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Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells
Open accessAbstract
In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed without alteration of the proto-oncogene. Helping to explain this phenomenon, we found that when compared to similarly proliferating nontransformed cell lines, cancer cell lines often expressed substantial amounts of mRNA isoforms with shorter 3' untranslated regions (UTRs). These shorter isoforms usually resulted from alternative cleavage and polyadenylation (APA). The APA had functional consequences, with the shorter mRNA isoforms exhibiting increased stability and typically producing ten-fold more protein, in part through the loss of microRNA-mediated repression. Moreover, expression of the shorter mRNA isoform of the proto-oncogene IGF2BP1/IMP-1 led to far more oncogenic transformation than did expression of the full-length, annotated mRNA. The high incidence of APA in cancer cells, with consequent loss of 3'UTR repressive elements, suggests a pervasive role for APA in oncogene activation without genetic alteration.
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“the importance of transcript 3′ UTRs as targets for miRNAs suggests that stem cell quiescence is controlled, at least in part, by mechanisms that alter 3′ UTR length and thus the susceptibility to regulation by miRNAs92–95.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [95]
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“Shortening of 3′ UTRs seems to correlate with proliferation in many cell types94, including aberrant proliferation in the case of cancer cells95 or during somatic cell reprogramming99”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [95]
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Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Self-citationThe C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
Self-citation(2008) · doi:10.1038/nrg2290 · Cited by 5,199
Alternative isoform regulation in human tissue transcriptomes
Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., Kingsmore, S. F., Schroth, G. P., & Burge, C. B. (2008) · Nature · doi:10.1038/nature07509 · Cited by 5,181
Self-citationCalin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766
Self-citationRAS Is Regulated by the let-7 MicroRNA Family
Johnson, S., Großhans, H., Shingara, J., Byrom, M., JARVIS, R., Cheng, A., Labourier, E., Reinert, K. L., Brown, D., & Slack, F. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.014 · Cited by 3,699
A microRNA polycistron as a potential human oncogene
He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642
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3 of the 62 references couldn’t be matched to a known paper.
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Predicting effective microRNA target sites in mammalian mRNAs
Agarwal, V., Bell, G. W., Nam, J.-W., & Bartel, D. P. (2015) · eLife · doi:10.7554/elife.05005 · Cited by 7,318
Self-citationA ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011) · Cell · doi:10.1016/j.cell.2011.07.014 · Cited by 7,262
U1 snRNP regulates cancer cell migration and invasion in vitro
Oh, J.-M., Venters, C. C., Di, C., Pinto, A. M., Wan, L., Younis, I., Cai, Z., Arai, C., So, B. R., Duan, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13993-7 · Cited by 7,157
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
Vogel, C., & Marcotte, E. M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3185 · Cited by 4,195
The multilayered complexity of ceRNA crosstalk and competition
Tay, Y., Rinn, J., & Pandolfi, P. P. (2014) · Nature · doi:10.1038/nature12986 · Cited by 3,910
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
Friedländer, M. R., Mackowiak, S. D., Li, N., Chen, W., & Rajewsky, N. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr688 · Cited by 3,207
The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
Cech, T. R., & Steitz, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.008 · Cited by 2,524
