The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
Open accessAbstract
Omega-3 fatty acids (omega-3 FAs), DHA and EPA, exert anti-inflammatory effects, but the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor 120 (GPR120) functions as an omega-3 FA receptor/sensor. Stimulation of GPR120 with omega-3 FAs or a chemical agonist causes broad anti-inflammatory effects in monocytic RAW 264.7 cells and in primary intraperitoneal macrophages. All of these effects are abrogated by GPR120 knockdown. Since chronic macrophage-mediated tissue inflammation is a key mechanism for insulin resistance in obesity, we fed obese WT and GPR120 knockout mice a high-fat diet with or without omega-3 FA supplementation. The omega-3 FA treatment inhibited inflammation and enhanced systemic insulin sensitivity in WT mice, but was without effect in GPR120 knockout mice. In conclusion, GPR120 is a functional omega-3 FA receptor/sensor and mediates potent insulin sensitizing and antidiabetic effects in vivo by repressing macrophage-induced tissue inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The anti-inflammatory effects of omega-3 fatty acids seems to be mediated by binding to the G-protein–coupled receptor 120 and inhibition of NLRP3 inflammasome activity (53,54).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [53]
In the citing paper
“in macrophages and adipocytes the G-protein coupled receptor GPR120 is an omega-3 sensitive receptor that exhibits anti-inflammatory properties through the suppression of TNF-activation [141]”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [141]
In the citing paper
“GPR120 expression is negligible in skeletal muscle and would therefore not explain the changes induced by omega-3 PUFAs in tissue culture models [141]”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [141]
In the citing paper
“In summary, the n-3 PUFAs EPA and DHA can reduce inflammation via their incorporation into membrane phospholipids, where they inhibit the production of pro-inflammatory eicosanoids, reducing of activation of immune cells and the associated release of pro-inflammatory cytokines [71,97,98].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · cited 2×
“Consistent with previous studies (Weisberg et al., 2003; Xu et al., 2003; Nguyen et al., 2007), HFD induced a large increase in F4/80 positive ATMs, which form crown-like structures (CLS) around adipocytes in both WT and GPR120 KO mice.”
InfluentialXu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Kawai, T., & Akira, S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401850 · Cited by 1,894
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · cited 4×
“Since chronic tissue inflammation is an important mechanism causing insulin resistance (Xu et al., 2003; Shoelson et al., 2007; Schenk et al., 2008), the anti-inflammatory actions of u-3 FAs exert potent insulin sensitizing effects.”
InfluentialFree fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., & Tsujimoto, G. (2004) · Nature Medicine · doi:10.1038/nm1168 · Cited by 1,580 · cited 4×
“Long-chain FAs can activate GPR40 (Itoh et al., 2003) and GPR120 (Hirasawa et al., 2005).”
InfluentialFree fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538 · cited 6×
“Recently, several groups reported that five orphan receptors, GPR40, GPR41, GPR43, GPR84, and GPR120, can be activated by free fatty acids (FFAs).”
Influentialβ-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
Luttrell, L. M., Ferguson, S. S. G., Daaka, Y., Miller, W. E., Maudsley, S. R., Rocca, G. J. D., Lin, F., Kawakatsu, H., Owada, K. M., Luttrell, D. K., et al. (1999) · Science · doi:10.1126/science.283.5402.655 · Cited by 1,473 · cited 1×
“Interestingly, only the full-length b-arrestin2 coprecipitated with GPR120 and TAB1, while a series of deletion/truncation b-arrestin2 mutants did not, indicating that the interactions are dependent on the complete tertiary structure of b-arrestin2 (Figure S2D; Luttrell et al., 1999).”
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
Gether, U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0390 · Cited by 1,264 · cited 1×
“…to GPCRs to stimulate and induce a variety of cellular responses via several second messenger pathways; e.g., modulation of cAMP production, the phospholipase C pathway, ion channels, and mitogen-activated protein kinases (Ulloa-Aguirre et al., 1999; Gether, 2000; Schulte and Fredholm, 2003.”
