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DNA Damage-Mediated Induction of a Chemoresistant Niche
Open accessAbstract
While numerous cell-intrinsic processes are known to play decisive roles in chemotherapeutic response, relatively little is known about the impact of the tumor microenvironment on therapeutic outcome. Here, we use a well-established mouse model of Burkitt's lymphoma to show that paracrine factors in the tumor microenvironment modulate lymphoma cell survival following the administration of genotoxic chemotherapy. Specifically, IL-6 and Timp-1 are released in the thymus in response to DNA damage, creating a "chemo-resistant niche" that promotes the survival of a minimal residual tumor burden and serves as a reservoir for eventual tumor relapse. Notably, IL-6 is released acutely from thymic endothelial cells in a p38-dependent manner following genotoxic stress, and this acute secretory response precedes the gradual induction of senescence in tumor-associated stromal cells. Thus, conventional chemotherapies can induce tumor regression while simultaneously eliciting stress responses that protect subsets of tumor cells in select anatomical locations from drug action.
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“These chemoprotective SASP factors include WNT16B, IL-6, and TIMP-1 (tissue inhibitor of metalloproteinases-1).”
From Aging, Cellular Senescence, and Cancer (2013) · cites this paper as [134]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Even more ironic is the finding that senescent cells, particularly those that senesce in response to DNA-damaging radiation or chemotherapeutic agents, secrete factors that can protect neighboring tumor cells from being killed by those same chemotherapeutic agents (133, 134).”
From Aging, Cellular Senescence, and Cancer (2013) · cites this paper as [134]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Antibody against IL-6, gp130 siRNA, or dominant-negative STAT3 enhanced chemo-induced death in lymphoma (Gilbert and Hemann, 2010), as well as colon cancer (Yun et al., 2012)”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Gilbert and Hemann, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“IL-6 and pY-STAT3 induced by chemotherapy promoted premature senescence in lymphoma cells in a paracrine manner, which maintained a minimal residual number of chemoresistant cells that could lead to relapse.”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Gilbert and Hemann, 2010
Experimental — accuracy not yet measuredIn the citing paper
“Recent evidence points to tumor microenvironment components as potential participants in the generation of chemoresistance (Denardo et al., 2011; Gilbert and Hemann, 2010; Roodhart et al., 2011; Shaked et al., 2008; Shree et al., 2011).”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Gilbert and Hemann, 2010
In the citing paper
“Recent reports (Denardo et al., 2011; Gilbert and Hemann, 2010) and the present work show that chemotherapy induces a storm of cytokines and chemokines in the tumor microenvironment many of which might be linked to chemoresistance.”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Gilbert and Hemann, 2010
In the citing paper
“The critical role of the microenvironment in tumor progression and response to therapy is being increasingly recognized (Condeelis and Pollard, 2006; Denardo et al., 2011; Gilbert and Hemann, 2010; Shree et al., 2011; Tan et al., 2011).”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Gilbert and Hemann, 2010
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Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Visvader, J. E., & Lindeman, G. J. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2499 · Cited by 3,501
Metastasis: from dissemination to organ-specific colonization
Nguyen, D. X., Bos, P. D., & Massagué, J. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2622 · Cited by 2,716
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232
Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.-Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.001 · Cited by 2,155
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027
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Imaging Biomarkers for Precision Medicine in Locally Advanced Breast Cancer
Tran, W. T., Childs, C., Probst, H., Farhat, G., & Czarnota, G. J. (2018) · Journal of medical imaging and radiation sciences · doi:10.1016/j.jmir.2017.09.006 · Cited by 14
The role of host response to chemotherapy: resistance, metastasis and clinical implications
Deo, A., Sleeman, J. P., & Shaked, Y. (2023) · Clinical & Experimental Metastasis · doi:10.1007/s10585-023-10243-5 · Cited by 14
Hamel, K. M., King, C. T., Cavalier, M., Liimatta, K. Q., Rozanski, G. L., King, T. A., Lam, M., Bingham, G. C., Byrne, C. E., Xing, D., et al. (2022) · Stem Cells and Development · doi:10.1089/scd.2021.0279 · Cited by 13
Roy-Luzarraga, M., Abdel-Fatah, T. M. A., Reynolds, L. E., Clear, A. J., Taylor, J. G., Gribben, J. G., Chan, S. Y. T., Jones, J. L., & Hodivala‐Dilke, K. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.19304 · Cited by 12
Xu, Y., Wu, Z., Ye, W., Xiao, Y., Zheng, W., Qinyan, C., Bai, P., Lin, Z., & Chen, C. (2021) · BMC Cancer · doi:10.1186/s12885-021-08285-7 · Cited by 12
Atrophied Thymus, a Tumor Reservoir for Harboring Melanoma Cells
Sizova, O. S., Kuriatnikov, D., Liu, Y. M., & Su, D. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0308 · Cited by 13
Aqaqe, N., Yassin, M., Yassin, A. A., Ershaid, N., Katz-Even, C., Zipin‐Roitman, A., Kugler, E., Lechman, E. R., Gan, O. I., Mitchell, A., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3215 · Cited by 11
Ke, B., Li, A., Fu, H., Kong, C., Liu, T., Zhu, Q., Zhang, Y., Zhang, Z., Chen, C., & Jin, C. (2021) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2021011 · Cited by 12
Lee, C. H., Nguyen, T. M., Lee, Y., Choi, S. G., Nguyễn, P. N., Park, J. H., & Park, M. K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010357 · Cited by 12
Intracellular signaling modules linking DNA damage to secretome changes in senescent melanoma cells
Chavanet, A., Hill, K. R., Jiménez-Andrade, Y., Choo, M., White, K., & Park, J. M. (2020) · Melanoma Research · doi:10.1097/cmr.0000000000000671 · Cited by 11
Najy, A. J., Jung, Y., Kim, S., Fridman, R. A., & Kim, H.-R. C. (2021) · Cells · doi:10.3390/cells10102721 · Cited by 11
Small, S. H., Tang, E. J., Ragland, R. L., Ruzankina, Y., Schoppy, D. W., Mandal, R. S., Glineburg, M. R., Ustelenca, Z., Powell, D. J., Simpkins, F. A., et al. (2021) · Science Signaling · doi:10.1126/scisignal.aba2611 · Cited by 12
Makrakis, D., Wright, J. L., Roudier, M. P., Garcia, J. M., Vakar‐Lopez, F., Porter, M. P., Wang, Y., Dash, A., Lin, D. W., Schade, G. R., et al. (2022) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2022.12.003 · Cited by 11
Jinushi, M. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9501-9 · Cited by 11
Yan, X., Kennedy, C. R., Tilkens, S. B., Wiedemeier, O., Guan, H., Park, J., & Chan, A. M.-L. (2011) · Genes & Cancer · doi:10.1177/1947601911416003 · Cited by 12
Wang, X., Zhang, H., He, H., Shen, Z., Tang, Z., Xu, J., & Sun, Y. (2014) · Cancer Science · doi:10.1111/cas.12531 · Cited by 11
Wu, Y., Zhang, K., Jiang, N., Chen, Z., Sun, X., Zha, H., Lin, M., Li, J., Pan, X., Chen, J., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1726210 · Cited by 10
Kamatani, T., Umeda, K., Iwasawa, T., Miya, F., Matsumoto, K., Mikami, S., Hara, K., Shimoda, M., Suzuki, Y., Nishino, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63309-1 · Cited by 10
Lim, Y., Quek, H., Offenhäuser, C., Fazry, S., Boyd, A., Lavin, M., Roberts, T., & Day, B. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-2838-0 · Cited by 11
Du, Y., Han, Y., Wang, X., Wang, H., Qu, Y., Guo, K., Ma, W., & Fu, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.772723 · Cited by 9
Macrophages and tumor progression: on the way to macrophage-specific therapy
