Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

MicroRNAs: Target Recognition and Regulatory Functions

Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948

Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855

Untitled work

(2008) · doi:10.1038/nrg2290 · Cited by 5,199

Alternative isoform regulation in human tissue transcriptomes

Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., Kingsmore, S. F., Schroth, G. P., & Burge, C. B. (2008) · Nature · doi:10.1038/nature07509 · Cited by 5,181

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766

RAS Is Regulated by the let-7 MicroRNA Family

Johnson, S., Großhans, H., Shingara, J., Byrom, M., JARVIS, R., Cheng, A., Labourier, E., Reinert, K. L., Brown, D., & Slack, F. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.014 · Cited by 3,699

A microRNA polycistron as a potential human oncogene

He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642

3′-UTR Shortening Contributes to Subtype-Specific Cancer Growth by Breaking Stable ceRNA Crosstalk of Housekeeping Genes

Fan, Z., Kim, S., Bai, Y., Diergaarde, B. B., Oesterreich, S., & Park, H. J. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00334 · Cited by 16

RNA epigenetic modifications as dynamic biomarkers in cancer: from mechanisms to clinical translation

Zhao, Y., Chen, X., Zhang, X., & Liu, H. (2025) · Biomarker Research · doi:10.1186/s40364-025-00794-y · Cited by 18

Decoding the interactions and functions of non-coding RNA with artificial intelligence

Jung, V., Vincent-Cuaz, C., Tumescheit, C., Fournier, L. M., Darsinou, M., Xu, Z. M., Saadat, A., Wang, Y., Tsantoulis, P. K., Michielin, O. A., et al. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00857-w · Cited by 18

CSTF2 Promotes Hepatocarcinogenesis and Hepatocellular Carcinoma Progression via Aerobic Glycolysis

Chen, Z., Hao, W., Tang, J., Gao, W., & Xu, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.897804 · Cited by 16

DNA methylation-activated full-length EMX1 facilitates metastasis through EMX1-EGFR-ERK axis in hepatocellular carcinoma

Wen, D.-S., Huang, L.-C., Bu, X., He, M., Lai, Z., Du, Z., Huang, Y., Kan, A., & Shi, M. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06293-y · Cited by 16

Regulation of lymphocyte development and function by RNA-binding proteins

Turner, M., & Hodson, D. J. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.01.011 · Cited by 16

A Global Analysis of Tandem 3′UTRs in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

Tian, P., Sun, Y., Li, Y., Liu, X., Wan, L., Li, J., Ma, Y., Xu, A., Fu, Y., & Zou, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048997 · Cited by 16

Perspectives of Integrative Cancer Genomics in Next Generation Sequencing Era

Kwon, S. M., Cho, H., Choi, J. H., Jee, B. A., Jo, Y., & Woo, H. G. (2012) · Genomics & Informatics · doi:10.5808/gi.2012.10.2.69 · Cited by 16

Distinct genome‐wide alternative polyadenylation during the response to silicon availability in the marine diatom Thalassiosira pseudonana

Fu, H., Wang, P., Wu, X., Zhou, X., Ji, G., Shen, Y., Gao, Y., Li, Q. Q., & Liang, J. (2019) · The Plant Journal · doi:10.1111/tpj.14309 · Cited by 16

Click-encoded rolling FISH for visualizing single-cell RNA polyadenylation and structures

Chen, F., Bai, M., Cao, X., Zhao, Y., Xue, J., & Zhao, Y. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz852 · Cited by 16

Identification of cyclin D1 as a major modulator of 3-nitropropionic acid-induced striatal neurodegeneration

Dietrich, P., Alli, S., Mulligan, M. K., Cox, R., Ashbrook, D. G., Williams, R. W., & Dragatsis, I. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105581 · Cited by 16

Male-specific splicing of the silkworm Imp gene is maintained by an autoregulatory mechanism

Suzuki, M. G., Kobayashi, S., & Aoki, F. (2013) · Mechanisms of Development · doi:10.1016/j.mod.2013.10.004 · Cited by 16

