Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

MicroRNAs: Target Recognition and Regulatory Functions

Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948

Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855

Untitled work

(2008) · doi:10.1038/nrg2290 · Cited by 5,199

Alternative isoform regulation in human tissue transcriptomes

Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., Kingsmore, S. F., Schroth, G. P., & Burge, C. B. (2008) · Nature · doi:10.1038/nature07509 · Cited by 5,181

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766

RAS Is Regulated by the let-7 MicroRNA Family

Johnson, S., Großhans, H., Shingara, J., Byrom, M., JARVIS, R., Cheng, A., Labourier, E., Reinert, K. L., Brown, D., & Slack, F. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.014 · Cited by 3,699

A microRNA polycistron as a potential human oncogene

He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642

Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation

Thomas, L. F., & Sætrom, P. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002621 · Cited by 49

Disruption of microRNA nuclear transport in human cancer

Melo, S. A., & Esteller, M. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.02.012 · Cited by 48

Multi-disciplinary methods to define RNA–protein interactions and regulatory networks

Ascano, M., Gerstberger, S. C., & Tuschl, T. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.01.003 · Cited by 48

Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies

Sun, Y., Fu, Y., Li, Y., & Xu, A. (2012) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs041 · Cited by 48

Alterations in Polyadenylation and Its Implications for Endocrine Disease

Rehfeld, A., Plass, M., Krogh, A., & Friis-Hansen, L. J. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00053 · Cited by 52

Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells

Tan, S. H., Ding, K., Chong, Q.-Y., Zhao, J., Liu, Y., Shao, Y., Zhang, Y., Yu, Q., Xiong, Z., Zhang, W., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.780973 · Cited by 48

FNDC3B 3′‐UTR shortening escapes from microRNA‐mediated gene repression and promotes nasopharyngeal carcinoma progression

Li, Y., Chen, Y., Xu, Y., He, Q., Yang, X., Li, Y., Hong, X.-H., Huang, S., Tang, L., & Liu, N. (2020) · Cancer Science · doi:10.1111/cas.14394 · Cited by 48

Computational meta-analysis of ribosomal RNA fragments: potential targets and interaction mechanisms

Guan, L., & Grigoriev, A. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab190 · Cited by 49

The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function

Blake, D., & Lynch, K. W. (2021) · Immunological Reviews · doi:10.1111/imr.13018 · Cited by 49

Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblastsPreprint

Gurtan, A. M., Ravi, A., Rahl, P. B., Bosson, A., JnBaptiste, C. K., Bhutkar, A. J., Whittaker, C. A., Young, R. A., & Sharp, P. A. (2013) · Genes & Development · doi:10.1101/gad.215376.113 · Cited by 45

The transcriptional elongation rate regulates alternative polyadenylation in yeast

Geisberg, J. V., Moqtaderi, Z., & Struhl, K. (2020) · eLife · doi:10.7554/elife.59810 · Cited by 45

From cellular senescence to age-associated diseases: the miRNA connection

Schraml, E., & Grillari, J. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-10 · Cited by 47

A precursor microRNA in a cancer cell nucleus

Melo, S. A., & Esteller, M. (2011) · Cell Cycle · doi:10.4161/cc.10.6.15119 · Cited by 47

An analysis of the role of HnRNP C dysregulation in cancers

Mo, L., Meng, L., Huang, Z.-C., Yi, L., Yang, N., & Li, G. (2022) · Biomarker Research · doi:10.1186/s40364-022-00366-4 · Cited by 50

Regulation and function of alternative polyadenylation in development and differentiation

Gallicchio, L., Olivares, G. H., Berry, C. W., & Fuller, M. T. (2023) · RNA Biology · doi:10.1080/15476286.2023.2275109 · Cited by 49

What’s the target: understanding two decades of in silico microRNA-target prediction

Kern, F., Backes, C., Hirsch, P., Fehlmann, T., Hart, M., Meese, E. U., & Keller, A. (2019) · Briefings in Bioinformatics · doi:10.1093/bib/bbz111 · Cited by 47

Integrative Analysis of Cancer-Related Signaling Pathways

Keßler, T., Hache, H., & Wierling, C. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00124 · Cited by 54

Global estimation of the 3′ untranslated region landscape using RNA sequencing

Kim, M.-H., Yu, B., & Nam, J. (2015) · Methods · doi:10.1016/j.ymeth.2015.04.011 · Cited by 47