Insulin sensitivity: Modulation by nutrients and inflammation
Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191 · cited 5×
“Since chronic macrophage-mediated tissue inflammation is a key mechanism for insulin resistance in obesity, we fed obese WT and GPR120 knockout mice a high-fat diet with or without u-3 FA supplementation.”
InfluentialSelf-citation
Cited by
Sorted by citations
Items 401–500 of 1,006
Dissecting the Physiology and Pathophysiology of Glucagon-Like Peptide-1
Paternoster, S., & Falasca, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00584 · Cited by 92
Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK–SERCA2b pathway
Jung, T. W., Kim, H., El‐Aty, A. M. A., & Jeong, J. H. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000885 · Cited by 89
Metabolomic analysis of male combat veterans with post traumatic stress disorder
Mellon, S. H., Bersani, F. S., Lindqvist, D., Hammamieh, R., Donohue, D., Dean, K., Jett, M., Yehuda, R., Flory, J., Reus, V. I., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0213839 · Cited by 85
Li, X., Yu, Y., & Funk, C. D. (2013) · The FASEB Journal · doi:10.1096/fj.13-235333 · Cited by 89
Zhuang, P., Zhang, Y., Shou, Q., Li, H., Zhu, Y., He, L., Chen, J., & Jiao, J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900946 · Cited by 94
Nutrition Regulates Innate Immunity in Health and Disease
Nobs, S. P., Zmora, N., & Elinav, E. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-120919-094440 · Cited by 93
“Omega-3 polyunsaturated fatty acids (PUFAs) decrease macrophage chemotaxis and shift macrophages toward an anti-inflammatory polarization state by stimulating G-protein-coupled receptor 120 (GPCR120), which subsequently results in the inactivation of transforming growth factor beta-activated kinase 1 (TAK1) and inhibi…”
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity
Shan, B., Shao, M., Zhang, Q., Hepler, C., Paschoal, V. A., Barnes, S. D., Vishvanath, L., An, Y., Jia, L., Malladi, V. S., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00301-7 · Cited by 91
Self-citationWatanabe, Y., Nagai, Y., & Takatsu, K. (2013) · Nutrients · doi:10.3390/nu5093757 · Cited by 92
Brankatschk, M., Gutmann, T., Knittelfelder, O. L., Palladini, A., Prince, E., Grzybek, M., Brankatschk, B., Shevchenko, A., Coskun, Ü., & Eaton, S. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.05.028 · Cited by 90
Siriwardhana, N., Kalupahana, N. S., Fletcher, S., Xin, W., Claycombe, K. J., Quignard-Boulange, A., Zhao, L., Saxton, A. M., & Moustaid-Moussa, N. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.11.009 · Cited by 89
Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1
Xiong, Y., Swaminath, G., Cao, Q., Li, Y., Guo, Q., Salomonis, H., Lu, J. Y.-L., Houze, J. B., Dransfield, P. J., Wang, Y., et al. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.009 · Cited by 90
Oh, D. Y., & Lagakos, W. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283479230 · Cited by 91
Self-citationMaternal nutrition: opportunities in the prevention of gestational diabetes
Silva‐Zolezzi, I., Samuel, T. M., & Spieldenner, J. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nuw033 · Cited by 92
Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity
Ruggiero, A. D., Key, C.-C. C., & Kavanagh, K. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.625331 · Cited by 93
Lipid remodeling of adipose tissue in metabolic health and disease
Cho, Y. K., Lee, S., Lee, J. R., Doh, J., Park, J., Jung, Y., & Lee, Y. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01071-4 · Cited by 103
n-3 Polyunsaturated Fatty Acids and Metabolic Syndrome Risk: A Meta-Analysis
Guo, X.-F., Li, X., Shi, M., & Li, D. (2017) · Nutrients · doi:10.3390/nu9070703 · Cited by 89
The Emerging Role of Polyphenols in the Management of Type 2 Diabetes
Wang, Y., Alkhalidy, H., & Liu, D. (2021) · Molecules · doi:10.3390/molecules26030703 · Cited by 88
“The binding of FFAR1 or FFAR4 by their ligands, mainly medium to long chain FAs, like linoleic acid [82,83] and omega-3 polyunsaturated FAs (PUFAs) [84], activates Gαq, which stimulates PLC to cleave membrane-associated phosphatidylinositol 4,5bisphosphate (PIP2) into IP3 and diacylglycerol (DAG).”
