IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Cited by (1,000)

Items 901–1,000 of 1,000

  1. Les IAP au cœur de la signalisation NF-κB
    Jessy Cartier, Arthur Marivin, Jean Berthelet, Laurence Dubrez · 2012 · médecine/sciences
  2. Selective IAP inhibition results in sensitization of unstimulated but not CD 40‐stimulated chronic lymphocytic leukaemia cells to TRAIL ‐induced apoptosis
    Jianguo Zhuang, Naomi M. Laing, Melanie Oates, Ke Lin, Gillian G. Johnson, Andrew R. Pettitt · 2014 · Pharmacology Research & Perspectives
  3. Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)
    Cinzia Scavullo, Federica Servida, Daniele Lecis, Francesco Onida, Carmelo Drago, Luca Ferrante, Pierfausto Seneci, Wilma Barcellini, Marta Lionetti, Katia Todoerti et al. · 2013 · Leukemia Research
  4. A TNF-NF-κB-STAT3 loop triggers resistance of glioma-stem-like cells to Smac mimetics while sensitizing to EZH2 inhibitors
    Bakhos A. Tannous, Christian E. Badr · 2019 · Cell Death and Disease
  5. Biomarker profile for prediction of response to SMAC mimetic monotherapy in pediatric precursor B‐cell acute lymphoblastic leukemia
    Julia Zinngrebe, Ferdinand Schlichtig, Johann Michael Kraus, Malcolm Meyer, Elena Boldrin, Hans Armin Kestler, Lüder Hinrich Meyer, Pamela Fischer‐Posovszky, Klaus‐Michael Debatin · 2019 · International Journal of Cancer
  6. Induction of interferon-β and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cells
    Victoria Granqvist, Christian Holmgren, Christer Larsson · 2021 · PLoS ONE
  7. BV6 enhances apoptosis in Lung cancer cells by ameliorating caspase expressions through attenuation of XIAP, cIAP-1, and cIAP-2 proteins
    Irfan S. Ahmad, Ayed A. Dera, Safia Irfan, Prasanna Rajagopalan, Mirza Masroor Ali Beg, Mohammad Yahya Alshahrani, Mushtaq Ahmad Mir, Mohammed Abohashrh, Mohammad Mahtab Alam, Shadma Wahab et al. · 2021 · Journal of Cancer Research and Therapeutics
  8. Ubiquitination in host immune response to human papillomavirus infection
    Qiang Zhou, Kejian Zhu, Hao Cheng · 2011 · Archives of Dermatological Research
  9. Smac mimetic sensitizes renal cell carcinoma cells to interferon-α-induced apoptosis
    Michael Reiter, Ines Eckhardt, Axel Haferkamp, Simone Fulda · 2016 · Cancer Letters
  10. Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models
    Emma Morrish, Anthony Copeland, Donia M. Moujalled, Jason A. Powell, Natasha Silke, Ann E.-J. Lin, Kate E. Jarman, Jarrod John Sandow, Gregor Ebert, Liana Mackiewicz et al. · 2020 · Blood Advances
  11. IAPs, TNF, inflammation and Jürg TSCHOPP; a personal perspective
    John Silke, James Edward Vince · 2011 · Cell Death and Differentiation
  12. Generation of transgenic mice expressing a FRET biosensor, SMART, that responds to necroptosis
    Shin Murai, Kanako Takakura, Kenta Sumiyama, Kenta Moriwaki, Kenta Terai, Sachiko Komazawa‐Sakon, Takao Seki, Yoshifumi Yamaguchi, Tetuo Mikami, Kimi Araki et al. · 2022 · Communications Biology
  13. Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization
    Teak‐Jung Oh, Vishnu Vardhan Krishnamurthy, Jeong Won Han, Junyao Zhu, Zayn Beg, Amna Mehfooz, Bryan Gworek, David J. Shapiro, Kai Zhang · 2024 · Journal of Molecular Biology