CD5 expression is regulated during human T‐cell activation by alternative polyadenylation, PTBP1, and miR‐204

Domingues, R. G., Lago‐Baldaia, I., Pereira‐Castro, I., Fachini, J. M., Oliveira, L., Drpic, D., Lopes, N., Henriques, T., Neilson, J. R., Carmo, A. M., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201545663 · Cited by 46

Factors Regulating microRNA Expression and Function in Multiple Myeloma

Misiewicz-Krzemińska, I., Krzemiński, P., Corchete, L. A., Quwaider, D., Rojas, E. A., Herrero, A. B., & Gutierrez, N. C. (2019) · Non-Coding RNA · doi:10.3390/ncrna5010009 · Cited by 48

A comprehensive expression landscape of RNA-binding proteins (RBPs) across 16 human cancer types

Zhang, B., Babu, K. R., Lim, C. Y., Kwok, Z. H., Li, J., Zhou, S., Yang, H. H., & Tay, Y. (2019) · RNA Biology · doi:10.1080/15476286.2019.1673657 · Cited by 50

CPSF6 regulates alternative polyadenylation and proliferation of cancer cells through phase separation

Liu, S., Wu, R., Chen, L., Deng, K., Ou, X., Lu, X., Li, M., Liu, C., Chen, S., Fu, Y., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113197 · Cited by 47

The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking

Neumann, D., Pillman, K. A., Dredge, B. K., Bert, A. G., Phillips, C. A., Lumb, R., Ramani, Y., Bracken, C. P., Hollier, B. G., Selth, L. A., et al. (2023) · RNA Biology · doi:10.1080/15476286.2023.2294222 · Cited by 45

Posttranscriptional Regulation of PTEN Dosage by Noncoding RNAs

He, L. (2010) · Science Signaling · doi:10.1126/scisignal.3146pe39 · Cited by 46

Distinct polyadenylation landscapes of diverse human tissues revealed by a modified PA-seq strategy

Ni, T., Yang, Y., Hafez, D., Yang, W., Kiesewetter, K., Wakabayashi, Y., Ohler, U., Peng, W., & Zhu, J. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-615 · Cited by 45

Heterogeneity in mammalian RNA 3′ end formation

Neilson, J. R., & Sandberg, R. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.02.040 · Cited by 45

αCP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation

Ji, X., Wan, J., Vishnu, M. R., Xing, Y., & Liebhaber, S. A. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01380-12 · Cited by 45

Context-specific microRNA function in developmental complexity

Carroll, A. P., Tooney, P. A., & Cairns, M. J. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt004 · Cited by 45

CFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function

Masamha, C. P., Xia, Z., Peart, N. J., Collum, S. D., Li, W., Wagner, E. J., & Shyu, A. (2016) · RNA · doi:10.1261/rna.055939.116 · Cited by 44

Roles of RNA-binding Proteins and Post-transcriptional Regulation in Driving Male Germ Cell Development in the Mouse

Licatalosi, D. D. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-29073-7_6 · Cited by 46

Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns

Movassat, M., Crabb, T. L., Busch, A., Yao, C., Reynolds, D. J., Shi, Y., & Hertel, K. J. (2016) · RNA Biology · doi:10.1080/15476286.2016.1191727 · Cited by 45

The differential expression of alternatively polyadenylated transcripts is a common stress-induced response mechanism that modulates mammalian mRNA expression in a quantitative and qualitative fashion

Hollerer, I., Curk, T., Haase, B., Beneš, V., Hauer, C., Neu‐Yilik, G., Bhuvanagiri, M., Hentze, M. W., & Kulozik, A. E. (2016) · RNA · doi:10.1261/rna.055657.115 · Cited by 49

MicroRNA Cancer Regulation

Schmitz, U., Wolkenhauer, O., & Vera, J. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-5590-1 · Cited by 56

Alterations in mRNA 3′ UTR Isoform Abundance Accompany Gene Expression Changes in Human Huntington’s Disease Brains

Romo, L., Ashar-Patel, A., Pfister, E. L., & D, N. A. M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.009 · Cited by 47