Чердынцева, Н. В., Митрофанова, И. В., Buldakov, M. A., Стахеева, М. Н., Patysheva, M. R., Zavjalova, M. V., & Kzhyshkowska, J. G. (2017) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2017-4-61-74 · Cited by 10
Ding, W., Zhou, X., Jiang, G., Xu, W., Long, S., Xiao, F., Liao, Y., & Liu, J. (2022) · Journal of Oncology · doi:10.1155/2022/3909030 · Cited by 8
Lv, J., Li, W., Wang, X., Guo, L., Wang, D., Zhang, Y., Yu, J. Q., Chen, T., Niu, B., Wang, X., et al. (2023) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0000000000002734 · Cited by 8
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Kamimura, D., Arima, Y., Hirano, T., Ogura, H., & Murakami, M. (2013) · Springer eBooks · doi:10.1007/978-4-431-54442-5_2 · Cited by 9
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Mosna, F., & Gottardi, M. (2016) · Stem Cells International · doi:10.1155/2016/7625827 · Cited by 8
Tang, H., Shu, M.-M., Dai, B., Xu, L., Dong, B., Gao, G., & Chen, X. (2017) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2017.1413188 · Cited by 8
Dong, H., Huang, Z., Zhang, H., Xiao, Z., & Liu, Q. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26733 · Cited by 8
Li, S., Li, R., Ma, Y., Zhang, C., Huang, T., & Zhu, S. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14100 · Cited by 8
Vázquez-Ibarra, K. C., Sánchez-López, J. Y., Pineda-Razo, T. D., Cruz-Lozano, J. R., Ortiz‐Tamayo, B., Palafox-Mariscal, L. A., González-Arreola, R. M., González‑García, J., & Ortiz‐Lazareno, P. C. (2024) · Oncology Letters · doi:10.3892/ol.2024.14590 · Cited by 7
Rhee, J., Adzavon, Y. M., & Sun, Z. (2024) · Oncogene · doi:10.1038/s41388-024-03175-1 · Cited by 7
Jia, Y., Li, J., Mei, W., Zhang, H., Wang, Z., Xie, X., Chongchong, G., Xu, X., & Li, F. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114528 · Cited by 7
Diabetes reshapes pancreatic cancer-associated endothelial niche by accelerating senescence
Ling, Y., Duan, J., Jiang, Z., Yang, Z., Liu, J.-J., Song, P., Fang, Z.-Q., Yue, Z., He, F., Ke-feng, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63801-8 · Cited by 8
Liu, S., Shi, C., Hou, X., Tian, X., Li, C., Ma, X., Wang, X., & Gao, P. (2022) · Journal of Cancer · doi:10.7150/jca.63234 · Cited by 7
Targeting the stress support network regulated by autophagy and senescence for cancer treatment
Kim, J., Lee, Y., Roh, K., Kim, M.-S., & Kang, C. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.01.003 · Cited by 7
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Lenz, G. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s315 · Cited by 7
Bone marrow fibrosis at diagnosis predicts survival for primary acute myeloid leukemia
Wu, Z., Chen, R., Wu, L., Zou, L., Ding, F., Wang, M., & Liu, X. (2017) · Clinical & Translational Oncology · doi:10.1007/s12094-017-1687-1 · Cited by 7
Controlling secretion to limit chemoresistancePreprint
Georgilis, A., & Gil, J. (2016) · Genes & Development · doi:10.1101/gad.288571.116 · Cited by 8
Zhang, Y., Chu, J., Hou, Q., Qian, S., Wang, Z., Yang, Q., Song, W., Dong, L., Shi, Z., Gao, Y., et al. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5653 · Cited by 7
Alghamdi, E., & Kono, K. (2025) · Cancer Science · doi:10.1111/cas.70223 · Cited by 7
A controlled release system for simultaneous promotion of gene transfection and antitumor effects
Chen, M., Zhu, X., & Yan, D. (2014) · RSC Advances · doi:10.1039/c4ra10447a · Cited by 6
Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche
Jinushi, M. (2012) · OncoImmunology · doi:10.4161/onci.19123 · Cited by 6
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Rowinski, E., Fournel, P., Bernichon, E., Bouleftour, W., Magné, N., & Méry, B. (2019) · American Journal of Clinical Oncology · doi:10.1097/coc.0000000000000574 · Cited by 7
Calvo, L., Cheng, S., Skulimowski, M., Clément, I., Portelance, L., Zhan, Y., Carmona, E., Lafontaine, J., de Ladurantaye, M., Rahimi, K., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/425199 · Cited by 6
