Cancer Genomes Evolve by Pulverizing Single Chromosomes

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

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THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

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Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

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Linking functional decline of telomeres, mitochondria and stem cells during ageing

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Telomeres and chromosome instability

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Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

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Structural variant calling: the long and the short of it

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Criteria for Inference of Chromothripsis in Cancer Genomes

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Mechanisms and Consequences of Double‐Strand DNA Break Formation in Chromatin

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Chromothripsis and cancer: causes and consequences of chromosome shattering

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The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

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Micronucleus Assay: The State of Art, and Future Directions

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Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangementsPreprint

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CHO Quasispecies—Implications for Manufacturing Processes

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Linking genomic reorganization to tumor initiation via the giant cell cycle

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Mechanisms of Genomic Instability in Breast Cancer

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Landscape of gene fusions in epithelial cancers: seq and ye shall find

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Whole-exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations

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Comprehensive genome analysis and variant detection at scale using DRAGEN

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Genome chaos: Survival strategy during crisis

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Chromosomal instability as a driver of cancer progression

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Functional mechanisms and abnormalities of the nuclear lamina

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Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens

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Chromothripsis in acute myeloid leukemia: biological features and impact on survival

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Genome evolution during progression to breast cancerPreprint

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Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

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Characterizing complex structural variation in germline and somatic genomes

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The consequences of structural genomic alterations in humans: Genomic Disorders, genomic instability and cancer

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Genome‐wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma

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Evolutionary Mechanisms and Diversity in Cancer

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Decoding the genome beyond sequencing: The new phase of genomic research

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G2/M-Phase Checkpoint Adaptation and Micronuclei Formation as Mechanisms That Contribute to Genomic Instability in Human Cells

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Micronuclear collapse from oxidative damage

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Evolutionary mechanism unifies the hallmarks of cancer

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Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability

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Chromosomal rearrangements in cancer

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On the Complexity of Mechanisms and Consequences of Chromothripsis: An Update

Koltsova, A. S., Pendina, A. A., Efimova, O. A., Chiryaeva, O. G., Kuznetzova, T. V., & Баранов, В. С. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00393 · Cited by 72

Chromothripsis: potential origin in gametogenesis and preimplantation cell divisions. A review

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Biogenesis of micronuclei

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Chromosomal Instability in Cell-Free DNA Is a Serum Biomarker for Prostate Cancer

Schütz, E., Akbari, M. R., Beck, J., Urnovitz, H. B., Zhang, W., Bornemann-Kolatzki, K., Mitchell, W. M., Nam, R. K., & Narod, S. A. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2014.226571 · Cited by 50

CTLPScanner: a web server for chromothripsis-like pattern detection

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New Insights in the Cytogenetic Practice: Karyotypic Chaos, Non-Clonal Chromosomal Alterations and Chromosomal Instability in Human Cancer and Therapy Response

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Challenges in studying genomic structural variant formation mechanisms: The short‐read dilemma and beyond

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Chromothripsis: Breakage-fusion-bridge over and over again

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Telomerase and hallmarks of cancer: An intricate interplay governing cancer cell evolution

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Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences

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Chromothripsis Is a Recurrent Genomic Abnormality in High-Risk Myelodysplastic Syndromes

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Cancer heterogeneity: converting a limitation into a source of biologic information

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Gene Amplification and the Extrachromosomal Circular DNA

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Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity

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Genes, Proteins, and Biological Pathways Preventing Chromothripsis

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Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time

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Chromothripsis under the microscope: a cytogenetic perspective of two cases of AML with catastrophic chromosome rearrangement

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Transient hypermutability, chromothripsis and replication-based mechanisms in the generation of concurrent clustered mutations

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Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover

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Targeting the IGF/PI3K/mTOR pathway and AXL/YAP1/TAZ pathways in primary bone cancer

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Whole‐genome sequencing reveals complex chromosome rearrangement disrupting NIPBL in infant with Cornelia de Lange syndrome

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The Landscape of Somatic Copy Number Alterations in Head and Neck Squamous Cell Carcinoma

Yang, J., Chen, Y., Luo, H., & Cai, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00321 · Cited by 26

Extrachromosomal Circular DNA: A New Target in Cancer

Wu, P., Liu, Y., Zhou, R., Liu, L., Zeng, H., Xiong, F., Zhang, S., Gong, Z., Zhang, W., Guo, C. J., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.814504 · Cited by 25

From Human Cytogenetics to Human Chromosomics

Liehr, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040826 · Cited by 25

Cancer Genomic Rearrangements and Copy Number Alterations from Errors in Cell Division

Zhang, C., & Pellman, D. S. (2022) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070620-094029 · Cited by 23

The antagonistic relationship between apoptosis and polyploidy in development and cancer

Herriage, H. C., Huang, Y., & Calvi, B. R. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.05.009 · Cited by 26

A Comparative Genomics Approach to Understanding Transmissible Cancer in Tasmanian Devils

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Revisiting characteristics of oncogenic extrachromosomal DNA as mobile enhancers on neuroblastoma and glioma cancers

Fath, M. K., Karimfar, N., Naghibi, A. F., Shafa, S., Shiran, M. G., Ataei, M., Dehghanzadeh, H., Nabi‐Afjadi, M., Ghadiri, T., Payandeh, Z., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02617-8 · Cited by 21

