Cancer Genomes Evolve by Pulverizing Single Chromosomes

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Structural variant calling: the long and the short of it

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Criteria for Inference of Chromothripsis in Cancer Genomes

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Mechanisms and Consequences of Double‐Strand DNA Break Formation in Chromatin

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Chromothripsis and cancer: causes and consequences of chromosome shattering

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The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

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Micronucleus Assay: The State of Art, and Future Directions

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Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangementsPreprint

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CHO Quasispecies—Implications for Manufacturing Processes

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Linking genomic reorganization to tumor initiation via the giant cell cycle

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Mechanisms of Genomic Instability in Breast Cancer

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Landscape of gene fusions in epithelial cancers: seq and ye shall find

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Whole-exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations

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Comprehensive genome analysis and variant detection at scale using DRAGEN

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Genome chaos: Survival strategy during crisis

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Chromosomal instability as a driver of cancer progression

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Functional mechanisms and abnormalities of the nuclear lamina

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Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens

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Chromothripsis in acute myeloid leukemia: biological features and impact on survival

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Genome evolution during progression to breast cancerPreprint

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Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

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Characterizing complex structural variation in germline and somatic genomes

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The consequences of structural genomic alterations in humans: Genomic Disorders, genomic instability and cancer

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Genome‐wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma

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Evolutionary Mechanisms and Diversity in Cancer

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Decoding the genome beyond sequencing: The new phase of genomic research

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G2/M-Phase Checkpoint Adaptation and Micronuclei Formation as Mechanisms That Contribute to Genomic Instability in Human Cells

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Micronuclear collapse from oxidative damage

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Evolutionary mechanism unifies the hallmarks of cancer

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Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability

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Chromosomal rearrangements in cancer

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On the Complexity of Mechanisms and Consequences of Chromothripsis: An Update

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Chromothripsis: potential origin in gametogenesis and preimplantation cell divisions. A review

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Biogenesis of micronuclei

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Chromosomal Instability in Cell-Free DNA Is a Serum Biomarker for Prostate Cancer

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CTLPScanner: a web server for chromothripsis-like pattern detection

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New Insights in the Cytogenetic Practice: Karyotypic Chaos, Non-Clonal Chromosomal Alterations and Chromosomal Instability in Human Cancer and Therapy Response

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Challenges in studying genomic structural variant formation mechanisms: The short‐read dilemma and beyond

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Chromothripsis: Breakage-fusion-bridge over and over again

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Telomerase and hallmarks of cancer: An intricate interplay governing cancer cell evolution

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Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences

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Chromothripsis Is a Recurrent Genomic Abnormality in High-Risk Myelodysplastic Syndromes

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Cancer heterogeneity: converting a limitation into a source of biologic information

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Gene Amplification and the Extrachromosomal Circular DNA

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Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity

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Genes, Proteins, and Biological Pathways Preventing Chromothripsis

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Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time

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Chromothripsis under the microscope: a cytogenetic perspective of two cases of AML with catastrophic chromosome rearrangement

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Transient hypermutability, chromothripsis and replication-based mechanisms in the generation of concurrent clustered mutations

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Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover

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Targeting the IGF/PI3K/mTOR pathway and AXL/YAP1/TAZ pathways in primary bone cancer

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Whole‐genome sequencing reveals complex chromosome rearrangement disrupting NIPBL in infant with Cornelia de Lange syndrome

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The Landscape of Somatic Copy Number Alterations in Head and Neck Squamous Cell Carcinoma

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Extrachromosomal Circular DNA: A New Target in Cancer

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From Human Cytogenetics to Human Chromosomics

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Cancer Genomic Rearrangements and Copy Number Alterations from Errors in Cell Division

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The antagonistic relationship between apoptosis and polyploidy in development and cancer

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A Comparative Genomics Approach to Understanding Transmissible Cancer in Tasmanian Devils

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Revisiting characteristics of oncogenic extrachromosomal DNA as mobile enhancers on neuroblastoma and glioma cancers

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Spatio-Genetic and Phenotypic Modelling Elucidates Resistance and Re-Sensitisation to Treatment in Heterogeneous Melanoma

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Comprehensive identification and characterization of somatic copy number alterations in triple‑negative breast cancer

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Pathways to chromothripsis

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Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model

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Mechanisms underlying genome instability mediated by formation of foldback inversions in Saccharomyces cerevisiae

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Genomic imbalance analysis provides new insight into prognostic factors in adult and pediatric T-ALL

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Emerging trends and converging evidence in tumor evolution: A comprehensive review

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Homologous recombination defects and how they affect replication fork maintenance

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Lechromothripsis

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Deep learning in variant detection and annotation

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Chromothripsis in acute myeloid leukemia: Biological features and impact on survival

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Complex Chromosomal Rearrangements in B-Cell Lymphoma: Evidence of Chromoanagenesis? A Case Report

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Stretching, scrambling, piercing and entangling: Challenges for telomeres in mitotic and meiotic chromosome segregation

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Constitutional Chromoanagenesis of Distal 13q in a Young Adult with Recurrent Strokes

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Structurally complex osteosarcoma genomes exhibit limited heterogeneity within individual tumors and across evolutionary time

Rajan, S., Zaccaria, S., Cannon, M. V., Cam, M., Gross, A. C., Raphael, B. J., & Roberts, R. D. (2021) · doi:10.1101/2021.08.30.458268 · Cited by 33 · see citing works

ChromothripsisDB: A Curated Database for the Documentation, Visualization, and Mining of Chromothripsis Data

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Cell-Free DNA, MicroRNAs, Proteins, and Peptides as Liquid Biopsy Biomarkers in Prostate Cancer and Bladder Cancer

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Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo

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Chromosomal Rearrangement: From Induction by Heavy-Ion Irradiation to in Vivo Engineering by Genome Editing

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In vitro assessment of the antioxidative, toxicological and antimicrobial properties of battery of parabens

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Losing control

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Unscheduled polyploidy synergizes with oncogenic mutations to enhance genome instability and tumorigenesis

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Gene amplifications and extrachromosomal circular DNAs: function and biogenesis

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Using large-scale genome variation cohorts to decipher the molecular mechanism of cancer

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High Rate of Mutation and Efficient Removal by Selection of Structural Variants From Natural Populations of Caenorhabditis Elegans

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Crosstalk between tumor and microenvironment: Insights from spatial transcriptomics

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