Alternative Polyadenylation of Tumor Suppressor Genes in Small Intestinal Neuroendocrine Tumors

Rehfeld, A., Plass, M., Døssing, K. B. V., Knigge, U., Kjær, A., Krogh, A., & Friis-Hansen, L. J. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00046 · Cited by 16

Regulation of AGR2 expression via 3’UTR shortening

Matoulková, E., Sommerová, L., Pastorek, M., Vojtěšek, B., & Hrstka, R. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.04.011 · Cited by 17

Interplay between splicing and transcriptional pausing exerts genome-wide control over alternative polyadenylation

Gallardo, C. M., de Diego, A. S., Martínez‐A, C., & van Wely, K. H. M. (2021) · Transcription · doi:10.1080/21541264.2021.1959244 · Cited by 15

MCL1 alternative polyadenylation is essential for cell survival and mitochondria morphology

Pereira‐Castro, I., García, B., Curinha, A., Neves‐Costa, A., Conde‐Sousa, E., Moita, L. F., & Moreira, A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04172-x · Cited by 16

The role and impact of alternative polyadenylation and miRNA regulation on the expression of the multidrug resistance-associated protein 1 (MRP-1/ABCC1) in epithelial ovarian cancer

Marjamaa, A., Gibbs, B. E., Kotrba, C., & Masamha, C. P. (2023) · Scientific Reports · doi:10.1038/s41598-023-44548-y · Cited by 15

Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis

Liu, X., Xie, H., Liu, W., Zuo, J. J., Li, S., Tian, Y., Zhao, J., Bai, M., Li, J., Bao, L., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114525 · Cited by 18

Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Haberman, N., Digby, H., Faraway, R., Cheung, R., Chakrabarti, A. M., Jobbins, A. M., Parr, C., Yasuzawa, K., Kasukawa, T., Yip, C. W., et al. (2024) · BMC Biology · doi:10.1186/s12915-024-02032-7 · Cited by 15

CSTF2 Supports Hypoxia Tolerance in Hepatocellular Carcinoma by Enabling m6A Modification Evasion of PGK1 to Enhance Glycolysis

Zhang, Q., Zhang, Y., Fu, C., He, X., Huang, Z., Wu, G., Wei, T., Jin, W., Yan, L., Wu, M., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-2283 · Cited by 15

Inhibition of mitochondrial genome-encoded mitomiR-3 contributes to ZEB1 mediated GPX4 downregulation and pro-ferroptotic lipid metabolism to induce ferroptosis in breast cancer cells

Kandettu, A., Ghosal, J., Tharayil, J. S., Kuthethur, R., Mallya, S. P., Narasimhamurthy, R. K., Mumbrekar, K. D., Subbannayya, Y., Kumar, N. A. N., Radhakrishnan, R. A., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.04.019 · Cited by 17

SVD Identifies Transcript Length Distribution Functions from DNA Microarray Data and Reveals Evolutionary Forces Globally Affecting GBM Metabolism

Bertagnolli, N. M., Drake, J. A., Tennessen, J. M., & Alter, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078913 · Cited by 15

The SNAI1 3′UTR functions as a sponge for multiple migration-/invasion-related microRNAs

Li, J., Yu, H., Xi, M., Ma, D., & Lu, X. (2014) · Tumor Biology · doi:10.1007/s13277-014-2733-z · Cited by 15

Hip flexion weakness is associated with impaired mobility in oculopharyngeal muscular dystrophy: A retrospective study with implications for trial design

Youssof, S., Schrader, R., Bear, D. G., & Morrison, L. A. (2014) · Neuromuscular Disorders · doi:10.1016/j.nmd.2014.11.010 · Cited by 15

miRSeqNovel: An R based workflow for analyzing miRNA sequencing data

Qian, K., Auvinen, E., Greco, D., & Auvinen, P. (2012) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2012.05.002 · Cited by 15