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Poliseno, L., Salmena, L., Zhang, J., Carver, B. S., Haveman, W. J., & Pandolfi, P. P. (2010) · Nature · doi:10.1038/nature09144 · Cited by 2,364
Non-coding RNA networks in cancer
Anastasiadou, E., Jacob, L. S., & Slack, F. J. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.99 · Cited by 1,920
Leva, G. D., Garofalo, M., & Croce, C. M. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104715 · Cited by 1,705
Roles for MicroRNAs in Conferring Robustness to Biological Processes
Ebert, M. S., & Sharp, P. A. (2012) · Cell · doi:10.1016/j.cell.2012.04.005 · Cited by 1,564
Analysis and design of RNA sequencing experiments for identifying isoform regulation
Katz, Y., Wang, E. T., Airoldi, E. M., & Burge, C. B. (2010) · Nature Methods · doi:10.1038/nmeth.1528 · Cited by 1,353
ceRNA in cancer: possible functions and clinical implications
Qi, X., Zhang, D., Wu, N., Xiao, J., Wang, X., & Ma, W. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103334 · Cited by 1,273
Genetic variation in microRNA networks: the implications for cancer research
Ryan, B. M., Robles, A. I., & Harris, C. C. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2867 · Cited by 1,269
Understanding mechanisms underlying human gene expression variation with RNA sequencing
Pickrell, J. K., Marioni, J. C., Pai, A. A., Degner, J. F., Engelhardt, B. E., Nkadori, E., Veyrieras, J.-B., Stephens, M., Gilad, Y., & Pritchard, J. K. (2010) · Nature · doi:10.1038/nature08872 · Cited by 1,256
Molecular regulation of stem cell quiescence
Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148
Alternative polyadenylation of mRNA precursors
Tian, B., & Manley, J. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.116 · Cited by 1,179
Jansson, M., & Lund, A. H. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.09.006 · Cited by 1,150
MicroRNAs in Development and Disease
Sayed, D. H., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,101
Mohr, A. M., & Mott, J. L. (2015) · Seminars in Liver Disease · doi:10.1055/s-0034-1397344 · Cited by 1,092
Goodall, G. J., & Wickramasinghe, V. O. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00306-0 · Cited by 1,090
Circular RNAs function as ceRNAs to regulate and control human cancer progression
Zhong, Y., Du, Y., Yang, X. F., Mo, Y., Fan, C., Xiong, F., Ren, D., Ye, X., Li, C., Wang, Y., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0827-8 · Cited by 1,002
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., Clark, S. J., & Kjems, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.359 · Cited by 996
The Human Mitochondrial Transcriptome
Mercer, T. R., Neph, S., Dinger, M. E., Crawford, J., Smith, M. A., Shearwood, A.-M. J., Haugen, E., Bracken, C. P., Rackham, O., Stamatoyannopoulos, J. A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.051 · Cited by 905
Farazi, T. A., Spitzer, J., Morozov, P. S., & Tuschl, T. (2010) · The Journal of Pathology · doi:10.1002/path.2806 · Cited by 900
ceRNA Cross-Talk in Cancer: When ce-bling Rivalries Go Awry
Karreth, F. A., & Pandolfi, P. P. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0202 · Cited by 847
Coupling mRNA processing with transcription in time and space
Bentley, D. L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3662 · Cited by 828
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhingedPreprint
David, C. J., & Manley, J. L. (2010) · Genes & Development · doi:10.1101/gad.1973010 · Cited by 848
Alternative cleavage and polyadenylation: extent, regulation and function
Elkon, R., Ugalde, A. P., & Agami, R. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3482 · Cited by 816
Bell, J. L., Wächter, K., Mühleck, B., Pazaitis, N., Köhn, M., Lederer, M., & Hüttelmaier, S. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1186-z · Cited by 785
RNA-Binding Proteins in Cancer: Old Players and New Actors
Pereira, B., Billaud, M., & Almeida, R. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.05.003 · Cited by 774
RNA processing and its regulation: global insights into biological networks
Licatalosi, D. D., & Darnell, R. B. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2673 · Cited by 777
Mechanisms and Consequences of Alternative Polyadenylation