Alternative polyadenylation factors link cell cycle to migration

Mitra, M., Johnson, E. L., Swamy, V. S., Nersesian, L., Corney, D. C., Robinson, D. G., Taylor, D. G., Ambrus, A., Jelínek, D., Wang, W., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1551-9 · Cited by 42

A change-point model for identifying 3′UTR switching by next-generation RNA sequencing

Wang, W., Wei, Z., & Li, H. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu189 · Cited by 45

MicroRNAs and Their Targets Are Differentially Regulated in Adult and Neonatal Mouse CD8+ T Cells

Wissink, E. M., Smith, N. L., Spektor, R., Rudd, B. D., & Grimson, A. (2015) · Genetics · doi:10.1534/genetics.115.179176 · Cited by 45

Experimental Genome-Wide Determination of RNA Polyadenylation in Chlamydomonas reinhardtii

Bell, S. A., Shen, C., Brown, A., & Hunt, A. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146107 · Cited by 44

The reciprocal regulation between splicing and 3′‐end processing

Kaida, D. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1348 · Cited by 47

Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases

Li, W., Li, W., Laishram, R. S., Hoque, M., Ji, Z., Tian, B., & Anderson, R. A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx560 · Cited by 45

Environmental influences on RNA processing: Biochemical, molecular and genetic regulators of cellular response

Pai, A. A., & Luca, F. (2018) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1503 · Cited by 48

Role of alternative polyadenylation dynamics in acute myeloid leukaemia at single-cell resolution

Ye, C., Zhou, Q., Hong, Y., & Li, Q. Q. (2019) · RNA Biology · doi:10.1080/15476286.2019.1586139 · Cited by 43

Dietary restriction induces posttranscriptional regulation of longevity genes

(2019) · doi:10.26508/lsa.201800281 · Cited by 44

PlantAPAdb: A Comprehensive Database for Alternative Polyadenylation Sites in Plants

Zhu, S. Z., Ye, W., Ye, L., Fu, H., Ye, C., Xiao, X., Ji, Y., Lin, W., Ji, G., & Wu, X. (2019) · PLANT PHYSIOLOGY · doi:10.1104/pp.19.00943 · Cited by 44

CPSF7 regulates liver cancer growth and metastasis by facilitating WWP2-FL and targeting the WWP2/PTEN/AKT signaling pathway

Fang, S., Zhang, D., Weng, W., Lv, X., Zheng, L., Chen, M., Fan, X., Mao, J., Mao, C., Ye, Y., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.118624 · Cited by 44

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

Navickas, A., Asgharian, H., Winkler, J., Fish, L., Garcia, K., Markett, D., Dodel, M., Culbertson, B., Miglani, S., Joshi, T. V., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01141-9 · Cited by 43

Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy

To, K. K. W., Huang, Z., Zhang, H., Ashby, C. R., & Fu, L. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101058 · Cited by 46

Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders

Long, J. M., & Lahiri, D. K. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.12.043 · Cited by 44

THOC5 controls 3′end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100)

Tran, D. D. H., Saran, S., Williamson, A. J. K., Pierce, A., Dittrich‐Breiholz, O., Wiehlmann, L., Koch, A., Whetton, A. D., & Tamura, T. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku911 · Cited by 43

Comprehensive Analysis of MicroRNA (miRNA) Targets in Breast Cancer Cells

Fan, M., Krutilina, R. I., Sun, J., Sethuraman, A., Yang, C. H., Wu, Z., Yue, J., & Pfeffer, L. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.491803 · Cited by 46

The oncogenic and tumor suppressive roles of RNA‐binding proteins in human cancers

Bitaraf, A., Razmara, E., Bakhshinejad, B., Yousefi, H., Vatanmakanian, M., Garshasbi, M., Cho, W. C. S., & Babashah, S. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30311 · Cited by 42

Dehydration stress extends mRNA 3′ untranslated regions with noncoding RNA functions in ArabidopsisPreprint

Sun, H., Li, Y., Niu, Q., & Chua, N. (2017) · Genome Research · doi:10.1101/gr.218669.116 · Cited by 43

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

Shlien, A., Raine, K. M., Fuligni, F., Arnold, R. R., Nik‐Zainal, S., Dronov, S., Mamanova, L., Rosic, A., Ju, Y. S., Cooke, S. L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.028 · Cited by 45

mRNA 3′end processing: A tale of the tail reaches the clinic

Hollerer, I., Grund, K., Hentze, M. W., & Kulozik, A. E. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201303300 · Cited by 42

p53 inhibits mRNA 3′ processing through its interaction with the CstF/BARD1 complex

