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Tumor Self-Seeding by Circulating Cancer Cells
Open accessAbstract
Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is thought that this is a unidirectional process. Here we show that circulating tumor cells (CTCs) can also colonize their tumors of origin, in a process that we call "tumor self-seeding." Self-seeding of breast cancer, colon cancer, and melanoma tumors in mice is preferentially mediated by aggressive CTCs, including those with bone, lung, or brain-metastatic tropism. We find that the tumor-derived cytokines IL-6 and IL-8 act as CTC attractants whereas MMP1/collagenase-1 and the actin cytoskeleton component fascin-1 are mediators of CTC infiltration into mammary tumors. We show that self-seeding can accelerate tumor growth, angiogenesis, and stromal recruitment through seed-derived factors including the chemokine CXCL1. Tumor self-seeding could explain the relationships between anaplasia, tumor size, vascularity and prognosis, and local recurrence seeded by disseminated cells following ostensibly complete tumor excision.
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“Consequently, tumor self-seeding leads to enhanced angiogenesis, tumor growth, stromal recruitment through seed-derived factors including the chemokine CXCL1, anaplasia, tumor size, and vascularity.”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
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“Mechanistically, tumors secrete IL-6 and IL-8 cytokines to attract CTC”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
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“In this way, aggressive CTCs preferentially mediate self-seeding of breast, melanoma, and colon cancers in mice, including those with bone, brain, or lung -metastatic tropism.”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
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“Even more interesting is that, in contrast to the traditional view that tumor cell metastases occur unidirectional, the reverse process is also possible through CTC-mediated “self-seeding”.”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
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“while CTC infiltration into mammary tumors is mediated by MMP1/collagenase-1 and the actin cytoskeleton component fascin-1.”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
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“Finally, there is the prognosis for local recurrence by seeding of disseminated cells after apparently complete tumor ablation [147, 148].”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
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“CXCL1 emerged among a set of genes whose expression is associated with lung relapse in breast tumors, including tumors that had not been exposed to prior chemotherapy (Minn et al., 2007; Minn et al., 2005), and as a gene that increases the aggressiveness of circulating breast tumor cells (Kim et al., 2009).”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Kim et al., 2009
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Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Microenvironmental regulation of metastasis
Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684
Haine, M. M.-L., & Meeùs, N. (1986) · Cited by 3,464
Genes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922
Self-citationMetastasis: from dissemination to organ-specific colonization
Nguyen, D. X., Bos, P. D., & Massagué, J. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2622 · Cited by 2,716
Self-citationA multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,605
Self-citationParadoxical roles of the immune system during cancer development
de Visser, K. E., Eichten, A., & Coussens, L. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1782 · Cited by 2,299
Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.-Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.001 · Cited by 2,155
Cited by
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Items 601–700 of 1,000
Kavan, S., Kruse, T. A., Vogsen, M., Hildebrandt, M. G., & Thomassen, M. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10023-9 · Cited by 30
Characterization of the melanoma brain metastatic niche in mice and humans
Amit, M., Laider‐Trejo, L., Shalom, V., Shabtay‐Orbach, A., Krelin, Y., & Gil, Z. (2013) · Cancer Medicine · doi:10.1002/cam4.45 · Cited by 28
The potential diagnostic power of circulating tumor cell analysis for non-small-cell lung cancer
Ross, K., Pailler, E., Faugeroux, V., Taylor, M., Oulhen, M., Auger, N., Planchard, D., Soria, J., Lindsay, C. R., Besse, B., et al. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2015.1111139 · Cited by 31
Liao, W., Tian, M., & Chen, N. (2019) · Cancer Management and Research · doi:10.2147/cmar.s219994 · Cited by 28
Oligometastatic and Oligoprogression Disease and Local Therapies in Prostate Cancer
Deek, M. P., & Tran, P. T. (2020) · The Cancer Journal · doi:10.1097/ppo.0000000000000432 · Cited by 26
Wilbaux, M., Tod, M. M., Bono, J. S. D., Lorente, D., Mateo, J., Freyer, G., You, B., & Hénin, É. (2015) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.34 · Cited by 28
Tan, W., Liang, G., Xie, X., Jiang, W. G., Tan, L., Sanders, A. J., Liu, Z., Ling, Y., Zhong, W., Tian, Z., et al. (2019) · The Oncologist · doi:10.1634/theoncologist.2018-0697 · Cited by 27
Markiewicz, A., Wełnicka-Jaśkiewicz, M., Seroczyńska, B., Skokowski, J., Majewska, H., Szade, J., & Zaczek, A. J. (2014) · Europe PMC (PubMed Central) · Cited by 27
Cytoreductive radical prostatectomy in metastatic prostate cancer: Does it really make sense?