  14. Knockdown of Second Mitochondria-Derived Activator of Caspase Expression by RNAi Enhances Growth and Cisplatin Resistance of Human Lung Cancer Cells
    Hui Zeng, Sheng Zhang, Kunyu Yang, Tao Wang, Jianli Hu, Lili Huang, Gang Wu · 2010 · Cancer Biotherapy and Radiopharmaceuticals
  15. NF-κB activation fails to protect cells to TNFα-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w
    Elisenda Casanelles, Raffaella Gozzelino, Fernando Marqués-Fernàndez, Victoria Iglesias‐Guimarais, Mercè García-Belinchón, María Sánchez‐Osuna, Carme Solé, Rana S. Moubarak, Joan X. Comella, Vı́ctor J. Yuste · 2013 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  16. Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins
    Yuen Lam Dora Ng, Aleša Bricelj, Jacqueline A. Jansen, Arunima Murgai, Kirsten Peter, Katherine A. Donovan, Michael Gütschow, Jan Krönke, Christian Steinebach, Izidor Sosič · 2023 · Journal of Medicinal Chemistry
  17. HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization
    Jin Sun Choi, Byoung Chul Park, Seung Wook Chi, Kwang‐Hee Bae, Sunhong Kim, Sayeon Cho, Woo‐Chan Son, Pyung Keun Myung, Jeong‐Hoon Kim, Sung Goo Park · 2014 · Oncotarget
  18. Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists
    Moriteru Asano, Kentaro Hashimoto, Bunnai Saito, Zenyu Shiokawa, Hiroyuki Sumi, Masato Yabuki, Mie Yoshimatsu, Kazunobu Aoyama, Teruki Hamada, Nao Morishita et al. · 2013 · Bioorganic & Medicinal Chemistry
  19. ARTS-Based Anticancer Therapy: Taking Aim at Cancer Stem Cells
    Ronit Elhasid, Sarit Larisch · 2011 · Future Oncology
  20. The Role of Ubiquitination in TWEAK-Stimulated Signaling
    Domagoj Vucic · 2013 · Frontiers in Immunology
  21. Identification of new IDH2R140Q inhibitors by discriminatory analysis‐based molecular docking and biological evaluation
    Xiaoyun Chen, Xianmin Wu, Jian Gao, Huazhou Ying, Xiaowu Dong, Jinxin Che, Zhijian Shen · 2020 · Archiv der Pharmazie
  22. Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B‐cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis
    Anna Dietz, Nahide Dalda, Svenja Zielke, Jessica Dittmann, Sjoerd J. L. van Wijk, Meike Vogler, Simone Fulda · 2020 · International Journal of Cancer
  23. Steuerung der intrazellulären Proteinmenge durch niedermolekulare Modulatoren des Ubiquitin‐Proteasom‐Systems
    Dennis L. Buckley, Craig M. Crews · 2014 · Angewandte Chemie
  24. Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo
    Emma Morrish, Liana Mackiewicz, Natasha Silke, Marc Pellegrini, John Silke, Gabriela Brumatti, Gregor Ebert · 2020 · Viruses
  25. Constitutive protein degradation induces acute cell death via proteolysis products
    Sihan Chen, Sumit Prakash, Elizabeth Helgason, Caroline L. Gilchrist, Lillian R. Kenner, Rajini Srinivasan, Tim Sterne‐Weiler, Marc A. Hafner, Robert Piskol, Erin C. Dueber et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  26. The Effect of Xevinapant Combined with Ionizing Radiation on HNSCC and Normal Tissue Cells and the Impact of Xevinapant on Its Targeted Proteins cIAP1 and XIAP
    Julia Fleischmann, Laura S. Hildebrand, Lukas Kuhlmann, Rainer Fietkau, Luitpold Valentin Distel · 2023 · Cells