Immunological contributions to adipose tissue homeostasis
DiSpirito, J. R., & Mathis, D. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.005 · Cited by 88
“Triggering of GPR120 by n-3 PUFA suppresses NFκB and JNK signaling in macrophages and, importantly, this signaling is required for the robust insulinsensitizing effects of n-3 PUFA in vivo [81].”
Treatment of Type 2 Diabetes by Free Fatty Acid Receptor Agonists
Watterson, K. R., Hudson, B. D., Ulven, T., & Milligan, G. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00137 · Cited by 89
Li, Z., Qiu, Q., Geng, X., Yang, J., Huang, W., & Qian, H. (2016) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2016.1189530 · Cited by 87
Shen, W., Chuang, C., Martinez, K., Reid, T., Brown, J. M., Lin, X., Hixson, L., Hopkins, R. G., Starnes, J. W., & McIntosh, M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m030924 · Cited by 89
Díaz, M., García-Beltrán, C., Sebastiani, G., de Zegher, F., López‐Bermejo, A., & Ibáñez, L. (2016) · Diabetes · doi:10.2337/db16-0776 · Cited by 89
Scoditti, E., Capurso, C. A., Capurso, A., & Massaro, M. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.07.001 · Cited by 94
The Effect of Marine Derived n-3 Fatty Acids on Adipose Tissue Metabolism and Function
Todorčević, M., & Hodson, L. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm5010003 · Cited by 93
Mediterranean diet and cognitive function: From methodology to mechanisms of action
Siervo, M., Shannon, O. M., Llewellyn, D. J., Stephan, B. C. M., & Fontana, L. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.09.018 · Cited by 91
Capel, F., Acquaviva, C., Pitois, E., Laillet, B., Rigaudière, J.-P., Jouve, C., Pouyet, C., Gladine, C., Comte, B., Vianey Saban, C., et al. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.04.003 · Cited by 86
Leptin and Nutrition in Gestational Diabetes
Pérez‐Pérez, A., Vilariño‐García, T., Guadix, P., Dueñas, J. L., & Sánchez‐Margalet, V. (2020) · Nutrients · doi:10.3390/nu12071970 · Cited by 95
“Another beneficial effect of the Ω-3 PUFAs on GPR120 is the increase in the translocation of intracellular vesicles containing GLUT4, which enhances glucose uptake by adipocytes [111].”
Margina, D. M., Ungurianu, A., Purdel, C. N., Nițulescu, G. M., Tsoukalas, D., Sarandi, E., Thanasoula, M., Burykina, T. I., Tekos, F., Djordjević, A. B., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111558 · Cited by 86
“Furthermore, some studies on GPR120 KO mice suggest that n-3 PUFAs that activate GPR120, interact with β-arrestin 2, and suppress NF-κB activation and macrophage-mediated inflammatory responses (Oh et al., 2010).”
The mechanisms linking obesity to colon cancer: An overview
Tarasiuk, A., Mosińska, P., & Fichna, J. (2018) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2018.01.005 · Cited by 87
Nutraceuticals as therapeutic agents for atherosclerosis
Moss, J. W. E., Williams, J. O., & Ramji, D. P. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.02.006 · Cited by 89
Ambrożewicz, E., Wójcik, P., Wroński, A., Łuczaj, W., Jastrząb, A., Žarković, N., & Skrzydlewska, E. (2018) · Cells · doi:10.3390/cells7100159 · Cited by 85
“Along with the actions of lipid peroxidation products as signaling molecules, free DHA may also bind to GPR120 and inhibit NF-κβ, which consequently reduces the severity of inflammation [69].”
Dahik, V. D., Frisdal, É., & Goff, W. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155505 · Cited by 88
“Gpr120 is highly expressed in adipocytes and macrophages, and its deficiency abrogates the anti-diabetic effects that come withω-3 PUFA supplementation [143,144].”