Alternative Polyadenylation in Glioblastoma Multiforme and Changes in Predicted RNA Binding Protein Profiles

Shao, J., Zhang, J., Zhang, Z., Jiang, H., Lou, X., Huang, B., Foltz, G., Lan, Q., Huang, Q., & Lin, B. (2013) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2012.0098 · Cited by 15

Ultrasensitive electrochemical detection of Dicer1 3′UTR for the fast analysis of alternative cleavage and polyadenylation

Zhao, H., Liu, F., Wu, S., Yang, L., Zhang, Y., & Li, C.-P. (2017) · Nanoscale · doi:10.1039/c6nr09300k · Cited by 15

Evolutionary and functional implications of 3′ untranslated region length of mRNAs by comprehensive investigation among four taxonomically diverse metazoan species

Wang, W., Fang, D., Gan, J., Shi, Y., Tang, H., Wang, H., Fu, M., & Yi, J. (2019) · Genes & Genomics · doi:10.1007/s13258-019-00808-8 · Cited by 14

Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease

Jordan, P., Gonçalves, V., Fernandes, S., Marques, T. M., Pereira, M. H. N., & Gama‐Carvalho, M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-19966-1_1 · Cited by 16

Single-cell alternative polyadenylation analysis delineates GABAergic neuron types

Yang, Y., Paul, A., Bach, T. N., Huang, Z. J., & Zhang, M. Q. (2021) · BMC Biology · doi:10.1186/s12915-021-01076-3 · Cited by 15

New technologies for improved relevance in miRNA research

Jacquet, K., Vidal-Cruchez, O., Rezzonico, R., Nicolini, V. J., Mograbi, B., Hofman, P. M., Vassaux, G., Mari, B. P., & Brest, P. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.08.006 · Cited by 15

Lung cancer cells expressing a shortened CDK16 3′UTR escape senescence through impaired miR‐485‐5p targeting

Jia, Q., Xie, B., Zhao, Z., Huang, L., Wei, G., & Ni, T. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13125 · Cited by 16

Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis

Desi, N., Tong, Q. Y., Teh, V., Chan, J. J., Zhang, B., Tabatabaeian, H., Tan, H. Q., Kapeli, K., Jin, W., Lim, C. Y., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04093-1 · Cited by 15

Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration

Wang, L., Lin, C., Lin, Y.-M., Buée, L., Sergeant, N., Blum, D. L., Chern, Y., & Wang, G. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.2006-21.2022 · Cited by 19

Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade

Tseng, H.-W., Mota-Sydor, A., Leventis, R., Jovanović, P., Topisirović, I., & Duchaîne, T. F. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac704 · Cited by 15

Comprehensive mapping of alternative polyadenylation site usage and its dynamics at single-cell resolution

Wang, J., Chen, W., Yue, W., Hou, W., Rao, F., Zhong, H., Qi, Y., Hong, N., Ni, T., & Jin, W. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113504119 · Cited by 16

Transcriptional activators enhance polyadenylation of mRNA precursors

Nagaike, T., & Manley, J. L. (2011) · RNA Biology · doi:10.4161/rna.8.6.17210 · Cited by 15

Genome-Wide Analysis of Polyadenylation Events in Schmidtea mediterranea

Lakshmanan, V., Bansal, D., Kulkarni, J., Poduval, D. B., Gopinath, S. K., Sasidharan, V., Anand, P., Seshasayee, A. S. N., & Palakodeti, D. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.031120 · Cited by 14

Imaging Organization of RNA Processing within the NucleusPreprint

Biswas, J., Li, W., Singer, R. H., & Coleman, R. A. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a039453 · Cited by 15

Modulation of diverse biological processes by CPSF, the master regulator of mRNA 3′ ends

Liu, L., & Manley, J. L. (2024) · RNA · doi:10.1261/rna.080108.124 · Cited by 14

Crosstalk Between mRNA 3'-End Processing and Epigenetics

Soles, L. V., & Shi, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.637705 · Cited by 14