  27. Regulation of apoptosis by ubiquitination in liver cancer.
    Yuxuan Li, Jie Zhu, Zongdong Yu, Fengguang Zhai, Hong Li, Xiaofeng Jin · 2023 · PubMed Central
  28. Noncanonical-NF-κB activation and DDX3 inhibition reduces the HIV-1 reservoir by elimination of latently infected cells ex-vivo
    Jade Jansen, Stefanie Kroeze, Shirley Man, Matteo Andreini, Jan-Willem Bakker, Claudio Zamperini, Alessia Tarditi, Neeltje A. Kootstra, Teunis B. H. Geijtenbeek · 2023 · Microbiology Spectrum
  29. Hyperosmotic stress enhances cytotoxicity of SMAC mimetics
    Sebastian Bittner, Gertrud Knoll, Martin Ehrenschwender · 2017 · Cell Death and Disease
  30. Induction of Autophagy to Achieve a Human Immunodeficiency Virus Type 1 Cure
    Grant R. Campbell, Stephen A. Spector · 2021 · Cells
  31. Combined Inhibition of IAPs and WEE1 Enhances TNFα- and Radiation-Induced Cell Death in Head and Neck Squamous Carcinoma
    Tiffany Toni, Ramya Viswanathan, Yvette L. Robbins, Sreenivasulu Gunti, Xinping Yang, Angel P. Huynh, Hui Wen Cheng, Anastasia L. Sowers, James B. Mitchell, Clint Tanner Allen et al. · 2023 · Cancers
  32. CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
    Javier Glez‐Vaz, Arantza Azpilikueta, María Carmen Ochoa, Irene Olivera, Gabriel Gomis, Asunta Cirella, Carlos Luri‐Rey, Maite Álvarez, José Luis Perez‐Gracia, Sergio Ciordia et al. · 2023 · Science Advances
  33. Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic
    Kumudha Balakrishnan, Min Fu, Francesco Onida, William G. Wierda, Michael J. Keating, Varsha V. Gandhi · 2016 · Oncotarget
  34. Identification of Smac mimetics as novel substrates for p-glycoprotein
    Manuela Hugle, Sebastian Czaplinski, Karoline Habermann, Meike Vogler, Simone Fulda · 2018 · Cancer Letters
  35. Dual Role of TLR3 in Inflammation and Cancer Cell Apoptosis
    Yann Estornes, Olivier Micheau, Toufic Renno, Serge Lebecque · 2013 · InTech eBooks
  36. Recombinant Mutated Human TNF in Combination with Chemotherapy for Stage IIIB/IV Non-Small Cell Lung Cancer: A Randomized, Phase III Study
    Xiaowen Ma, Yang Song, Kuo Zhang, Lei Shang, Yuan Gao, Wei Zhang, Xiaochang Xue, Huimin Jia, Jian Geng, Wei Jie Zhou et al. · 2015 · Scientific Reports
  37. Isolation of peptides blocking the function of anti-apoptotic Livin protein
    Irena Crnković‐Mertens, Julia Bulkescher, Christina Mensger, Felix Hoppe‐Seyler, Karin Hoppe‐Seyler · 2010 · Cellular and Molecular Life Sciences