Nazeer, F. I., Devany, E., Mohammed, S., Fonseca, D., Akukwe, B., Taveras, C., & Kleiman, F. E. (2011) · Oncogene · doi:10.1038/onc.2011.29 · Cited by 42

CPEB2, CPEB3 and CPEB4 are coordinately regulated by miRNAs recognizing conserved binding sites in paralog positions of their 3′-UTRs

Morgan, M., Iaconcig, A., & Muro, A. F. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq635 · Cited by 29

Characterization of a Cleavage Stimulation Factor, 3′ pre-RNA, Subunit 2, 64 kDa (CSTF2) as a Therapeutic Target for Lung Cancer

Aragaki, M., Takahashi, K., Akiyama, H., Tsuchiya, E., Kondo, S., Nakamura, Y., & Daigo, Y. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0240 · Cited by 42

PACE4 Undergoes an Oncogenic Alternative Splicing Switch in Cancer

Couture, F., Sabbagh, R., Kwiatkowska, A., Desjardins, R., Guay, S., Bouchard, L., & Day, R. W. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1397 · Cited by 44

Alternative polyadenylation: An enigma of transcript length variation in health and disease

Mohanan, N. K., Shaji, F., Koshre, G. R., & Laishram, R. S. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1692 · Cited by 43

Deep learning of human polyadenylation sites at nucleotide resolution reveals molecular determinants of site usage and relevance in disease

Stroup, E. K., & Ji, Z. (2023) · Nature Communications · doi:10.1038/s41467-023-43266-3 · Cited by 40

Role of microRNAs in HTLV-1 infection and transformation

Ruggero, K., Corradin, A., Zanovello, P., Amadori, A., Bronte, V., Ciminale, V., & D’Agostino, D. M. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.05.001 · Cited by 41

Alternative polyadenylation is associated with lower expression of PABPN 1 and poor prognosis in non‐small cell lung cancer

Ichinose, J., Watanabe, K., Sano, A., Nagase, T., Nakajima, J., Fukayama, M., Yatomi, Y., Ohishi, N., & Takai, D. (2014) · Cancer Science · doi:10.1111/cas.12472 · Cited by 40

High throughput characterizations of poly(A) site choice in plants

Ma, L., Pati, P. K., Liu, M., Li, Q. Q., & Hunt, A. G. (2013) · Methods · doi:10.1016/j.ymeth.2013.06.037 · Cited by 41

Genome-wide maps of polyadenylation reveal dynamic mRNA 3′-end formation in mammalian cell lineages

Wang, L., Dowell, R. D., & Yi, R. (2013) · RNA · doi:10.1261/rna.035360.112 · Cited by 41

Protein arginylation regulates cellular stress response by stabilizing HSP70 and HSP40 transcripts

Deka, K., Singh, A., Chakraborty, S., Mukhopadhyay, R., & Saha, S. (2016) · Cell Death Discovery · doi:10.1038/cddiscovery.2016.74 · Cited by 41

microRNAs in Cancer Susceptibility

Ryan, B. M. (2017) · Advances in cancer research · doi:10.1016/bs.acr.2017.06.004 · Cited by 41

Mechanistic insights into the role of microRNAs in cancer: influence of nutrient crosstalk

Shah, M. S., Davidson, L. A., & Chapkin, R. S. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00305 · Cited by 41

Crosstalk between Wnt Signaling and RNA Processing in Colorectal Cancer

Bordonaro, M. (2013) · Journal of Cancer · doi:10.7150/jca.5470 · Cited by 40

The cell polarity protein Scrib functions as a tumor suppressor in liver cancer

Kapil, S., Sharma, B. K., Patil, M., Elattar, S., Yuan, J., Hou, X. S., Kolhe, R. B., & Ande, S. (2017) · Oncotarget · doi:10.18632/oncotarget.15713 · Cited by 46

Isoform Evolution in Primates through Independent Combination of Alternative RNA Processing Events

Zhang, S., Wang, C., Yan, S., Fu, A., Luan, X., Li, Y., Shen, Q. S., Zhong, X., Chen, J., Wang, X., et al. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx212 · Cited by 43

