Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

MicroRNAs: Target Recognition and Regulatory Functions

Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948

Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855

Untitled work

(2008) · doi:10.1038/nrg2290 · Cited by 5,199

Alternative isoform regulation in human tissue transcriptomes

Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., Kingsmore, S. F., Schroth, G. P., & Burge, C. B. (2008) · Nature · doi:10.1038/nature07509 · Cited by 5,181

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766

RAS Is Regulated by the let-7 MicroRNA Family

Johnson, S., Großhans, H., Shingara, J., Byrom, M., JARVIS, R., Cheng, A., Labourier, E., Reinert, K. L., Brown, D., & Slack, F. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.014 · Cited by 3,699

A microRNA polycistron as a potential human oncogene

He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642

Expression of Alternative Ago2 Isoform Associated with Loss of microRNA-Driven Translational Repression in Mouse Oocytes

Freimer, J. W., Krishnakumar, R., Cook, M. S., & Blelloch, R. H. (2018) · Current Biology · doi:10.1016/j.cub.2017.11.067 · Cited by 24

Androgen-dependent alternative mRNA isoform expression in prostate cancer cells

Munkley, J., Maia, T. M., Ibarluzea, N., Livermore, K. E., Vodák, D., Ehrmann, I. E., James, K., Rajan, P., Barbosa‐Morais, N. L., & Elliott, D. J. (2018) · F1000Research · doi:10.12688/f1000research.15604.1 · Cited by 22

Identification and Characterization of Transcripts Regulated by Circadian Alternative Polyadenylation in Mouse Liver

Gendreau, K. L., Unruh, B. A., Zhou, C., & Kojima, S. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200559 · Cited by 18

Defective transcription elongation in a subset of cancers confers immunotherapy resistance

Modur, V., Singh, N., Mohanty, V., Chung, E., Muhammad, B. A., Choi, K., Chen, X., Chetal, K., Ratner, N., Salomonis, N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06810-0 · Cited by 22

Alternative Polyadenylation of ABC Transporters of the C-Family (ABCC1, ABCC2, ABCC3) and Implications on Posttranscriptional Micro-RNA Regulation

Bruhn, O., Lindsay, M., Wiebel, F., Kaehler, M., Nagel, I., Böhm, R., Röder, C., & Cascorbi, I. (2019) · Molecular Pharmacology · doi:10.1124/mol.119.116590 · Cited by 22

Coordinated AR and microRNA regulation in prostate cancer

Eringyte, I., Losada, J. N. Z., Powell, S. M., Bevan, C. L., & Fletcher, C. E. (2020) · Asian journal of urology · doi:10.1016/j.ajur.2020.06.003 · Cited by 24

Could MicroRNAs Be Useful Tools to Improve the Diagnosis and Treatment of Rare Gynecological Cancers? A Brief Overview

Fiore, R. D., Suleiman, S., Pentimalli, F., O’Toole, S. A., O’Leary, J. J., Ward, M. P., Conlon, N. T., Sabol, M., Ozretić, P., Erson-Bensan, A. E., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083822 · Cited by 22

3′ untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein

Zhao, Y., Ling, S., Li, J., Zhong, G., Du, R., Li, Y., Wang, Y., Liu, C., Jin, X., Liu, W., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab503 · Cited by 22

Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle

Chaudhuri, L., Sarsour, E. H., Kalen, A. L., Aykin‐Burns, N., Spitz, D. R., & Goswami, P. C. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.012 · Cited by 22

Genome-Wide Polyadenylation Site Mapping

Pelechano, V., Wilkening, S., Järvelin, A. I., Tekkedil, M. M., & Steinmetz, L. M. (2012) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-391938-0.00012-4 · Cited by 22

Preferential selection of MnSOD transcripts in proliferating normal and cancer cells

Chaudhuri, L., Nicholson, A. M., Kalen, A. L., & Goswami, P. C. (2011) · Oncogene · doi:10.1038/onc.2011.325 · Cited by 21

