IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

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Smac Mimetic SM-164 Potentiates APO2L/TRAIL- and Doxorubicin-Mediated Anticancer Activity in Human Hepatocellular Carcinoma Cells

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Smac Mimetic Compounds Potentiate Interleukin-1β-mediated Cell Death

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Development of a peptide-based inducer of nuclear receptors degradation

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Translational strategies exploiting TNF-α that sensitize tumors to radiation therapy

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Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy

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CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells

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SMAC Mimetics as Therapeutic Agents in HIV Infection

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A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins

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Deubiquitinases in cell death and inflammation

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cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation

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Use of E2~Ubiquitin Conjugates for the Characterization of Ubiquitin Transfer by RING E3 Ligases Such as the Inhibitor of Apoptosis Proteins

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Control of NF-κB Activity by Proteolysis

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Regulation of antiapoptotic and cytoprotective pathways in colonic epithelial cells in ulcerative colitis

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cIAP-2 protects cardiac fibroblasts from oxidative damage: An obligate regulatory role for ERK1/2 MAPK and NF-κB

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Tristetraprolin controls the stability of cIAP2 mRNA through binding to the 3′UTR of cIAP2 mRNA

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Human serum-derived hydroxy long-chain fatty acids exhibit anti-inflammatory and anti-proliferative activity

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H. pylori infection confers resistance to apoptosis via Brd4-dependent BIRC3 eRNA synthesis

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Apoptosis repressor with caspase recruitment domain modulates second mitochondrial‐derived activator of caspases mimetic‐induced cell death through BIRC 2/ MAP 3K14 signalling in acute myeloid leukaemia

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Mouse lung fibroblasts are highly susceptible to necroptosis in a reactive oxygen species-dependent manner

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Time‐Dependent Inhibition and Induction of Human Cytochrome P4503A4/5 by an Oral IAP Antagonist, LCL161, In Vitro and In Vivo in Healthy Subjects

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cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation

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Smac Modulates Chemosensitivity in Head and Neck Cancer Cells through the Mitochondrial Apoptotic Pathway

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Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis

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Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death

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cIAP1/2–TRAF2–SHP-1–Src–MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages

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A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways

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The kinase NIK as a therapeutic target in multiple myeloma

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Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711

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Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways

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A Systematic Review of Apoptosis in Correlation With Cancer: Should Apoptosis Be the Ultimate Target for Cancer Treatment?

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Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells

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cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation

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Smac mimetic-induced upregulation of interferon-β sensitizes glioblastoma to temozolomide-induced cell death

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IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

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Roles of c-IAP Proteins in TNF Receptor Family Activation of NF-κB Signaling

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Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis

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IAPs as E3 ligases of Rac1

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An apoptosis-independent role of SMAC in tumor suppression

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H3K4me3 mediates the NF-κB p50 homodimer binding to thepdcd1promoter to activate PD-1 transcription in T cells

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Caspase-9 Activation by the Apoptosome Is Not Required for Fas-mediated Apoptosis in Type II Jurkat Cells

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Inhibitor of Apoptosis Proteins Determines Glioblastoma Stem-Like Cell Fate in an Oxygen-Dependent Manner

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Bufalin Induces Glioma Cell Death by Apoptosis or Necroptosis

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Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death

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Inhibiting the inhibitors: Development of the IAP inhibitor xevinapant for the treatment of locally advanced squamous cell carcinoma of the head and neck

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Inhibition of the Inflammatory Cytokine TNF-α Increases Adenovirus Activity in Ovarian Cancer via Modulation of cIAP1/2 Expression

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Protease Activity of the API2–MALT1 Fusion Oncoprotein in MALT Lymphoma Development and Treatment

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Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis

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Acute Sensitivity of Ph-like Acute Lymphoblastic Leukemia to the SMAC-Mimetic Birinapant

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TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling

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Smac mimetic with TNF-α targets Pim-1 isoforms and reactive oxygen species production to abrogate transformation from blebbishields

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Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes

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Current strategies to induce selective killing of HIV-1-infected cells

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Function, mechanism and drug discovery of ubiquitin and ubiquitin-like modification with multiomics profiling for cancer therapy

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Fn14 and TNFR2 as regulators of cytotoxic TNFR1 signaling

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SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells

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SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy

Rettinger, E., Glatthaar, A., Abhari, B. A., Oelsner, S., Pfirrmann, V., Huenecke, S., Kuçi, S., Kreyenberg, H., Willasch, A. M., Klingebiel, T. E., et al. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00075 · Cited by 21

Therapeutic opportunities for counteracting apoptosis resistance in childhood leukaemia

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Two distinct signalling cascades target the NF-κB regulatory factor c-IAP1 for degradation

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Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells

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Characterization of ML-IAP protein stability and physiological role in vivo

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Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface

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Smac mimetic LCL161 supports neuroblastoma chemotherapy in a drug class-dependent manner and synergistically interacts with ALK inhibitor TAE684 in cells with ALK mutation F1174L

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SMAC mimetics promote NIK-dependent inhibition of CD4 + T H 17 cell differentiation

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A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes

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cIAP-1 Controls Innate Immunity to C. pneumoniae Pulmonary Infection

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A novel antagonist to the inhibitors of apoptosis (IAPs) potentiates cell death in EGFR-overexpressing non-small-cell lung cancer cells

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Discovery of aminopiperidine-based Smac mimetics as IAP antagonists

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