The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Tumor Self-Seeding by Circulating Cancer Cells
Open accessAbstract
Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is thought that this is a unidirectional process. Here we show that circulating tumor cells (CTCs) can also colonize their tumors of origin, in a process that we call "tumor self-seeding." Self-seeding of breast cancer, colon cancer, and melanoma tumors in mice is preferentially mediated by aggressive CTCs, including those with bone, lung, or brain-metastatic tropism. We find that the tumor-derived cytokines IL-6 and IL-8 act as CTC attractants whereas MMP1/collagenase-1 and the actin cytoskeleton component fascin-1 are mediators of CTC infiltration into mammary tumors. We show that self-seeding can accelerate tumor growth, angiogenesis, and stromal recruitment through seed-derived factors including the chemokine CXCL1. Tumor self-seeding could explain the relationships between anaplasia, tumor size, vascularity and prognosis, and local recurrence seeded by disseminated cells following ostensibly complete tumor excision.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Consequently, tumor self-seeding leads to enhanced angiogenesis, tumor growth, stromal recruitment through seed-derived factors including the chemokine CXCL1, anaplasia, tumor size, and vascularity.”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Mechanistically, tumors secrete IL-6 and IL-8 cytokines to attract CTC”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“In this way, aggressive CTCs preferentially mediate self-seeding of breast, melanoma, and colon cancers in mice, including those with bone, brain, or lung -metastatic tropism.”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
The cited source says what the claim attributes to it.
In the citing paper
“Even more interesting is that, in contrast to the traditional view that tumor cell metastases occur unidirectional, the reverse process is also possible through CTC-mediated “self-seeding”.”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
The cited source says what the claim attributes to it.
In the citing paper
“while CTC infiltration into mammary tumors is mediated by MMP1/collagenase-1 and the actin cytoskeleton component fascin-1.”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
The cited source says what the claim attributes to it.
In the citing paper
“Finally, there is the prognosis for local recurrence by seeding of disseminated cells after apparently complete tumor ablation [147, 148].”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [147]
In the citing paper
“CXCL1 emerged among a set of genes whose expression is associated with lung relapse in breast tumors, including tumors that had not been exposed to prior chemotherapy (Minn et al., 2007; Minn et al., 2005), and as a gene that increases the aggressiveness of circulating breast tumor cells (Kim et al., 2009).”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Kim et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Microenvironmental regulation of metastasis
Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684
Haine, M. M.-L., & Meeùs, N. (1986) · Cited by 3,464
Genes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922
Self-citationMetastasis: from dissemination to organ-specific colonization
Nguyen, D. X., Bos, P. D., & Massagué, J. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2622 · Cited by 2,716
Self-citationA multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,605
Self-citationParadoxical roles of the immune system during cancer development
de Visser, K. E., Eichten, A., & Coussens, L. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1782 · Cited by 2,299
Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.-Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.001 · Cited by 2,155
Flagged first, then by citations
Cited by
Sorted by citations
Items 801–900 of 1,000
Duran, C. L., Surve, C. R., Ye, X., Chen, X., Lin, Y., Harney, A. S., Wang, Y., Sharma, V. P., Stanley, E. R., Cox, D., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03485-y · Cited by 14
Role of the Hypoxic-Secretome in Seed and Soil Metastatic Preparation
Clemente-González, C., & Carnero, A. (2022) · Cancers · doi:10.3390/cancers14235930 · Cited by 13
Polverini, P. J., Nör, F., & Nor, J. E. (2023) · Frontiers in Oral Health · doi:10.3389/froh.2022.1095842 · Cited by 13
Obiri‐Yeboah, D., Soni, P., Oyem, P. C., Almeida, J. P., Murayi, R., Recinos, P. F., & Kshettry, V. R. (2023) · World Neurosurgery · doi:10.1016/j.wneu.2023.06.100 · Cited by 12
Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation?