Mathiéu, R., Korn, S. M., Bensalah, K., Kramer, G., & Shariat, S. F. (2016) · World Journal of Urology · doi:10.1007/s00345-016-1906-3 · Cited by 27
In VivoFlow Cytometry of Circulating Tumor-Associated Exosomes
Nolan, J., Sarimollaoglu, M., Nedosekin, D. A., Jamshidi‐Parsian, A., Galanzha, E. I., Kore, R. A., Griffin, R. J., & Zharov, V. P. (2016) · Analytical Cellular Pathology · doi:10.1155/2016/1628057 · Cited by 27
Teixeira, A. F., Wang, Y., Iaria, J., ten Dijke, P., & Zhu, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01711-1 · Cited by 27
Fusion gene and splice variant analyses in liquid biopsies of lung cancer patients
Aguado, C., Giménez-Capitán, A. A., Karachaliou, N., Pérez-Rosado, A., Viteri, S., Morales-Espinosa, D., & Rosell, R. (2016) · Translational Lung Cancer Research · doi:10.21037/tlcr.2016.09.02 · Cited by 26
He, C., Huang, X.-J., Su, X., Tang, T., Zhang, X., Ma, J., Guo, X., & Lv, X. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1281493 · Cited by 26
Self-citationŠkereňová, M., Mikulová, V., Čapoun, O., Zima, T., & Tesařová, P. (2017) · Biomedical Papers · doi:10.5507/bp.2017.022 · Cited by 26
Kim, H. M., Heo, C. M., Oh, J., Chung, H. H., Lee, E. M., Park, J., Lee, S., Lee, K. H., Lee, K. T., Lee, J. K., et al. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101321 · Cited by 26
NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy
Garces, I., Kotzur, R., Cerwenka, A., & Mandelboim, O. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.924775 · Cited by 30
Histology: The gold standard for diagnosis?
Tseng, L.-J., Matsuyama, A., & MacDonald‐Dickinson, V. (2023) · PubMed Central · Cited by 26
Currently Used Markers for CTC Isolation - Advantages, Limitations and Impact on Cancer Prognosis
Man, Y., Wáng, Q., & Kemmner, W. (2011) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.1000102 · Cited by 26
Nakayama, J., Ito, E., Fujimoto, J., Watanabe, S., & Semba, K. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3809 · Cited by 26
The clinical significance of the Ezrin gene and circulating tumor cells in osteosarcoma
Zhong, G., Feng, S., Shen, R., Wu, Z., Chen, F., & Zhu, X. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s125589 · Cited by 27
Liu, D.-G., Xue, L., Li, J., Yang, Q., & Peng, J. (2018) · Cancer Biomarkers · doi:10.3233/cbm-170995 · Cited by 26
Maddipati, R. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191943 · Cited by 31
Xue, P., Wu, Y., Guo, J., & Kang, Y. (2015) · Biomedical Microdevices · doi:10.1007/s10544-015-9945-x · Cited by 25
Wang, J., Fang, Z.-T., Wang, G., Zhang, W., Qu, X.-D., Liu, R., Qian, S., Zhu, L., & Zhou, B. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s52973 · Cited by 25
Advances in genomic characterization of circulating tumor cells
Magbanua, M. J. M., & Park, J. W. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9503-7 · Cited by 25
Mohr, A., Chu, T., Brooke, G. N., & Zwacka, R. M. (2019) · Cancers · doi:10.3390/cancers11040568 · Cited by 25
Natural Fish Trap‐Like Nanocage for Label‐Free Capture of Circulating Tumor Cells
Jiang, W., Han, L., Yang, L., Xu, T., He, J., Peng, R., Liu, Z., Zhang, C., Yu, X., & Jia, L. (2020) · Advanced Science · doi:10.1002/advs.202002259 · Cited by 25
Therapeutic Targeting of the Tumour Microenvironment in Metastatic Colorectal Cancer
Dmello, R. S., To, S. Q., & Chand, A. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042067 · Cited by 25
Cao, L., Zhang, Y., Mi, J., Shi, Z., Fang, Z., Jia, D., Pan, Z., & Peng, P. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106180 · Cited by 25