Di Giammartino, D. C., Nishida, K., & Manley, J. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.017 · Cited by 737
Evolution of microRNA diversity and regulation in animals
Berezikov, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3079 · Cited by 712
Farazi, T. A., Hoell, J. I., Morozov, P. S., & Tuschl, T. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-5590-1_1 · Cited by 709
Jiang, S., Zhang, H.-W., Lu, M.-H., He, X.-H., Li, Y., Gu, H., Liu, M.-F., & Wang, E.-D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4250 · Cited by 679
A network-biology perspective of microRNA function and dysfunction in cancer
Bracken, C. P., Scott, H. S., & Goodall, G. J. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.134 · Cited by 688
A molecular portrait of microsatellite instability across multiple cancers
Cortés‐Ciriano, I., Lee, S., Park, W., Kim, T., & Park, P. J. (2017) · Nature Communications · doi:10.1038/ncomms15180 · Cited by 669
Regulation of cytoplasmic mRNA decay
Schoenberg, D. R., & Maquat, L. E. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3160 · Cited by 656
A quantitative atlas of polyadenylation in five mammalsPreprint
Derti, A., Garrett-Engele, P. W., MacIsaac, K. D., Stevens, R. C., Sriram, S., Chen, R., Rohl, C. A., Johnson, J. M., & Babak, T. (2012) · Genome Research · doi:10.1101/gr.132563.111 · Cited by 663
Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
Kataoka, K., Shiraishi, Y., Takeda, Y., Sakata, S., Matsumoto, M., Nagano, S., Maeda, T., Nagata, Y., Kitanaka, A., Mizuno, S., et al. (2016) · Nature · doi:10.1038/nature18294 · Cited by 659
Kumar, P., Anaya, J., Mudunuri, S. B., & Dutta, A. (2014) · BMC Biology · doi:10.1186/s12915-014-0078-0 · Cited by 671
MicroRNA regulation by RNA-binding proteins and its implications for cancer
van Kouwenhove, M., Kedde, M., & Agami, R. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3107 · Cited by 617
Ending the message: poly(A) signals then and nowPreprint
Proudfoot, N. J. (2011) · Genes & Development · doi:10.1101/gad.17268411 · Cited by 640
Vogel, C., de Sousa Abreu, R., Ko, D., Le, S., Shapiro, B. A., Burns, S. C., Sandhu, D., Boutz, D. R., Marcotte, E. M., & Penalva, L. O. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.59 · Cited by 608
Ratti, M., Lampis, A., Ghidini, M., Salati, M., Mirchev, M. B., Valeri, N., & Hahne, J. C. (2020) · Targeted Oncology · doi:10.1007/s11523-020-00717-x · Cited by 632
Barrett, L. W., Fletcher, S., & Wilton, S. D. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0990-9 · Cited by 641
Regulation by 3′-Untranslated Regions
Mayr, C. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-120116-024704 · Cited by 588
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Banerjee, A. K., Blanco, M. R., Bruce, E. A., Honson, D. D., Chen, L. M., Chow, A., Bhat, P., Ollikainen, N., Quinodoz, S. A., Loney, C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.004 · Cited by 583
Xia, Z., Donehower, L. A., Cooper, T. A., Neilson, J. R., Wheeler, D. A., Wagner, E. J., & Li, W. (2014) · Nature Communications · doi:10.1038/ncomms6274 · Cited by 581
m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency
Chen, T., Hao, Y., Zhang, Y., Li, M., Wang, M., Han, W., Yong-sheng, W., Lv, Y., Hao, J., Wang, L., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.01.016 · Cited by 552
Mayr, C. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a034728 · Cited by 519
Self-citationMicroRNAs in the p53 network: micromanagement of tumour suppression
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Ireland, A. S., Micinski, A. M., Kastner, D. W., Guo, B., Wait, S. J., Spainhower, K. B., Conley, C. C., Chen, O. S., Guthrie, M. R., Soltero, D., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.001 · Cited by 515
ShortStack: Comprehensive annotation and quantification of small RNA genes
Axtell, M. J. (2013) · RNA · doi:10.1261/rna.035279.112 · Cited by 514
The complexity of miRNA-mediated repression
Wilczynska, A., & Bushell, M. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.112 · Cited by 522