Alternative polyadenylation is a determinant of oncogenic Ras function

Subramanian, A., Hall, M., Hou, H., Mufteev, M., Yu, B., Yuki, K. E., Nishimura, H., Sathaseevan, A., Lant, B., Zhai, B., et al. (2021) · Science Advances · doi:10.1126/sciadv.abh0562 · Cited by 15

REPAC: analysis of alternative polyadenylation from RNA-sequencing data

Imada, E. L., Wilks, C., Langmead, B., & Marchionni, L. (2023) · Genome biology · doi:10.1186/s13059-023-02865-5 · Cited by 14

Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages

Wilton, J., de Mendonça, F. L., Pereira‐Castro, I., Tellier, M., Nojima, T., Costa, Â. M., Freitas, J., Murphy, S., Oliveira, M. J., Proudfoot, N. J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1182525 · Cited by 14

Multiplexed screening reveals how cancer-specific alternative polyadenylation shapes tumor growth in vivo

Gabel, A. M., Belleville, A. E., Thomas, J. D., McKellar, S. A., Nicholas, T. R., Banjo, T., Crosse, E. I., & Bradley, R. K. (2024) · Nature Communications · doi:10.1038/s41467-024-44931-x · Cited by 15

Using synthetic RNA to benchmark poly(A) length inference from direct RNA sequencing

Chang, J. J. ‐., Yang, X., Teng, H., Zhang, J., Reames, B., Zhang, S., Corbin, V., & Coin, L. (2025) · GigaScience · doi:10.1093/gigascience/giaf098 · Cited by 13

The Role of CYP3A4 mRNA Transcript with Shortened 3′-Untranslated Region in Hepatocyte Differentiation, Liver Development, and Response to Drug Induction

Li, D., Gaedigk, R., Hart, S. N., Leeder, J. S., & Zhong, X.-B. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.074393 · Cited by 14

Expression of Rac1 alternative 3′ UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons

Bráz, S., Cruz, A., Lobo, A. C., Bravo, J., Moreira-Ribeiro, J., Pereira‐Castro, I., Freitas, J., Relvas, J. B., Summavielle, T., & Moreira, A. (2017) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2017.03.002 · Cited by 13

Arginylation regulates adipogenesis by regulating expression of PPARγ at transcript and protein level

Singh, A., Borah, A. K., Deka, K., Gogoi, A. P., Verma, K., Barah, P., & Saha, S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.12.015 · Cited by 14

Alternative Splicing of MXD3 and Its Regulation of MXD3 Levels in Glioblastoma

Ngo, T., Corrales, A., Bourne, T., Elmojahid, S., Lam, K. S., & Dı́az, E. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00005 · Cited by 14

Endothelin-Converting Enzyme-1 (ECE-1) Is Post-Transcriptionally Regulated by Alternative Polyadenylation

Whyteside, A. R., Turner, A. J., & Lambert, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083260 · Cited by 14

Knockout of miR-221 and miR-222 reveals common and specific targets for paralogous miRNAs

Jeong, G. H., Lim, Y.-H., Kim, N. J., Wee, G., & Kim, Y. (2016) · RNA Biology · doi:10.1080/15476286.2016.1269994 · Cited by 14

Dysfunctional transcripts are formed by alternative polyadenylation in OPMD

Raz, V., Dickson, G., & Hoen, P. A. C. ’. (2017) · Oncotarget · doi:10.18632/oncotarget.20640 · Cited by 14

Nuclear Phosphatidylinositol-Phosphate Type I Kinase α-Coupled Star-PAP Polyadenylation Regulates Cell Invasion

Parambil, S. A., & Laishram, R. S. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00457-17 · Cited by 14

Alteration in microRNA‐17‐92 dynamics accounts for differential nature of cellular proliferation

