IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis
Varfolomeev, Eugene, Blankenship, John W., Wayson, Sarah M., Fedorova, Anna V., Kayagaki, Nobuhiko, Garg, Parie, Zobel, Kerry, Dynek, Jasmin N. +7 more·2007·Cell
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- NF-κB and Therapeutic ApproachChang‐Hoon Lee, Soo‐Youl Kim · 2009 · Biomolecules & Therapeutics
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- Simultaneous Targeting of Two Master Regulators of Apoptosis with Dual-Action PNA– and DNA–Peptide ConjugatesYannic Altrichter, Oliver Seitz · 2020 · Bioconjugate Chemistry
- The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory LymphomaEiji Sugihara, Norisato Hashimoto, Satoru Osuka, Takatsune Shimizu, Sayaka Ueno, Shogo Okazaki, Tomonori Yaguchi, Yutaka Kawakami, Kenjiro Kosaki, Taka-Aki Sato et al. · 2020 · Cancer Research
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- Negative feedback regulation of NF-κB-inducing kinase is proteasome-dependent but does not require cellular inhibitors of apoptosisCarolyn M. Gray, Kelly A. McCorkell, Srinivas K. Chunduru, Mark A. McKinlay, Michael J. May · 2014 · Biochemical and Biophysical Research Communications
- The transcription factor SP3 drives TNF-α expression in response to Smac mimeticsShawn T. Beug, Herman H. Cheung, Tarun Sanda, Martine St-Jean, Caroline E. Beauregard, Hapsatou Mamady, Stephen D. Baird, Eric Charles LaCasse, Robert G. Korneluk · 2019 · Science Signaling
- Inhibitor of Apoptosis (IAP) Proteins: Novel Insights into the Cancer-Relevant Targets for Cell Death InductionSimone Fulda · 2009 · ACS Chemical Biology
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- Recent advances in PROTAC-based antiviral and antibacterial therapeuticsCan Zhou, Shiwei Yang, Jun Joelle Wang, Wei Pan, Hongliang Yao, Gang Li, Minhong Niu · 2025 · Bioorganic Chemistry
- Identification of a novel protein kinase Cδ–Smac complex that dissociates during paclitaxel‐induced cell deathKatarzyna Chmielarska Masoumi, Louise Cornmark, Gry Kalstad Lønne, Ulf Hellman, Christer Larsson · 2012 · FEBS Letters
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- Transcriptomic analysis identifies dysregulated genes and functional networks in human small airway epithelial cells exposed to ambient PM2.5.Yang Lan, C. Ng, C. Ong, Liya E. Yu, B. Bay · 2021 · Ecotoxicology and Environmental Safety
- Ubiquitination and cell-autonomous immunityJoão Mello-Vieira, Tobias Bopp, Ivan Đikić · 2023 · Current Opinion in Immunology