  38. Doxorubicin overcomes resistance to drozitumab by antagonizing Inhibitor of Apoptosis Proteins (IAPs).
    Irene Zinonos, Agatha Labrinidis, Vasilios Liapis, Shelley J. Hay, Vasilios Panagopoulos, Mark O. DeNichilo, Vladimir Ponomarev, Wendy V. Ingman, Gerald J. Atkins, David M. Findlay et al. · 2014 · PubMed
  39. MK2 balances inflammation and cell death
    Andrew Oberst · 2017 · Nature Cell Biology
  40. Effects of rheumatoid arthritis associated transcriptional changes on osteoclast differentiation network in the synovium
    Shilpa Harshan, Poulami Dey, Srivatsan Raghunathan · 2018 · PeerJ
  41. Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease
    Yuting Jiang, Jie Chen, Yaoyao Du, Minwei Fan, Lan Shen · 2025 · International Immunopharmacology
  42. FADD DED filaments coordinate complex IIa assembly during TNF-induced apoptosis
    Ying Chen, Vinh Thang Huynh, Lihua Lai, Ping Liu, Tongyang Li, Yaw Bia Tan, Che Shin Chew, Amhed Missael Vargas Velazquez, Firdaus Samsudin, Jan K. Marzinek et al. · 2025 · Proceedings of the National Academy of Sciences
  43. Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic
    Mark A. Miles, Sarah Caruso, Amy A. Baxter, Ivan K. H. Poon, Christine J. Hawkins · 2020 · APOPTOSIS
  44. The non‐peptidomimetic IAP antagonist ASTX660 sensitizes colorectal cancer cells for extrinsic apoptosis
    Gertrud Knoll, Martin Ehrenschwender · 2021 · FEBS Open Bio
  45. cIAP1/2 are involved in the radiosensitizing effect of birinapant on NSCLC cell line in vitro
    Hao Sun, Yanan Du, Ming Yao, Qin Wang, Kaihua Ji, Liqing Du, Chang Xu, Ningning He, Jinhan Wang, Manman Zhang et al. · 2021 · Journal of Cellular and Molecular Medicine
  46. The roles of long non-coding RNAs in the necroptotic signaling of colon cancer cells
    Esra Bozgeyi̇k, Haydar Bağış, İbrahim Bozgeyik, Sayad Kocahan · 2023 · Molecular Biology Reports
  47. NF-κB inhibition compromises cardiac fibroblast viability under hypoxia
    M. Sangeetha, Malini S. Pillai, Linda Philip, Edward G. Lakatta, K. Shivakumar · 2011 · Experimental Cell Research
  48. Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling
    Andrew J. Kocab, Artur Veloso, Michelle T. Paulsen, Mats E. Ljungman, Colin S. Duckett · 2015 · Oncogene
  49. Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells
    Tanmay M. Shekhar, Maja M. Green, David M. Rayner, Mark A. Miles, Suzanne M. Cutts, Christine J. Hawkins · 2015 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
  50. Cellular Inhibitors of Apoptosis Proteins cIAP 1 and cIAP 2 are Increased after Labour in Foetal Membranes and Myometrium and are Essential for TNF ‐α‐Induced Expression of Pro‐Labour Mediators
    Martha Lappas · 2014 · American Journal of Reproductive Immunology
  51. Expression and Correlation of Cell-Free cIAP-1 and cIAP-2 mRNA in Breast Cancer Patients: A Study from India
    Amit Kumar Verma, Irfan S. Ahmad, Prasant Yadav, Arshad Husain Rahmani, Bazila Bazila, Mohammed A. Alsahli, P. C. Joshi, Hafiz Ahmad, Mirza Masroor Ali Beg · 2020 · Journal of Oncology
  52. Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages
    Ramon Edwin Caballero, Simon Xin Min Dong, Niranjala Gajanayaka, Hamza Ali, Edana Cassol, D. William Cameron, Robert G. Korneluk, Michel J. Tremblay, Jonathan Benjamin Angel, Ashok Kumar · 2021 · Scientific Reports
  53. X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL
    Michela Carlet, Karin Schmelz, Jenny Vergalli, Tobias Herold, Daniela Senft, Vindi Jurinović, Thomas Hoffmann, Jutta Proba, Nina Weichert, Christian Junghanß et al. · 2022 · EMBO Molecular Medicine
  54. Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment
    Eugene E. Varfolomeev, Anita Izrael-Tomasevic, Kebing Yu, Daisy J. Bustos, Tatiana Goncharov, Lisa D. Belmont, Alexandre Masselot, Corey E. Bakalarski, Donald S. Kirkpatrick, Domagoj Vucic · 2014 · Biochemical Journal
  55. Analysis of inhibitor of apoptosis protein family expression during mammary gland development
    Thomas W. Owens, Fiona M. Foster, Jolanta Tanianis-Hughes, Julia Cheung, Lisa Brackenbury, Charles H. Streuli · 2010 · BMC Developmental Biology
  56. The Cellular Inhibitor of Apoptosis Protein‐2 is a Possible Target of Novel Treatment for Endometriosis
    Fuminori Taniguchi, Hiroko Higaki, Masao Izawa, Yukihiro Azuma, Eriko Hirakawa, Imari Deura, Tomio Iwabe, Kohkichi Hata, Tasuku Harada · 2014 · American Journal of Reproductive Immunology
  57. Peptides and Peptide Mimics as Modulators of Apoptotic Pathways
    Mar Orzáez, Anna Gortat, Laura Mondragón, Enríque Pérez‐Payá · 2008 · ChemMedChem
  58. Phase II multicenter, randomized, double‐blind study of recombinant mutated human tumor necrosis factor‐α in combination with chemotherapies in cancer patients
    Meng Li, Tianjiao Xu, Zhao Zhang, Xiaochang Xue, Cun Zhang, Xin Qin, Weina Li, Qiang Hao, Wei Zhang, Yingqi Zhang · 2011 · Cancer Science
  59. cIAP2 Is an Independent Signaling and Survival Factor during Mammary Lactational Involution and Tumorigenesis
    David Carr, Rosanna Lau, Alexandra D. Hnatykiw, Gwendoline C. D. Ward, Manijeh Daneshmand, Miguel A. Cabrita, M.A. Christine Pratt · 2018 · Journal of Mammary Gland Biology and Neoplasia
  60. Downregulation of Smac attenuates H2O2-induced apoptosis via endoplasmic reticulum stress in human lens epithelial cells
    Kong De-qian, Yue Liu, Li Li, Zheng Guangying · 2017 · Medicine
  61. Development of Novel Drugs Targeting Inhibitors of Apoptosis
    John A. Flygare, Domagoj Vucic · 2009 · Future Oncology
  62. CDK4/6 inhibitors upregulate cIAP1/2, and Smac mimetic LCL161 enhances their antitumor effects in cholangiocarcinoma cells
    Pimchanok Menapree, Nattaya Duangthim, Apiwit Sae-Fung, Sasiprapa Sonkaew, Siriporn Jitkaew · 2025 · Scientific Reports
  63. PROTAC‐Based HDAC Degradation: A Paradigm Shift in Targeted Epigenetic Therapies
    Ambati Himaja, Debojyoti Halder, Suvankar Banerjee, Swati Biswas, Nilanjan Adhikari, Balaram Ghosh · 2025 · ChemMedChem
  64. Targeting caspase-8/c-FLIPL heterodimer in complex II promotes DL-mediated cell death
    Laura K. Hillert-Richter, Corinna König, Nikita V. Ivanisenko, Dirk Reinhold, Inna N. Lavrik · 2024 · Frontiers in Cell and Developmental Biology
  65. Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells
    Sebastian Czaplinski, Behnaz Ahangarian Abhari, Alica Torkov, Dominik Seggewiß, Manuela Hugle, Simone Fulda · 2015 · Oncotarget
  66. Comparison of apoptosis between adult worms of Schistosoma japonicum from susceptible (BALB/c mice) and less-susceptible (Wistar rats) hosts
    Tao Wang, Xiaoyong Guo, Yang Hong, Hongxiao Han, Xiaodan Cao, Yanhui Han, Min Zhang, Miaoli Wu, Zhiqiang Fu, Lu Ke et al. · 2016 · Gene
  67. Ubiquitination and TNFR1 Signaling
    Ken-ichi Fujita, Srinivasa Murty Srinivasula · 2009 · Results and problems in cell differentiation
  68. Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain
    Fernando R. Pinacho Crisóstomo, Yongmei Feng, Xuejun Zhu, Kate Welsh, Jing An, John C. Reed, Ziwei Huang · 2009 · Bioorganic & Medicinal Chemistry Letters
  69. Cellular inhibitors of apoptosis (cIAP) 1 and 2 are increased in placenta from obese pregnant women
    Martha Lappas · 2014 · Placenta
  70. Integrity of XIAP is essential for effective activity recovery of apoptosome and its downstream caspases by Smac/Diablo
    Faezeh Attaran-Bandarabadi, Behnaz Ahangarian Abhari, Shima Hallaj Neishabouri, Jamshid Davoodi · 2017 · International Journal of Biological Macromolecules
  71. TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classic IKK complex in hematopoietic cells in mice
    Laiqun Zhang, Ken Blackwell, Lauren M. Workman, Katherine Nicole Gibson-Corley, Alicia K. Olivier, Gail Abendroth Bishop, Hasem Habelhah · 2016 · Journal of Cell Science
  72. Getting MAD at MYC
    Maria Letizia Giardino Torchia, Jonathan D. Ashwell · 2018 · Proceedings of the National Academy of Sciences
  73. Differential involvement of TAK1, RIPK1 and NF-κB signaling in Smac mimetic-induced cell death in breast cancer cells
    Nadine Schmidt, Lisa Kowald, Sjoerd J. L. van Wijk, Simone Fulda · 2018 · Biological Chemistry
  74. Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis
    Debolina D. Biswas, Rebecca Martin, LaShardai N. Brown, Karli Mockenhaupt, Angela Satya Gupta, Michael J. Surace, Anuj Tharakan, Jessie Yester, Reetika Bhardwaj, Daniel H. Conrad et al. · 2022 · Journal of Neuroinflammation
  75. Application and progress of CRISPR/Cas9 gene editing in B-cell lymphoma: a narrative review
    Ying Jin, Haiyi Wu, Jianzhao Liu, William Chi Shing Cho, Guoqi Song · 2024 · Translational Cancer Research
  76. Clinically relevant SMAC mimetics do not enhance human T cell proliferation or cytokine production
    Ashley Burton, Brittany R. Ligman, Claire A. Kearney, Susan Murray · 2021 · Cellular Immunology
  77. Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death
    Xinhe Gao, Teng Teng, Yifei Liu, Tingting Ai, Rui Zhao, Yilong Fu, Peipei Zhang, Jiahuai Han, Yingying Zhang · 2023 · Protein & Cell
  78. Targeting oncoproteins for degradation by small molecules in myeloid leukemia
    Hu Lei, Weiwei Wang, Yingli Wu · 2017 · Leukemia & lymphoma/Leukemia and lymphoma
  79. Functional interplay between NF-κB-inducing kinase and c-Abl kinases limits response to Aurora inhibitors in multiple myeloma
    Laura Mazzera, Manuela Abeltino, Guerino Lombardi, Anna Maria Cantoni, Roberto Ria, Micaela Ricca, Ilaria Saltarella, Valeria Naponelli, Federica Rizzi, Roberto Perris et al. · 2019 · Haematologica
  80. Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design
    James J. Crawford, Jianwen A. Feng, Hans D. Brightbill, Adam R. Johnson, Matthew R. Wright, Aleksandr Kolesnikov, Wendy Lee, Georgette M. Castanedo, Steven Do, Nicole Blaquière et al. · 2023 · Bioorganic & Medicinal Chemistry Letters
  81. Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2
    Adam H. Tencer, Yucong Yu, Sébastien Causse, Grant R. Campbell, Brianna J. Klein, Hongwen Xuan, Jessy Cartier, Mark A. Miles, Nitika Gaurav, Aymeric Zadoroznyj et al. · 2023 · Nature Structural & Molecular Biology
  82. Conjugation to SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer
    Gunjal Garg, Suwanna Vangveravong, C. Zeng, Matthew A. Powell, David Gardner Mutch, David R Piwnica-Worms, Robert H. Mach, Dirk Spitzer, Williams G. Hawkins · 2014 · Gynecologic Oncology
