The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
Open accessAbstract
Omega-3 fatty acids (omega-3 FAs), DHA and EPA, exert anti-inflammatory effects, but the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor 120 (GPR120) functions as an omega-3 FA receptor/sensor. Stimulation of GPR120 with omega-3 FAs or a chemical agonist causes broad anti-inflammatory effects in monocytic RAW 264.7 cells and in primary intraperitoneal macrophages. All of these effects are abrogated by GPR120 knockdown. Since chronic macrophage-mediated tissue inflammation is a key mechanism for insulin resistance in obesity, we fed obese WT and GPR120 knockout mice a high-fat diet with or without omega-3 FA supplementation. The omega-3 FA treatment inhibited inflammation and enhanced systemic insulin sensitivity in WT mice, but was without effect in GPR120 knockout mice. In conclusion, GPR120 is a functional omega-3 FA receptor/sensor and mediates potent insulin sensitizing and antidiabetic effects in vivo by repressing macrophage-induced tissue inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The anti-inflammatory effects of omega-3 fatty acids seems to be mediated by binding to the G-protein–coupled receptor 120 and inhibition of NLRP3 inflammasome activity (53,54).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [53]
In the citing paper
“in macrophages and adipocytes the G-protein coupled receptor GPR120 is an omega-3 sensitive receptor that exhibits anti-inflammatory properties through the suppression of TNF-activation [141]”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [141]
In the citing paper
“GPR120 expression is negligible in skeletal muscle and would therefore not explain the changes induced by omega-3 PUFAs in tissue culture models [141]”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [141]
In the citing paper
“In summary, the n-3 PUFAs EPA and DHA can reduce inflammation via their incorporation into membrane phospholipids, where they inhibit the production of pro-inflammatory eicosanoids, reducing of activation of immune cells and the associated release of pro-inflammatory cytokines [71,97,98].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · cited 2×
“Consistent with previous studies (Weisberg et al., 2003; Xu et al., 2003; Nguyen et al., 2007), HFD induced a large increase in F4/80 positive ATMs, which form crown-like structures (CLS) around adipocytes in both WT and GPR120 KO mice.”
InfluentialXu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Kawai, T., & Akira, S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401850 · Cited by 1,894
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · cited 4×
“Since chronic tissue inflammation is an important mechanism causing insulin resistance (Xu et al., 2003; Shoelson et al., 2007; Schenk et al., 2008), the anti-inflammatory actions of u-3 FAs exert potent insulin sensitizing effects.”
InfluentialFree fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., & Tsujimoto, G. (2004) · Nature Medicine · doi:10.1038/nm1168 · Cited by 1,580 · cited 4×
“Long-chain FAs can activate GPR40 (Itoh et al., 2003) and GPR120 (Hirasawa et al., 2005).”
InfluentialFree fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538 · cited 6×
“Recently, several groups reported that five orphan receptors, GPR40, GPR41, GPR43, GPR84, and GPR120, can be activated by free fatty acids (FFAs).”
Influentialβ-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
Luttrell, L. M., Ferguson, S. S. G., Daaka, Y., Miller, W. E., Maudsley, S. R., Rocca, G. J. D., Lin, F., Kawakatsu, H., Owada, K. M., Luttrell, D. K., et al. (1999) · Science · doi:10.1126/science.283.5402.655 · Cited by 1,473 · cited 1×
“Interestingly, only the full-length b-arrestin2 coprecipitated with GPR120 and TAB1, while a series of deletion/truncation b-arrestin2 mutants did not, indicating that the interactions are dependent on the complete tertiary structure of b-arrestin2 (Figure S2D; Luttrell et al., 1999).”
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
Gether, U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0390 · Cited by 1,264 · cited 1×
“…to GPCRs to stimulate and induce a variety of cellular responses via several second messenger pathways; e.g., modulation of cAMP production, the phospholipase C pathway, ion channels, and mitogen-activated protein kinases (Ulloa-Aguirre et al., 1999; Gether, 2000; Schulte and Fredholm, 2003.”
Insulin sensitivity: Modulation by nutrients and inflammation
Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191 · cited 5×
“Since chronic macrophage-mediated tissue inflammation is a key mechanism for insulin resistance in obesity, we fed obese WT and GPR120 knockout mice a high-fat diet with or without u-3 FA supplementation.”