Yu, S., Ye, J., Wang, Y., Lu, T., Liu, Y., Liu, N., Zhang, J., Lu, F., Ma, D., Gale, R. P., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102787 · Cited by 5
Arroyo-Berdugo, Y., Sendino, M., Greaves, D., Nojszewska, N., Idilli, O., So, C. W. E., Silvio, L. D., Quartey‐Papafio, R., Farzaneh, F., Rodríguez, J. A., et al. (2023) · Cancers · doi:10.3390/cancers15071988 · Cited by 5
von Fournier, A., Würflein, E., Moratin, H., Stöth, M., Kasemo, T. E., Herrmann, M., Goncalves, M., Hagen, R., Hackenberg, S., Gehrke, T. E., et al. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47040231 · Cited by 5
Integrating microRNA and mRNA expression in rapamycin-treated T-cell acute lymphoblastic leukemia
Chen, X., Guo, Z., Fan, S., Sun, L., Li, H., Zhou, J., & Li, Y. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.152494 · Cited by 5
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Barney, L. E., Hall, C. L., Schwartz, A. D., Parks, A. N., Sparages, C., Galarza, S., Platt, M. O., Mercurio, A. M., & Peyton, S. R. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/686527 · Cited by 5
Seraji, N., & Berger, I. (2025) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-025-01214-y · Cited by 4
Envisioning the Application of Systems Biology in Cancer Immunology
Vera, J., Gupta, S. K., Wolkenhauer, O., & Schuler, G. (2014) · Springer eBooks · doi:10.1007/978-3-662-44006-3_23 · Cited by 4
Mapping cancer genetics at single-cell resolution
Gilbert, L. A. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abd3049 · Cited by 4
Self-citationLive Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer
Nakasone, E. S., Askautrud, H. A., & Egeblad, M. (2013) · Journal of Visualized Experiments · doi:10.3791/50088-v · Cited by 4
Somsura, R., Kamkajon, K., Chaimongkolnukul, K., Chantip, S., Teerapornpuntakit, J., Wongdee, K., Kamonsutthipaijit, N., Tangtrongsup, S., Panupinthu, N., Tiyasatkulkovit, W., et al. (2023) · PeerJ · doi:10.7717/peerj.16300 · Cited by 4
Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers and Therapeutic Targets?
Hanly, D. J., Esteller, M., & Berdasco, M. (2019) · Topics in medicinal chemistry · doi:10.1007/7355_2019_83 · Cited by 4
Envisioning the Application of Systems Biology in Cancer Immunology
Jaitly, T., Gupta, S. K., Wolkenhauer, O., Schuler, G., & Vera, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-30845-2_27 · Cited by 4
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Herzog, A. E., Zheng, S., Warner, K. A., Vanini, J. V., Somayaji, R., Johnson, M. R., Zhang, Z., Polverini, P. J., CASTILHO, R. M., Pearson, A. T., et al. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102603 · Cited by 3
Kikuchi, H., Amofa, E., McEnery, M., Schey, S., Ramasamy, K., Farzaneh, F., & Calle, Y. (2023) · Cancers · doi:10.3390/cancers15020462 · Cited by 4
Shi, P., Lin, Z., Song, Y., Li, Z., Zeng, M., Luo, L., Cao, Y., & Zhu, X. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05692-8 · Cited by 3
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Tang, Z., Wang, Q., Shigdar, S. L., Duan, W., & Xiang, D. (2016) · InTech eBooks · doi:10.5772/61861 · Cited by 3
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Wijshake, T., & van Deursen, J. M. A. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-26239-0_16 · Cited by 3
Cetinbas, N. M., Roper, J., & Yilmaz, Ö. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802734-9.00011-1 · Cited by 3
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Wang, S., Hu, H., Zeng, W., Qin, L., Chen, X., Liao, Z., Liu, F., & Zhang, Z. (2026) · MedComm · doi:10.1002/mco2.70763 · Cited by 2
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Tremblay, C. S., Ting, S. B., McCluskey, A., Robinson, P. J., & Curtis, D. J. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.09.003 · Cited by 2
Jena, D., Bhatta, P., & Mishra, K. (2024) · Asian Journal of Research in Pharmaceutical Sciences · doi:10.52711/2231-5659.2024.00033 · Cited by 2
Long non‑coding RNA signatures in breast cancer: Properties as biomarkers?
