The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways
Open accessAbstract
Summary Stringent control of the NF-κB and type I interferon pathways is critical to effective host immune responses, yet the molecular mechanisms that negatively regulate these pathways are poorly understood. Here we show that NLRC5, a member of the NOD-like protein family, can inhibit the IKK complex and RIG-I/MDA5 function. NLRC5 strongly inhibited NF-κB-dependent responses by interacting with IKKα/IKKβ and blocking their phosphorylation. It also interacted with RIG-I and MDA5, but not with MAVS, to potently inhibit RIG-I-like receptor-mediated type I interferon responses. Consistent with these observations, NLRC5-specific siRNA knockdown not only enhanced the activation of NF-κB and its responsive genes, TNF-α and IL-6, but also promoted type I interferon signaling and antiviral immunity. Our findings identify NLRC5 as a key negative regulator that blocks two central components of the NF-κB and type I interferon pathways, and hence is a pivotal element in the homeostatic control of the innate immune system.
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Cites
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576
Recognition of microorganisms and activation of the immune response
Medzhitov, R. (2007) · Nature · doi:10.1038/nature06246 · Cited by 2,862
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates
Pichlmair, A., Schulz, O., Tan, C. P., Näslund, T. I., Liljeström, P., Weber, F., & Reis e Sousa, C. (2006) · Science · doi:10.1126/science.1132998 · Cited by 2,210
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542
Negative regulation of Toll-like receptor-mediated immune responses
Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509
Ubiquitin signalling in the NF-κB pathway
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Self-citationNod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB
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Cited by
Immune Signaling by RIG-I-like Receptors
Loo, Y.-M., & Gale, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.003 · Cited by 1,875
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618
Lee (2019) · doi:10.1038/s12276-019-0299-y · Cited by 635
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes
Meissner, T. B., Li, A., Biswas, A., Lee, K.-H., Liu, Y.-J., Bayir, E., Iliopoulos, D., van den Elsen, P. J., & Kobayashi, K. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008684107 · Cited by 447
Dissecting negative regulation of Toll-like receptor signaling
Kondo, T., Kawai, T., & Akira, S. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.05.002 · Cited by 419
Metadata
- Authors
- Cui, J., Zhu, L., Xia, X., Wang, H. Y., Legras, X., Hong, J., Ji, J., Shen, P., Zheng, S., Chen, Z. J., & Wang, R.-F.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 141
- Issue
- 3
- Pages
- 483-496
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2067262890
- Cited by
- 447
- References
- 9
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cui, J., Zhu, L., Xia, X., Wang, H. Y., Legras, X., Hong, J., Ji, J., Shen, P., Zheng, S., Chen, Z. J., & Wang, R.-F. (2010). NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways. Cell. https://doi.org/10.1016/j.cell.2010.03.040
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