RNA modifications in brain tumorigenesis

Huang, A., Delaidelli, A., & Sorensen, P. H. B. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00941-6 · Cited by 22

CRISPR-iPAS: a novel dCAS13-based method for alternative polyadenylation interference

Tian, S., Zhang, B., He, Y., Sun, Z., Li, J., Li, Y., Yi, H., Zhao, Y., Zou, X., Li, Y., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac108 · Cited by 21

An Alternatively Spliced p62 Isoform Confers Resistance to Chemotherapy in Breast Cancer

Guo, Q., Wang, H., Duan, J., Luo, W., Zhao, R., Shen, Y., Wang, B., Tao, S., Sun, Y., Ye, Q., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0909 · Cited by 21

APA-Scan: detection and visualization of 3′-UTR alternative polyadenylation with RNA-seq and 3′-end-seq data

Fahmi, N. A., Ahmed, K. T., Chang, J., Nassereddeen, H., Fan, D., Yong, J., & Zhang, W. (2022) · BMC Bioinformatics · doi:10.1186/s12859-022-04939-w · Cited by 21

Macrophage differentiation is marked by increased abundance of the mRNA 3’ end processing machinery, altered poly(A) site usage, and sensitivity to the level of CstF64

Mukherjee, S., Graber, J. H., & Moore, C. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1091403 · Cited by 21

The emerging theme of 3′UTR mRNA isoform regulation in reprogramming of cell metabolism

Zhang, Q., & Tian, B. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221128 · Cited by 21

The expression and functional roles of microRNAs in stem cell differentiation

Shim, J., & Nam, J. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.1.217 · Cited by 22

Selective targeting of KRAS-Mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-Mutant cells

Hara, T., Jones, M. F., Subramanian, M., Li, X. L., Ou, O. L., Zhu, Y. J., Yang, Y.-A., Wakefield, L. M., Hussain, S. P., Gaedcke, J., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2284 · Cited by 21

Alternative CHRNB4 3′-UTRs Mediate the Allelic Effects of SNP rs1948 on Gene Expression

Gallego, X., Cox, R. J., Laughlin, J. R., Stitzel, J. A., & Ehringer, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063699 · Cited by 24

Loss ofCPSF2Expression Is Associated with Increased Thyroid Cancer Cellular Invasion and Cancer Stem Cell Population, and More Aggressive Disease

Nilubol, N., Boufraqech, M., Zhang, L., & Kebebew, E. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4140 · Cited by 21

A meiotic gene regulatory cascade driven by alternative fates for newly synthesized transcripts

Cremona, N., Potter, K., & Wise, J. A. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-05-0448 · Cited by 21

Alternative polyadenylation sites reveal distinct chromatin accessibility and histone modification in human cell lines

Lee, C.-Y., & Chen, L. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt288 · Cited by 20

Regulators of alternative polyadenylation operate at the transition from mitosis to meiosis

Shan, L., Wu, C., Chen, D., Hou, L., Li, X., Wang, L., Chu, X., Hou, Y., & Wang, Z. (2017) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2016.12.007 · Cited by 21

RNA control in pain: Blame it on the messenger

de la Peña, J. B., Song, J. J., & Campbell, Z. T. (2019) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1546 · Cited by 21

Histone lysine demethylase KDM5B maintains chronic myeloid leukemia via multiple epigenetic actions

Xue, S., Lam, Y. M., He, Z., Zheng, Y., Li, L., Zhang, Y., Li, C., Mbadhi, M. N., Zheng, L., Cheng, Z., et al. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.006 · Cited by 20

m6A-seq analysis of microRNAs reveals that the N6-methyladenosine modification of miR-21–5p affects its target expression

Wang, H., Song, X., Song, C. H., Wang, X., & Cao, H. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109023 · Cited by 21