InfluentialSelf-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–600 of 1,006
Yan, G., Li, L., Zhu, B., & Li, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.7960 · Cited by 72
Du, L., Lei, X., Wang, J., Wang, L., Zhong, Q., Fang, X., Li, P., Bing, D., Wang, Y., & Liao, Z. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1996573 · Cited by 72
“that can ameliorate insulin resistance in obesity [66].”
Self-citationGPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome
Qin, Z., Song, J., Lin, A., Yang, W. L., Zhang, W., Zhong, F., Huang, L., Lü, Y., & Yu, W. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02482-2 · Cited by 76
“It has been previously demonstrated that GPR120 is involved in energy control and regulation of energy metabolic efficiency in metabolic diseases such as obesity and diabetes [5, 6].”
The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus
Ağagündüz, D., İçer, M. A., Yeşildemir, Ö., Koçak, T., Koçyiğit, E., & Capasso, R. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04088-5 · Cited by 85
Milligan, G., Alvarez‐Curto, E., Watterson, K. R., Ulven, T., & Hudson, B. D. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12879 · Cited by 71
GPR40 is a low-affinity epoxyeicosatrienoic acid receptor in vascular cells
Park, S.-K., Herrnreiter, A. M., Pfister, S. L., Gauthier, K. M., Falck, B., Falck, J. R., & Campbell, W. B. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001297 · Cited by 71
“GPR120 is a receptor for long chain -3 fatty acids (36); however, the -3 epoxide, 17,18-EEQ, was without effect on this receptor.”
Hepatic Macrophage as a Key Player in Fatty Liver Disease
Xu, L., Liu, W., Bai, F., Xu, Y., Liang, X., Ma, C., & Gao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708978 · Cited by 73
n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus
do Nascimento, L. F. R., de Souza, G. F. P., Morari, J., Barbosa, G. O., Solon, C., de Moura, R. F., Victorio, S. C. D. S., Ignácio-Souza, L. M., Razolli, D. S., Carvalho, H. F., et al. (2015) · Diabetes · doi:10.2337/db15-0008 · Cited by 76
G protein-coupled receptors and the regulation of autophagy
Wauson, E., Dbouk, H. A., Ghosh, A. B., & Cobb, M. H. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.03.006 · Cited by 71
The effects of the microbiota on the host immune system
Karczewski, J., Poniedziałek, B., Adamski, Z., & Rzymski, P. (2014) · Autoimmunity · doi:10.3109/08916934.2014.938322 · Cited by 73
Brown, A. L., Zhu, X., Rong, S., Shewale, S. V., Seo, J., Boudyguina, E. Y., Gebre, A. K., Alexander‐Miller, M. A., & Parks, J. S. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.253435 · Cited by 73
Kinase-KCC2 coupling: Cl − rheostasis, disease susceptibility, therapeutic target
Kahle, K. T., & Delpire, E. J. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00865.2015 · Cited by 69
A novel anti-inflammatory role of GPR120 in intestinal epithelial cells
Anbazhagan, A. N., Priyamvada, S., Gujral, T., Bhattacharyya, S., Alrefai, W. A., Dudeja, P. K., & Borthakur, A. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00123.2015 · Cited by 71
What Have Metabolomics Approaches Taught Us About Type 2 Diabetes?
