The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae Virulence
Open accessAbstract
SUMMARY The function of the Vibrio 7th pandemic island-1 (VSP-1) in cholera pathogenesis has remained obscure. Utilizing ChIP-seq and RNA-seq to map the regulon of the master virulence regulator ToxT, we identify a TCP island encoded small RNA that reduces the expression of a previously unrecognized VSP-1 encoded transcription factor termed VspR. VspR modulates the expression of several VSP-1 genes including one that encodes a novel class of di-nucleotide cyclase (DncV), which preferentially synthesizes a previously undescribed hybrid cyclic AMP-GMP molecule. We show that DncV is required for efficient intestinal colonization and downregulates V. cholerae chemotaxis, a phenotype previously associated with hyperinfectivity. This pathway couples the actions of previously disparate genomic islands, defines VSP-1 as a pathogenicity island in V. cholerae and implicates its occurrence in 7th pandemic strains as a benefit for host adaptation through the production of a regulatory cyclic di-nucleotide.
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Self-citationSTING is a direct innate immune sensor of cyclic di-GMP
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Self-citation
Cited by
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
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CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.
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The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer
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Metadata
- Authors
- Davies, B. W., Bogard, R. W., Young, T. S., & Mekalanos, J. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 149
- Issue
- 2
- Pages
- 358-370
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2021364411
- Cited by
- 431
- References
- 37
- FWCI
- 18.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Davies, B. W., Bogard, R. W., Young, T. S., & Mekalanos, J. J. (2012). Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae Virulence. Cell. https://doi.org/10.1016/j.cell.2012.01.053
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