Asberger, J., Ge, I., Schmidt, B., Jäger, M., Weiß, D., Berner, K., Erbes, T., Juhasz‐Böss, I., & Mayer, S. (2025) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2025.12804 · Cited by 2
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Pritchard, J. R., Lee, M. J., & Peyton, S. R. (2022) · Soft Matter · doi:10.1039/d2sm00071g · Cited by 1
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Wang, S., & Dudley, A. C. (2022) · Springer eBooks · doi:10.1007/978-3-030-98950-7_32 · Cited by 2
Overcoming head and neck cancer stem cells
Oklejas, A. E., & Nor, J. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817868-3.00007-x · Cited by 2
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Deryugina, E. I. (2012) · doi:10.1002/9783527649327.ch8 · Cited by 2
DiCenzo, D., Quiaoit, K., Fatima, K., Bhardwaj, D., Sannachi, L., Gangeh, M. J., Naini, A. S., Dasgupta, A., Kolios, M. C., Trudeau, M., et al. (2022) · doi:10.32920/21290982 · Cited by 2
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Cao, S., Xiong, Q., Ding, B., Wang, X., Wei, F., Sun, Q., Yang, F., Luo, J., Chang, G., Li, S., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9306614 · Cited by 1
Wu, Y.-W., Jiang, Z.-Z., Wang, J., Ye, S.-Q., Zou, W.-L., & Tan, N. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107733 · Cited by 1
Lu, P., Zheng, C., Zhang, J., Zhu, X., Chen, X., Zhang, J., Cao, Y., & Huang, Z. (2026) · Discover Oncology · doi:10.1007/s12672-026-04530-2 · Cited by 1
Manni, E., Al‐kuraishy, H. M., Fawzy, M. N., & Batiha, G. E. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05416-4 · Cited by 1
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Li, Y., Zhang, X., Zeng, X. L., Wang, S., & Wang, H. (2022) · Springer eBooks · doi:10.1007/978-3-030-84164-5_13 · Cited by 1
(2010) · Nature reviews. Cancer · doi:10.1038/nrc2977 · Cited by 1
Meng, W., Li, N., Chen, B., Zhang, H., Ma, L., & Guan, Y. (2024) · Translational Andrology and Urology · doi:10.21037/tau-23-422 · Cited by 1
The Bone Marrow Microenvironment and Its Impact in Acute and Chronic B Cell Malignancies
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Pritchard, J. R., Gilbert, L. A., Meacham, C. E., Ricks, J. L., Jiang, H., Lauffenburger, D. A., & Hemann, M. T. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1014 · Cited by 15
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Metadata
- Authors
- Gilbert, L. A., & Hemann, M. T.
- Affiliations
- Koch Institute for Integrative Cancer Research At MIT (US)
- Corresponding author
- Hemann, Michael T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 143
- Issue
- 3
- Pages
- 355-366
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2972353
- OpenAlex
- W2124472585
- Cited by
- 428
- References
- 42
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 12 · 2023: 19 · 2022: 32 · 2021: 35 · 2020: 27 · 2019: 37 · 2018: 33 · 2017: 26 · 2016: 29 · 2015: 25 · 2014: 25 · 2013: 40 · 2012: 40
- FWCI
- 22.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1056 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Elsevier eBooks
- Funders
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- National Institutes of Health (5r01ca128803-05)
- Ludwig Center for Molecular Oncology
- National Cancer Institute (R01-CA128803)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- chemoresistance, tumor microenvironment, DNA damage, Burkitt lymphoma, interleukin-6, TIMP-1, thymus, p38 MAPK, genotoxic stress response, senescence, tumor stromal cells, minimal residual disease, tumor recurrence, paracrine signaling
- MeSH terms
- Animals, Burkitt Lymphoma, Cell Survival, DNA Damage, Doxorubicin, Humans, Liver Neoplasms, Thymus Gland, Interleukin-6, Cytokines, Cellular Senescence, Culture Media, Conditioned, Neoplasm, Residual, Cell Culture Techniques, Drug Resistance, Neoplasm, Tissue Inhibitor of Metalloproteinase-1, Paracrine Communication, Endothelial Cells, p38 Mitogen-Activated Protein Kinases, Mice, Janus Kinase 2
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