González-Franquesa, A., Burkart, A., ISGANAITIS, E. M., & Patti, M. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0763-1 · Cited by 70
Effectiveness of omega-3 polyunsaturated fatty acids against microbial pathogens
Chanda, W., Joseph, T. P., Guo, X.-F., Wang, W.-D., Liu, M., Vuai, M. S., Padhiar, A. A., & Zhong, M. (2018) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1700063 · Cited by 71
Host and microbiota metabolic signals in aging and longevity
Zhou, Y., Hu, G., & Wang, M. C. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00837-z · Cited by 70
De Novo Lipogenesis Products and Endogenous Lipokines
Yilmaz, M., Claiborn, K. C., & Hotamışlıgil, G. S. (2016) · Diabetes · doi:10.2337/db16-0251 · Cited by 72
Ungaro, F., Rubbino, F., Danese, S., & D’Alessio, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01331 · Cited by 74
Free Fatty Acid Receptors as Mediators and Therapeutic Targets in Liver Disease
Secor, J. D., Fligor, S. C., Tsikis, S. T., Yu, L. J., & Puder, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.656441 · Cited by 73
Bóbbo, V. C. D., Engel, D. F., Jara, C. P., Mendes, N. F., Haddad-Tóvolli, R., do Prado, T. P., Sidarta-Oliveira, D., Morari, J., Velloso, L. A., & ARAUJO, E. P. D. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02242-8 · Cited by 71
“The reduction of POMC could result from the abnormal neurogenic process and contribute to the obese-prone phenotype of IL6-deficient mice [31, 88, 89].”
Katturajan, R., Vijayalakshmi, S. P., Rasool, M., & Prince, S. E. (2021) · Toxicology · doi:10.1016/j.tox.2021.152909 · Cited by 69
Seriously cilia: A tiny organelle illuminates evolution, disease, and intercellular communication
Derderian, C., Canales, G., & Reiter, J. F. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.06.013 · Cited by 70
González‐Becerra, K., Barrón‐Cabrera, E., Muñóz-Valle, J. F., Torres‐Castillo, N., Rivera-Valdes, J. J., Rodriguez‐Echevarría, R., & Martínez‐López, E. (2023) · Healthcare · doi:10.3390/healthcare11162333 · Cited by 76
“that can regulate the transcription of genes involved in the differentiation of preadipocytes and fat cells, including the regulation of lipoprotein lipase expression [10,41], but also in the fact that a higher percentage of this fatty acid has been found in other cell tissues, i.”
Chang, C. L., & Deckelbaum, R. J. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283616364 · Cited by 73
Treatment of Parenteral Nutrition-Associated Liver Disease: The Role of Lipid Emulsions
Nandivada, P., Carlson, S. J., Chang, M. I., Cowan, E. A., Gura, K. M., & Puder, M. (2013) · Advances in Nutrition · doi:10.3945/an.113.004770 · Cited by 69
Zheng, J., Lin, M., Fang, L., Yu, Y., Yuan, L., Jin, Y., Feng, J., Wang, L., Yang, H., Chen, W., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600230 · Cited by 70
Synthesis and concentration of 2-monoacylglycerols rich in polyunsaturated fatty acids
Zhang, Y., Wang, X., Xie, D., Zou, S., Jin, Q., & Wang, X. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.01.027 · Cited by 69
Kogure, R., Toyama, K., Hiyamuta, S., Kojima, I., & Takeda, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.141 · Cited by 67
Bae, E. J., Xu, J., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Keshwani, M. M., & Olefsky, J. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.365544 · Cited by 70
Self-citationG protein–coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice
Osborn, O., Oh, D. Y., McNelis, J., Sánchez-Alavez, M., Talukdar, S., Lu, M. M., Li, P., Thiede, L., Morinaga, H., Kim, J. J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61953 · Cited by 68
Self-citationMatoba, A., Matsuyama, N., Shibata, S., Masaki, E., Emala, C. W., & Mizuta, K. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00129.2017 · Cited by 70
Huang, J., Xue, M., Zhang, J., Yu, H., Gu, Y., Du, M., Ye, W., Wan, B., Jin, M., & Zhang, Y. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.019 · Cited by 68
“G-protein-coupled receptor 120 (GPR120), the receptor of ω-3 PUFAs, has been implicated in the pathogenesis of diabetes, cancers and inflammatory diseases [12,13].”
Omega-3 Fatty Acids and Adipose Tissue: Inflammation and Browning
Kalupahana, N. S., Goonapienuwala, B. L., & Moustaid-Moussa, N. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122319-034142 · Cited by 72
Free Fatty Acid Receptors as new potential therapeutic target in inflammatory bowel diseases
Bartoszek, A., Moo, E. V., Binienda, A., Fabisiak, A., Krajewska, J. B., Mosińska, P., Niewinna, K., Tarasiuk, A., Martemyanov, K. A., Sałaga, M., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104604 · Cited by 66
Takić, M. M., Ranković, S., Girek, Z., Pavlović, S., Jovanović, P., Jovanović, V. B., & Šarac, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094909 · Cited by 75
“Upon binding and activation of n-3 PUFA to G120 (also called free fatty acid receptor 4), highly expressed in adipocytes, endothelial cells, and macrophages, a complex with β -arrestin-2 can be formed that inhibits NLRP3-dependent inflammation [172,173].”