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Gałgański, Ł., Urbanek-Trzeciak, M. O., & Krzyżosiak, W. J. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx759 · Cited by 489
Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs
Jan, C. H., Friedman, R. C., Ruby, J. G., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09616 · Cited by 485
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Thomas, M., Lieberman, J., & Lal, A. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1921 · Cited by 487
Alternative cleavage and polyadenylation in health and disease
Gruber, A. J., & Zavolan, M. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0145-z · Cited by 493
Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization
Berkovits, B. D., & Mayr, C. (2015) · Nature · doi:10.1038/nature14321 · Cited by 474
Self-citationU1 snRNP Determines mRNA Length and Regulates Isoform Expression
Berg, M. G., Singh, L. N., Younis, I., Liu, Q., Pinto, A. M., Kaida, D., Zhang, Z., Cho, S., Sherrill-Mix, S. A., Wan, L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.029 · Cited by 482
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression
Masamha, C. P., Xia, Z., Yang, J., Albrecht, T. R., Li, M., Shyu, A., Li, W., & Wagner, E. J. (2014) · Nature · doi:10.1038/nature13261 · Cited by 450
The Role of miRNAs in Regulating Gene Expression Networks
Gurtan, A. M., & Sharp, P. A. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.03.007 · Cited by 454
Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing
Hoque, M., Ji, Z., Zheng, D., Luo, W., Li, W., You, B., Park, J. Y., Yehia, G., & Tian, B. (2012) · Nature Methods · doi:10.1038/nmeth.2288 · Cited by 456
Pathogenesis of Human B Cell Lymphomas
Shaffer, A. L., Young, R. M., & Staudt, L. M. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075027 · Cited by 457
Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq
Shepard, P. J., Choi, E., Lu, J., Flanagan, L. A., Hertel, K. J., & Shi, Y. (2011) · RNA · doi:10.1261/rna.2581711 · Cited by 440
Dynamic integration of splicing within gene regulatory pathways
Braunschweig, U., Gueroussov, S., Plocik, A. M., Graveley, B. R., & Blencowe, B. J. (2013) · Cell · doi:10.1016/j.cell.2013.02.034 · Cited by 406
Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation
Kartha, R. V., & Subramanian, S. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00008 · Cited by 408
Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expressionPreprint
Lianoglou, S., Garg, V., Yang, J. L., Leslie, C. S., & Mayr, C. (2013) · Genes & Development · doi:10.1101/gad.229328.113 · Cited by 402
Self-citationUpf1 Senses 3′UTR Length to Potentiate mRNA Decay
Hogg, J. R., & Goff, S. P. (2010) · Cell · doi:10.1016/j.cell.2010.10.005 · Cited by 408
The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion
Singh, G., Pratt, G. A., Yeo, G. W.-M., & Moore, M. J. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-080111-092106 · Cited by 407
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Millevoi, S., & Vagner, S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1176 · Cited by 416
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Truitt, M. L., & Ruggero, D. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.27 · Cited by 378
RNA-binding proteins in tumor progression
Qin, H., Ni, H., Liu, Y., Yuan, Y., Xi, T., Li, X., & Zheng, L. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00927-w · Cited by 387
EIN2-Directed Translational Regulation of Ethylene Signaling in Arabidopsis
Li, W., Ma, M., Feng, Y., Li, H., Wang, Y., Ma, Y., Li, M., An, F., & Guo, H. (2015) · Cell · doi:10.1016/j.cell.2015.09.037 · Cited by 383
HITS-CLIP: panoramic views of protein-RNA regulation in living cells
Darnell, R. B. (2010) · WIREs RNA · doi:10.1002/wrna.31 · Cited by 382
Tushev, G., Glock, C., Heumüller, M., Biever, A., Jovanovic, M., & Schuman, E. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.030 · Cited by 377
The Pivotal Regulatory Landscape of RNA Modifications
Li, S., & Mason, C. E. (2014) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090413-025405 · Cited by 386
A transgenic mouse for in vivo detection of endogenous labeled mRNA
