IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Cited by (1,000)

Items 201–300 of 1,000

  1. Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus
    Shinya Omoto, Hongyan Guo, Ganesh R. Talekar, Linda Roback, William J. Kaiser, Edward S. Mocarski · 2015 · Journal of Biological Chemistry
  2. Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells
    Arnim Weber, Zofia Kirejczyk, Robert Besch, Stephanie Potthoff, M. Leverkus, Georg Alexander Häcker · 2009 · Cell Death and Differentiation
  3. XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation
    Kate E. Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A. Conos, Kaiwen W. Chen, Stephanie Ziehe, Carina Graß, Yifan Zhan, Tan A. Nguyen, Cathrine M. Hall et al. · 2017 · Cell Reports
  4. Targeting signaling factors for degradation, an emerging mechanism for TRAF functions
    Xiaodong Yang, Shao‐Cong Sun · 2015 · Immunological Reviews
  5. Sublethal necroptosis signaling promotes inflammation and liver cancer
    Mihael Vucur, Ahmed Ghallab, Anne T. Schneider, Arlind Adili, Mingbo Cheng, Mirco Castoldi, Michael T. Singer, Veronika Büttner, Leonie S. Keysberg, Lena Küsgens et al. · 2023 · Immunity
  6. Structural studies of NF-κB signaling
    Zheng, Chao, Yin, Qian, Wu, Hao · 2011 · Cell Research
  7. IAP proteins as targets for drug development in oncology
    Laurence Dubrez, Jean Berthelet, Valérie Glorian · 2013 · OncoTargets and Therapy
  8. Response and Resistance to NF-κB Inhibitors in Mouse Models of Lung Adenocarcinoma
    Wen Xue, Etienne Meylan, Trudy G. Oliver, David M. Feldser, Monte M. Winslow, Roderick Terry Bronson, Tyler Jacks · 2011 · Cancer Discovery
  9. Smac mimetics and innate immune stimuli synergize to promote tumor death
    Shawn T. Beug, Vera A. Tang, Eric Charles LaCasse, Herman H. Cheung, Caroline E. Beauregard, Jan Brun, Jeffrey P Nuyens, Nathalie Earl, Martine St-Jean, Janelle Holbrook et al. · 2014 · Nature Biotechnology
  10. The Two Faces of Receptor Interacting Protein Kinase-1
    Ricardo Weinlich, Douglas R. Green · 2014 · Molecular Cell
  11. Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?
    Ae R Noort, Paul Peter Tak, Sander W. Tas · 2015 · Arthritis Research & Therapy
  12. TRAIL Signaling and Synergy Mechanisms Used in TRAIL-Based Combination Therapies
    Christian T. Hellwig, Markus Rehm · 2012 · Molecular Cancer Therapeutics
  13. A Phase I Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma
    Ravi K. Amaravadi, Russell J. Schilder, Lainie P. Martin, Myron J. Levin, Martin A. Graham, David Edward Weng, Alex A. Adjei · 2015 · Molecular Cancer Therapeutics