Witz, A., Dardare, J., Betz, M., Gilson, P., Merlin, J., & Harlé, A. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01278-9 · Cited by 16
Deciphering Asthma Biomarkers with Protein Profiling Technology
Kuang, Z., Wilson, J. J., Luo, S., Zhu, S., & Huang, R. (2015) · International Journal of Inflammation · doi:10.1155/2015/630637 · Cited by 12
Generalized principles of stochasticity can be used to control dynamic heterogeneity
Liao, D., Estévez-Salmerón, L., & Tlsty, T. D. (2012) · Physical Biology · doi:10.1088/1478-3975/9/6/065006 · Cited by 12
Molecular Interactions in the Development of Brain Metastases
Martinez, N., Boire, A. A., & DeAngelis, L. M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140817157 · Cited by 12
Trends in Management of Oligometastatic Hormone-Sensitive Prostate Cancer
Kothari, G., Ost, P., Cheung, P., Blanchard, P., Tree, A. C., van As, N. J., Lo, S. S.-M., Moghanaki, D. M., Loblaw, A., & Siva, S. (2019) · Current Oncology Reports · doi:10.1007/s11912-019-0791-5 · Cited by 12
Evidence of a role for interleukin-6 in anoikis resistance in oral squamous cell carcinoma
Karavyraki, M., & Porter, R. K. (2022) · Medical Oncology · doi:10.1007/s12032-022-01664-5 · Cited by 12
Circulating cancer stem cells: a novel prognostic predictor of hepatocellular carcinoma.
Chiba, T., Kanai, F., Iwama, A., & Yokosuka, O. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2012.09.02 · Cited by 12
Razmara, A. M., Sollier, E., Kisirkoi, G. N., Baker, S. W., Bellon, M. B., McMillan, A., Lemaire, C. A., Ramani, V. C., Jeffrey, S. S., & Casey, K. M. (2020) · Clinical & Experimental Metastasis · doi:10.1007/s10585-020-10033-3 · Cited by 12
Zhang, L., Zou, L., Ma, Y., Feng, C., Zhan, R., Yang, H., Song, B., & Han, Z. (2020) · Cell Biology International · doi:10.1002/cbin.11491 · Cited by 12
Huang, X., Qiao, Y., Brady, S. W., Factor, R. E., Downs-Kelly, E. P., Farrell, A., McQuerry, J. A., Shrestha, G., Jenkins, D. F., Johnson, W. E., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00989-6 · Cited by 10
Kershaw, S., Cummings, J., Morris, K. L., Tugwood, J. D., & Dive, C. (2015) · BMC Cancer · doi:10.1186/s12885-015-1382-y · Cited by 12
Sakuma, T., Nakamoto, T., Hemmi, H., Kitazawa, S., Kitazawa, R., Notomi, T., Hayata, T., Ezura, Y., Amagasa, T., & Noda, M. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24066 · Cited by 12
Targeting Metastasis Through the Inhibition of Interleukin 6 and 8
Jayatilaka, H., & Phillip, J. M. (2019) · Breast Cancer Management · doi:10.2217/bmt-2019-0002 · Cited by 10
Zhao, X., Gao, H., Wen, J., Wang, H., Wu, L.-Y., Song, C., Deng, W., Zhu, S., & Shen, W. (2023) · Discover Oncology · doi:10.1007/s12672-023-00783-3 · Cited by 11
Malara, N., Givigliano, F., Trunzo, V., Macrina, L., Raso, C. A., Amodio, N., Aprigliano, S., Minniti, A. M., Russo, V., Roveda, L., et al. (2014) · PubMed · Cited by 11
Defining hypoxic microenvironments by non-invasive functional optical imaging
Iglesias, P., Fraga, M., & Costoya, J. A. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.06.001 · Cited by 11
Vallvé-Juanico, J., Suárez-Salvador, E., Castellví, J., Ballesteros, A., Taylor, H. S., Gil‐Moreno, A., & Santamaría, X. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.08.018 · Cited by 11
Yıldırım, B. A., Önal, C., Köse, F., Oymak, E., Sedef, A. M., Beşen, A. A., Aksoy, S., Güler, O. C., Sümbül, A. T., Muallaoğlu, S., et al. (2019) · Strahlentherapie und Onkologie · doi:10.1007/s00066-019-01429-6 · Cited by 11
Cancer Stem Cells and Tumour Aggressiveness
Chengizkhan, G., Bhaskaran, N., Kumaran, R., & Ramachandran, I. (2020) · Springer eBooks · doi:10.1007/978-981-15-5120-8_8 · Cited by 11
D’Oronzo, S., Gregory, W. M., Nicholson, S., Chong, Y. K., Brown, J. E., & Coleman, R. E. (2021) · Journal of bone oncology · doi:10.1016/j.jbo.2021.100367 · Cited by 11
Stock, C. M. (2021) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2021_68 · Cited by 11
