Alzheimer Mechanisms and Therapeutic Strategies

Huang, Yadong, Mucke, Lennart·2012·Cell

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Items 201–300 of 1,005

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  2. Nanotechnology-Based Drug Delivery Systems for Targeting, Imaging and Diagnosis of Neurodegenerative Diseases
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  3. Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease
    R. Alkallas, L. Fish, H. Goodarzi, H. Najafabadi · 2017 · Nature Communications
  4. Theories of Aging: An Ever-Evolving Field
    Сергиев Петр Владимирович, Olga А. Dontsova, Grigory V. Berezkin · 2015 · Acta Naturae
  5. High resolution dissection of reactive glial nets in Alzheimer’s disease
    Bouvier, David S., Jones, Emma V., Quesseveur, Gaël, Davoli, Maria Antonietta, A. Ferreira, Tiago, Quirion, Rémi, Mechawar, Naguib, Murai, Keith K. · 2016 · Scientific Reports
  6. Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APP swe/ PS 1dE9 mice
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  7. Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model
    Hui-Feng Mai, Weihao Fan, Yan Wang, Yu-Jie Cai, Xiaohui Li, Feng Chen, Xiongjin Chen, Jing-Qi Yang, Pei Tang, Hui-Yi Chen et al. · 2019 · Molecular Therapy: Nucleic Acids
  8. Near-Infrared Light-Powered Janus Nanomotor Significantly Facilitates Inhibition of Amyloid-β Fibrillogenesis
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  9. Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data
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  11. Apolipoprotein E4 Causes Age- and Sex-Dependent Impairments of Hilar GABAergic Interneurons and Learning and Memory Deficits in Mice
    Leung, Laura, Andrews-Zwilling, Yaisa, Yoon, Seo Yeon, Jain, Sachi, Ring, Karen, Dai, Jessica, Wang, Max Mu, Tong, Leslie, Walker, David, Huang, Yadong · 2012 · PLoS ONE
  12. Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway
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  13. Executive Function Changes before Memory in Preclinical Alzheimer’s Pathology: A Prospective, Cross-Sectional, Case Control Study
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  14. Lactate metabolism in neurodegenerative diseases
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  15. Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6
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  16. Protective Effects of Ferulic Acid in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mouse Model of Alzheimer Disease
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  17. Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology
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  18. Purinergic receptors as potential therapeutic targets in Alzheimer's disease
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  19. Astroglia as a cellular target for neuroprotection and treatment of neuro‐psychiatric disorders
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  20. Advances in developing therapeutic strategies for Alzheimer's disease
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  21. Brilliant Blue G improves cognition in an animal model of Alzheimer’s disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons
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  22. GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer’s disease
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  23. Preparation and Evaluation of Phospholipid-Based Complex of Standardized Centella Extract (SCE) for the Enhanced Delivery of Phytoconstituents
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  24. Design of a Molecular Hybrid of Dual Peptide Inhibitors Coupled on AuNPs for Enhanced Inhibition of Amyloid β‐Protein Aggregation and Cytotoxicity
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  25. Recent Advances in Molecular Pathways and Therapeutic Implications Targeting Mitochondrial Dysfunction for Alzheimer’s Disease
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  26. β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors
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  27. Physiological β-amyloid clearance by the liver and its therapeutic potential for Alzheimer’s disease
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  28. Intermittent fasting protects against Alzheimer’s disease in mice by altering metabolism through remodeling of the gut microbiota
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  29. Microglia in Alzheimer’s disease: A target for immunotherapy
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  32. Review of the advances in treatment for Alzheimer disease: strategies for combating β-amyloid protein
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  33. A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse
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  34. Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function
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  35. Design, synthesis and evaluation of novel ferulic acid- O -alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease
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  36. Altered d -glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI
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  38. A Step into the Future: Applications of Nanoparticle Enzyme Mimics
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  40. ACE Inhibition with Captopril Retards the Development of Signs of Neurodegeneration in an Animal Model of Alzheimer’s Disease
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  41. Acat1 Knockdown Gene Therapy Decreases Amyloid-β in a Mouse Model of Alzheimer's Disease
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  42. Transient dynamics of Aβ contribute to toxicity in Alzheimer’s disease
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  43. Immunotherapy for Alzheimer's disease
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  46. Protective effects of flavonoids against Alzheimer’s disease-related neural dysfunctions
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  47. Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review
    Hena Khanam, Abad Ali, Mohd Asif, Shamsuzzaman · 2016 · European Journal of Medicinal Chemistry
  48. Antioxidant Berberine-Derivative Inhibits Multifaceted Amyloid Toxicity
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  49. The Essential Role of p53-up-regulated Modulator of Apoptosis (Puma) and Its Regulation by FoxO3a Transcription Factor in β-Amyloid-induced Neuron Death
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  50. Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy
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  51. The Gastrointestinal Tract Microbiome and Potential Link to Alzheimer’s Disease
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  52. Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice
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  53. Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteína β-amiloide
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  54. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer’s Disease Mouse Model
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  55. Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment
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  56. A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression
    Danielle A. Simmons, Juliet K. Knowles, Nadia P. Belichenko, Gargi Banerjee, Carly Finkle, Stephen M. Massa, Frank M. Longo · 2014 · PLoS ONE
  57. Cognitive deficits caused by prefrontal cortical and hippocampal neural disinhibition
    Tobias Bast, Marie A. Pezze, Stephanie McGarrity · 2017 · British Journal of Pharmacology
  58. Green Tea Consumption Affects Cognitive Dysfunction in the Elderly: A Pilot Study
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  59. A spiropyran-based fluorescent probe for the specific detection of β-amyloid peptide oligomers in Alzheimer's disease
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  60. Anti-Viral Properties of Amyloid-β Peptides
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  61. Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a
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  64. Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease
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  65. GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis
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  66. Circular RNA circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels via directly sponging miR-103 in Alzheimer’s disease
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  67. RETRACTED ARTICLE: Neuron tau-targeting biomimetic nanoparticles for curcumin delivery to delay progression of Alzheimer’s disease
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  89. Multipronged diagnostic and therapeutic strategies for Alzheimer's disease
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  90. Inflammation in Alzheimer’s Disease and Molecular Genetics: Recent Update
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  91. Impaired expression of GABA transporters in the human Alzheimer’s disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus
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  93. Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology
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