  14. Is TRAIL the holy grail of cancer therapy?
    Thomas E. Newsom-Davis, Silvia Prieske, Henning Walczak · 2009 · APOPTOSIS
  15. Smac Mimetics and TNFα: A Dangerous Liaison?
    Hao Wu, Jürg Tschopp, Su‐Chang Lin · 2007 · Cell
  16. IAP Family of Cell Death and Signaling Regulators
    John Silke, Domagoj Vucic · 2014 · Methods in enzymology on CD-ROM/Methods in enzymology
  17. Discovery of E3 Ligase Ligands for Target Protein Degradation
    Jaeseok Lee, Young‐Jun Lee, Young Mee Jung, Ju Hyun Park, Hyuk Sang Yoo, Jongmin Park · 2022 · Molecules
  18. IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation
    Tripat Kaur Oberoi‐Khanuja, Taner Dogan, Jennifer C. Hocking, Rolf‐Peter Scholz, Juliane Mooz, Carrie L Anderson, Christiaan Karreman, Dagmar Meyer zu Heringdorf, Gudula Schmidt, Mika O. Ruonala et al. · 2011 · The EMBO Journal
  19. CARD-Mediated Autoinhibition of cIAP1's E3 Ligase Activity Suppresses Cell Proliferation and Migration
    Juanita Suzanne Lopez, Sidonie Wicky John, Tencho Tenev, Gilles J. P. Rautureau, Mark G. Hinds, Floriana Francalanci, Rebecca Wilson, Meike Broemer, Massimo Mattia Santoro, Catherine L. Day et al. · 2011 · Molecular Cell
  20. NF-κB inducing kinase: A key regulator in the immune system and in cancer
    Yee Mon Thu, Ann J. Richmond · 2010 · Cytokine & Growth Factor Reviews
  21. Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling
    Axel Witt, Domagoj Vucic · 2017 · Cell Death and Differentiation
  22. Biological determinants of radioresistance and their remediation in pancreatic cancer
    Parthasarathy Seshacharyulu, Michael J. Baine, Joshua J. Souchek, Melanie Menning, Sukhwinder Kaur, Ying Yan, Michel M. Ouellette, Maneesh Jain, Chi H. Lin, Surinder K. Batra · 2017 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  23. All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity
    Ariel Ramírez-Labrada, Cecilia Pesini, Llipsy Santiago, Sandra Hidalgo, Adanays Calvo-Pérez, Carmen Oñate, Alejandro Andrés-Tovar, Marcela Garzón-Tituaña, Iratxe Uranga-Murillo, Maykel A. Arias et al. · 2022 · Frontiers in Immunology
  24. Inhibitor of apoptosis proteins and apoptosis
    Yunbo Wei, Ting‐Jun Fan, Miaomiao Yu · 2008 · Acta Biochimica et Biophysica Sinica
  25. Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
    Tatiana Goncharov, Stefanie Hedayati, Melinda M. Mulvihill, Anita Izrael-Tomasevic, Kerry Zobel, Surinder Jeet, Anna V. Fedorova, Céline Eidenschenk, Jason DeVoss, Kebing Yu et al. · 2018 · Molecular Cell
  26. Protein–protein interactions as targets for small-molecule therapeutics in cancer
    White, Alex W., Westwell, Andrew D., Brahemi, Ghali · 2008 · Expert Reviews in Molecular Medicine
  27. Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2
    John W. Blankenship, Eugene E. Varfolomeev, Tatiana Goncharov, Anna V. Fedorova, Donald S. Kirkpatrick, Anita Izrael-Tomasevic, Lilian Phu, David P. Arnott, Mariam Aghajan, Kerry Zobel et al. · 2008 · Biochemical Journal
  28. Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis
    L Steinhart, Katharina Belz, Simone Fulda · 2013 · Cell Death and Disease
  29. Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs
    John Silke, Robert Adrian Brink · 2009 · Cell Death and Differentiation
  30. Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis
    Jue Hou, Jie Ju, Zili Zhang, Cong Zhao, Zhanhui Li, Jiyue Zheng, Sheng Tian, Hongjian Zhang, Linkun Hu, Xiaoliang Yu et al. · 2019 · Cell Death and Disease
  31. Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression
    Sean L. Petersen, Michael Peyton, John Dorrance Minna, Xiaodong Wang · 2010 · Proceedings of the National Academy of Sciences
  32. A new kind of cell suicide: mechanisms and functions of programmed necrosis
    Liming Sun, Xiaodong Wang · 2014 · Trends in Biochemical Sciences
  33. OTUB1 modulates c‐IAP1 stability to regulate signalling pathways
    Tatiana Goncharov, Kyle S. Niessen, M. Cristina de Almagro, Anita Izrael-Tomasevic, Anna V Fedorova, Eugene E. Varfolomeev, David P. Arnott, Kurt Deshayes, Donald S. Kirkpatrick, Domagoj Vucic · 2013 · The EMBO Journal
  34. Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)
    Edward J. Hennessy, Ammar Adam, Brian M. Aquila, Lillian Castriotta, Donald J. Cook, Maureen Mertens Hattersley, Alexander W. Hird, Christopher Huntington, Victor M. Kamhi, Naomi M. Laing et al. · 2013 · Journal of Medicinal Chemistry
  35. Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death
    M. Cristina de Almagro, Tatiana Goncharov, Anita Izrael-Tomasevic, Stefanie Duttler, Matthias Kist, Eugene E. Varfolomeev, Xiumin Wu, Wyne P. Lee, Jeremy M. Murray, Joshua D. Webster et al. · 2016 · Cell Death and Differentiation
  36. The regulation of TNF signalling: what a tangled web we weave
    John Silke · 2011 · Current Opinion in Immunology
  37. Bacteria-host relationship: ubiquitin ligases as weapons of invasion
    Timurs Maculins, Evgenij Fiškin, Sagar Bhogaraju, Ivan Đikić · 2016 · Cell Research
  38. Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL
    Scott McComb, Júlia Aguadé-Gorgorió, Lena Behrmann, Blerim Marovca, Gunnar Cario, Cornelia Eckert, Martin Schrappe, Martin Stanulla, Arend von Stackelberg, Jean‐Pierre Bourquin et al. · 2016 · Science Translational Medicine
  39. Targeting XIAP for Promoting Cancer Cell Death—The Story of ARTS and SMAC
    Ruqaia Abbas, Sarit Larisch · 2020 · Cells
  40. Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms
    Fisher, Daniel Arthur Corpuz, Fowles, Jared Scott, Zhou, Amy, Oh, Stephen Tracy · 2021 · Frontiers in Immunology
  41. Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination
    M. Cristina de Almagro, Tatiana Goncharov, Kim Newton, Domagoj Vucic · 2015 · Cell Death and Disease
  42. cIAP1/2 Are Direct E3 Ligases Conjugating Diverse Types of Ubiquitin Chains to Receptor Interacting Proteins Kinases 1 to 4 (RIP1–4)
    Mathieu J.M. Bertrand, Saskia Lippens, An Staes, Barbara Gilbert, Ria Roelandt, Jelle De Medts, Kris Gevaert, Wim Declercq, Peter Vandenabeele · 2011 · PLoS ONE
  43. Smac mimetics as new cancer therapeutics
    Derrick J. Chen, Sergio Huerta · 2009 · Anti-Cancer Drugs
  44. IAPs: Guardians of RIPK1
    Maurice Darding, Pascal Meier · 2011 · Cell Death and Differentiation
  45. Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism
    Jennifer L. Allensworth, Scott J. Sauer, Herbert Kim Lyerly, Michael Andrew Morse, Gayathri R. Devi · 2012 · Breast Cancer Research and Treatment
  46. Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2
    Qian Yin, Betty Lamothe, Bryant G. Darnay, Hao Wu · 2009 · Biochemistry
  47. Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives
    Hui Cong, Lijuan Xu, Yougen Wu, Zhuo Qu, Tengfei Bian, Wannian Zhang, Chengguo Xing, Chunlin Zhuang · 2019 · Journal of Medicinal Chemistry
  48. Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
    Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen et al. · 2021 · Nature Chemical Biology
  49. SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death
    Lisa Schlicher, Manuela Wissler, Florian Preiss, Prisca Brauns‐Schubert, Celia Jakob, Verónica I. Dumit, Christoph Borner, Jörn Dengjel, Ulrich Maurer · 2016 · EMBO Reports
  50. The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils
    Akshay A. D’Cruz, Mary Speir, Meghan Bliss‐Moreau, Sylvia Dietrich, Shu Wang, Alyce A. Chen, Mathilde Gavillet, Arshed Al‐Obeidi, Kate E. Lawlor, James Edward Vince et al. · 2018 · Science Signaling
  51. Knocking ’em Dead: Pore-Forming Proteins in Immune Defense
    Xing Liu, Judy Lieberman · 2020 · Annual Review of Immunology
  52. Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2
    Maurice Darding, Rebecca Feltham, Tencho Tenev, Katiuscia Bianchi, Christopher A. Benetatos, John Silke, Pascal Meier · 2011 · Cell Death and Differentiation
  53. PERK-dependent regulation of IAP translation during ER stress
    Robert B. Hamanaka, Ekaterina V. Bobrovnikova-Marjon, Xiao‐Dan Ji, Stephen A. Liebhaber, John Alan Diehl · 2008 · Oncogene
  54. Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB
    Marie Oliver Metzig, Dominik Fuchs, Katrin Elisabeth Tagscherer, H‐J Gröne, Peter Schirmacher, Wilfried Roth · 2015 · Oncogene
  55. Necroptosis: The Trojan horse in cell autonomous antiviral host defense
    Edward S. Mocarski, Hongyan Guo, William J. Kaiser · 2015 · Virology
  56. Lucifer's Labyrinth—Ten Years of Path Finding in Cell Death
    Pascal Meier, Karen H. Vousden · 2007 · Molecular Cell
  57. Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation
    Jannie Pedersen, Eric Charles LaCasse, Jakob Benedict Seidelin, Mehmet Coskun, Ole Haagen Nielsen · 2014 · Trends in Molecular Medicine
  58. Inhibitor of apoptosis proteins in Drosophila: gatekeepers of death
    Mariam H. Orme, Pascal Meier · 2009 · APOPTOSIS
  59. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation
    Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata et al. · 2018 · Journal of Biological Chemistry
  60. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
    Sandra Gardam, Vivian M. Turner, Holly Anderton, Sandhya Limaye, Antony Basten, Frank Köentgen, David Lawrence Vaux, John Silke, Robert Adrian Brink · 2011 · Blood
  61. Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
    Deborah Fanfone, Zhichong Wu, Jade Mammi, Kévin Berthenet, David Neves, Kathrin Weber, Andrea Halaburkova, François Virard, Félix Bunel, Catherine Jamard et al. · 2022 · eLife
  62. Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner
    Brandon Probst, L. Liu, V Ramesh, L. Li, Haiying Sun, John Dorrance Minna, Lai Wang · 2010 · Cell Death and Differentiation
  63. The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells
    Clemens Krepler, Srinivas K. Chunduru, Molly B. Halloran, Xu He, Min Xiao, Adina Vultur, Jessie Villanueva, Yasuhiro Mitsuuchi, Eric M. Neiman, Christopher A. Benetatos et al. · 2013 · Clinical Cancer Research
  64. Emerging roles of hnRNPA1 in modulating malignant transformation
