The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Rapid, Transcription-Independent Loss of Nucleosomes over a Large Chromatin Domain at Hsp70 Loci
Open accessAbstract
SUMMARY To efficiently transcribe genes, RNA Polymerase II (Pol II) must overcome the barrier imposed by nucleosomes and higher order chromatin structure. Many genes, including Drosophila melanogaster Hsp70, undergo changes in chromatin structure upon activation. To characterize these changes, we mapped the nucleosome landscape of Hsp70 following an instantaneous heat shock at high spatial and unprecedented temporal resolution. Surprisingly, we find an initial disruption of nucleosomes across the entire gene within 30 seconds following activation, faster than the rate of Pol II transcription, followed by a second further disruption within 2 minutes. This initial change occurs independently of Pol II transcription. Furthermore, the rapid loss of nucleosomes extends beyond Hsp70 and halts at the scs and scs’ insulating elements. An RNAi screen of 28 transcription and chromatin-related factors reveal that depletion of heat shock factor, GAGA Factor, or Poly(ADP)-Ribose Polymerase or its activity abolishes the loss of nucleosomes upon Hsp70 activation.
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New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
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H2A.Z-containing nucleosomes mediate the thermosensory response in Arabidopsis
Kumar, S. V., & Wigge, P. A. (2010) · Cell · doi:10.1016/j.cell.2009.11.006 · Cited by 971
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
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Metadata
- Authors
- Petesch, S. J., & Lis, J. T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 134
- Issue
- 1
- Pages
- 74-84
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2053110665
- Cited by
- 317
- References
- 64
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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