Recent Advances in Optimizing Radiation Therapy Decisions in Early Invasive Breast Cancer
Riaz, N., Jeen, T., Whelan, T. J., & Nielsen, T. O. (2023) · Cancers · doi:10.3390/cancers15041260 · Cited by 27
Zhang, H., Wang, Y., Li, Q., Zhang, F., & Tang, B. (2014) · Chemical Communications · doi:10.1039/c4cc02342k · Cited by 25
The Clinicopathological Significance of miR-133a in Colorectal Cancer
Wan, T. M.-H., Lam, C. S.-C., Ng, L., Chow, A. K.-M., Wong, S. K., Li, H. S., Man, J. H.-W., Lo, O. S., Foo, C. C., Cheung, A. H. K., et al. (2014) · Disease Markers · doi:10.1155/2014/919283 · Cited by 25
Antiresorptive therapies in oncology and their effects on cancer progression
Bundred, N. J. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.02.002 · Cited by 26
Detection of Apoptotic Circulating Tumor Cells Using in vivo Fluorescence Flow Cytometry
Nolan, J., Nedosekin, D. A., Galanzha, E. I., & Zharov, V. P. (2018) · Cytometry Part A · doi:10.1002/cyto.a.23642 · Cited by 25
Magbanua, M. J. M., Savenkov, O., Asmus, E. J., Ballman, K. V., Scott, J. H., Park, J. W., Dickler, M. N., Partridge, A. H., Carey, L., Winer, E. P., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1329 · Cited by 25
Han, S., Xue, L., Wei, Y., Yong, T., Jia, W., Qi, Y., Luo, Y., Liang, J., Wen, J., Bie, N., et al. (2023) · Advanced Science · doi:10.1002/advs.202207080 · Cited by 24
Önal, C., Gültekin, M., Oymak, E., Güler, O. C., Yılmaz, M. T., Sarı, S. Y., Yıldırım, B. A., & Yıldız, F. (2020) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-2019-001115 · Cited by 24
Meng, Y., Bian, L., Zhang, M., Bo, F., Lu, X., & Li, D. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2020-0022 · Cited by 24
Connor, M. J., Shah, T. T., Smigielska, K., Day, E., Sukumar, J., Fiorentino, F., Sarwar, N., Gonzalez, M., Falconer, A., Klimowska‐Nassar, N., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-042953 · Cited by 24
Automatic particle detection and sorting in an electrokinetic microfluidic chip
Song, Y., Peng, R., Wang, J., Pan, X., Sun, Y., & Li, D. (2012) · Electrophoresis · doi:10.1002/elps.201200416 · Cited by 24
Risk factors for survival and recurrence after lung metastasectomy
Pagès, P., Serayssol, C., Brioude, G., Falcoz, P., Brouchet, L., Pimpec‐Barthes, F. L., Thomas, P. A., & Bernard, A. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.01.028 · Cited by 24
Kim, J., Park, J. S., & Ham, W. S. (2017) · Korean journal of urology · doi:10.4111/icu.2017.58.5.307 · Cited by 24
Kouam, P. N., Bühler, H., Hero, T., & Adamietz, I. U. A. (2019) · Radiation Oncology · doi:10.1186/s13014-019-1230-3 · Cited by 24
Innate extracellular vesicles from melanoma patients suppress β-catenin in tumor cells by miRNA-34a
Lee, J., Dindorf, J., Eberhardt, M., Lai, X., Ostalecki, C., Koliha, N., Gross, S., Blume, K., Bruns, H., Wild, S., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201800205 · Cited by 23
Liao, R., Fu, Y., Wang, T., Deng, Z., Li, D., Fan, J., Zhou, J., Feng, G., Qiu, S., & Du, C. (2016) · Oncotarget · doi:10.18632/oncotarget.12152 · Cited by 23
Identification and validation of novel circulating biomarkers for early diagnosis of lung cancer
Zhang, L., Pu, D., Liu, D., Wang, Y., Luo, W., Tang, H., Huang, Y., & Li, W. (2019) · Lung Cancer · doi:10.1016/j.lungcan.2019.06.019 · Cited by 23
Breast Cancer Cell Re-Dissemination from Lung Metastases—A Mechanism for Enhancing Metastatic Burden
Borriello, L., Condeelis, J. S., Entenberg, D. R., & Oktay, M. H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112340 · Cited by 23
MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy
