The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cancer Genomes Evolve by Pulverizing Single Chromosomes
Open accessAbstract
A report in this issue describes "chromothripsis," a new mechanism for genetic instability in cancer cells. Chromothripsis appears to be a cataclysmic event in which a single chromosome is fragmented and then reassembled. The phenomenon raises important questions of how chromosome rearrangements can be confined to defined genome segments.
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“Over the past decade, we and others have highlighted that not only SNVs and indels but also SVs and CNVs represent a significant portion of the genetic variation responsible for clinical phenotypes70,71, such as cancer and rare genetic disorders.”
From Comprehensive genome analysis and variant detection at scale using DRAGEN (2025) · cites this paper as [71]
Citations
Cites
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Massive genomic rearrangement acquired in a single catastrophic event during cancer development
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THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS
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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
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Self-citationMammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis
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Linking functional decline of telomeres, mitochondria and stem cells during ageing
Sahin, E., & DePinho, R. A. (2010) · Nature · doi:10.1038/nature08982 · Cited by 759
Telomeres and chromosome instability
Murnane, J. P. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.030 · Cited by 178
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Pampalona, J., Soler, D., Genescà, A., & Tusell, L. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.10.001 · Cited by 69
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Cannan, W. J., & Pederson, D. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.06208-7 · Cited by 2
Molecular Pathology of Osteosarcoma
Bell, W. C., & Siegal, G. P. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374895-9.00016-5 · Cited by 1
Chromothripsie, et pourquoi pas chromosomothripsie ?
Samson, J. (2012) · Médecine Buccale Chirurgie Buccale · doi:10.1051/mbcb/2012015
de Almeida, D. C. N. (2014) · Americanae (AECID Library)
Mutations in Adenomatous Polyposis Coli, Their Role in Cytoskeletal Dynamics and Cancer Onset
Davies, A. E., & Kaplan, K. B. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2904-7_9
The inheritance of heterogeneity
Regan, & Sarah, S. (2015)
Prinzipien der Pathologie in der Onkologie
Gaiser, T., & Tannapfel, A. (2021) · Springer Reference Medizin · doi:10.1007/978-3-662-46764-0_146-1
Rajan, S., Zaccaria, S., Cannon, M. V., Cam, M., Gross, A. C., Raphael, B. J., & Roberts, R. D. (2023) · doi:10.1158/2767-9764.c.6551261
The use of acupuncture in radiation-induced complications among cancer patients
Joubert, K. S. (2023) · Complementary Medicine Education and Research · doi:10.62415/vmij7249
Mathematical Methods for Modelling Biological Heterogeneity
Hodgkinson, A. (2019) · theses.fr (ABES) · doi:10.70675/e9459bf2ze8f3z459cz9c28zf5629cbbd949
Chiarle, R., Cheong, T.-C., Wang, Q., Jang, A., Atabay, E. K., & Lee, J. (2026) · Research Square · doi:10.21203/rs.3.rs-9060910/v1
Metadata
- Authors
- Meyerson, M., & Pellman, D.
- Affiliations
- Broad Institute (US)
- Boston Children's Hospital (US)
- Corresponding author
- Meyerson, Matthew
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 144
- Issue
- 1
- Pages
- 9-10
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2165664339
- Cited by
- 115
- References
- 10
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 13 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 6
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- chromothripsis, chromosomal instability, chromosome fragmentation, chromosomal rearrangements, cancer genome, genome evolution
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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