Hou, R., Lu, T., Gao, W., Shen, J., Yu, Z., Li, D., Zhang, R., Zheng, Y., & Cai, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c02832 · Cited by 85
The physiological and pathophysiological roles of taurine in adipose tissue in relation to obesity
Murakami, S. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.08.008 · Cited by 86
Wauquier, F., Philippe, C., Léotoing, L., Mercier, S., Davicco, M.-J., Lebecque, P., Guicheux, J., Pilet, P., Miot-Noirault, E., Poitout, V., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.429084 · Cited by 84
Kwon, Y. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900824 · Cited by 93
Shores, D. R., Binion, D. G., Freeman, B. Α., & Baker, P. R. S. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21560 · Cited by 87
Xu, J., Morinaga, H., Oh, D., Li, P., Chen, A., Talukdar, S., Lazarowski, E. R., Olefsky, J. M., & Kim, J. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103207 · Cited by 85
Self-citationMandard, S., & Patsouris, D. (2013) · PPAR Research · doi:10.1155/2013/613864 · Cited by 84
Zhang, X., Xue, C., Xu, Q., Zhang, Y., Li, H., Li, F., Liu, Y., & Guo, C. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0359-2 · Cited by 87
“Pro-inflammatory genres, such as saturated fatty acids (SFAs) [3, 4] and n-6 polyunsaturated fatty acids (PUFAs), can induce atherosclerosis, whereas n-3 fatty acids that are rich in fish oil, such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), can inhibit many aspects of inflammation, including leucoc…”
Yang, W., Jiang, W., & Guo, S. (2023) · Nutrients · doi:10.3390/nu15214671 · Cited by 97
4-Hydroxy Hexenal Derived from Docosahexaenoic Acid Protects Endothelial Cells via Nrf2 Activation
Ishikado, A., Morino, K., Nishio, Y., Nakagawa, F., Mukose, A., Sono, Y., Nagisa, Y., Kondo, K., Sekine, O., Yoshizaki, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069415 · Cited by 89
Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD
Fuchs, C. D., Claudel, T., & Trauner, M. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.08.001 · Cited by 85
Alterations of specific lipid groups in serum of obese humans: a review
Mika, A., & Śledziński, T. (2016) · Obesity Reviews · doi:10.1111/obr.12475 · Cited by 83
Martins, A. R., Crisma, A. R., Masi, L. N., do Amaral, C. L., Marzuca-Nassr, G. N., Bomfim, L. H. M., Teodoro, B. G., Queiroz, A. L., Serdan, T. D. A., Torres, R. P., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.11.012 · Cited by 86
Wen, J., Satyanarayanan, S. K., Li, A., Yan, L., Zhao, Z., Yuan, Q., Su, K., & Su, H. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.018 · Cited by 86
“3B) (Oh et al., 2010).”
Lu, D., He, A., Tan, M., Mrad, M., Daibani, A. E., Hu, D., Liu, X., Kleiboeker, B. A., Che, T., Hsu, F., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48471-2 · Cited by 91
Diet-induced Obesity Up-regulates the Abundance of GPR43 and GPR120 in a Tissue Specific Manner
Cornall, L. M., Mathai, M. L., Hryciw, D. H., & McAinch, A. J. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000335820 · Cited by 89
Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice
Guo, X.-F., Sinclair, A. J., Kaur, G., & Li, D. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.09.011 · Cited by 82
Exposure to omega-3 fatty acids at early age accelerate bone growth and improve bone quality
Koren, N., Simsa-Maziel, S., Shahar, R., Schwartz, B., & Monsonego-Ornan, E. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.01.012 · Cited by 81
Paoli, A., Moro, T., Bosco, G., Bianco, A., Grimaldi, K., Camporesi, E., & Mangar, D. (2015) · Marine Drugs · doi:10.3390/md13020996 · Cited by 81
Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
Ježek, P., Jabůrek, M., Holendová, B., & Plecitá‐Hlavatá, L. (2018) · Molecules · doi:10.3390/molecules23061483 · Cited by 87
“Another mechanism was described forω3-PUFAs during the suppression of pro-inflammatory action, through their initial binding to the GPR120 receptor in macrophages [189].”