Rapanotti, M. C., Cugini, E., Nuccetelli, M., Terrinoni, A., Raimondo, C. D., Lombardo, P., Costanza, G., Cosio, T., Rossi, P., Orlandi, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212416 · Cited by 23
Emerging landscapes of nanosystems based on pre-metastatic microenvironment for cancer theranostics
Chu, Y., Sun, T., & Jiang, C. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.02.051 · Cited by 23
Bartkowiak, K., Riethdorf, S., & Pantel, K. (2011) · Cancer Microenvironment · doi:10.1007/s12307-011-0067-6 · Cited by 23
Xu, H., Pan, Y., Chen, Z.-W., Lin, Y., Wang, L., Chen, Y.-H., Jie, T.-T., Lu, Y., & Liu, J. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.01.007 · Cited by 23
Pro-Metastatic Tumor–Stroma Interactions in Breast Cancer
Gangadhara, S., Barrett-Lee, P. J., Nicholson, R. I., & Hiscox, S. (2012) · Future Oncology · doi:10.2217/fon.12.134 · Cited by 23
Ito, K., Smith, B. R., Parashurama, N., Yoon, J., Song, S. Y., Miething, C., Mallick, P., Lowe, S. W., & Gambhir, S. S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2579 · Cited by 23
Local Anesthetics and Recurrence after Cancer Surgery-What’s New? A Narrative Review
Müller, S. D., Ziegler, J. S. H., & Piegeler, T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040719 · Cited by 23
Sequential metastases of colorectal cancer
Keim, S., Zoernig, I., Spille, A., Lahrmann, B., Brand, K., Herpel, E., Grabe, N., Jäger, D., & Halama, N. (2012) · OncoImmunology · doi:10.4161/onci.20179 · Cited by 23
Cytoreductive prostatectomy: Evidence in support of a new surgical paradigm (Review)
Faiena, I., Singer, E. A., Pumill, C., & Kim, I. Y. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2656 · Cited by 22
Lu, S., Wu, J., Fang, Y., Wang, W., Zong, Y., Chen, X., Huang, O., He, J., Chen, W., Li, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23189 · Cited by 22
Fascin-1: Updated biological functions and therapeutic implications in cancer biology
Li, C., Chan, M., Liang, S., Chang, Y., & Hsiao, M. (2022) · BBA Advances · doi:10.1016/j.bbadva.2022.100052 · Cited by 22
Nuclear fascin regulates cancer cell survival
Lawson, C. D., Peel, S. E., Jayo, A., Corrigan, A. M., Iyer, P., Dalrymple, M. B., Marsh, R. J., Cox, S., Audenhove, I. V., Gettemans, J., et al. (2022) · eLife · doi:10.7554/elife.79283 · Cited by 22
Mahboobnia, K., Beveridge, D. J., Yeoh, G. C., Kabir, T. D., & Leedman, P. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179393 · Cited by 23
Cinobufocini inhibits NF-κB and COX-2 activation induced by TNF-α in lung adenocarcinoma cells
Xu, L. (2012) · Oncology Reports · doi:10.3892/or.2012.1647 · Cited by 22
Lieto, E., Galizia, G., Orditura, M., Romano, C. P., Zamboli, A. G. I., Castellano, P., Mabilia, A., AURICCHIO, A., Vita, F. D., & Gemei, M. (2014) · Oncology Letters · doi:10.3892/ol.2014.2749 · Cited by 22
Aykul, S., & Martı́nez-Hackert, E. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.01.011 · Cited by 22
Malara, N., Guzzi, G., Mignogna, C., Trunzo, V., Camastra, C., Torre, A. D., Vito, A. D., Lavecchia, A. M., Gliozzi, M., Ceccotti, C., et al. (2016) · BMC Neurology · doi:10.1186/s12883-016-0652-x · Cited by 22
ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer
Strietz, J., Stepputtis, S. S., Preca, B., Vannier, C., Kim, M. M., Castro, D. J., Au, Q., Boerries, M., Busch, H. S., Aza‐Blanc, P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13086 · Cited by 22
Self-citationCirculating Tumor Cells as Cancer Biomarkers in the Clinic
Chinen, L. T. D., Abdallah, E. A., Braun, A. C., Flores, B. C. T., Corassa, M. P., Sanches, S. M., & Fanelli, M. F. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55947-6_1 · Cited by 23
