Host and microbiota metabolic signals in aging and longevity

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Wang, M., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., Nguyen, D. D., Watrous, J., Kapono, C. A., Luzzatto-Knaan, T., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3597 · Cited by 4,629 · see citing works

The role of short-chain fatty acids in microbiota–gut–brain communication

Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357 · see citing works

Gut microbiota composition correlates with diet and health in the elderly

Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works

Gut biogeography of the bacterial microbiota

Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro3552 · Cited by 2,535 · see citing works

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428 · see citing works

Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

Özcan, U., Yilmaz, E., Özcan, L., Furuhashi, M., Vaillancourt, E., Smith, R. O., Görgün, C. Z., & Hotamisligil, G. S. (2006) · Science · doi:10.1126/science.1128294 · Cited by 2,413 · see citing works

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409 · see citing works

Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy

Freudiger, C. W., Min, W., Saar, B. G., Lü, S., Holtom, G. R., He, C., Tsai, J. C.-S., Kang, J. X., & Xie, X. S. (2008) · Science · doi:10.1126/science.1165758 · Cited by 2,244 · see citing works

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

Furuhashi, M., & Hotamışlıgil, G. S. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2589 · Cited by 1,771 · see citing works

Induction of autophagy by spermidine promotes longevity

Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680 · see citing works

Branched-chain amino acids in metabolic signalling and insulin resistance

Lynch, C. J., & Adams, S. H. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.171 · Cited by 1,461 · see citing works

Introduction to biosensors

Bhalla, N., Jolly, P., Formisano, N., & Estrela, P. (2016) · Essays in Biochemistry · doi:10.1042/ebc20150001 · Cited by 1,370 · see citing works

Hypothalamic mTOR Signaling Regulates Food Intake

Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works

Minireview: Gut microbiota: The neglected endocrine organ

Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192 · see citing works

Spermidine in health and disease

Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018) · Science · doi:10.1126/science.aan2788 · Cited by 1,154 · see citing works

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α

Fu, J., Gaetani, S., Oveisi, F., Verme, J., Serrano, A., de Fonseca, F. D., Rosengarth, A., Luecke, H., Giacomo, B. D., Tarzia, G., et al. (2003) · Nature · doi:10.1038/nature01921 · Cited by 1,113 · see citing works

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals

Hulbert, A. J., Pamplona, R., Buffenstein, R., & Buttemer, W. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00047.2006 · Cited by 926 · see citing works

The fecal metabolome as a functional readout of the gut microbiome

Zierer, J., Jackson, M. A., Kastenmüller, G., Mangino, M., Long, T., Telenti, A., Mohney, R. P., Small, K. S., Bell, J. T., Steves, C. J., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0135-7 · Cited by 736 · see citing works

Branched Chain Amino Acids

Neinast, M. D., Murashige, D., & Arany, Z. P. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114455 · Cited by 727 · see citing works

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610 · see citing works

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues

Krautkramer, K. A., Kreznar, J. H., Romano, K. A., Vivas, E. I., Barrett-Wilt, G. A., Rabaglia, M. E., Keller, M. P., Attie, A. D., Rey, F. E., & Denu, J. M. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.025 · Cited by 607 · see citing works

Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice

D'Antona, G., Ragni, M., Cardile, A., Tedesco, L., Dossena, M., Bruttini, F., Caliaro, F., Corsetti, G., Bottinelli, R., Carruba, M. O., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.08.016 · Cited by 568 · see citing works

Microbiota Derived Short Chain Fatty Acids Promote Histone Crotonylation in the Colon Through Histone Deacetylases

Fellows, R., Denizot, J., Stellato, C., Cuomo, A., Jain, P., Stoyanova, E., Balázsi, S., Hajnády, Z., Liebert, A., Kazakevych, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02651-5 · Cited by 568 · see citing works

The Gut Microbiome, Aging, and Longevity: A Systematic Review

Badal, V. D., Vaccariello, E. D., Murray, E. R., Yu, K. E., Knight, R., Jeste, D. V., & Nguyen, T. T. (2020) · Nutrients · doi:10.3390/nu12123759 · Cited by 551 · see citing works

A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication

Piazza, I., Kochanowski, K., Cappelletti, V., Fuhrer, T., Noor, Ε., Sauer, U., & Picotti, P. (2018) · Cell · doi:10.1016/j.cell.2017.12.006 · Cited by 547 · see citing works