Spatio-Genetic and Phenotypic Modelling Elucidates Resistance and Re-Sensitisation to Treatment in Heterogeneous Melanoma

Hodgkinson, A., Cam, L. L., Trucu, D., & Radulescu, O. (2018) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2018.11.037 · Cited by 21

Comprehensive identification and characterization of somatic copy number alterations in triple‑negative breast cancer

Li, Z., Zhang, X., Hou, C., Zhou, Y., Chen, J., Cai, H., Ye, Y., Liu, J., & Huang, N. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4950 · Cited by 20

Pathways to chromothripsis

Ivkov, R., & Bunz, F. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1068483 · Cited by 15

Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model

de Groot, D., Spanjaard, A., Hogenbirk, M. A., & Jacobs, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010794 · Cited by 15

Mechanisms underlying genome instability mediated by formation of foldback inversions in Saccharomyces cerevisiae

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Genomic imbalance analysis provides new insight into prognostic factors in adult and pediatric T-ALL

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Emerging trends and converging evidence in tumor evolution: A comprehensive review

Jin, C., Li, W., Liu, B., Cao, L.-Q., Stefan, S. M., Yuan, L., Yu, X., Shi, L., & Yu, H. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101380 · Cited by 12

Homologous recombination defects and how they affect replication fork maintenance

Son, M. Y., & Hasty, P. (2018) · Global Medical Genetics · doi:10.3934/genet.2018.4.192 · Cited by 14

Lechromothripsis

Pellestor, F., Gâtinois, V., Puechberty, J., Geneviève, D., & Lefort, G. (2014) · médecine/sciences · doi:10.1051/medsci/20143003014 · Cited by 11

Deep learning in variant detection and annotation

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Chromothripsis in acute myeloid leukemia: Biological features and impact on survival

Fontana, M. C., Marconi, G., Feenstra, J. D. M., Fonzi, E., Papayannidis, C., di Rorá, A. G. L., Padella, A., Solli, V., Franchini, E., Ottaviani, E., et al. (2017) · Leukemia · doi:10.1038/leu.2017.351 · Cited by 9

Complex Chromosomal Rearrangements in B-Cell Lymphoma: Evidence of Chromoanagenesis? A Case Report

Ortega, V., Chaubey, A., Mendiola, C., Ehman, W., Vadlamudi, K., DuPont, B. R., & Velagaleti, G. V. N. (2016) · Neoplasia · doi:10.1016/j.neo.2016.02.004 · Cited by 9

Stretching, scrambling, piercing and entangling: Challenges for telomeres in mitotic and meiotic chromosome segregation

Hou, H., & Cooper, J. P. (2018) · Differentiation · doi:10.1016/j.diff.2018.01.002 · Cited by 10

Constitutional Chromoanagenesis of Distal 13q in a Young Adult with Recurrent Strokes

Burnside, R. D., Harris, A., Speyer, D., Burgin, W. S., Rose, D. Z., & Sanchez‐Valle, A. (2016) · Cytogenetic and Genome Research · doi:10.1159/000452144 · Cited by 8

Structurally complex osteosarcoma genomes exhibit limited heterogeneity within individual tumors and across evolutionary time

Rajan, S., Zaccaria, S., Cannon, M. V., Cam, M., Gross, A. C., Raphael, B. J., & Roberts, R. D. (2021) · doi:10.1101/2021.08.30.458268 · Cited by 33

ChromothripsisDB: A Curated Database for the Documentation, Visualization, and Mining of Chromothripsis Data

Cai, H. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7780-2_18 · Cited by 7

Cell-Free DNA, MicroRNAs, Proteins, and Peptides as Liquid Biopsy Biomarkers in Prostate Cancer and Bladder Cancer

Chen, H., Xu, C., Fang, Z., & Mao, S. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3346-5_11 · Cited by 6

Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo

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Chromosomal Rearrangement: From Induction by Heavy-Ion Irradiation to in Vivo Engineering by Genome Editing

Kazama, Y., Hirano, T., Abe, T., & Matsunaga, S. (2018) · CYTOLOGIA · doi:10.1508/cytologia.83.125 · Cited by 6

In vitro assessment of the antioxidative, toxicological and antimicrobial properties of battery of parabens

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Losing control

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Unscheduled polyploidy synergizes with oncogenic mutations to enhance genome instability and tumorigenesis

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Gene amplifications and extrachromosomal circular DNAs: function and biogenesis

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Using large-scale genome variation cohorts to decipher the molecular mechanism of cancer

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High Rate of Mutation and Efficient Removal by Selection of Structural Variants From Natural Populations of Caenorhabditis Elegans

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Crosstalk between tumor and microenvironment: Insights from spatial transcriptomics

Sudhakar, M., Vignesh, H., & Natarajan, K. N. (2024) · Advances in cancer research · doi:10.1016/bs.acr.2024.06.009 · Cited by 4

The In-Vitro Effect of Homeopathically Prepared Rubus idaeus and 680 nm Laser Irradiation on Cervical Cancer Cells

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Detection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma

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Molecular pathology of osteosarcoma

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PARP and Carcinogenesis

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Therapy-induced rapid drug resistance driven by genome chaos and polyploid giant cancer cells

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