Salvage Proton Beam Therapy in Local Recurrent Uveal Melanoma
Riechardt, A. I., Cordini, D., Dobner, B. C., Seibel, I., Gundlach, E., Rehák, M., Hager, A., Stark, R., Moser, L., & Joussen, A. M. (2014) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2014.07.013 · Cited by 21
Cytoreductive cryosurgery in patients with bone metastatic prostate cancer: A retrospective analysis
Sheng, M., Wan, L., Liu, C., Liu, C., & Chen, S. (2017) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2017.07.002 · Cited by 21
Treatment of Oligometastatic Hormone-Sensitive Prostate Cancer: A Comprehensive Review
Koo, K. C., & Prokar Dasgupta, A. (2018) · Yonsei Medical Journal · doi:10.3349/ymj.2018.59.5.567 · Cited by 21
Sherry, A. D., Bathala, T. K., Liu, S., Fellman, B. M., Chun, S. G., Jasani, N., Guadagnolo, B. A., Jhingran, A., Reddy, J. P., Corn, P. G., et al. (2022) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2022.05.023 · Cited by 21
Yu, P., Han, Y., Meng, L., Tian, Y., Jin, Z., Luo, J. F., Han, C. Q., Xu, W., Kong, L., & Zhang, C. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.01.016 · Cited by 22
Marsden, C. G., Wright, M. J., Carrier, L., Moroz, K., & Rowan, B. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047587 · Cited by 21
In vivo Dual Substrate Bioluminescent Imaging
Wendt, M. K., Molter, J. P., Flask, C. A., & Schiemann, W. P. (2011) · Journal of Visualized Experiments · doi:10.3791/3245 · Cited by 21
Perioperative circulating tumor cell detection: Current perspectives
Kaifi, J. T., Li, G., Clawson, G. A., Kimchi, E. T., & Staveley-O’Carroll, K. F. (2016) · Cancer Biology & Therapy · doi:10.1080/15384047.2016.1167296 · Cited by 21
Hikimoto, D., Nishiguchi, A., Matsusaki, M., & Akashi, M. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600180 · Cited by 20
Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes
Li, J., Yang, X., Wang, X., Jia, X., Wang, Z., Deng, A., Bai, X., Zhu, L., Li, B., Feng, Z., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11820-x · Cited by 21
Circulating tumor cells as biomarkers in head and neck cancer: recent advances and future outlook
Tinhofer, I., & Staudte, S. (2018) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1522251 · Cited by 21
Nicaraven Attenuates Postoperative Systemic Inflammatory Responses-Induced Tumor Metastasis
Zhang, X., Moriwaki, T., Kawabata, T., Goto, S., Liu, K.-X., Guo, C., & Li, T. (2019) · Annals of Surgical Oncology · doi:10.1245/s10434-019-08076-2 · Cited by 21
Self-citationCirculating tumour cells: telling the truth about metastasis
Cristofanilli, M. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70091-9 · Cited by 21
Gwark, S., Kim, J., Kwon, N., Kim, K.-Y., Kim, Y.-N., Lee, C. H., Kim, Y. H., Kim, M. S., Hong, S. W., Choi, M. Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74577-w · Cited by 23
Self-citationThe current role of precision surgery in oligometastatic prostate cancer
von Deimling, M., Rajwa, P., Derya Tilki, A., Heidenreich, A., Pallauf, M., Bianchi, A., Yanagisawa, T., Kawada, T., Karakiewicz, P. I., Gontero, P., et al. (2022) · ESMO Open · doi:10.1016/j.esmoop.2022.100597 · Cited by 20
Wu, J., Liu, R., Zheng, X., Chen, L., & Wu, Z. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101808 · Cited by 20
Bustelo, X. R. (2012) · BioEssays · doi:10.1002/bies.201200041 · Cited by 20
Hu, W., Fang, M., Zhao, H., Yan, S.-G., Yuan, J., Peng, C., Yang, G., Li, Y., & Li, J. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.059 · Cited by 20
Metabolism and cancer: an up-to-date review of a mutual connection.