An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response

Chang, J.-W., Zhang, W., Yeh, H.-S., Park, M., Yao, C., Shi, Y., Kuang, R., & Yong, J. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky340 · Cited by 41

Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms

Yoon, Y., Klomp, J. A., Martín-Martín, I., Criscione, F., Calvo, E., Ribeiro, J. M. C., & Schmidt‐Ott, U. (2019) · eLife · doi:10.7554/elife.46711 · Cited by 37

Emerging translation strategies during virus–host interaction

Hoang, H., Neault, S., Pelin, A., & Alain, T. (2020) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1619 · Cited by 39

Systematic identification of functional SNPs interrupting 3’UTR polyadenylation signals

Shulman, E. D., & Elkon, R. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008977 · Cited by 40

Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis

Hansen, T. B., Kjems, J., & Bramsen, J. B. (2011) · RNA Biology · doi:10.4161/rna.8.3.14333 · Cited by 40

Quantifying 3′UTR length from scRNA-seq data reveals changes independent of gene expression

Fansler, M. M., Mitschka, S., & Mayr, C. (2024) · Nature Communications · doi:10.1038/s41467-024-48254-9 · Cited by 52

Global insights into alternative polyadenylation regulation

Batra, R., Manchanda, M., & Swanson, M. S. (2015) · RNA Biology · doi:10.1080/15476286.2015.1040974 · Cited by 41

Antimutagenic Effects of Selenium-Enriched Polysaccharides from Pyracantha fortuneana through Suppression of Cytochrome P450 1A Subfamily in the Mouse Liver

Peng, F., Guo, X., Li, Z., Li, C., Wang, C., Lv, W., Wang, J., Xiao, F., Kamal, M. A., & Yuan, C. (2016) · Molecules · doi:10.3390/molecules21121731 · Cited by 39

Analysis of alternative cleavage and polyadenylation in mature and differentiating neurons using RNA‐seq data

Güvenek, A., & Tian, B. (2018) · Quantitative Biology · doi:10.1007/s40484-018-0148-3 · Cited by 38

Elimination of Calm1 long 3′-UTR mRNA isoform by CRISPR–Cas9 gene editing impairs dorsal root ganglion development and hippocampal neuron activation in mice

Bae, B., Gruner, H. N., Lynch, M., Feng, T., So, K., Oliver, D., Mastick, G., Yan, W., Pieraut, S., & Miura, P. (2020) · RNA: A publication of the RNA Society · doi:10.1261/rna.076430.120 · Cited by 42

The Role of Alternative Polyadenylation in the Regulation of Subcellular RNA Localization

Arora, A., Goering, R., Lo, H. G., Lo, J., Moffatt, C., & Taliaferro, J. M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.818668 · Cited by 40

Breast Cancer and the Other Non-Coding RNAs

Dvorská, D., Braný, D., Ňachajová, M., Halašová, E., & Danková, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063280 · Cited by 38

Polyuridylation in Eukaryotes: A 3′-End Modification Regulating RNA Life

Munoz‐Tello, P., Rajappa, L., Coquille, S., & Thore, S. (2015) · BioMed Research International · doi:10.1155/2015/968127 · Cited by 37

Interplay between steroid signalling and microRNAs: implications for hormone-dependent cancers

Fletcher, C. E., Dart, D. A., & Bevan, C. L. (2014) · Endocrine Related Cancer · doi:10.1530/erc-14-0208 · Cited by 37

Alternative polyadenylation and RNA-binding proteins

Erson-Bensan, A. E. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0070 · Cited by 39

Processing and transcriptome expansion at the mRNA 3′ end in health and disease: finding the right end

Ogorodnikov, A., Kargapolova, Y., & Danckwardt, S. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1828-3 · Cited by 39

Emerging Themes in Regulation of Global mRNA Turnover in cis

Chen, C. A., & Shyu, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.08.014 · Cited by 42

Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer

Taniguchi, H., Hoshino, D., Moriya, C., Zembutsu, H., Nishiyama, N., Yamamoto, H., Kataoka, K., & Imai, K. (2017) · Oncotarget · doi:10.18632/oncotarget.16776 · Cited by 38

Combined loss of function of two different loci of miR-15/16 drives the pathogenesis of acute myeloid leukemia

