulation of programmed necrotic cell injuryDavid Moquin, Francis Ka-Ming Chan · 2010 · Trends in Biochemical Sciences
- Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic CarcinomaMeike Vogler, Henning Walczak, Dominic Stadel, Tobias L. Haas, Felicitas Genze, Marjana Jovanovic, Umesh Kumar Bhanot, Cornelia Hasel, Peter Möller, Jürgen E. Gschwend et al. · 2009 · Cancer Research
- TRAF‐Mediated TNFR‐Family SignalingHyunil Ha, Daehee Han, Yongwon Choi · 2009 · Current Protocols in Immunology
- Small‐Molecule Control of Intracellular Protein Levels through Modulation of the Ubiquitin Proteasome SystemDennis L. Buckley, Craig M. Crews · 2014 · Angewandte Chemie International Edition
- Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological MalignanciesStephen M. Condon, Yasuhiro Mitsuuchi, Yijun Deng, Matthew G. LaPorte, Susan R. Rippin, Thomas Haimowitz, Matthew D. Alexander, Pavan Tirunahari Kumar, Mukta S. Hendi, Yu-Hua Lee et al. · 2014 · Journal of Medicinal Chemistry
- Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs SurvivalAmelia J. Johnston, Kate T. Murphy, Laura Jenkinson, David Laine, Kerstin Emmrich, Pierre Faou, Ross Tim Weston, Krishnath M. Jayatilleke, Jessie Schloegel, Gert Hoy Talbo et al. · 2015 · Cell
- Programmed necrosis and necroptosis signallingMaria Feoktistova, Martin Leverkus · 2014 · FEBS Journal
- Analysis of clonogenic growth in vitroNikko Brix, Daniel Samaga, Claus Belka, Horst F. Zitzelsberger, Kirsten Lauber · 2021 · Nature Protocols
- Modulation of immune signalling by inhibitors of apoptosisShawn T. Beug, Herman H. Cheung, Eric Charles LaCasse, Robert G. Korneluk · 2012 · Trends in Immunology
- Necroptosis is preceded by nuclear translocation of the signaling proteins that induce itS Yoon, K Bogdanov, Andrew Kovalenko, David Wallach · 2015 · Cell Death and Differentiation
- Wasting Mechanisms in Muscular DystrophyJonghyun Shin, M. M. Tajrishi, Y. Ogura, Ashok Kumar · 2013 · International Journal of Biochemistry and Cell Biology
- NF-κB Directly Regulates Fas Transcription to Modulate Fas-mediated Apoptosis and Tumor SuppressionFeiyan Liu, Kankana Bardhan, Dafeng Yang, Muthusamy Thangaraju, Vadivel Ganapathy, Jennifer L. Waller, Georgia B. Liles, Jeffrey R. Lee, Kebin Liu · 2012 · Journal of Biological Chemistry
- Disease‐causing mutations in the XIAP BIR2 domain impair NOD2‐dependent immune signallingRune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker‐Jensen, Philipp Jakob Jost, Stephan R. Ehl, Niels Mailand, Mads Gyrd‐Hansen · 2013 · EMBO Molecular Medicine
- Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein LigandsNorihito Shibata, Katsunori Nagai, Yoko Morita, Osamu Ujikawa, Nobumichi Ohoka, Takayuki Hattori, Ryokichi Koyama, Osamu Sano, Yasuhiro Imaeda, Hiroshi Nara et al. · 2017 · Journal of Medicinal Chemistry
- IAP inhibitors enhance co-stimulation to promote tumor immunityMichael Lawrence Dougan, Stephanie K. Dougan, Joanna K. Slisz, Brant Firestone, Matthew W. Vanneman, Dobrin Draganov, Girija Goyal, Weibo Li, Donna S Neuberg, Richard S. Blumberg et al. · 2010 · The Journal of Experimental Medicine
- Improved Quantitative Mass Spectrometry Methods for Characterizing Complex Ubiquitin SignalsLilian Phu, Anita Izrael-Tomasevic, Marissa L. Matsumoto, Daisy J. Bustos, Jasmin N. Dynek, Anna V. Fedorova, Corey E. Bakalarski, David P. Arnott, Kurt Deshayes, Vishva M. Dixit et al. · 2010 · Molecular & Cellular Proteomics
- Future Therapeutic Directions for Smac-MimeticsEmma Morrish, Gabriela Brumatti, John Silke · 2020 · Cells
- The zebrafish as a model organism for the study of apoptosisPeter M. Eimon, Avi Ashkenazi · 2009 · APOPTOSIS
- Degradation of Activated Protein Kinases by UbiquitinationLU Zhi-min, Hunter Tony · 2009 · Annual Review of Biochemistry