Ahmad, E., Ali, A., Nimisha, Sharma, A. K., Apurva, A., Kumar, A., Dar, G. M., Sattar, R. S. A., Verma, R., Mahajan, B., et al. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.05.029 · Cited by 11
m6A Methylation Regulators Are Predictive Biomarkers for Tumour Metastasis in Prostate Cancer
Wu, X., Ge, Q., Yang, C., Hu, J., 胡梦博, Ma, C., Jiang, H., & Hu, J. (2022) · Cancers · doi:10.3390/cancers14164035 · Cited by 10
Self-citationCellules tumorales circulantes : biopsie liquide du cancer
Alix‐Panabières, C., & Pierga, J. (2014) · Bulletin du Cancer · doi:10.1684/bdc.2014.1883 · Cited by 11
Resection of the primary tumor in stage IV breast cancer
Shien, T. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i2.82 · Cited by 11
Buschhaus, J. M., Luker, K. E., & Luker, G. D. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7371-2_15 · Cited by 11
CIRCULATING TUMOR CELLS: CLINICAL SIGNIFICANCE IN BREAST CANCER (REVIEW)
Кайгородова, Е. В. (2017) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn833 · Cited by 11
Performance of different biomarkers for the management of hepatocellular carcinoma
Rojas, Á., Sanchez-Torrijos, Y. M., Gil‐Gómez, A., Liu, C.-H., Rivas, C. R., Ferrer, M. T., & Romero‐Gómez, M. (2018) · Hepatoma Research · doi:10.20517/2394-5079.2018.60 · Cited by 10
Future perspectives from lung cancer pre-clinical models: new treatments are coming?
Bersani, F., Morena, D., Picca, F., Morotti, A., Tabbò, F., Bironzo, P., Righi, L., & Taulli, R. (2020) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-189 · Cited by 10
Local Therapies in Oligometastatic and Oligoprogressive Prostate Cancer
Deek, M. P., Phillips, R., & Tran, P. T. (2021) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2021.03.007 · Cited by 11
Protein deregulation associated with breast cancer metastasis
Chan, K. K., Matchett, K. B., McEnhill, P., Dakir, E. H., McMullin, M. F., El‐Tanani, Y., Patterson, L. H., Faheem, A., Rudland, P. S., McCarron, P. A., et al. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.05.002 · Cited by 12
Split Gaussia Luciferase for Imaging Ligand–Receptor Binding
Luker, K. E., & Luker, G. D. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-718-1_5 · Cited by 11
Cancer Stem Cells – Basic Biological Properties and Experimental Approaches
Hatina, J., Fernandes, M. I., Hoffmann, M. J., & Zeimet, A. G. (2013) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0021164.pub2 · Cited by 11
Seeds and Soil: Unraveling the Role of Local Tumor Stroma in Distant Metastasis
Duda, D. G., Ancukiewicz, M., Isakoff, S. J., Krop, I. E., & Jain, R. K. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju187 · Cited by 11
Sikandar, S. S., Gulati, G. S., Antony, J., Fetter, I. J., Kuo, A. H., Ho, W. H. D., Acosta, V. H., Das, S., Steen, C. B., Pereira, T. A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm3548 · Cited by 10
Wang, X., Bai, L., Kong, L., & Guo, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1411731 · Cited by 11
Significance of Tumor Self-Seeding As An Augmentation to the Classic Metastasis Paradigm
Hahnfeldt, P. (2010) · Future Oncology · doi:10.2217/fon.10.43 · Cited by 10
Markers of Circulating Breast Cancer Cells
López-Muñoz, E., & Méndez-Montes, M. (2013) · Advances in clinical chemistry · doi:10.1016/b978-0-12-407680-8.00007-5 · Cited by 10
Molecular characterization of circulating tumor cells in lung cancer: moving beyond enumeration
Wang, L., Duménil, C., Julié, C., Giraud, V., Dumoulin, J., Labrune, S., Chinet, T., Emile, J., He, B., & Leprieur, E. G. (2017) · Oncotarget · doi:10.18632/oncotarget.22651 · Cited by 10
Utility of Circulating Tumor Cells and DNA in the Management of Advanced Colorectal Cancer
Pan, X., & Zhang, X. (2020) · Future Oncology · doi:10.2217/fon-2020-0073 · Cited by 10
Self-citationShemshaki, H., AL-Mamari, S. A., Geelani, I. A., & Kumar, S. (2021) · Urologia Journal · doi:10.1177/03915603211036631 · Cited by 10