Lionnet, T., Czaplinski, K., Darzacq, X., Shav-Tal, Y., Wells, A. L., Chao, J., Park, H., de Turris, V., Lopez-Jones, M., & Singer, R. (2011) · Nature Methods · doi:10.1038/nmeth.1551 · Cited by 372
Schweingruber, C., Rufener, S. C., Zünd, D., Yamashita, A., & Mühlemann, O. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.02.005 · Cited by 369
Martin, G., Gruber, A. R., Keller, W., & Zavolan, M. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.05.003 · Cited by 366
Matoulkova, E., Michalova, E., Vojtesek, B., & Hrstka, R. (2012) · RNA Biology · doi:10.4161/rna.20231 · Cited by 357
“Cotranscriptionality”: The Transcription Elongation Complex as a Nexus for Nuclear Transactions
Perales, R., & Bentley, D. L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.018 · Cited by 369
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
de Klerk, E., & ‘t Hoen, P. A. C. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.01.001 · Cited by 350
Burroughs, A. M., Ando, Y., de Hoon, M., Tomaru, Y., Nishibu, T., Ukekawa, R., Funakoshi, T., Kurokawa, T., Suzuki, H., Hayashizaki, Y., et al. (2010) · Genome Research · doi:10.1101/gr.106054.110 · Cited by 346
Translational control by changes in poly(A) tail length: recycling mRNAs
Weill, L., Belloc, E., Bava, F.-A., & Méndez, R. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2311 · Cited by 328
Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting
Nam, J., Rissland, O. S., Koppstein, D., Abreu‐Goodger, C., Jan, C. H., Agarwal, V., Yıldırım, M. A., Rodríguez, A., & Bartel, D. P. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.02.013 · Cited by 337
Self-citationExtensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs
Li, Z., Ender, C., Meister, G., Moore, P. S., Chang, Y., & John, B. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks307 · Cited by 340
Context-specific regulation and function of mRNA alternative polyadenylation
Mitschka, S., & Mayr, C. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00507-5 · Cited by 349
Self-citationThe Poly(A)-Binding Protein Nuclear 1 Suppresses Alternative Cleavage and Polyadenylation Sites
Jenal, M., Elkon, R., Loayza‐Puch, F., van Haaften, G. W., Kühn, U., Menzies, F. M., Vrielink, J. A. F. O., Bos, A., Drost, J., Rooijers, K., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.022 · Cited by 343
Widespread and extensive lengthening of 3′ UTRs in the mammalian brainPreprint
Miura, P., Shenker, S., Andreu-Agulló, C., Westholm, J. O., & Lai, E. C. (2013) · Genome Research · doi:10.1101/gr.146886.112 · Cited by 349
Evolution and Biological Roles of Alternative 3′UTRs
Mayr, C. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.012 · Cited by 343
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Metadata
- Authors
- Mayr, C., & Bartel, D. P.
- Affiliations
- Howard Hughes Medical Institute (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Mayr, Christine
- Bartel, David P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 138
- Issue
- 4
- Pages
- 673-684
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2819821
- OpenAlex
- W1542927170
- Cited by
- 1,613
- References
- 62
- Citations by year
- 2026: 57 · 2025: 60 · 2024: 87 · 2023: 98 · 2022: 99 · 2021: 118 · 2020: 96 · 2019: 95 · 2018: 100 · 2017: 100 · 2016: 87 · 2015: 86 · 2014: 116 · 2013: 129 · 2012: 114
- FWCI
- 37.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- PMC
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (P30CA008748)
- National Institute of General Medical Sciences (R01GM067031)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK068348)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- alternative polyadenylation, mRNA isoforms, oncogene activation, proto-oncogenes, mRNA stability, oncogenic transformation, cancer cells
- MeSH terms
- Proto-Oncogene Mas, Cell Transformation, Neoplastic, Humans, Mutation, Oncogenes, Gene Expression Regulation, Neoplastic, S Phase, Cyclins, RNA-Binding Proteins, Alternative Splicing, 3' Untranslated Regions, RNA Stability, Polyadenylation, Cell Line, Tumor, Cyclin D2
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