Sengupta, D., Govindaraj, V., & Kar, S. (2018) · FEBS Letters · doi:10.1002/1873-3468.12974 · Cited by 14

Ethylene Prunes Translation

Salehin, M., & Estelle, M. A. (2015) · Cell · doi:10.1016/j.cell.2015.10.032 · Cited by 14

Developmentally regulated alternate 3′ end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineagePreprint

Berry, C. W., Olivares, G. H., Gallicchio, L., Ramaswami, G., Glavic, Á., Olguı́n, P., Li, J. B., & Fuller, M. T. (2022) · Genes & Development · doi:10.1101/gad.349689.122 · Cited by 14

Alternative polyadenylation in cancer: Molecular mechanisms and clinical application

Zhang, Y., Huang, Z., Lu, W., & Liu, Z. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104599 · Cited by 13

FilTar: using RNA-Seq data to improve microRNA target prediction accuracy in animals

Bradley, T., & Moxon, S. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa007 · Cited by 13

Cell-type-specific alternative polyadenylation promotes oncogenic gene expression in non-small cell lung cancer progression

Huang, K., Zhang, Y., Shi, X., Yin, Z., Zhao, W., Huang, L., Wang, F., & Zhou, X. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.08.005 · Cited by 14

PABPN1 loss-of-function causes APA-shift in oculopharyngeal muscular dystrophy

Shademan, M., Mei, H., van Engelen, B. G. M., Ariyürek, Y., Kloet, S. L., & Raz, V. (2024) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2024.100269 · Cited by 13

Viral miRNA targeting of bicistronic and polycistronic transcripts

Zhu, Y., Huang, Y., Jung, J. U., Lu, C., & Gao, S. (2014) · Current Opinion in Virology · doi:10.1016/j.coviro.2014.04.004 · Cited by 12

Expression of Multiple engrailed Family Genes in Eyespots of Bicyclus anynana Butterflies Does Not Implicate the Duplication Events in the Evolution of This Morphological Novelty

Banerjee, T. D., Ramos, D., & Monteiro, A. (2020) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2020.00227 · Cited by 11

Shortening of HO1 3′UTRs by Alternative Polyadenylation Suppresses Adipogenesis in 3T3-L1

Cui, J., Li, C., Cui, X., Liu, X., Meng, C., & Zhou, G. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c01822 · Cited by 13

MicroRNA-mediated posttranscriptional mechanisms of gene expression in proliferating and quiescent cancer cells

Tonquèze, O. L., Lee, J., & Vasudevan, S. (2012) · RNA Biology · doi:10.4161/rna.20806 · Cited by 16

The landscape of alternative splicing in buccal mucosa squamous cell carcinoma

Shah, T. M., Patel, A. K., Bhatt, V. D., Tripathi, A. K., Shah, S., Shankar, V., & Joshi, C. G. (2013) · Oral Oncology · doi:10.1016/j.oraloncology.2013.03.431 · Cited by 13

Alternative polyadenylation can regulate post-translational membrane localization.

Mitra, M., Johnson, E. L., & Coller, H. A. (2015) · PubMed · Cited by 13

Genome-Wide Analysis and Functional Characterization of the Polyadenylation Site in Pigs Using RNAseq Data

Wang, H., Li, R., Zhou, X., Xue, L., Xu, X., & Liu, B. (2016) · Scientific Reports · doi:10.1038/srep36388 · Cited by 13

Cellular Localization and Regulation of Expression of the PLET1 Gene in Porcine Placenta

Liu, T., Hong, L., Liu, R., Chen, R., Li, X., & Yu, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122048 · Cited by 13

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

Wu, Q., Ferry, Q. R. V., Baeumler, T. A., Michaels, Y. S., Vitsios, D., Habib, O., Arnold, R. R., Jiang, X., Maio, S., Steinkraus, B. R., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00686-2 · Cited by 13