Tumors Are Evolutionary Island-Like Ecosystems
Chroni, A., & Kumar, S. (2021) · Genome Biology and Evolution · doi:10.1093/gbe/evab276 · Cited by 10
Kim, N., Kim, H., Park, W., Cho, W. K., Kim, T. G., Im, Y., Ahn, J. S., Park, Y. H., & Kim, J. (2023) · Radiation Oncology · doi:10.1186/s13014-023-02357-7 · Cited by 10
Moschini, M., Soria, F., Briganti, A., & Shariat, S. F. (2016) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2016.52 · Cited by 10
Exosomes, microvesicles, and their friends in solid tumors
Corbeil, D., & Lorico, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816053-4.00003-1 · Cited by 10
Boussommier-Calleja, A. (2020) · Bioengineering Innovative Solutions for Cancer · doi:10.1016/b978-0-12-813886-1.00013-9 · Cited by 10
Wang, W., Ding, H., Sun, Z.-Y. J., Jin, C., Zhu, Y., & Wang, X. (2020) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-020-01592-y · Cited by 10
Liu, S., Nyström, N. N., Kelly, J. J., Hamilton, A. M., Fu, Y., & Ronald, J. A. (2021) · Molecular Imaging and Biology · doi:10.1007/s11307-021-01630-z · Cited by 10
Cao, Y., Chen, H., Sahgal, A., Erler, D., Badellino, S., Biswas, T., Dagan, R., Foote, M. C., Louie, A. V., Poon, I., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.4332 · Cited by 10
Luo, S., Ou, Y., Zheng, T., Jiang, H., Wu, Y., Zhao, J., & Zhang, Z. (2021) · Journal of Oncology · doi:10.1155/2021/1517488 · Cited by 10
Engel, J., Eckel, R., Schrodi, S., Halfter, K., Schubert-Fritschle, G., & Hölzel, D. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04369-4 · Cited by 11
Ziegler, V., Knaup, J., Stahl, D., Krammer, B. E., & Plaetzer, K. (2011) · Lasers in Surgery and Medicine · doi:10.1002/lsm.21089 · Cited by 10
Hsieh, C., & Wu, M. (2016) · InTech eBooks · doi:10.5772/64812 · Cited by 10
Drug development for noncastrate prostate cancer in a changed therapeutic landscape
Teo, M. Y., O’Shaughnessy, M. J., McBride, S. M., Vargas, H. A., & Scher, H. I. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.160 · Cited by 10
Limiting tumor seeding as a therapeutic approach for metastatic disease
Worrede, A., Meucci, O., & Fatatis, A. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.007 · Cited by 11
PremetastasisPreprint
Maru, Y. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036897 · Cited by 10
Takagi, K., Kawase, M., Kato, D., Kawase, K., Takai, M., Iinuma, K., Nakane, K., Hagiwara, N., Yamada, T., Tomioka, M., et al. (2022) · Current Oncology · doi:10.3390/curroncol29040233 · Cited by 9
Imber, B. S., Sehgal, R. R., Saganty, R., Reiner, A. S., Ilıca, A. T., Miao, E., Li, B. T., Riely, G. J., Yu, H. A., Panageas, K. S., et al. (2023) · JTO Clinical and Research Reports · doi:10.1016/j.jtocrr.2023.100607 · Cited by 9
Gits, H. C., Flanigan, M. A. K., Kapplinger, J. D., Reisenauer, J. S., Eiken, P. W., Breen, W. G., Vu, L. H., Welch, B. T., Harmsen, W. S., Day, C. N., et al. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.12.013 · Cited by 10
Zhou, W., Yue, Y., Xiong, J., Li, W., & Zeng, X. (2024) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2024.102784 · Cited by 8
Oxygen/Nitric Oxide Dual-Releasing Nanozyme for Augmenting TMZ-Mediated Apoptosis and Necrosis
Ma, J., Qiu, J., Wright, G. A., & Wang, S. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c00817 · Cited by 11
Tsai, M., Yen, Y., Huang, P., Sou, F., Lin, C., Cho, W.-R., Wang, H., Chen, D.-W., Chang, K., Wu, C., et al. (2019) · Gastroenterology Research and Practice · doi:10.1155/2019/8945798 · Cited by 9
The Role of Liquid Biopsy in the Diagnosis and Prognosis of WHO Grade 4 Astrocytoma
Halawa, T. F., Baeesa, S. S., Fadul, M. M., Badahdah, A. A., Enani, M., Fathaddin, A., Kawass, D., Alkhotani, A., Bahakeem, B., & Kurdi, M. E. (2023) · Cureus · doi:10.7759/cureus.41221 · Cited by 9
Biomarkers in Cancer Micrometastasis: Where are We At?