Filippis, A. D., Ullah, H., Baldi, A., Dacrema, M., Esposito, C., Garzarella, E. U., Santarcangelo, C., Tantipongpiradet, A., & Daglia, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144929 · Cited by 87
Wachten, D., & Mick, D. U. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107836 · Cited by 78
Bioactive Lipids and Their Derivatives in Biomedical Applications
Park, J.-W., Choi, J., Kim, D., Lee, S., Lee, B., Lee, Y., Kim, S., Kwon, S., Noh, M., Lee, M., et al. (2021) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2021.107 · Cited by 86
“GRP40 and GRP120 have been identified as receptors of omega-3 and omega-6 fatty acids (Oh et al., 2010).”
Nutrient-induced inflammation in the intestine
Ji, Y. H., Sakata, Y., & Tso, P. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283476e74 · Cited by 84
Dasilva, G., Pazos, M., García-Egido, E., Gallardo, J. M., Rodríguez, I., Cela, R., & Medina, I. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.07.007 · Cited by 81
N-3 Polyunsaturated Fatty Acids and Inflammation in Obesity: Local Effect and Systemic Benefit
Wang, Y., & Huang, F. (2015) · BioMed Research International · doi:10.1155/2015/581469 · Cited by 89
Yoshihara, T., Shimada, K., Fukao, K., Sai, E., Sato-Okabayashi, Y., Matsumori, R., Shiozawa, T., Shahi, H. A., Miyazaki, T., Tada, N., et al. (2015) · Circulation Journal · doi:10.1253/circj.cj-14-0471 · Cited by 81
Salas‐Salvadó, J., Becerra‐Tomás, N., Papandreou, C., & Bulló, M. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy102 · Cited by 83
“Even the conversion of α-linolenic acid to EPA and DHA acids is inefficient (78), especially when linoleic acid is consumed in high amounts, because these longchain PUFAs exert anti-inflammatory effects by stimulating G protein-coupled receptor 120, a potent insulin sensitizer, thus enhancing systemic insulin sensitiv…”
Lin, S., Hirai, S., Yamaguchi, Y., Goto, T., Takahashi, N., Tani, F., Mutoh, C., Sakurai, T., Murakami, S., Yu, R., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300150 · Cited by 80
Xie, K., Miles, E. A., & Calder, P. C. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.03.003 · Cited by 80
Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer
Miki, Y., Kidoguchi, Y., Sato, M., Taketomi, Y., Taya, C., Muramatsu, K., Gelb, M. H., Yamamoto, K., & Murakami, M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.734624 · Cited by 80
GPR120 Inhibits Colitis Through Regulation of CD4+ T Cell Interleukin 10 Production
Yang, W., Liu, H., Xu, L., Yu, T., Zhao, X., Yao, S., Zhao, Q., Barnes, S., Cohn, S. M., Dann, S. M., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.09.018 · Cited by 79
An atlas of G-protein coupled receptor expression and function in human subcutaneous adipose tissue
Amisten, S., Neville, M. J., Hawkes, R. G., Persaud, S. J., Karpe, F., & Salehi, A. A. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.09.007 · Cited by 82
Negative regulation of the inflammasome: keeping inflammation under control
Pedraza‐Alva, G., Pérez‐Martínez, L., Valdez‐Hernández, L., Meza‐Sosa, K. F., & Ando‐Kuri, M. (2015) · Immunological Reviews · doi:10.1111/imr.12294 · Cited by 76
Sankoda, A., Harada, N., Iwasaki, K., Yamane, S., Murata, Y., Shibue, K., Thewjitcharoen, Y., Suzuki, K., Harada, T., Kanemaru, Y., et al. (2017) · Endocrinology · doi:10.1210/en.2017-00090 · Cited by 81
It is all about fluidity: Fatty acids and macrophage phagocytosis
Schumann, J. E. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.04.057 · Cited by 81
Adipose tissues as endocrine target organs
Lanthier, N., & Leclercq, I. A. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.07.002 · Cited by 82