Shortening of 3′ UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolism

Bürri, D., & Zavolan, M. (2021) · RNA · doi:10.1261/rna.078886.121 · Cited by 14

mRNA isoform balance in neuronal development and disease

LaForce, G. R., Philippidou, P., & Schaffer, A. E. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1762 · Cited by 15

Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency

Homa, N. J., Salinas, R., Forte, E., Robinson, T. J., García-Blanco, M. A., & Luftig, M. A. (2013) · Journal of Virology · doi:10.1128/jvi.02464-13 · Cited by 13

Regulation of CYP24 splicing by 1,25-dihydroxyvitamin D3 in human colon cancer cells

Peng, X., Tiwari, N., Roy, S., Yuan, L., Murillo, G., Mehta, R. R., Benya, R. V., & Mehta, R. G. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0305 · Cited by 13

Dynamic Regulation of Tandem 3′ Untranslated Regions in Zebrafish Spleen Cells during Immune Response

Huang, G., Huang, S., Wang, R., Yan, X., Li, Y., Feng, Y., Wang, S., Yang, X., Chen, L., Li, J., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500847 · Cited by 13

3’UTR cleavage of transcripts localized in axons of sympathetic neuronsPreprint

Andreassi, C., Luisier, R., Crerar, H., Blokzijl-Franke, S., Luscombe, N. M., Cuda, G., Gaspari, M., & Riccio, A. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/170100 · Cited by 15

3′ UTRs Regulate Protein Functions by Providing a Nurturing Niche during Protein SynthesisPreprint

Mayr, C. (2019) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2019.84.039206 · Cited by 13

Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer

Vodička, P., Pardini, B., Vymetalkova, V. P., & Naccarati, A. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-42059-2_7 · Cited by 12

Sequential Polyadenylation to Enable Alternative mRNA 3’ End Formation

Hao, Y., Cai, T., Liu, C., Zhang, X., & Fu, X. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.2176 · Cited by 12

Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A

Cacioppo, R., Akman, H. B., Tuncer, T., Erson-Bensan, A. E., & Lindon, C. (2023) · eLife · doi:10.7554/elife.87253 · Cited by 15

PABPN1 promotes clear cell renal cell carcinoma progression by suppressing the alternative polyadenylation of SGPL1 and CREG1

Xiong, M., Liu, C., Li, W., Jiang, H., Long, W., Zhou, M., Yang, C., Kazobinka, G., Sun, Y., Zhao, J., et al. (2023) · Carcinogenesis · doi:10.1093/carcin/bgad049 · Cited by 12

Biomarkers in acute myeloid leukemia: From state of the art in risk classification to future challenges of RNA editing as disease predictor and therapy target

Quattrocchi, A., Cappelli, L. V., Simone, G. D., Marinis, E. D., Gentile, M., Gasperi, T., Pulsoni, A., Ascenzi, P., & Nervi, C. (2023) · Aspects of Molecular Medicine · doi:10.1016/j.amolm.2023.100023 · Cited by 12

Poly(A) tale: From A to A; RNA polyadenylation in prokaryotes and eukaryotes

Mofayezi, A., Jadaliha, M., Zangeneh, F., & Khoddami, V. (2024) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1837 · Cited by 12

Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate

Geisberg, J. V., Moqtaderi, Z., & Struhl, K. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2405827121 · Cited by 12

PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency

Chen, M., Hsu, W.-C., Hsu, S., Yang, Y.-S., Chuang, T., Lin, W., Tan, T., & Su, Y. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0199-z · Cited by 12

Ultrasensitive electrochemical detection of alternative cleavage and polyadenylation of CCND2 gene at the single-cell level

Zhao, H., Liu, F., Lu, Y., Jin, L. J., Tan, S., Zhang, Y., & Li, C.-P. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.01.071 · Cited by 12

Multifaceted control of mRNA translation machinery in cancer

Alboushi, L., Hackett, A. P., Naeli, P., Bakhti, M., & Jafarnejad, S. M. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110037 · Cited by 13

Cancer research: A hurdle race

Lichtenstein, A. V. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914050010 · Cited by 12

