Cited by 1,095Inflammatory mediators and NSAID effectsNF-κB Signaling PathwaysNatural Compounds in Disease Treatment

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Anti-inflammatory Agents: Present and Future

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Dinarello, Charles A.·2010·Cell

DOI 10.1016/j.cell.2010.02.043PMC PMC3752337

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Abstract

Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective anti-inflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. In particular, the new era of anti-inflammatory agents includes "biologicals" such as anticytokine therapies and small molecules that block the activity of kinases. Other anti-inflammatories currently in use or under development include statins, histone deacetylase inhibitors, PPAR agonists, and small RNAs. This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics.

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Authors: Dinarello, C. A.
Affiliations: Radboud University Nijmegen (NL)
Corresponding author: Dinarello, Charles A.
ORCID: Dinarello, Charles A.
Venue: Cell
Publisher: Elsevier BV
Published: 2010-03
Volume: 140
Issue: 6
Pages: 935-950
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2010.02.043
PMC: PMC3752337
OpenAlex: W2126894693
Cited by: 1,095
References: 127
Citations by year: 2026: 50 · 2025: 92 · 2024: 97 · 2023: 79 · 2022: 79 · 2021: 90 · 2020: 73 · 2019: 63 · 2018: 64 · 2017: 62 · 2016: 60 · 2015: 64 · 2014: 51 · 2013: 48 · 2012: 51
FWCI: 6.09
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1234 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: National Cancer Institute (CA 6934)
National Institute of Allergy and Infectious Diseases (AI‑15614, R56AI015614, R01AI015614)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: anti-inflammatory agents, inflammation, autoimmune disease, autoinflammatory disease, neurodegenerative diseases, cancer, aspirin, nonsteroidal anti-inflammatory drugs, biologicals, anti-cytokine therapy, kinase inhibitors, statins, histone deacetylase inhibitors, PPAR agonists, small RNA, drug development
MeSH terms: Animals, Anti-Inflammatory Agents, Autoimmune Diseases, Humans, Inflammation, Drug Design

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