    Rajat Roy, Yueyang Huang, Michael J. Seckl, Olivier E. Pardo · 2017 · Wiley Interdisciplinary Reviews - RNA
  65. MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), Amplified on Chromosome 9, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression
    Ou Ma, Wei‐Wen Cai, Lars Zender, Tajhal Dayaram, Jianhe Shen, Alan J. Herron, Scott W. Lowe, Tsz‐Kwong Man, Ching C. Lau, Lawrence A. Donehower · 2009 · Cancer Research
  66. Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics
    Najoua Lalaoui, Kay Hänggi, Gabriela Brumatti, Diep Chau, Nhu-Y. N. Nguyen, Lazaros Vasilikos, Lisanne M. Spilgies, Denise A. Heckmann, Chunyan Ma, Margherita Ghisi et al. · 2016 · Cancer Cell
  67. BH3-mimetics: recent developments in cancer therapy
    Paul A. Townsend, Maria V. Kozhevnikova, Olivier Cexus, Andrey A. Zamyatnin, Surinder M. Soond · 2021 · Journal of Experimental & Clinical Cancer Research
  68. Molecular Pathways: Targeting Inhibitor of Apoptosis Proteins in Cancer—From Molecular Mechanism to Therapeutic Application
    Simone Fulda · 2013 · Clinical Cancer Research
  69. Smac Mimetic Bypasses Apoptosis Resistance in FADD- or Caspase-8-Deficient Cells by Priming for Tumor Necrosis Factor α-Induced Necroptosis
    Bram Laukens, Claudia Jennewein, Barbara Schenk, Nele Vanlangenakker, Alexander Schier, Silvia Cristofanon, Kerry Zobel, Kurt Deshayes, Domagoj Vucic, Irmela Jeremias et al. · 2011 · Neoplasia
  70. Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists
    Chudi O. Ndubaku, Eugene E. Varfolomeev, Lan Wang, Kerry Zobel, Kevin Lau, Linda O. Elliott, Brigitte Maurer, Anna V. Fedorova, Jasmin N. Dynek, Michael F. T. Koehler et al. · 2009 · ACS Chemical Biology
  71. Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins
    David Simon Ziegler, Renee D. Wright, Santosh Kesari, Madeleine E. Lemieux, Mary A. Tran, Monish Jain, Leigh S. Zawel, Andrew L. Kung · 2008 · Journal of Clinical Investigation
  72. IAPs, regulators of innate immunity and inflammation
    Yann Estornes, Mathieu J.M. Bertrand · 2014 · Seminars in Cell and Developmental Biology
  73. Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance
    Xin Lin, Hua Xiang, Guoshun Luo · 2020 · European Journal of Medicinal Chemistry
  74. Smac Mimetic Increases Chemotherapy Response and Improves Survival in Mice with Pancreatic Cancer
    Sean Patrick Dineen, Christina Lynn Roland, Rachel M. Greer, Juliet G. Carbon, Jason E. Toombs, Puja K. Gupta, Nabeel M. Bardeesy, Haizhou Sun, Noelle Sevilir Williams, John Dorrance Minna et al. · 2010 · Cancer Research
  75. Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment
    Federica Cossu, Mario Milani, Eloise Mastrangelo, Daniele Lecis · 2019 · Computational and Structural Biotechnology Journal
  76. Macrophage and neutrophil death programs differentially confer resistance to tuberculosis
    Michael D. Stutz, Cody C. Allison, Samar Ojaimi, Simon Preston, Marcel Doerflinger, Philip Arandjelovic, Lachlan W. Whitehead, Stefanie M. Bader, Daniel Batey, Marie-Liesse Asselin-Labat et al. · 2021 · Immunity
  77. Mouse hepatocyte overexpression of NF‐κB‐inducing kinase (NIK) triggers fatal macrophage‐dependent liver injury and fibrosis
    Hong Shen, Liang Sheng, Zheng Chen, Lin Jiang, Haoran Su, Lei Yin, M. Bishr Omary, Liangyou Rui · 2014 · Hepatology
  78. Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation.