Dicer Ablation Impairs Prostate Stem Cell Activity and Causes Prostate Atrophy

Zhang, L., Zhang, B., Valdez, J. M., Wang, F., Ittmann, M., & Xin, L. (2010) · Stem Cells · doi:10.1002/stem.455 · Cited by 21

Connections between 3′ end processing and DNA damage response: Ten years later

Murphy, M. R., & Kleiman, F. E. (2019) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1571 · Cited by 21

Lipid Nanoparticle–Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth

Huang, X., Magnus, J., Kaimal, V., Karmali, P. P., Li, J., Walls, M., Prudente, R. Y., Sung, E., Sorourian, M., Lee, R., et al. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0613 · Cited by 20

mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus

Bergant, V., Schnepf, D., Krätzig, N. D. A., Hubel, P., Urban, C., Engleitner, T., Dijkman, R., Ryffel, B., Steiger, K., Knolle, P. A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40469-6 · Cited by 19

Genetic Variations in the KCNJ5 Gene in Primary Aldosteronism Patients from Xinjiang, China

Li, N., Li, H., Zhang, D., Zhang, J., Yao, X., Wang, H., Abulikemu, S., Zhou, K., & Zhang, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054051 · Cited by 20

Symplekin Specifies Mitotic Fidelity by Supporting Microtubule Dynamics

Cappell, K. M., Larson, B., Sciaky, N., & Whitehurst, A. W. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00758-10 · Cited by 24

The miR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase

Hu, T., Chong, Y., Qin, H., Kitamura, E., Chang, C.-S., Silva, J., Ren, M., & Cowell, J. K. (2018) · Oncogene · doi:10.1038/s41388-017-0091-1 · Cited by 20

Integrative 3′ Untranslated Region-Based Model to Identify Patients with Low Risk of Axillary Lymph Node Metastasis in Operable Triple-Negative Breast Cancer

Wang, L., Hu, X., Wang, P., & Shao, Z. (2018) · The Oncologist · doi:10.1634/theoncologist.2017-0609 · Cited by 20

Requirement for cleavage factor II m in the control of alternative polyadenylation in breast cancer cells

Turner, R. E., Henneken, L. M., Liem-Weits, M., Harrison, P. F., Swaminathan, A., Vary, R., Nikolić, I., Simpson, K. J., Powell, D., Beilharz, T. H., et al. (2020) · RNA · doi:10.1261/rna.075226.120 · Cited by 20

Circulating hsa-miR-323b-3p in Huntington's Disease: A Pilot Study

Ferraldeschi, M., Romano, S., Giglio, S., Romano, C., Morena, E., Mechelli, R., Annibali, V., Ubaldi, M., Buscarinu, M. C., Umeton, R., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.657973 · Cited by 20

Cancer: evolutionary, genetic and epigenetic aspects

Lichtenstein, A. V. (2010) · Clinical Epigenetics · doi:10.1007/s13148-010-0010-6 · Cited by 20

The C. elegans 3′ UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3′-UTR biology, and miRNA targetingPreprint

Steber, H. S., Gallante, C., O'Brien, S., Chiu, P., & Mangone, M. (2019) · Genome Research · doi:10.1101/gr.254839.119 · Cited by 20

Alternative Polyadenylation and Nonsense-Mediated Decay Coordinately Regulate the Human HFE mRNA Levels

Martins, R., Proença, D., Silva, B. D. R., Barbosa, C., Silva, A. L., Faustino, P., & Romão, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035461 · Cited by 19

PAPOLA contributes to cyclin D1 mRNA alternative polyadenylation and promotes breast cancer cell proliferation

Komini, C., Theohari, I., Lambrianidou, A., Nakopoulou, L., & Trangas, T. T. (2021) · Journal of Cell Science · doi:10.1242/jcs.252304 · Cited by 18

Integrative profiling of Epstein–Barr virus transcriptome using a multiplatform approach