Gerges, N., & Jabado, N. (2010) · Bioanalysis · doi:10.4155/bio.10.49 · Cited by 9
Biology in prevention and treatment of brain metastases
Berghoff, A. S., & Preusser, M. (2013) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2013.852067 · Cited by 10
Cancer Stem Cell Biomarker Discovery Using Antibody Array Technology
Burgess, R., & Huang, R. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.10.001 · Cited by 9
Cell reintegration: Stray epithelial cells make their way home
Wilson, T. J., & Bergstralh, D. T. (2017) · BioEssays · doi:10.1002/bies.201600248 · Cited by 8
The role of radiotherapy in metastatic prostate cancer.
Khullar, K., & Parikh, R. R. (2019) · PubMed Central · Cited by 9
Circulating tumor cells and breast cancer‑specific mutations in primary breast cancer
Mego, M., Karaba, M., Sedláčková, T., Benca, J., Repiská, G., Krasničanová, L., Macúch, J., Sieberova, G., Jurišová, S., Pinďák, D., et al. (2020) · Molecular and Clinical Oncology · doi:10.3892/mco.2020.2026 · Cited by 9
Wang, P., Cheng, J., & Yang, X. (2020) · Hepatoma Research · doi:10.20517/2394-5079.2020.55 · Cited by 9
Mao, Y., Hu, M., Yang, G., Gao, E., & Xu, W. (2022) · World Journal of Surgical Oncology · doi:10.1186/s12957-022-02715-x · Cited by 9
Yan, C., Xiao, Y., Zhang, W., Sun, Y., Lin, Y., & Cai, W. (2023) · Annals of Surgical Oncology · doi:10.1245/s10434-023-14231-7 · Cited by 9
Partial breast irradiation: Targeting volume or breast molecular subtypes?
Orecchia, R., & Leonardi, M. C. (2013) · The Breast · doi:10.1016/j.breast.2013.07.025 · Cited by 9
Significance of primary lesion resection in Stage IV breast cancer
Shien, T., & Iwata, H. (2017) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyx027 · Cited by 9
Zhang, C., Pan, Y., Zhang, Q., Shi, O., Zheng, L., Gui, L., & Luo, M. (2017) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-017-2442-2 · Cited by 9
Bestandsaufnahme der Lokalanästhetika 2020
Zink, W., Steinfeldt, T., & Wiesmann, T. (2020) · Der Anaesthesist · doi:10.1007/s00101-020-00740-7 · Cited by 9
Tran, P. T., & Antonarakis, E. S. (2017) · Journal of Oncology Practice · doi:10.1200/jop.2016.018846 · Cited by 10
Xu, Y., Wang, C., Wu, N., & Mi, X. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c00301 · Cited by 8
Carbone, L., Incognito, G. G., Incognito, D., Nibid, L., Caruso, G., Berretta, M., Taffon, C., Palumbo, M. A., Perrone, G., Roviello, F., et al. (2025) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03837-2 · Cited by 9
Huang, G., Xu, G., Cao, Q., Li, S., Li, Z., Zhang, X., & Li, X. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00833-9 · Cited by 11
Self-citationWang, J., Tang, J., Liang, A., Cui, Z. D., Huo, J., Li, Q., Ke, B., Yang, D., & Yao, C. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c00648 · Cited by 8
de Córdoba, B. R.-F., Valencia, K., Welch, C., Moreno, H., Martínez-Canarias, S., Zandueta, C., Gómez, E., Calvo, A., Otegui, N., Echepare, M., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02271-2 · Cited by 7
Rationale for local treatment in the management of metastatic prostate cancer
Gandaglia, G., Fossati, N., Dell’Oglio, P., Moschini, M., Cucchiara, V., Suardi, N. R., Mottrie, A., Mirone, V., Montorsi, F., & Briganti, A. (2016) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000218 · Cited by 8
Yang, Y., Lu, Y.-J., Jiang, W. G., Zhu, J., & Yan, S. (2020) · World Journal of Surgical Oncology · doi:10.1186/s12957-020-01972-y · Cited by 8
IL-6 and Inflammatory Diseases
Kamimura, D., Arima, Y., Hirano, T., Ogura, H., & Murakami, M. (2013) · Springer eBooks · doi:10.1007/978-4-431-54442-5_2 · Cited by 9