Polyamines in aging and disease

Minois, N., Carmona‐Gutiérrez, D., & Madeo, F. (2011) · Aging · doi:10.18632/aging.100361 · Cited by 522 · see citing works

Super-multiplex vibrational imaging

Wei, L., Chen, Z., Shi, L., Long, R., Anzalone, A. V., Zhang, L., Hu, F., Yuste, R., Cornish, V. W., & Min, W. (2017) · Nature · doi:10.1038/nature22051 · Cited by 514 · see citing works

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

Clark, R. I., Salazar, A., Yamada, R., Fitz-Gibbon, S., Morselli, M., Alcaraz, J., Rana, A., Rera, M., Pellegrini, M., Ja, W. W., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.004 · Cited by 510 · see citing works

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

Smith, P., Willemsen, D., Popkes, M., Metge, F., Gandiwa, E., Reichard, M., & Valenzano, D. R. (2017) · eLife · doi:10.7554/elife.27014 · Cited by 423 · see citing works

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

Gupta, V., Scheunemann, L., Eisenberg, T., Mertel, S., Bhukel, A., Koemans, T. S., Kramer, J. M., Liu, K. S. Y., Schroeder, S., Stunnenberg, H. G., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3512 · Cited by 370 · see citing works

Structural variation in the gut microbiome associates with host health

Zeevi, D., Korem, T., Godneva, A., Bar, N., Kurilshikov, A., Lotan-Pompan, M., Weinberger, A., Fu, J., Wijmenga, C., Zhernakova, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1065-y · Cited by 351 · see citing works

Microbial Genetic Composition Tunes Host Longevity

Han, B., Sivaramakrishnan, P., Lin, C.-C., Neve, I. A. A., He, J., Tay, L. W. R., Sowa, J. N., Sizovs, A., Du, G., Wang, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.036 · Cited by 349 · see citing works

Impact of intestinal microbiota on intestinal luminal metabolome

Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Kurihara, S., Sawaki, E., Koga, Y., & Benno, Y. (2012) · Scientific Reports · doi:10.1038/srep00233 · Cited by 334 · see citing works

Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control

Solon‐Biet, S. M., Cogger, V. C., Pulpitel, T., Wahl, D., Clark, X., Bagley, E. E., Gregoriou, G. C., Senior, A. M., Wang, Q., Brandon, A. E., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0059-2 · Cited by 327 · see citing works

Assembly of Bacterial Capsular Polysaccharides and Exopolysaccharides

Whitfield, C., Wear, S. S., & Sande, C. (2020) · Annual Review of Microbiology · doi:10.1146/annurev-micro-011420-075607 · Cited by 312 · see citing works

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

Han, S., Schroeder, E. A., Silva-García, C. G., Hebestreit, K., Mair, W. B., & Brunet, A. (2017) · Nature · doi:10.1038/nature21686 · Cited by 311 · see citing works

Longevity in Mice Is Promoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production

Matsumoto, M., Kurihara, S., Kibe, R., Ashida, H., & Benno, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023652 · Cited by 290 · see citing works

Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

Folick, A., Oakley, H. D., Yu, Y., Armstrong, E. H., Kumari, M., Sanor, L., Moore, D. D., Ortlund, E. A., Zechner, R., & Wang, M. C. (2015) · Science · doi:10.1126/science.1258857 · Cited by 283 · see citing works

Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy

Pryor, R., Norvaisas, P., Marinos, G., Best, L., Thingholm, L. B., Quintaneiro, L. M., De Haes, W., Esser, D., Waschina, S., Lujan, C., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.003 · Cited by 274 · see citing works

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice

Kibe, R., Kurihara, S., Sakai, Y., Suzuki, H., Ooga, T., Sawaki, E., Muramatsu, K., Nakamura, A., Yamashita, A., Kitada, Y., et al. (2014) · Scientific Reports · doi:10.1038/srep04548 · Cited by 270 · see citing works

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

Lee, B. C., Kaya, A., Ma, S., Kim, G., Gerashchenko, M. V., Yim, S. H., Hu, Z., Harshman, L. G., & Gladyshev, V. N. (2014) · Nature Communications · doi:10.1038/ncomms4592 · Cited by 270 · see citing works

Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice

Richardson, N. E., Konon, E. N., Schuster, H. S., Mitchell, A. T., Boyle, C., Rodgers, A. C., Finke, M., Haider, L. R., Yu, D., Flores, V., et al. (2021) · Nature Aging · doi:10.1038/s43587-020-00006-2 · Cited by 260 · see citing works

Higher spermidine intake is linked to lower mortality: a prospective population-based study

Kiechl, S. J., Pechlaner, R., Willeit, P., Notdurfter, M., Paulweber, B., Willeit, K., Werner, P., Ruckenstuhl, C., Iglseder, B., Weger, S., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy102 · Cited by 251 · see citing works

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Santoro, A., Ostan, R., Candela, M., Biagi, E., Brigidi, P., Capri, M., & Franceschi, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2674-y · Cited by 250 · see citing works

Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity

Lewis, K. N., Mele, J., Hayes, J. D., & Buffenstein, R. (2010) · Integrative and Comparative Biology · doi:10.1093/icb/icq034 · Cited by 247 · see citing works

Capsule synthesis in Escherichia coli K-12 is regulated by proteolysis

Torres-Cabassa, A., & Gottesman, S. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.3.981-989.1987 · Cited by 244 · see citing works

Bile acid modifications at the microbe-host interface: potential for nutraceutical and pharmaceutical interventions in host health

Joyce, S. A., & Gahan, C. G. M. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033159 · Cited by 241 · see citing works

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells

Niphakis, M. J., Lum, K. M., Cognetta, A. B., Correia, B. E., Ichu, T.-A., Olucha, J., Brown, S. J., Kundu, S., Piscitelli, F., Rosen, H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.045 · Cited by 239 · see citing works

Age-Associated Changes in Gut Microbiota and Dietary Components Related with the Immune System in Adulthood and Old Age: A Cross-Sectional Study

Salazar, N., Arboleya, S., Fernández-Navarro, T., Reyes‐Gavilán, C. G. D. L., González, S., & Gueimonde, M. (2019) · Nutrients · doi:10.3390/nu11081765 · Cited by 231 · see citing works

Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae

Alvers, A. L., Fishwick, L. K., Wood, M. S., Hu, D., Chung, H. S., Dunn, W. A., & Aris, J. P. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00469.x · Cited by 230 · see citing works

Advances in mass spectrometry based single-cell metabolomics

Duncan, K. D., Fyrestam, J., & Lanekoff, I. (2018) · The Analyst · doi:10.1039/c8an01581c · Cited by 224 · see citing works

In Vivo Metabolic Fingerprinting of Neutral Lipids with Hyperspectral Stimulated Raman Scattering Microscopy

Fu, D., Yu, Y., Folick, A., Currie, E., Farese, R. V., Tsai, T., Xie, X. S., & Wang, M. C. (2014) · Journal of the American Chemical Society · doi:10.1021/ja504199s · Cited by 222 · see citing works

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

Steinbaugh, M. J., Narasimhan, S. D., Robida-Stubbs, S., Mazzeo, L. E. M., Dreyfuss, J. M., Hourihan, J. M., Raghavan, P., Operaña, T. N., Esmaillie, R., & Blackwell, T. K. (2015) · eLife · doi:10.7554/elife.07836 · Cited by 215 · see citing works

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling

Huber, K., Olek, K., Müller, A. C., Tan, C. S. H., Bennett, K. L., Colinge, J., & Superti‐Furga, G. (2015) · Nature Methods · doi:10.1038/nmeth.3590 · Cited by 210 · see citing works

The Microbiome and Aging

Bana, B., & Cabreiro, F. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043650 · Cited by 207 · see citing works

D-beta-hydroxybutyrate extends lifespan in C. elegans

Edwards, C., Canfield, J., Copes, N., Rehan, M., Lipps, D., & Bradshaw, P. C. (2014) · Aging · doi:10.18632/aging.100683 · Cited by 203 · see citing works

TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

Nunes, A. F., Amaral, J. D., Lo, A. C., Fonseca, M. B., Viana, R. J. S., Callaerts-Vegh, Z., D’Hooge, R., & Rodrigues, C. M. P. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8256-y · Cited by 192 · see citing works

ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagyPreprint

O’Rourke, E. J., Kuballa, P., Xavier, R. J., & Ruvkun, G. (2013) · Genes & Development · doi:10.1101/gad.205294.112 · Cited by 189 · see citing works

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

Bárcena, C., Quirós, P. M., Durand, S., Mayoral, P., Rodríguez, F., Caravia, X. M., Mariño, G., Garabaya, C., Fernández-García, M. T., Kroemer, G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.089 · Cited by 185 · see citing works

Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants

Reis, R. J. S., Xu, L., Lee, H., Chae, M., Thaden, J. J., Bharill, P., Tazearslan, C., Siegel, E. R., Alla, R., Zimniak, P., et al. (2011) · Aging · doi:10.18632/aging.100275 · Cited by 182 · see citing works

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

Bodogai, M., O’Connell, J., Kim, K., Kim, Y., Moritoh, K., Chen, C., Gusev, F., Vaughan, K., Shulzhenko, N., Mattison, J. A., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat4271 · Cited by 182 · see citing works

Lipidomics of familial longevity

González-Covarrubias, V., Beekman, M., Uh, H., Dane, A. D., Troost, J., Paliukhovich, I., van der Kloet, F. M., Houwing‐Duistermaat, J. J., Vreeken, R. J., Hankemeier, T., et al. (2013) · Aging Cell · doi:10.1111/acel.12064 · Cited by 178 · see citing works

Molecular Basis of the ‘Anti-Aging' Effect of Spermidine and Other Natural Polyamines - A Mini-Review

Minois, N. (2014) · Gerontology · doi:10.1159/000356748 · Cited by 176 · see citing works

Gut microbiota remodeling reverses aging-associated inflammation and dysregulation of systemic bile acid homeostasis in mice sex-specifically

Ma, J., Hong, Y., Zheng, N., Xie, G., Lyu, Y., Gu, Y., Xi, C., Chen, L., Wu, G., Li, Y., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1763770 · Cited by 171 · see citing works

Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer’s Disease Transgenic Mouse Model at an Early Disease Stage

Fernando, W. M. A. D. B., Martins, I. J., Morici, M., Bharadwaj, P., Rainey-Smith, S. R., Lim, W. L. F., & Martins, R. N. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-190120 · Cited by 164 · see citing works

Distinct metabolomic signatures are associated with longevity in humans

Cheng, S. C., Larson, M. G., McCabe, E. L., Murabito, J. M., Rhee, E. P., Ho, J. E., Jacques, P. F., Ghorbani, A., Magnusson, M., Souza, A. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7791 · Cited by 161 · see citing works

Aging and the human gut microbiota—from correlation to causality

Saraswati, S., & Sitaraman, R. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00764 · Cited by 153 · see citing works

Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance

Lee, J., Venna, V. R., Durgan, D. J., Shi, H., Hudobenko, J., Putluri, N., Petrosino, J. F., McCullough, L. D., & Bryan, R. M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1814107 · Cited by 151 · see citing works

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

Mansfeld, J., Urban, N., Priebe, S., Groth, M., Frahm, C., Hartmann, N., Gebauer, J., Ravichandran, M., Dommaschk, A., Schmeisser, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms10043 · Cited by 149 · see citing works

A metabolic signature of long life in Caenorhabditis elegans

Fuchs, S., Bundy, J. G., Davies, S. K., Viney, J. M., Swire, J. S., & Leroi, A. M. (2010) · BMC Biology · doi:10.1186/1741-7007-8-14 · Cited by 148 · see citing works

Spermidine and spermine are enriched in whole blood of nona/centenarians

Pucciarelli, S., Moreschini, B., Micozzi, D., De Fronzo, G. S., Carpi, F. M., Polzonetti, V., Vincenzetti, S., Mignini, F., & Napolioni, V. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1349 · Cited by 144 · see citing works

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans

Lucanic, M., Held, J. M., Vantipalli, M. C., Klang, I. M., Graham, J. B., Gibson, B. W., Lithgow, G. J., & Gill, M. S. (2011) · Nature · doi:10.1038/nature10007 · Cited by 141 · see citing works

Alterations in xenobiotic metabolism in the long‐lived Little mice

Amador‐Noguez, D., Dean, A., Huang, W., Setchell, K., Moore, D., & Darlington, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00300.x · Cited by 134 · see citing works