Fülöp, Á., Torma, G., Moldován, N., Szenthe, K., Bánáti, F., Almsarrhad, I. A. A., Csabai, Z., Tombácz, D., Minárovits, J., & Boldogkői, Z. (2022) · Virology Journal · doi:10.1186/s12985-021-01734-6 · Cited by 20

Alternative polyadenylation regulation in cardiac development and cardiovascular disease

Cao, J., & Kuyumcu‐Martinez, M. N. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad014 · Cited by 19

A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study

Chen, H., Wang, Z., Gong, L., Wang, Q., Chen, W., Wang, J., Ma, X., Ding, R., Li, X., Zou, X., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46064-7 · Cited by 19

Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter

Ni, Z., Ahmed, N., Nabeel‐Shah, S., Guo, X., Pu, S., Song, J., Marcon, E., Burke, G. L., Tong, A. H. Y., Chan, K., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae240 · Cited by 20

Nuclear export is a limiting factor in eukaryotic mRNA metabolism

Müller, J. M., Moos, K., Baar, T., Maier, K. C., Žumer, K., & Tresch, A. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012059 · Cited by 23

Computational inference of mRNA stability from histone modification and transcriptome profiles

Wang, C., Tian, R., Zhao, Q. C., Xu, H., Meyer, C. A., Li, C., Zhang, Y., & Liu, X. S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks304 · Cited by 19

Global irradiation effects, stem cell genes and rare transcripts in the planarian transcriptome

Galloni, M. (2012) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113455mg · Cited by 19

miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling

Martin, E. C., Krebs, A. E., Burks, H. E., Elliott, S. G., Baddoo, M., Collins‐Burow, B. M., Flemington, E. K., & Burow, M. E. (2014) · Genes & Cancer · doi:10.18632/genesandcancer.33 · Cited by 19

UV damage regulates alternative polyadenylation of the RPB2 gene in yeast

Yu, L., & Volkert, M. R. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt020 · Cited by 19

Roles of Non-coding RNAs During Herpesvirus Infection

Hancock, M. H., & Skalsky, R. L. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_31 · Cited by 19

Identification and characterization of a novel adenomatous polyposis coli mutation in adult pancreatoblastoma

Yamaguchi, S., Fujii, T., Izumi, Y., Fukumura, Y., Han, M. Y., Yamaguchi, H., Akita, T., Yamashita, C., Kato, S., & Sekiya, T. (2018) · Oncotarget · doi:10.18632/oncotarget.24017 · Cited by 19

Impact of dietary compounds on cancer-related gut microbiota and microRNA

Rajoka, M. S. R., Jin, M., Zhao, H., Li, Q., Shao, D., Huang, Q., & Shi, J. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-8935-3 · Cited by 19

Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

Guyon, C., Jmari, N., Padonou, F., Li, Y.-C., Ucar, O., Fujikado, N., Coulpier, F., Blanchet, C., Root, D. E., & Giraud, M. (2020) · eLife · doi:10.7554/elife.52985 · Cited by 21

Heat stress induced arginylation of HuR promotes alternative polyadenylation of Hsp70.3 by regulating HuR stability and RNA binding

Deka, K., & Saha, S. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00619-5 · Cited by 19

The stress-induced heat shock protein 70.3 expression is regulated by a dual-component mechanism involving alternative polyadenylation and HuR

Kraynik, S. M., Gabanic, A., Anthony, S., Kelley, M., Paulding, W. R., Roessler, A. E., McGuinness, M., & Tranter, M. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.02.004 · Cited by 19

Prediction of Poly(A) Sites by Poly(A) Read Mapping

Bonfert, T., & Friedel, C. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170914 · Cited by 19

Alternative Polyadenylation Patterns for Novel Gene Discovery and Classification in Cancer

Begik, O., Oyken, M., Alican, T. C., Can, T., & Erson-Bensan, A. E. (2017) · Neoplasia · doi:10.1016/j.neo.2017.04.008 · Cited by 20