Moreno‐Ulloa, A., Méndez-Luna, D., Beltrán‐Partida, E., Castillo, C., Guevara, G., Ramírez‐Sánchez, I., Correa‐Basurto, J., Ceballos, G. M., & Villarreal, F. J. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.08.014 · Cited by 67
Hasan, A. U., Ohmori, K., Konishi, K., Igarashi, J., Hashimoto, T., Kamitori, K., Yamaguchi, F., Tsukamoto, I., Uyama, T., Ishihara, Y., et al. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.02.012 · Cited by 67
Teague, H., Harris, M., Fenton, J. I., Lallemand, P., Shewchuk, B. M., & Shaikh, S. R. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m049809 · Cited by 66
Nutrient sensing, signal transduction and immune responses
Walls, J. F., Sinclair, L. V., & Finlay, D. K. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.09.001 · Cited by 69
Immune Modulation of Brown(ing) Adipose Tissue in Obesity
van den Berg, S. M., van Dam, A. D., Rensen, P. C. N., de Winther, M. P. J., & Lutgens, E. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1066 · Cited by 69
Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity
Paschoal, V. A., Walenta, E., Talukdar, S., Pessentheiner, A. R., Osborn, O., Hah, N., Chi, T. J., Tye, G. L., Armando, A. M., Evans, R. M., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.020 · Cited by 67
“These results indicate that macrophage GPR120 largely mediates this aspect of the anti-inflammatory effects of CpdA, as previously demonstrated (Oh da et al., 2014; Oh et al., 2010).”
InfluentialSelf-citationThe interplay of obesity, gut microbiome and diet in the immune check point inhibitors therapy era
Spyrou, N., Vallianou, N. G., Kadillari, J., & Dalamaga, Μ. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.008 · Cited by 66
Jiang, L., Wang, J., Xiong, K., Xu, L., Zhang, B., & Ma, A. (2021) · Nutrients · doi:10.3390/nu13072342 · Cited by 72
“EPA and DHA derived from fish can activate the G protein–coupled receptor 120 to reverse insulin resistance [53].”
Meidenbauer, J. J., Ta, N. L., & Seyfried, T. N. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-23 · Cited by 67
GPCR expression in tissues and cells: Are the optimal receptors being used as drug targets?
Insel, P., Snead, A. N., Murray, F., Zhang, L., Yokouchi, H., Katakia, T., Kwon, O., DiMucci, D., & Wilderman, A. S. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01434.x · Cited by 67
Significant advancement of mass spectrometry imaging for food chemistry
Yoshimura, Y., Goto‐Inoue, N., Moriyama, T., & Zaima, N. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.04.096 · Cited by 66
Impact of Sarcopenia as a Prognostic Biomarker of Bladder Cancer
Fukushima, H., Takemura, K. N., Suzuki, H., & Koga, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102999 · Cited by 65
“[42] Moreover, n-3 fatty acids, including eicosapentaenoic acid and docosahexaenoic acid, can recover a cancer-induced hyper-catabolic state and improve sarcopenia and cachexia by its anti-inflammatory effects, involving the attenuation of NF-kB signaling, deceleration of the ubiquitin proteasome pathway, and antagoni…”
New lipid-lowering drugs: an update
Wierzbicki, A. S., Hardman, T. C., & Viljoen, A. (2012) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2011.02867.x · Cited by 65
Montgomery, M. K., Osborne, B., Brandon, A. E., O’Reilly, L., Fiveash, C. E., Brown, S. H. J., Wilkins, B. P., Samsudeen, A., Yu, J., Devanapalli, B., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900234r · Cited by 60
Essential Fatty Acids as Biomedicines in Cardiac Health
Balta, I., Ştef, L., Peț, I., Iancu, T., Stef, D. S., & Corcionivoschi, N. (2021) · Biomedicines · doi:10.3390/biomedicines9101466 · Cited by 67
“The coupled complex of TAB-1and TAK-1 is a merging point for stimuli induced by the toll-like receptor 4 (TLR4) signaling pathway, including tumor necrosis factor receptor (TNFr) [17,18].”