Lovat, F., Nigita, G., Distefano, R., Nakamura, T., Gasparini, P., Tomasello, L., Fadda, P., Ibrahimova, N., Catricalà, S., Palamarchuk, A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003597117 · Cited by 38

An APEX2 proximity ligation method for mapping interactions with the nuclear lamina

Tran, J. R., Paulson, D. I., Moresco, J. J., Adam, S. A., Yates, J. R., Goldman, R. D., & Zheng, Y. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202002129 · Cited by 36

Cancer-associated dynamics and potential regulators of intronic polyadenylation revealed by IPAFinder using standard RNA-seq dataPreprint

Zhao, Z., Xu, Q., Wei, R., Wang, W., Ding, D., Yang, Y., Yao, J., Zhang, L., Hu, Y., Wei, G., et al. (2021) · Genome Research · doi:10.1101/gr.271627.120 · Cited by 40

SCAPE: a mixture model revealing single-cell polyadenylation diversity and cellular dynamics during cell differentiation and reprogramming

Zhou, R., Xiao, X., He, P., Zhao, Y., Xu, M., Zheng, X., Yang, R., Chen, S., Zhou, L., Zhang, D., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac167 · Cited by 38

Genome-wide analysis of poly(A) site selection in Schizosaccharomyces pombe

Schlackow, M., Marguerat, S., Proudfoot, N. J., Bähler, J., Radek Erban, A., & Gullerová, M. (2013) · RNA · doi:10.1261/rna.040675.113 · Cited by 38

Maximizing the Utility of Cancer Transcriptomic Data

Xiang, Y., Ye, Y., Zhang, Z., & Han, L. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.09.009 · Cited by 38

Extensive Structural Differences of Closely Related 3′ mRNA Isoforms: Links to Pab1 Binding and mRNA Stability

Moqtaderi, Z., Geisberg, J. V., & Struhl, K. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.044 · Cited by 35

Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms

Afzali, F., & Salimi, M. (2019) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-019-00339-6 · Cited by 37

ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue

Carrasco, J., Rauer, M., Hummel, B., Grzejda, D., Alfonso-Gonzalez, C., Lee, Y. J., Wang, Q., Puchalska, M., Mittler, G., & Hilgers, V. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.09.011 · Cited by 38

An alternative miRISC targets a cancer‐associated coding sequence mutation in FOXL2

Shin, E., Jin, H., Suh, D., Luo, Y., Ha, H., Kim, T. H., Hahn, Y., Hyun, S., Lee, K., & Bae, J. (2020) · The EMBO Journal · doi:10.15252/embj.2020104719 · Cited by 35

Small Players With Big Roles: MicroRNAs as Targets to Inhibit Breast Cancer Progression

Greene, S. B., Herschkowitz, J. I., & Rosen, J. M. (2010) · Current Drug Targets · doi:10.2174/138945010792006762 · Cited by 39

Expression analysis and function of mitochondrial genome-encoded microRNAs

Kuthethur, R., Shukla, V., Mallya, S. P., Adiga, D., Kabekkodu, S. P., Ramachandra, L., Saxena, P. P., Satyamoorthy, K., & Chakrabarty, S. (2022) · Journal of Cell Science · doi:10.1242/jcs.258937 · Cited by 36

UTR cutbacks give free rein to oncogenes

Atkinson, S. R. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2668 · Cited by 1

Lengthening of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation Is Associated With Tumor Progression and Poor Prognosis of Clear Cell Renal Cell Carcinoma

Zhang, F., Chen, L., Li, W., Yang, C., Xiong, M., Zhou, M., Kazobinka, G., Zhao, J., & Hou, T. (2023) · Laboratory Investigation · doi:10.1016/j.labinv.2023.100125 · Cited by 4

The 3′ UTR Landscape in Cancer

Schmidt, R., Ghosh, S., & Zavolan, M. (2018) · Wiley eBooks · doi:10.1002/9780470015902.a0027958 · Cited by 3

Resolving the complexity of the cancer transcriptome through 3’ UTRs

Erson-Bensan, A. E. (2017) · OpenMETU (Middle East Technical University)

Abstract A14: Alternative polyadenylation drives oncogenic gene expression in pancreatic cancer

Venkat, S., Tisdale, A. A., Eng, K. H., & Feigin, M. E. (2019) · Cancer Research · doi:10.1158/1538-7445.panca19-a14