Integrating transcription kinetics with alternative polyadenylation and cell cycle control

Moreira, A. (2011) · Nucleus · doi:10.4161/nucl.2.6.18064 · Cited by 18

Analyses of alternative polyadenylation: from old school biochemistry to high-throughput technologies

Yeh, H.-S., Zhang, W., & Yong, J. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.4.019 · Cited by 18

Long 3'UTR of Nurr1 mRNAs is targeted by miRNAs in mesencephalic dopamine neurons

Pereira, L. A. S., Munita, R., González, M., & Andrés, M. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188177 · Cited by 18

Effects of Long-Chain Fatty Acyl-CoA Synthetase 1 on Diglyceride Synthesis and Arachidonic Acid Metabolism in Sheep Adipocytes

Cao, Y., Wang, S., Liu, S., Wang, Y., Jin, H., Ma, H., Luo, X., Cao, Y., & Lian, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062044 · Cited by 18

Full-length transcriptome analysis and identification of transcript structures in Eimeria necatrix from different developmental stages by single-molecule real-time sequencing

Gao, Y., Suding, Z., Wang, L., Liu, D., Su, S., Xu, J., Hu, J., & Tao, J. (2021) · Parasites & Vectors · doi:10.1186/s13071-021-05015-7 · Cited by 18

MiR-138 is a potent regulator of the heterogenous MYC transcript population in cancers

Desi, N., Teh, V., Tong, Q. Y., Lim, C. Y., Tabatabaeian, H., Chew, X. H., Sánchez-Mejías, A., Chan, J. J., Zhang, B., Pitcheshwar, P., et al. (2021) · Oncogene · doi:10.1038/s41388-021-02084-x · Cited by 19

Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy

Wang, G., Xie, Z., Su, J., Chen, M., Du, Y., Gao, Q., Zhang, G., Zhang, H., Chen, X., Liu, H., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1417 · Cited by 18

Transcriptomics-proteomics Integration reveals alternative polyadenylation driving inflammation-related protein translation in patients with diabetic nephropathy

Zhao, T., Zhan, D., Qu, S., Jiang, S., Gan, W., Qin, W., Zheng, C.-X., Cheng, F., Lu, Y., Liu, M., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03934-w · Cited by 19

The role of lamin B2 in human diseases

Li, Y., Zhu, J., Yu, Z., Li, H., & Jin, X. (2023) · Gene · doi:10.1016/j.gene.2023.147423 · Cited by 18

The Effects of Deregulated Ribosomal Biogenesis in Cancer

Lu, Y., Wang, S., & Jiao, Y. (2023) · Biomolecules · doi:10.3390/biom13111593 · Cited by 19

Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1

Hu, Z., Li, M., Chen, Y., Chen, L., Han, Y., Chen, C., Lü, X., You, N., Lou, Y., Huang, Y., et al. (2024) · Science China Life Sciences · doi:10.1007/s11427-023-2495-x · Cited by 21

The value of new high-throughput technologies for diagnosis and prognosis in solid tumors

Pinto, R., Summa, S. D., Petriella, D., Tudoran, O. M., Danza, K., & Tommasi, S. (2014) · Cancer Biomarkers · doi:10.3233/cbm-130328 · Cited by 18

A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12

Klinke, D. J. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-242 · Cited by 18

Small Nuclear Ribonucleoprotein Polypeptide A–Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation

Qiu, F., Fu, Y., Lu, C., Feng, Y., Wang, Q., Huo, Z., Jia, X., Chen, C., Chen, S., & Xu, A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601872 · Cited by 18

Induction of an Alternative mRNA 5′ Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection

Hoang, H.-D., Graber, T. E., Jia, J.-J., Vaidya, N., Gilchrist, V. H., Xiang, X., Li, W., Cowan, K. N., Gkogkas, C. G., Jaramillo, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.072 · Cited by 18

CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via miR-590-5p/YAP1 axis

Liu, K., Wang, B.-J., Han, W., Chi, C., Gu, C., Wang, Y., Fu, X., Huang, W., Liu, Z., & Song, X. (2020) · Oncogene · doi:10.1038/s41388-020-1213-8 · Cited by 18

EBV–encoded miRNAs can sensitize nasopharyngeal carcinoma to chemotherapeutic drugs by targeting BRCA1

Lung, R. W. M., TONG, J. H. M., Ip, L., Lam, K.-H., Chan, A. W. H., Chak, W., Chung, L., Yeung, W. W., Hau, P., Chau, S. L., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16007 · Cited by 18

Nuclear pre-mRNA 3′-end processing regulates synapse and axon development in C. elegans

Epps, H. V., Dai, Y., Qi, Y. B., Goncharov, A., & Jin, Y. (2010) · Development · doi:10.1242/dev.049692 · Cited by 18

The quantitative impact of 3′UTRs on gene expression

West, J. D., Smith, H. J., Vu, L. T., Fogarty, E. A., Matreyek, K. A., Fowler, D. M., & Grimson, A. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf568 · Cited by 20

Comprehensive Analysis of APA Events and Their Association With Tumor Microenvironment in Lung Adenocarcinoma

Zhang, Y., Shen, L., Shi, Q., Zhao, G., & Wang, F. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.645360 · Cited by 17

A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA

Gourvest, M., Clara, E. D., Wu, H.-C., Touriol, C., Meggetto, F., de Thé, H., Pyronnet, S., Brousset, P., & Bousquet, M. (2021) · Leukemia · doi:10.1038/s41375-021-01307-0 · Cited by 17

FMRP and MOV10 regulate Dicer1 expression and dendrite development

Lannom, M. C., Nielsen, J., Nawaz, A., Shilikbay, T., & Ceman, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260005 · Cited by 17

Structured 3′ UTRs destabilize mRNAs in plants

Zhang, T., Li, C., Zhu, J., Li, Y., Wang, Z., Tong, C.-Y., Xi, Y., Han, Y., Koiwa, H., Xu, P., et al. (2024) · Genome biology · doi:10.1186/s13059-024-03186-x · Cited by 16

Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity

Farberov, S., Ziv, O., Lau, J. Y., Perry, R. B., Lubelsky, Y., Miska, E. A., Kudla, G. R., & Ulitsky, I. (2024) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01393-5 · Cited by 17

A miR Image of Stem Cells and Their Lineages

Yi, R., & Fuchs, E. V. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-387038-4.00007-0 · Cited by 17

Mapping 3′ mRNA Isoforms on a Genomic Scale

Jin, Y., Geisberg, J. V., Moqtaderi, Z., Ji, Z., Hoque, M., Tian, B., & Struhl, K. (2015) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb0423s110 · Cited by 17

Genome-wide characterization of intergenic polyadenylation sites redefines gene spaces in Arabidopsis thaliana

Wu, X., Zeng, Y., Guan, J., Ji, G., Huang, R., & Li, Q. Q. (2015) · BMC Genomics · doi:10.1186/s12864-015-1691-1 · Cited by 17

Altered CELF1 binding to target transcripts in malignant T cells

Bohjanen, P. R., Moua, M. L., Guo, L., Taye, A., & Louis, I. V.-S. (2015) · RNA · doi:10.1261/rna.049940.115 · Cited by 16

Alternative polyadenylation: less than meets the eye?