    Lorena A. Puto, John Calvin Reed · 2008 · Genes & Development
  79. Opposing Roles for TRAF1 in the Alternative versus Classical NF-κB Pathway in T Cells
    Ann J. McPherson, Laura M. Snell, Tak W. Mak, Tania H. Watts · 2012 · Journal of Biological Chemistry
  80. In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8
    Gentle, Ian E., Wong, W. Wei-Lynn, Evans, Joseph M., Bankovacki, Alexandra, Cook, Wendy D., Khan, Nufail R., Nachbur, Ulrich, Rickard, James, Anderton, Holly, Moulin, Maryline et al. · 2011 · Journal of Biological Chemistry
  81. Assembling the building blocks: structure and function of inhibitor of apoptosis proteins
    Peter D. Mace, Sarah Shirley, Catherine L. Day · 2009 · Cell Death and Differentiation
  82. Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma
    Yibin Yang, Priscilla N. Kelly, Arthur L. Shaffer, Roland Schmitz, Hee Min Yoo, Xinyue Liu, Da Wei Huang, Daniel E. Webster, Ryan M. Young, Masao Nakagawa et al. · 2016 · Cancer Cell
  83. Ubiquitin-mediated regulation of apoptosis
    Meike Broemer, Pascal Meier · 2009 · Trends in Cell Biology
  84. An Atypical E3 Ligase Zinc Finger Protein 91 Stabilizes and Activates NF-κB-inducing Kinase via Lys63-linked Ubiquitination
    Jin, Xuejun, Jin, Hong Ri, Jung, Haeng Sun, Lee, Se Jeong, Lee, Jeong-Hyung, Lee, Jung Joon · 2010 · Journal of Biological Chemistry
  85. Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection
    Aram Asatryan, Nicolas Guillermo Bazan · 2017 · Journal of Biological Chemistry
  86. TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8
    Aminah Ikner, Avi Ashkenazi · 2011 · Journal of Biological Chemistry
  87. Necroptosis pathways in tumorigenesis
    Tao Zhang, Yingnan Wang, Hiroyuki Inuzuka, Wenyi Wei · 2022 · Seminars in Cancer Biology
  88. NF-κB and cancer: a paradigm of Yin-Yang.
    Gutian Xiao, Jing Fu · 2011 · Europe PMC (PubMed Central)
  89. Ubiquitin-mediated regulation of TNFR1 signaling
    Ingrid E. Wertz, Vishva M. Dixit · 2008 · Cytokine & Growth Factor Reviews
  90. Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
    Giulia Furlan, Hirofumi Nakagami, Lennart Eschen‐Lippold, Xiyuan Jiang, Petra Majovsky, Kathrin Kowarschik, Wolfgang Hoehenwarter, Justin Lee, Marco Trujillo · 2017 · The Plant Cell
  91. The USP19 Deubiquitinase Regulates the Stability of c-IAP1 and c-IAP2
    Yide Mei, Allison Alcivar, Shimin Hu, Xiaolu Yang · 2011 · Journal of Biological Chemistry
  92. Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner
    Liane Wagner, Viola Marschall, Sabine Karl, Silvia Cristofanon, Kerry Zobel, Kurt Deshayes, Domagoj Vucic, Klaus‐Michael Debatin, Simone Fulda · 2012 · Oncogene
  93. Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures
    Sandra Gardam, Robert Adrian Brink · 2014 · Frontiers in Immunology
  94. Molecular cell death platforms and assemblies
    Peter D. Mace, Stefan J. Riedl · 2010 · Current Opinion in Cell Biology
  95. IAP antagonists: promising candidates for cancer therapy
    Raimund Mannhold, Simone Fulda, Emanuele Carosati · 2010 · Drug Discovery Today
  96. X-linked Inhibitor of Apoptosis: A Chemoresistance Factor or a Hollow Promise
    Hamid Kashkar · 2010 · Clinical Cancer Research
  97. Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked
    Sabine Hannes, Behnaz Ahangarian Abhari, Simone Fulda · 2016 · Cancer Letters
  98. Inhibitor of Apoptosis Proteins in Eukaryotic Evolution and Development: A Model of Thematic Conservation
    Mary X O’Riordan, Laura D. Bauler, Fiona L. Scott, Colin S. Duckett · 2008 · Developmental Cell
  99. Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis
    Ishita Gupta, Kanika Singh, Nishant Kumar Varshney, Sameena M. Khan · 2018 · Frontiers in Cell and Developmental Biology
  100. Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
    Erinna F. Lee, Peter E. Czabotar, Hong Jun Yang, Brad E. Sleebs, Guillaume Lessène, Peter M. Colman, Brian James Smith, Walter Douglas Fairlie · 2009 · Journal of Biological Chemistry