Potential roles of GPR120 and its agonists in the management of diabetes
Leung, P. S., & Zhang, D. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s53892 · Cited by 67
Salimifar, M., Fatehi‐Hassanabad, Z., & Fatehi, M. (2013) · Current Diabetes Reviews · doi:10.2174/15733998113099990076 · Cited by 66
Derosa, G., Cicero, A. F. G., D’Angelo, A., Borghi, C., & Maffioli, P. (2016) · BioFactors · doi:10.1002/biof.1277 · Cited by 66
Macrophage fatty acid metabolism and atherosclerosis: The rise of PUFAs
Ménégaut, L., Jalil, A., Thomas, C., & Masson, D. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.10.002 · Cited by 64
Zhao, L., Wang, Y., Zhang, G., Zhang, T., Lou, J., & Liu, J. (2019) · Nutrients · doi:10.3390/nu11123054 · Cited by 64
“Besides, HFD increased and low-dose of L-arabinose treatment further increased mRNA levels of Ffar4 (free fatty acid receptor 4 or GPR120, G-protein coupled receptor 120) (Figure 5C), which encodes a G-protein coupled receptor for medium and long-chain free fatty acids that is reported to mediate potent insulin sensit…”
Sato, H., Taketomi, Y., Miki, Y., Murase, R., Yamamoto, K., & Murakami, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107579 · Cited by 65
Butcher, A. J., Hudson, B. D., Shimpukade, B., Alvarez‐Curto, E., Prihandoko, R., Ulven, T., Milligan, G., & Tobin, A. B. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.568816 · Cited by 64
Darwesh, A. M., Bassiouni, W., Sosnowski, D. K., & Seubert, J. M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107703 · Cited by 66
“Knockdown of GPR120 attenuates the protective effects attributed to n-3 PUFA consumption (Oh et al., 2010).”
Do patients benefit from omega-3 fatty acids?
Sherratt, S. C. R., Mason, R. P., Libby, P., Steg, P. G., & Bhatt, D. L. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad188 · Cited by 75
“181,182 185 Upon binding free fatty acids, this receptor increases glucose transporter type 4 (GLUT4) translocation and subsequent glucose uptake in adipocytes and increases insulin sensitivity in mice fed O3FA-enriched diets.”
Paulsen, S. J., Larsen, L. K., Hansen, G., Chelur, S., Larsen, P. J., & Vrang, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088227 · Cited by 64
Han, S. C., Kang, G.-J., Ko, Y.-J., Kang, H. K., Moon, S.-W., Ann, Y.-S., & Yoo, E. S. (2012) · BMC Immunology · doi:10.1186/1471-2172-13-44 · Cited by 64
Satoh‐Asahara, N., Shimatsu, A., Sasaki, Y., Nakaoka, H., Himeno, A., Tochiya, M., Kono, S., Takaya, T., Ono, K., Wada, H., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0269 · Cited by 64
Teague, H., Fhaner, C. J., Harris, M., Duriancik, D. M., Reid, G. E., & Shaikh, S. R. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m042457 · Cited by 64
Carpino, G., Nobili, V., Renzi, A., Stefanis, C. D., Stronati, L., Franchitto, A., Alisi, A., Onori, P., Vito, R. D., Alpini, G. D., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157246 · Cited by 64
GPR120: a critical role in adipogenesis, inflammation, and energy metabolism in adipose tissue
Song, T., Yang, Y., Zhou, Y., Wei, H., & Peng, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2492-2 · Cited by 67
Wang, M., Zhang, X., Ma, L., Feng, R., Yan, C., Su, H., He, C., Kang, J. X., Liu, B., & Wan, J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.026 · Cited by 65
Distribution of Fatty Acids and Lipids During Pregnancy
Chavan, P., Rani, A., & Freeman, D. J. (2018) · Advances in clinical chemistry · doi:10.1016/bs.acc.2017.12.006 · Cited by 68
Ren, Z.-P., Chen, L., Wang, Y., Wei, X., Zeng, S., Zheng, Y., Gao, C., & Liu, H. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800637 · Cited by 66