Essential role of docosahexaenoic acid towards development of a smarter brain
Gharami, K., Das, M., & Das, S. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.014 · Cited by 82
Fatty-acid-mediated hypothalamic inflammation and epigenetic programming
César, H., & Pisani, L. P. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.08.008 · Cited by 80
Si, B., Tao, H., Zhang, X., Guo, J., Cui, K., Tu, Y., & Diao, Q. (2018) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.17.0847 · Cited by 74
Alvheim, A. R., Torstensen, B. E., Lin, Y. H., Lillefosse, H. H., Lock, E., Madsen, L., Hibbeln, J. R., & Kjellevold, M. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003364 · Cited by 82
Gastrointestinal defense mechanisms
Palileo, C., & Kaunitz, J. D. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32834b3fcb · Cited by 78
Cellular metabolism of tumor‐associated macrophages – functional impact and consequences
Rabold, K., Netea, M. G., Adema, G. J., & Netea-Maier, R. T. (2017) · FEBS Letters · doi:10.1002/1873-3468.12771 · Cited by 82
n-3 Polyunsaturated Fatty Acids and Their Role in Cancer Chemoprevention
Gu, Z., Shan, K., Chen, H., & Chen, Y. Q. (2015) · Current Pharmacology Reports · doi:10.1007/s40495-015-0043-9 · Cited by 78
Seafood intake and the development of obesity, insulin resistance and type 2 diabetes
Liaset, B., Øyen, J., Jacques, H., Kristiansen, K., & Madsen, L. (2019) · Nutrition Research Reviews · doi:10.1017/s0954422418000240 · Cited by 77
LU, J., CHEN, X., Zhang, Y., XU, J., Zhang, L., Li, Z., Liu, W., Ouyang, J., Han, S. H., & He, X. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1335 · Cited by 76
Winnik, S. H., Lohmann, C., Richter, E., Schäfer, N., Song, W., Leiber, F., Mocharla, P., Hofmann, J., Klingenberg, R., Borén, J., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq501 · Cited by 80
Liang, P., Henning, S. M., Schokrpur, S., Wu, L., Doan, N., SAID, J. W., Grogan, T., Elashoff, D. A., Cohen, P., & Aronson, W. J. (2016) · The Prostate · doi:10.1002/pros.23218 · Cited by 76
Biological features of placental programming
Thornburg, K. L. R., Kolahi, K. S., Pierce, M. J., Valent, A. M., Drake, R., & Louey, S. (2016) · Placenta · doi:10.1016/j.placenta.2016.10.012 · Cited by 81
O’Connell, T. D., Block, R., Huang, S., & Shearer, G. C. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.12.003 · Cited by 76
Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1
Balta, M. G., Loos, B. G., & Nicu, E. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01682 · Cited by 77
Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease
Valenzuela, R., Ortíz, M., Hernández‐Rodas, M. C., Echeverría, F., & Videla, L. A. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190410121716 · Cited by 75
Lipid metabolism in dendritic cell biology
You, Z., & Chi, H. (2023) · Immunological Reviews · doi:10.1111/imr.13215 · Cited by 83
The Effect of Omega-3 Fatty Acids on Sarcopenia: Mechanism of Action and Potential Efficacy
Therdyothin, A., Phiphopthatsanee, N., & Isanejad, M. (2023) · Marine Drugs · doi:10.3390/md21070399 · Cited by 85
Fujita, T., Matsuoka, T., Honda, T., Kabashima, K., Hirata, T., & Narumiya, S. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.123 · Cited by 75
Pharma–nutrition interface: The gap is narrowing
Georgiou, N., Garssen, J., & Witkamp, R. F. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.11.007 · Cited by 78
Murase, R., Sato, H., Yamamoto, K., Ushida, A., Nishito, Y., Ikeda, K., Kobayashi, T., Yamamoto, T., Taketomi, Y., & Murakami, M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.715672 · Cited by 76
Lipid-mediated muscle insulin resistance: different fat, different pathways?
