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Anti-inflammatory Agents: Present and Future
Open accessAbstract
Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective anti-inflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. In particular, the new era of anti-inflammatory agents includes "biologicals" such as anticytokine therapies and small molecules that block the activity of kinases. Other anti-inflammatories currently in use or under development include statins, histone deacetylase inhibitors, PPAR agonists, and small RNAs. This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics.
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“Inflammation, as a basic pathological process, is critically implicated in the pathogenesis and progression of numerous diseases.”
From Picroside II as a Potential Anti-Inflammatory Agent (2026) · cites this paper as [3]
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Metadata
- Authors
- Dinarello, C. A.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Dinarello, Charles A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 140
- Issue
- 6
- Pages
- 935-950
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3752337
- OpenAlex
- W2126894693
- Cited by
- 1,095
- References
- 127
- Citations by year
- 2026: 50 · 2025: 92 · 2024: 97 · 2023: 79 · 2022: 79 · 2021: 90 · 2020: 73 · 2019: 63 · 2018: 64 · 2017: 62 · 2016: 60 · 2015: 64 · 2014: 51 · 2013: 48 · 2012: 51
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Cancer Institute (CA 6934)
- National Institute of Allergy and Infectious Diseases (AI‑15614, R56AI015614, R01AI015614)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- anti-inflammatory agents, inflammation, autoimmune disease, autoinflammatory disease, neurodegenerative diseases, cancer, aspirin, nonsteroidal anti-inflammatory drugs, biologicals, anti-cytokine therapy, kinase inhibitors, statins, histone deacetylase inhibitors, PPAR agonists, small RNA, drug development
- MeSH terms
- Animals, Anti-Inflammatory Agents, Autoimmune Diseases, Humans, Inflammation, Drug Design
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