“Among the orphan GPCRs, GPR40 and GPR120 were found to be activated by long-chain fatty acids: in particular, omega-3 fatty acids (v-3 FAs) (9, 10). v-3 FAs, mainly including docosahexaenoic acid (DHA) and eicosapentaenoic acid, are rich in fish oil and significantly improve the health of patients suffering from chron…”
InfluentialMeijerink, J., Poland, M., Balvers, M. G. J., Plastina, P., Lute, C., Dwarkasing, J. T., van Norren, K., & Witkamp, R. F. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12747 · Cited by 63
Das, U. N. (2010) · Journal of Inflammation Research · doi:10.2147/jir.s9425 · Cited by 63
Belchior, T., Paschoal, V. A., Magdalon, J., Chimin, P., Farias, T. M., Chaves‐Filho, A. B., Gorjão, R., St.‐Pierre, P., Miyamoto, S., Kang, J. X., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400914 · Cited by 68
Karlsen, T. A., & Brinchmann, J. E. (2013) · Molecular Therapy · doi:10.1038/mt.2013.55 · Cited by 64
Impact of obesity on autoimmune arthritis and its cardiovascular complications
Raemdonck, K. V., Umar, S., Szekanecz, Z., Zomorrodi, R. K., & Shahrara, S. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.02.007 · Cited by 66
Moran, B. M., Abdel‐Wahab, Y. H. A., Flatt, P. R., & McKillop, A. M. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12330 · Cited by 64
Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain
Tao, X., Lee, M. S., Donnelly, C. R., & Ji, R. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00892-9 · Cited by 63
Anti-obesity effects of DHA and EPA in high fat-induced insulin resistant mice
Wei, W., Hu, M., Huang, J., Yu, S., Li, X., Li, Y., & Mao, L. (2020) · Food & Function · doi:10.1039/d0fo02448a · Cited by 65
Liu, Q. K. (2021) · Journal of clinical lipidology · doi:10.1016/j.jacl.2021.05.007 · Cited by 65
Casali, B. T., Corona, A. W., Mariani, M. M., Karlo, J. C., Ghosal, K., & Landreth, G. E. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1000-15.2015 · Cited by 63
Thota, R. N., Ferguson, J. J. A., Abbott, K. A., Dias, C. B., & Garg, M. L. (2018) · Food & Function · doi:10.1039/c8fo00348c · Cited by 60
Can inflammation be resolved in Alzheimer’s disease?
Zhu, M., Wang, X., Sun, L., Schultzberg, M., & Hjorth, E. (2018) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418791107 · Cited by 62
Gao, X., Xu, J., Jiang, C., Zhang, Y., Xue, Y., Li, Z., Wang, J., Xue, C., & Wang, Y. (2015) · Food & Function · doi:10.1039/c5fo00007f · Cited by 60
Pflimlin, E., Bielohuby, M., Korn, M., Breitschopf, K., Löhn, M., Wohlfart, P., Konkar, A. A., Podeschwa, M. A. L., Bärenz, F., Pfenninger, A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.028 · Cited by 61
Zhang, Y., Zhang, B., Dong, L., & Chang, P. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy076 · Cited by 62
“Apart from this action, DHA was shown to be capable of suppressing the bioactivity of the IκB kinase (IKK) complex by inhibiting its phosphorylation (Figure 5) (127).”
Advances in Technologies for Highly Active Omega-3 Fatty Acids from Krill Oil: Clinical Applications
Colletti, A., Cravotto, G., Citi, V., Martelli, A., Testai, L., & Cicero, A. F. G. (2021) · Marine Drugs · doi:10.3390/md19060306 · Cited by 61
Jin, X., Dong, X., Sun, Y., Liu, Z., Liu, L., & Gu, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3711371 · Cited by 61
“[55] found that the stimulation of G protein-coupled receptor 120 with n-3 PUFAs inhibited TLR4 signaling, possibly due to the binding of β-arrestin-2 to TAB1, leading to the inhibition of TAK1 phosphorylation and activation, which in turn blocks TLR4 signaling.”
