The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity
Open accessAbstract
Summary Several cell-surface lipid-tethered proteins exhibit a concentration-independent, cholesterol-sensitive organization of nanoscale clusters and monomers. To understand the mechanism of formation of these clusters, we investigate the spatial distribution and steady-state dynamics of fluorescently tagged GPI-anchored protein nanoclusters using high-spatial and temporal resolution FRET microscopy. These studies reveal a nonrandom spatial distribution of nanoclusters, concentrated in optically resolvable domains. Monitoring the dynamics of recovery of fluorescence intensity and anisotropy, we find that nanoclusters are immobile, and the dynamics of interconversion between nanoclusters and monomers, over a range of temperatures, is spatially heterogeneous and non-Arrhenius, with a sharp crossover coinciding with a reduction in the activity of cortical actin. Cholesterol depletion perturbs cortical actin and the spatial scale and interconversion dynamics of nanoclusters. Direct perturbations of cortical actin activity also affect the construction, dynamics, and spatial organization of nanoclusters. These results suggest a unique mechanism of complexation of cell-surface molecules regulated by cortical actin activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757 · cited 1×
“Lateral segregation of specific molecules in the construction of signaling complexes and sorting platforms is the central idea behind rafts (Simons and Ikonen, 1997).”
BackgroundPrinciples of Condensed Matter Physics
Chaikin, P. M., & Lubensky, T. C. (1995) · Cambridge University Press eBooks · doi:10.1017/cbo9780511813467 · Cited by 3,503
Srimaroeng, C., Cecile, J. P., Walden, R., & Pritchard, J. B. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350077 · Cited by 2,989
Principles of Condensed Matter Physics
Chaikin, P. M., Lubensky, T. C., & Witten, T. A. (1995) · Physics Today · doi:10.1063/1.2808258 · Cited by 2,257
Model Systems, Lipid Rafts, and Cell Membranes
Simons, K., & Vaz, W. L. C. (2004) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.141803 · Cited by 1,670
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor
Straight, A. F., Cheung, A., Limouze, J., Chen, I., Westwood, N. J., Sellers, J. R., & Mitchison, T. J. (2003) · Science · doi:10.1126/science.1081412 · Cited by 1,412
The State of Lipid Rafts: From Model Membranes to Cells
Edidin, M. (2003) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.142439 · Cited by 1,341
GPI-anchored proteins are organized in submicron domains at the cell surface
Varma, R., & Mayor, S. (1998) · Nature · doi:10.1038/29563 · Cited by 1,209
Self-citationLipid rafts: at a crossroad between cell biology and physics
Jacobson, K., Mouritsen, O. G., & Anderson, R. G. W. (2007) · Nature Cell Biology · doi:10.1038/ncb0107-7 · Cited by 1,102
Advanced Time-Correlated Single Photon Counting Techniques
Becker, W. (2005) · Springer Series in Chemical Physics · doi:10.1007/3-540-28882-1 · Cited by 1,019
Cited by
Lipid rafts as a membrane-organizing principle
Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417
The mystery of membrane organization: composition, regulation and roles of lipid rafts
Sezgin, E., Levental, I., Mayor, S., & Eggeling, C. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.16 · Cited by 2,124
Self-citationThe Mechanics and Statistics of Active Matter
Ramaswamy, S. (2010) · Annual Review of Condensed Matter Physics · doi:10.1146/annurev-conmatphys-070909-104101 · Cited by 2,038
Revitalizing membrane rafts: new tools and insights
Simons, K., & Gerl, M. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2977 · Cited by 1,234
Signalling ballet in space and time
Kholodenko, B. N., Hancock, J. F., & Kolch, W. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2901 · Cited by 614
Metadata
- Authors
- Goswami, D., Gowrishankar, K., Bilgrami, S., Ghosh, S., Raghupathy, R., Chadda, R., Vishwakarma, R., Rao, M., & Mayor, S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 135
- Issue
- 6
- Pages
- 1085-1097
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2067346789
- Cited by
- 450
- References
- 33
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity. https://app.cochat.ai/papers/10.1016/j.cell.2008.11.032
- The paper
- Goswami, D., Gowrishankar, K., Bilgrami, S., Ghosh, S., Raghupathy, R., Chadda, R., Vishwakarma, R., Rao, M., & Mayor, S. (2008). Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity. Cell. https://doi.org/10.1016/j.cell.2008.11.032
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