Ritter, O., Jelenik, T., & Roden, M. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1310-2 · Cited by 74
Uncovering pathophysiological changes in frontotemporal dementia using serum lipids
Phan, K., He, Y., Pickford, R., Bhatia, S., Katzeff, J. S., Hodges, J. R., Piguet, O., Halliday, G. M., & Kim, W. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-60457-w · Cited by 72
Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid
Brouwers, H., Jónasdóttir, H. S., Kuipers, M. E., Kwekkeboom, J. C., Auger, J. L., González‐Torres, M. I., López‐Vicario, C., Clària, J., Freysdóttir, J., Harðardóttir, I., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1801653 · Cited by 72
“Moreover, free n-3 PUFAs can mediate anti-inflammatory effects by acti- vating their specific G protein–coupled receptor GPR120 (9).”
Polyunsaturated fatty acids and type 2 diabetes: Impact on the glycemic control mechanism
Coelho, O. G. L., da Silva, B. P., Rocha, D. M. U. P., Lopes, L. L., & Alfenas, R. D. C. G. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1130016 · Cited by 73
Lalia, A. Z., Johnson, M. L., Jensen, M. D., Hames, K. C., Port, J. D., & Lanza, I. R. (2015) · Diabetes Care · doi:10.2337/dc14-3101 · Cited by 73
The Complex Interplay between Lipids, Immune System and Interleukins in Cardio-Metabolic Diseases
Bernardi, S., Marcuzzi, A., Piscianz, E., Tommasini, A., & Fabris, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124058 · Cited by 71
“For instance, they are capable of inhibiting many aspects of leukocyte trafficking [187] and they inhibit TRL4 activation upon G-protein coupled receptor 120 (GPR120) binding [186]; they prevent activation of NLRP3 inflammasome in human monocytes/macrophages [188]; moreover, they can produce anti-inflammatory and infl…”
Chen, K.-H. E., Lainez, N. M., & Coss, D. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000490 · Cited by 72
“Similar to CCL2, macrophages had to be stimulated with LPS to observe the effect of GPR120 on inflammatory cytokine expression (64).”
InfluentialBjursell, M., Xu, X., Admyre, T., Böttcher, G., Lundin, S., Nilsson, R. G., Stone, V. M., Morgan, N. G., Lam, Y. Y., Storlien, L. H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114942 · Cited by 72
Omega-3 polyunsaturated fatty acids
Hull, M. A. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.08.001 · Cited by 73
Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treg induction in mice
Onodera, T., Fukuhara, A., Shin, J., Hayakawa, T., Otsuki, M., & Shimomura, I. (2017) · Scientific Reports · doi:10.1038/s41598-017-04474-2 · Cited by 76
The Molecular Basis of Ligand Interaction at Free Fatty Acid Receptor 4 (FFA4/GPR120)
Hudson, B. D., Shimpukade, B., Milligan, G., & Ulven, T. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.561449 · Cited by 72
Metadata
- Authors
- Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M.
- Affiliations
- University of California San Diego (US)
- Shiga University of Medical Science (JP)
- Corresponding author
- Olefsky, Jerrold M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 142
- Issue
- 5
- Pages
- 687-698
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2956412
- OpenAlex
- W2131094572
- Cited by
- 2,428
- References
- 49
- Citations by year
- 2026: 97 · 2025: 134 · 2024: 123 · 2023: 129 · 2022: 134 · 2021: 180 · 2020: 172 · 2019: 157 · 2018: 158 · 2017: 181 · 2016: 197 · 2015: 177 · 2014: 165 · 2013: 162 · 2012: 143
- FWCI
- 127.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NIDDK DK033651, DK 074868, DK063491, U54 HD 012303-25)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- GPR120, docosahexaenoic acid, eicosapentaenoic acid, anti-inflammatory activity, insulin sensitivity, insulin resistance, macrophage inflammation, obesity, high-fat diet, G protein-coupled receptors, RAW 264.7 macrophages
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Line, Dietary Fats, Humans, Hypoglycemic Agents, Insulin Resistance, Macrophages, Obesity, Fatty Acids, Omega-3, Mice, Knockout, Dietary Supplements, 3T3-L1 Cells, Receptors, G-Protein-Coupled, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