Guo, Y., Zhou, M., Mu, Z., Guo, J., Hou, Y., Xu, Y., & Geng, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115138 · Cited by 61
Casas‐Agustench, P., Fernandes, F. S., do Carmo, M. G. T., Visioli, F., Herrera, E., & Dávalos, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117858 · Cited by 61
Burns, R. N., Singh, M., Senatorov, I. S., & Moniri, N. H. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.016 · Cited by 62
Zhang, K., Chang, Y., Shi, Z., Han, X., Han, Y., Yao, Q., Hu, Z., Cui, H., Zheng, L., Han, T., et al. (2016) · Scientific Reports · doi:10.1038/srep30029 · Cited by 61
Fonte‐Faria, T., Citelli, M., Atella, G. C., Raposo, H. F., Zago, L., de Souza, T., da Silva, S. V., & Barja‐Fidalgo, C. (2018) · Nutrition · doi:10.1016/j.nut.2018.08.011 · Cited by 62
Application of Mass Spectrometry Imaging for Visualizing Food Components
Yoshimura, Y., & Zaima, N. (2020) · Foods · doi:10.3390/foods9050575 · Cited by 62
“Eicosapentaenoic acid (EPA), which is contained in fish oil, has several beneficial functions, including anti-inflammatory [3], anti-atherosclerosis effects [4],”
Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse
Jayasimhan, A., Mansour, K. P., & Slattery, R. M. (2013) · Clinical Science · doi:10.1042/cs20120627 · Cited by 63
Tatsumi, Y., Kato, A., Sango, K., Himeno, T., Kondo, M., Kato, Y., Kamiya, H., Nakamura, J., & Kato, K. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12931 · Cited by 61
Unsaturated Fatty Acids and Pain
Tokuyama, S., & Nakamoto, K. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1174 · Cited by 61
Shimano, H. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.12.004 · Cited by 62
Westermeier, F., Sáez, P. J., Villalobos-Labra, R., Sobrevía, L., & Farías, M. (2014) · BioMed Research International · doi:10.1155/2014/917672 · Cited by 59
Santangelo, C., Zicari, A., Mandosi, E., Scazzocchio, B., Mari, E., Morano, S., & Masella, R. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516000222 · Cited by 59
Si, T., Liu, Q., REN, Y.-F., Li, H., XU, X.-Y., Li, E., Pan, S., Zhang, J., & Wang, K. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5259 · Cited by 60
Yamada, H., Umemoto, T., Kakei, M., Momomura, S., Kawakami, M., Ishikawa, S., & Hara, K. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0188-0 · Cited by 60
Silva, R. V., Oliveira, J. T., dos Santos, B. L. R., Dias, F. C., Martinez, A. M. B., de Lima, C. K. F., & Miranda, A. L. P. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00723 · Cited by 63
Metadata
- Authors
- Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M.
- Affiliations
- University of California San Diego (US)
- Shiga University of Medical Science (JP)
- Corresponding author
- Olefsky, Jerrold M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 142
- Issue
- 5
- Pages
- 687-698
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2956412
- OpenAlex
- W2131094572
- Cited by
- 2,428
- References
- 49
- Citations by year
- 2026: 97 · 2025: 134 · 2024: 123 · 2023: 129 · 2022: 134 · 2021: 180 · 2020: 172 · 2019: 157 · 2018: 158 · 2017: 181 · 2016: 197 · 2015: 177 · 2014: 165 · 2013: 162 · 2012: 143
- FWCI
- 127.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NIDDK DK033651, DK 074868, DK063491, U54 HD 012303-25)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- GPR120, docosahexaenoic acid, eicosapentaenoic acid, anti-inflammatory activity, insulin sensitivity, insulin resistance, macrophage inflammation, obesity, high-fat diet, G protein-coupled receptors, RAW 264.7 macrophages
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Line, Dietary Fats, Humans, Hypoglycemic Agents, Insulin Resistance, Macrophages, Obesity, Fatty Acids, Omega-3, Mice, Knockout, Dietary Supplements, 3T3-L1 Cells, Receptors, G-Protein-Coupled, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