Mentis, A. A., & Kararizou, E. G. (2010) · PubMed · Cited by 20
Ferreira, A. R., Alho, I., Shan, N., Matias, M., Faria, M., Casimiro, S., Leitzel, K. E., Ali, S. M., Lipton, A., & Costa, L. (2016) · The Oncologist · doi:10.1634/theoncologist.2015-0527 · Cited by 20
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Gao, Y., Zhu, Y., & Yuan, Z. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.16734 · Cited by 21
Minami, T., Fujii, Y., Hirano, K., Higaki, T., Nagasaki, A., Ishikawa, R., Okajima, T., & Katoh, K. (2019) · Genes to Cells · doi:10.1111/gtc.12671 · Cited by 20
Zhang, Y., Li, J., Wang, L., Meng, P., Zhao, J., Han, P., Xia, J., Xu, J., Wang, L., Shen, F., et al. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10420 · Cited by 20
Engineering Circulating Tumor Cells as Novel Cancer Theranostics
Parkins, K. M., Dubois, V. P., Kelly, J. J., Chen, Y., Knier, N. N., Foster, P. J., & Ronald, J. A. (2020) · Theranostics · doi:10.7150/thno.44259 · Cited by 22
Zhang, Y., Ma, Q., Liu, T., Shi, K., Jiang, K., Wen, Y., Ma, B., Zhou, Y., Fan, Q., & Qiu, X. (2013) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-013-1561-7 · Cited by 20
The importance of histopathological evaluation in cancer diagnosis and treatment
Aljehani, . R., Alamri, F. H., Elyas, M. E. K., Almohammadi, A. S., Alanazi, A., & Alharbi, M. A. (2023) · International Journal of Health Sciences · doi:10.53730/ijhs.v7ns1.15270 · Cited by 19
Gong, X., Dai, X., Cheng, W., Li, B., Liu, J., Chen, H., Wu, M., Yang, J., & Liu, B. (2025) · Advanced Materials · doi:10.1002/adma.202501144 · Cited by 19
“Hit the primary”: A paradigm shift in the treatment of metastatic prostate cancer?
Arcangeli, S., Zilli, T., Bari, B. D., & Alongi, F. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.08.023 · Cited by 19
Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding
Huang, H., Zheng, X. F. S., Cai, C., Yao, Z., Lu, S., Meng, X., Miao, Y., He, Z., Cai, C., & Zou, F. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.009 · Cited by 20
Characterizing causality in cancer
Rondeau, E., Larmonier, N., Pradeu, T., & Bikfalvi, A. (2019) · eLife · doi:10.7554/elife.53755 · Cited by 22
Role of surgery in oligometastatic prostate cancer
Jenjitranant, P., & Touijer, K. A. (2019) · Prostate International · doi:10.1016/j.prnil.2019.10.001 · Cited by 19
Tostivint, E. P., Alouani, E. L., Kirova, Y., Dalenc, F., & Vaysse, C. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103146 · Cited by 20
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Metadata
- Authors
- Kim, M.-Y., Oskarsson, T., Acharyya, S., Nguyen, D. X., Zhang, X. H.-F., Norton, L., & Massagué, J.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Massagué, Joan
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 139
- Issue
- 7
- Pages
- 1315-1326
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2810531
- OpenAlex
- W2152393981
- Cited by
- 1,335
- References
- 57
- Citations by year
- 2026: 16 · 2025: 44 · 2024: 61 · 2023: 90 · 2022: 89 · 2021: 88 · 2020: 96 · 2019: 87 · 2018: 68 · 2017: 82 · 2016: 91 · 2015: 96 · 2014: 102 · 2013: 82 · 2012: 98
- FWCI
- 40.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense
- Howard Hughes Medical Institute
- National Institutes of Health
- National Cancer Institute (P01CA094060, CA94060, P30CA008748)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- circulating tumor cells, breast cancer, colon cancer, melanoma, interleukin-6, interleukin-8, MMP-1, fascin, CXCL1, tumor angiogenesis, tumor growth, local recurrence, metastatic tropism, actin cytoskeleton
- MeSH terms
- Animals, Breast Neoplasms, Humans, Melanoma, Mice, Inbred BALB C, Neoplastic Cells, Circulating, Neoplasm Proteins, Neoplasm Recurrence, Local, Neoplasms, Prognosis, Skin Neoplasms, Mice
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