Gene expression profile of long‐lived Ames dwarf mice and Little mice

Amador‐Noguez, D., Yagi, K., Venable, S., & Darlington, G. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00125.x · Cited by 132 · see citing works

A community resource for paired genomic and metabolomic data mining

Schorn, M., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., et al. (2021) · Nature Chemical Biology · doi:10.1038/s41589-020-00724-z · Cited by 131 · see citing works

A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema

Ta, L. D. H., Chan, J. C. Y., Yap, G. C., Purbojati, R. W., Drautz‐Moses, D. I., Michelle, K. Y., Tay, C. J. X., Huang, C., Kioh, D. Y. Q., Woon, J. Y., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1801964 · Cited by 121 · see citing works

Microbial metabolites regulate host lipid metabolism through NR5A–Hedgehog signalling

Lin, C.-C., & Wang, M. C. (2017) · Nature Cell Biology · doi:10.1038/ncb3515 · Cited by 111 · see citing works

Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity

Ramachandran, P. V., Savini, M., Folick, A., Hu, K. Y., Masand, R., Graham, B. H., & Wang, M. C. (2019) · Developmental Cell · doi:10.1016/j.devcel.2018.12.022 · Cited by 110 · see citing works

Label‐Free Quantitative Imaging of Cholesterol in Intact Tissues by Hyperspectral Stimulated Raman Scattering Microscopy

Wang, P., Li, J., Wang, P., Hu, C., Zhang, D., Sturek, M. S., & Cheng, J. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201306234 · Cited by 109 · see citing works

Heterochronic faecal transplantation boosts gut germinal centres in aged mice

Stebegg, M., Silva-Cayetano, A., Innocentin, S., Jenkins, T. P., Cantacessi, C., Gilbert, C., & Linterman, M. A. (2019) · Nature Communications · doi:10.1038/s41467-019-10430-7 · Cited by 107 · see citing works

Chemoproteomic Profiling of Bile Acid Interacting Proteins

Zhuang, S., Li, Q., Cai, L., Wang, C., & Lei, X. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00134 · Cited by 105 · see citing works

XBP-1 Remodels Lipid Metabolism to Extend Longevity

Imanikia, S., Sheng, M., Castro, C., Griffin, J. L., & Taylor, R. C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.057 · Cited by 104 · see citing works

Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations

Tuikhar, N., Keisam, S., Labala, R. K., Imrat, Ramakrishnan, P., Arunkumar, M. C., Ahmed, G., Biagi, E., & Jeyaram, K. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.02.001 · Cited by 103 · see citing works

Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota

Kim, W.-K., Jang, Y. J., Han, D. H., Jeon, K., Lee, C., Han, H. S., & Ko, G. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1819156 · Cited by 96 · see citing works

Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans

Mutlu, A. S., Gao, S. M., Zhang, H., & Wang, M. C. (2020) · Nature Communications · doi:10.1038/s41467-020-15296-8 · Cited by 90 · see citing works

The ω‐3 fatty acid α‐linolenic acid extends Caenorhabditis elegans lifespan via NHR ‐49/ PPAR α and oxidation to oxylipins

Qi, W., Gutierrez, G. E., Gao, X., Dixon, H., McDonough, J. A., Marini, A. M., & Fisher, A. L. (2017) · Aging Cell · doi:10.1111/acel.12651 · Cited by 83 · see citing works

Optogenetic control of gut bacterial metabolism to promote longevity

Hartsough, L. A., Park, M., Kotlajich, M. V., Lazar, J. T., Han, B., Lin, C.-C., Musteata, E., Gambill, L., Wang, M. C., & Tabor, J. J. (2020) · eLife · doi:10.7554/elife.56849 · Cited by 79 · see citing works

Activity and modulation of ornithine decarboxylase and concentrations of polyamines in various tissues of rats as a function of age

Das, R., & Kanungo, M. S. (1982) · Experimental Gerontology · doi:10.1016/0531-5565(82)90042-0 · Cited by 75 · see citing works

Genetically encoded FRET-based nanosensor for in vivo measurement of leucine

Mohsin, M., Abdin, M. Z., Nischal, L., et al. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.06.028 · Cited by 68 · see citing works

Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1

Kim, S. Y., Chae, C. W., Lee, H. J., Jung, Y. H., Choi, G. E., Kim, J. S., Lim, J. R., Lee, J., Cho, J. H., Park, H., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2663-1 · Cited by 68 · see citing works

High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation

Yu, Y., Mutlu, A. S., Liu, H., & Wang, M. C. (2017) · Nature Communications · doi:10.1038/s41467-017-00944-3 · Cited by 67 · see citing works

The year 2020 in natural product bioinformatics: an overview of the latest tools and databases

Medema, M. H. (2021) · Natural Product Reports · doi:10.1039/d0np00090f · Cited by 63 · see citing works

Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan

Burstein, M. T., Kyryakov, P., Beach, A., Richard, V. R., Koupaki, O., Gomez-Perez, A., Leonov, A., Levy, S., Noohi, F., & Titorenko, V. I. (2012) · Cell Cycle · doi:10.4161/cc.21754 · Cited by 54 · see citing works

Fingerprint Stimulated Raman Scattering Imaging Reveals Retinoid Coupling Lipid Metabolism and Survival

Chen, A. J., Li, J., Jannasch, A., Mutlu, A. S., Wang, M. C., & Cheng, J. (2018) · ChemPhysChem · doi:10.1002/cphc.201800545 · Cited by 37 · see citing works

OLIVe: A Genetically Encoded Fluorescent Biosensor for Quantitative Imaging of Branched-Chain Amino Acid Levels inside Single Living Cells

Yoshida, T., Nakajima, H., Takahashi, S., Kakizuka, A., & Imamura, H. (2019) · ACS Sensors · doi:10.1021/acssensors.9b02067 · Cited by 37 · see citing works

Chemical regulation of mid- and late-life longevities in Drosophila

McDonald, P. J., Maizi, B. M., & Arking, R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.09.006 · Cited by 35 · see citing works

The effects of exopolysaccharides and exopolysaccharide-producing Lactobacillus on the intestinal microbiome of zebrafish (Danio rerio)

Ma, C., Guo, H., Chang, H., Huang, S. W., Jiang, S., Huo, D., Zhang, J., & Zhu, X. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01990-6 · Cited by 35 · see citing works

D-beta-Hydroxybutyrate Extends Lifespan in

Edwards, C., Canfield, J., Copes, N., Rehan, M., Lipps, D., & Bradshaw, P. C. (2014) · Digital Commons - University of South Florida (University of South Florida) · Cited by 34 · see citing works

Biological Effects of Polyamines on the Prevention of Aging-associated Diseases and on Lifespan Extension

Soda, K. (2015) · Food Science and Technology Research · doi:10.3136/fstr.21.145 · Cited by 19 · see citing works

Lithocholic Acid Improves the Survival of Drosophila Melanogaster

Staats, S., Rimbach, G. H., Künstner, A., Graspeuntner, S., Rupp, J., Busch, H. S., Sina, C., Ipharraguerre, I. R., & Wagner, A. E. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800424 · Cited by 18 · see citing works

Mammalian Fatty Acid Amides of the Brain and CNS

Waluk, D. P., Battistini, M. R., Dempsey, D. R., Farrell, E. K., Jeffries, K. A., Mitchell, P. R., Hernandez, L. W., McBride, J. C., Merkler, D. J., & Hunt, M. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410527-0.00009-0 · Cited by 15 · see citing works

Identification of unique bile acid-metabolizing bacteria from the microbiome of centenariansPreprint

Honda, K., Sato, Y., Atarashi, K., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-115113/v1 · Cited by 3 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Population Attributable Fractions for Modifiable Factors of Longevity and Healthy Longevity Among the Late-Elderly Aged 75 Years or Older — China, 1998–2018

Zhou, J., Gao, X., Wei, Y., et al. (2023) · China CDC Weekly · doi:10.46234/ccdcw2023.005 · Cited by 2 · see citing works

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works

Queen Honeybee and Me: Forever Young? Conserved Pathways for Longevity

Knäblein, J., & Huber, R. (2013) · Wiley eBooks · doi:10.1002/9783527669417.ch26

EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUS

Grimm, B. (2002) · Journal of Molluscan Studies · doi:10.1093/mollus/68.1.25 · Cited by 41 · see citing works