The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Hematopoietic Stem Cell Development Is Dependent on Blood Flow
Open accessAbstract
During vertebrate embryogenesis, hematopoietic stem cells (HSC) arise in the aorta-gonads-mesonephros (AGM) region. A zebrafish chemical genetic screen identified compounds that regulate blood flow as modulators of HSC formation. silent heart (sih) embryos that lack a heartbeat and blood circulation exhibited severely reduced HSCs. Blood flow modifiers exerted their effects after the onset of heartbeat; however, nitric oxide (NO) donors affected HSC induction even when treatment occurred prior to the initiation of circulation, and rescued HSCs in sih mutants. NO synthase (Nos) inhibitors and morpholino-knockdown of nos1 (nnos/enos) blocked HSC development. Embryonic transplantation assays demonstrated a cell-autonomous requirement for nos1. Nos3 (eNos) was expressed in HSCs in the murine AGM. Intrauterine Nos inhibition or Nos3 deficiency in mice resulted in the absence of hematopoietic clusters and reduced transplantable progenitors and HSCs. This work links blood flow to AGM hematopoiesis, and identifies NO as a conserved downstream regulator of HSC development.
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Citations
Cites
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Self-citationA role for Wnt signalling in self-renewal of haematopoietic stem cells
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Self-citationCbfa2 is required for the formation of intra-aortic hematopoietic clusters
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“Pulsatile flow achieved by a regular heartbeat has been shown to trigger NO production in the endothelium (White and Frangos, 2007).”
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Mechanical forces direct stem cell behaviour in development and regeneration
Vining, K. H., & Mooney, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.108 · Cited by 1,656
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
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Forcing cells to change lineages
Graf, T., & Enver, T. (2009) · Nature · doi:10.1038/nature08533 · Cited by 899
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
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McGrath, K. E., Frame, J. M., Fegan, K. H., Bowen, J. R., Conway, S. J., Catherman, S. C., Kingsley, P. D., Koniski, A. D., & Palis, J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.036 · Cited by 433
The Effects of Hemodynamic Force on Embryonic Development
CULVER, J. C., & DICKINSON, M. E. (2010) · Microcirculation · doi:10.1111/j.1549-8719.2010.00025.x · Cited by 173
The role of interferon-gamma in hematopoietic stem cell development, homeostasis, and disease
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Stress and non-stress roles of inflammatory signals during HSC Emergence and maintenance
Clapes, T., Lefkopoulos, S., & Trompouki, E. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00487 · Cited by 62
Metadata
- Authors
- North, T. E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A. M., Weber, G. J., Harris, J., Cutting, C. C., Huang, P., Dzierzak, E., & Zon, L. I.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 137
- Issue
- 4
- Pages
- 736-748
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2131404238
- Cited by
- 447
- References
- 7
- FWCI
- 23.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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