A Distinct Expression Pattern of the Long 3′-Untranslated Region Dicer mRNA and Its Implications for Posttranscriptional Regulation in Colorectal Cancer

Hamaya, Y., Kuriyama, S., Takai, T., Yoshida, K.-I., Yamada, T., Sugimoto, M., Osawa, S., Sugimoto, K., Miyajima, H., & Kanaoka, S. (2012) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2012.12 · Cited by 12

Cis-acting elements in its 3′ UTR mediate post-transcriptional regulation ofKRAS

Kim, M., Kogan, N., & Slack, F. J. (2016) · Oncotarget · doi:10.18632/oncotarget.7599 · Cited by 12

Genome-wide atlas of alternative polyadenylation in the forage legume red clover

Chakrabarti, M., Dinkins, R. D., & Hunt, A. G. (2018) · Scientific Reports · doi:10.1038/s41598-018-29699-7 · Cited by 12

Detection of Differentially Expressed Cleavage Site Intervals Within 3′ Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs

Harrison, B. J., Park, J. W., Gomes, C., Petruska, J. C., Sapio, M. R., Iadarola, M. J., Chariker, J. H., & Rouchka, E. C. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00182 · Cited by 12

Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells

Emmerich, A. C., Wellstein, J., Ossipova, E., Baumann, I., Lengqvist, J., Kultima, K., Jakobsson, P., Steinhilber, D., & Saul, M. J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00196 · Cited by 12

Application of Transcriptional Gene Modules to Analysis of Caenorhabditis elegans’ Gene Expression Data

Cary, M. P., Podshivalova, K., & Kenyon, C. J. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.120.401270 · Cited by 12

3′ Untranslated Regions Are Modular Entities That Determine Polyadenylation Profiles

Lui, K. H., Geisberg, J. V., Moqtaderi, Z., & Struhl, K. (2022) · Molecular and Cellular Biology · doi:10.1128/mcb.00244-22 · Cited by 11

Is Transcription the Dominant Force During Dynamic Changes in Gene Expression?

Turner, M. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-5632-3_1 · Cited by 13

Bioinformatics Tools for RNA-seq Gene and Isoform Quantification

Zhang, C., Zhang, B., Vincent, M. S., & Zhao, S. (2016) · Journal of Next Generation Sequencing & Applications · doi:10.4172/2469-9853.1000140 · Cited by 10

The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium

Desi, N., & Tay, Y. (2019) · Cells · doi:10.3390/cells8121634 · Cited by 12

Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal developmentPreprint

Chen, F., Zhou, Y., Qi, Y. B., Khivansara, V., Li, H., Chun, S. Y., Kim, J. K., Fu, X., & Jin, Y. (2015) · Genes & Development · doi:10.1101/gad.266650.115 · Cited by 12

UTR cutbacks give free rein to oncogenes

Atkinson, S. R. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2668 · Cited by 1

Lengthening of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation Is Associated With Tumor Progression and Poor Prognosis of Clear Cell Renal Cell Carcinoma

Zhang, F., Chen, L., Li, W., Yang, C., Xiong, M., Zhou, M., Kazobinka, G., Zhao, J., & Hou, T. (2023) · Laboratory Investigation · doi:10.1016/j.labinv.2023.100125 · Cited by 4

The 3′ UTR Landscape in Cancer

Schmidt, R., Ghosh, S., & Zavolan, M. (2018) · Wiley eBooks · doi:10.1002/9780470015902.a0027958 · Cited by 3

Resolving the complexity of the cancer transcriptome through 3’ UTRs

Erson-Bensan, A. E. (2017) · OpenMETU (Middle East Technical University)

Abstract A14: Alternative polyadenylation drives oncogenic gene expression in pancreatic cancer

Venkat, S., Tisdale, A. A., Eng, K. H., & Feigin, M. E. (2019) · Cancer Research · doi:10.1158/1538-7445.panca19-a14