  83. Monomerization of Cytosolic Mature Smac Attenuates Interaction with IAPs and Potentiation of Caspase Activation
    Stephen P. Burke, Jeffrey Bingham Smith · 2010 · PLoS ONE
  84. PKC activation sensitizes basal-like breast cancer cell lines to Smac mimetics
    Louise Cornmark, Christian Holmgren, Katarzyna Chmielarska Masoumi, Christer Larsson · 2016 · Cell Death Discovery
  85. Modulation of apoptotic response by LAR family phosphatases–cIAP1 signaling during urinary tract morphogenesis
    Katherine S. Stewart, You Chi Tang, Maxwell E. R. Shafer, Adda-Lee Graham-Paquin, Maxime Bouchard · 2017 · Proceedings of the National Academy of Sciences
  86. Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
    I‐Ting Chen, Hsiao‐Chi Chen, Yu‐Hsun Lo, Peng‐Yeh Lai, Fu‐Yi Hsieh, Yung‐Hsuan Wu, Hsiu‐Ming Shih, Ming‐Zong Lai · 2021 · EMBO Reports
  87. TRAF2 and Cellular IAPs: A Critical Link in TNFR Family Signaling
    Domagoj Vucic · 2010 · Advances in experimental medicine and biology
  88. TWEAKing death
    Jonathan D. Ashwell · 2008 · The Journal of Cell Biology
  89. Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma
    Leanne S. Stevenson, Lauren Cairns, Xiaodun Li, Sriganesh Jammula, Harriet Taylor, Rosalie V. Douglas, Niamh McCabe, Gérald Gavory, Xavier Jacq, Rebecca Claire Fitzgerald et al. · 2024 · Scientific Reports
  90. Corynebacterium glutamicum alleviated colitis by downregulating the TNF signaling pathway mediated by cIAP1/2 in mice
    Ting Liu, Qiang Meng, Yijun Zhang, Mengxi Yu, Jianming Ye, Wei Song, Yane Luo, Tianli Yue · 2025 · Food & Function
  91. Mycoplasma hyorhinis infection promotes TNF-α signaling and SMAC mimetic-mediated apoptosis in human prostate cancer
    Jin Koo Kim, Insoon Chang, Younghun Jung, Zach Kaplan, Elliott E. Hill, Russell S. Taichman, Paul H. Krebsbach · 2023 · Heliyon
  92. Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin
    Ye Mon Soe, Seen-Ling Sim, Snehlata Kumari · 2025 · Viruses
  93. Dual action Smac mimetics–zinc chelators as pro-apoptotic antitumoral agents
    Leonardo Manzoni, Davide Gornati, Mattia Manzotti, Silvia Cairati, Alberto Bossi, Daniela Arosio, Daniele Lecis, Pierfausto Seneci · 2016 · Bioorganic & Medicinal Chemistry Letters
  94. Pharmacodynamic modeling of synergistic birinapant/paclitaxel interactions in pancreatic cancer cells
    Jin Niu, Xue Wang, Jun Qu, Donald E. Mager, Robert M. Straubinger · 2020 · BMC Cancer
  95. Downregulation of BIRC2 hinders the progression of rheumatoid arthritis through regulating TRADD
    Yanting Rao, Shengjing Xu, Ting Lu, Yuanyuan Wang, Manman Liu, Wei Zhang · 2023 · Immunity Inflammation and Disease
  96. Apoptotic Signaling Pathway and Resistance to Apoptosis in Breast Cancer Stem Cells
    Prasanthi Karna, Lily P H Yang · 2009 · Springer eBooks
  97. Cell death: From initial concepts to pathways to clinical applications – Personal reflections of a clinical researcher
    Klaus‐Michael Debatin · 2017 · Biochemical and Biophysical Research Communications
  98. NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis
    Behnaz Ahangarian Abhari, Nicole McCarthy, Patrizia Agostinis, Simone Fulda · 2019 · APOPTOSIS
  99. Alternative Splicing of RIOK3 Engages the Noncanonical NFκB Pathway during Rift Valley Fever Virus Infection
    Thomas C. Bisom, Hope Smelser, Jean-Marc Lanchy, J. Stephen Lodmell · 2023 · Viruses
  100. Necroptosis, ADAM proteases and intestinal (dys)function
    Michelle Heib, Stefan Rose‐John, Dieter Adam · 2020 · International review of cytology