Neve, J., & Furger, A. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140054 · Cited by 17

New Links between mRNA Polyadenylation and Diverse Nuclear Pathways

Giammartino, D. C. D., & Manley, J. L. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0177 · Cited by 17

Disruption of the expression and function of microRNAs in lung cancer as a result of epigenetic changes

Watanabe, K., & Takai, D. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00275 · Cited by 17

Computational challenges, tools, and resources for analyzing co‐ and post‐transcriptional events in high throughput

Bahrami‐Samani, E., Vo, D. T., Araujo, P. R. D., Vogel, C., Smith, A. D., Penalva, L. O. F., & Uren, P. J. (2014) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1274 · Cited by 15

piRNA-like small RNAs mark extended 3’UTRs present in germ and somatic cells

Yamtich, J., Heo, S., Dhahbi, J. M., Martin, D. I. K., & Boffelli, D. (2015) · BMC Genomics · doi:10.1186/s12864-015-1662-6 · Cited by 17

Oncogenic p95HER2 regulates Na+–HCO3− cotransporter NBCn1 mRNA stability in breast cancer cells via 3′UTR-dependent processes

Gorbatenko, A., Olesen, C. W., Loebl, N., Sigurðsson, H. H., Bianchi, C., Pedraz‐Cuesta, E., Christiansen, J., & Pedersen, S. F. (2016) · Biochemical Journal · doi:10.1042/bcj20160054 · Cited by 17

Aberrant Ki‐67 expression through 3′ UTR alternative polyadenylation in breast cancers

Yan, H., Tian, R., Wang, W., Zhang, M., Wu, J., & He, J. (2017) · FEBS Open Bio · doi:10.1002/2211-5463.12364 · Cited by 17

Post-transcriptional regulation in planarian stem cells

Gopinath, S. K., Palakodeti, D., & Solana, J. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.05.013 · Cited by 15

The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models

Vicente, C., Stirparo, R., Demeyer, S., de Bock, C. E., Gielen, O., Atkins, M., Yan, J., Halder, G. A., Hassan, B. A., & Cools, J. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0650-0 · Cited by 17

A Developmental Program Truncates Long Transcripts to Temporally Regulate Cell Signaling

Sandler, J. E., Irizarry, J., Stepanik, V. A., Dunipace, L., Amrhein, H., & Stathopoulos, A. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.11.019 · Cited by 17

The polyadenylation code: a unified model for the regulation of mRNA alternative poly adenylation

Davis, R. T., & Shi, Y. (2014) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400076 · Cited by 17

Suppression of vascular endothelial growth factor abrogates the immunosuppressive capability of murine gastric cancer cells and elicits antitumor immunity

Shi, Y., Yu, P.-W., Zeng, D.-Z., Qian, F., Lei, X., Zhao, Y., Tang, B., Hao, Y., Luo, H.-X., Chen, J., et al. (2014) · FEBS Journal · doi:10.1111/febs.12923 · Cited by 17

Alternative Polyadenylation and Its Impact on Cellular Processes

Akman, H. B., & Erson-Bensan, A. E. (2014) · MicroRNA · doi:10.2174/2211536602666131210001152 · Cited by 17

From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform

Tian, N., Li, J., Shi, J., & Sui, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030191 · Cited by 17

UTR cutbacks give free rein to oncogenes

Atkinson, S. R. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2668 · Cited by 1

Lengthening of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation Is Associated With Tumor Progression and Poor Prognosis of Clear Cell Renal Cell Carcinoma

Zhang, F., Chen, L., Li, W., Yang, C., Xiong, M., Zhou, M., Kazobinka, G., Zhao, J., & Hou, T. (2023) · Laboratory Investigation · doi:10.1016/j.labinv.2023.100125 · Cited by 4

The 3′ UTR Landscape in Cancer

Schmidt, R., Ghosh, S., & Zavolan, M. (2018) · Wiley eBooks · doi:10.1002/9780470015902.a0027958 · Cited by 3

Resolving the complexity of the cancer transcriptome through 3’ UTRs

Erson-Bensan, A. E. (2017) · OpenMETU (Middle East Technical University)

Abstract A14: Alternative polyadenylation drives oncogenic gene expression in pancreatic cancer

Venkat, S., Tisdale, A. A., Eng, K. H., & Feigin, M. E. (2019) · Cancer Research · doi:10.1158/1538-7445.panca19-a14