Metastatic disease: A drug discovery perspective
Lehembre, F., & Regenass, U. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.03.005 · Cited by 8
Liquid biopsy - emergence of a new era in personalized cancer care
Abraham, J., Singh, S., & Joshi, S. P. (2018) · Applied cancer research/Applied Cancer Research · doi:10.1186/s41241-018-0053-0 · Cited by 8
Circulating Tumor Cells in Desmoid Tumors: New Perspectives
Braun, A. C., Campos, F. A. B., Abdallah, E. A., Ruano, A. P. C., Medina, T. D. S., Tariki, M. S., Pinto, F. F. E., de Mello, C. A. L., & Chinen, L. T. D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.622626 · Cited by 8
Sheng, M., Guo, S., & Liu, C. (2021) · World Journal of Surgical Oncology · doi:10.1186/s12957-021-02455-4 · Cited by 8
Protection of bone in premenopausal women with breast cancer: focus on zoledronic acid
Aft, R. (2012) · International Journal of Women s Health · doi:10.2147/ijwh.s29101 · Cited by 8
Dose-Dense Chemotherapy for Breast Cancer: What Does the Future Hold?
Morris, P. G., McArthur, H. L., Hudis, C. A., & Norton, L. (2010) · Future Oncology · doi:10.2217/fon.10.59 · Cited by 8
Self-citationLoco-regional therapy and breast cancer survival: Searching for a link
Ponzone, R., & Baum, M. (2012) · The Breast · doi:10.1016/j.breast.2012.10.004 · Cited by 8
Circulating Tumor Cells: Personalized Medicine in Interventional Oncology?
Sheth, R. A., Hesketh, R., Deipolyi, A. R., & Öklü, R. (2012) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2012.10.018 · Cited by 8
Monitoring cancer stem cells: insights into clinical oncology
Min, D., Lin, S., Xu, Y., Gan, Z.-H., Han, K., Hu, H., Yao, Y., & Huang, M. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s96645 · Cited by 8
Significance of EGFR Expression in Circulating Tumor Cells
Serrano, M. J., Álvarez-Cubero, M. J., de Miguel‐Pérez, D., Martínez, A. R., González-Herrera, L., Robles‐Fernandez, I., Hernández, J. E., Puche, J. L. G., & Lorente, J. A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55947-6_16 · Cited by 8
Zhou, K., Ding, Y., Vuletic, I., Tian, Y., Li, J., Liu, J., Huang, Y., Sun, H., Li, C., Ren, Q., et al. (2018) · BioMedical Engineering OnLine · doi:10.1186/s12938-018-0615-0 · Cited by 8
Metadata
- Authors
- Kim, M.-Y., Oskarsson, T., Acharyya, S., Nguyen, D. X., Zhang, X. H.-F., Norton, L., & Massagué, J.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Massagué, Joan
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 139
- Issue
- 7
- Pages
- 1315-1326
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2810531
- OpenAlex
- W2152393981
- Cited by
- 1,335
- References
- 57
- Citations by year
- 2026: 16 · 2025: 44 · 2024: 61 · 2023: 90 · 2022: 89 · 2021: 88 · 2020: 96 · 2019: 87 · 2018: 68 · 2017: 82 · 2016: 91 · 2015: 96 · 2014: 102 · 2013: 82 · 2012: 98
- FWCI
- 40.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense
- Howard Hughes Medical Institute
- National Institutes of Health
- National Cancer Institute (P01CA094060, CA94060, P30CA008748)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- circulating tumor cells, breast cancer, colon cancer, melanoma, interleukin-6, interleukin-8, MMP-1, fascin, CXCL1, tumor angiogenesis, tumor growth, local recurrence, metastatic tropism, actin cytoskeleton
- MeSH terms
- Animals, Breast Neoplasms, Humans, Melanoma, Mice, Inbred BALB C, Neoplastic Cells, Circulating, Neoplasm Proteins, Neoplasm Recurrence, Local, Neoplasms, Prognosis, Skin Neoplasms, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
