The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cancer Genomes Evolve by Pulverizing Single Chromosomes
Open accessAbstract
A report in this issue describes "chromothripsis," a new mechanism for genetic instability in cancer cells. Chromothripsis appears to be a cataclysmic event in which a single chromosome is fragmented and then reassembled. The phenomenon raises important questions of how chromosome rearrangements can be confined to defined genome segments.
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“Over the past decade, we and others have highlighted that not only SNVs and indels but also SVs and CNVs represent a significant portion of the genetic variation responsible for clinical phenotypes70,71, such as cancer and rare genetic disorders.”
From Comprehensive genome analysis and variant detection at scale using DRAGEN (2025) · cites this paper as [71]
Citations
Cites
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Massive genomic rearrangement acquired in a single catastrophic event during cancer development
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THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS
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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
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Self-citationMammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis
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Linking functional decline of telomeres, mitochondria and stem cells during ageing
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Telomeres and chromosome instability
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Rausch, T., Jones, D. T. W., Zapatka, M., Stütz, A. M., Zichner, T., Weischenfeldt, J., Jäger, N., Remke, M., Shih, D., Northcott, P. A., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.013 · Cited by 865
Structural variant calling: the long and the short of it
Mahmoud, M., Gobet, N., Cruz-Dávalos, D. I., Mounier, N., Dessimoz, C., & Sedlazeck, F. J. (2019) · Genome Biology · doi:10.1186/s13059-019-1828-7 · Cited by 725
Criteria for Inference of Chromothripsis in Cancer Genomes
Korbel, J. O., & Campbell, P. J. (2013) · Cell · doi:10.1016/j.cell.2013.02.023 · Cited by 519
Mechanisms and Consequences of Double‐Strand DNA Break Formation in Chromatin
Cannan, W. J., & Pederson, D. S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25048 · Cited by 499
Chromothripsis and cancer: causes and consequences of chromosome shattering
Forment, J. V., Kaidi, A., & Jackson, S. P. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3352 · Cited by 393
Metadata
- Authors
- Meyerson, M., & Pellman, D.
- Affiliations
- Broad Institute (US)
- Boston Children's Hospital (US)
- Corresponding author
- Meyerson, Matthew
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 144
- Issue
- 1
- Pages
- 9-10
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2165664339
- Cited by
- 115
- References
- 10
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 13 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 6
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- chromothripsis, chromosomal instability, chromosome fragmentation, chromosomal rearrangements, cancer genome, genome evolution
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